CN-121987768-A - Composition, preparation method thereof and application thereof in preparation of anti-aging products

Abstract

The application belongs to the technical field of anti-aging, and particularly discloses a composition, a preparation method thereof and application thereof in preparing a product with an anti-aging effect. The composition provided by the application has the effects of resisting aging from the core pathways of oxidative stress removal, cell damage repair, metabolism regulation, immunity enhancement and the like, realizes the synergistic effect of resisting aging by the way of pathway complementation, target spot synergy and function amplification, and effectively improves the anti-aging effect.

Inventors

• YUAN LING
• GE TING
• GONG YANHUI
• SUN ZHIMIN
• Chen Xiashi

Assignees

• 广东时代食品与生命健康研究有限公司

Dates

Publication Date

20260508

Application Date

20260203

Claims (10)

1. 1. The composition is characterized by comprising, by mass, 10-50 parts of SOD yeast powder, 5-30 parts of epigallocatechin gallate, 10-60 parts of Pleurotus citrinopileatus concentrate powder and 10-40 parts of phyllanthus emblica extract.
2. 2. The composition of claim 1, which is characterized by comprising, by mass, 20-40 parts of SOD yeast powder, 10-25 parts of epigallocatechin gallate, 20-50 parts of Pleurotus citrinopileatus concentrate powder and 15-35 parts of phyllanthus emblica extract.
3. 3. The composition of claim 1, wherein the phyllanthus emblica extract is prepared by the process of: (1) Pulverizing phyllanthus emblica to 50-400 meshes to obtain phyllanthus emblica powder; (2) Adding phyllanthus emblica powder into water, and then adding cellulase, papain and neutral protease for ultrasonic enzymolysis to obtain enzymolysis liquid; (3) Ultrafiltering the enzymolysis liquid with ultrafilter membrane with molecular weight cut-off of 500Da and ultrafilter membrane with molecular weight cut-off of 5000Da to obtain fructus Phyllanthi extract.
4. 4. The composition of claim 3, wherein the mass ratio of the phyllanthus emblica powder to the water is 1 (2-10).
5. 5. The composition according to claim 3, wherein the mass ratio of the phyllanthus emblica powder, the cellulase, the papain and the neutral protease is 1 (0.008-0.012): 0.005-0.01): 0.004-0.008.
6. 6. The composition of claim 3, wherein the ultrasonic enzymolysis is carried out at a temperature of 45-52 ℃ for a time of 1-4 hours.
7. 7. The composition of claim 3, wherein the power of the ultrasonic enzymolysis is 200-600 w.
8. 8. The composition of claim 1, wherein the mass ratio of the concentrated powder of Pleurotus citrinopileatus and the extract of Phyllanthus emblica is 1 (1.2-1.75).
9. 9. A method of preparing the composition of any one of claims 1 to 8, comprising the steps of: Mixing SOD yeast powder, epigallocatechin gallate, concentrated powder of Pleurotus Citrinopileatus Sing and fructus Phyllanthi extract uniformly to obtain the composition.
10. 10. Use of a composition according to any one of claims 1 to 8 for the preparation of a product having an anti-ageing effect.

Description

Composition, preparation method thereof and application thereof in preparation of anti-aging products Technical Field The invention relates to the technical field of anti-aging, in particular to a composition, a preparation method thereof and application thereof in preparing products with anti-aging effect. Background Aging is a complex biological process in which body function gradually declines with age, and is a major risk factor for many chronic diseases (e.g., neurodegenerative diseases, cardiovascular diseases, diabetes, etc.). Therefore, the development of an intervention strategy capable of delaying aging and prolonging the health life (HEALTHSPAN) has great scientific and social significance. Currently, the field of anti-aging research has found a variety of potential pathways and substances, such as caloric restriction mimics (e.g., bailu alcohols), NAD + precursors (e.g., NMN), sirolimus target protein (mTOR) inhibitors, and the like. However, these materials either have low bioavailability or have potential side effects or are costly, limiting their wide application. In addition, many traditional antioxidants (e.g., single vitamins C, E) failed to exhibit a clear life-prolonging effect in clinical trials suggesting that single-target intervention strategies may be of limited efficacy. On the other hand, the search for safe and effective anti-aging components from natural products is a current research hotspot. In view of this, the present application has been proposed. Disclosure of Invention The invention provides a composition, a preparation method thereof and application thereof in preparing products with anti-aging effect, wherein the composition has excellent anti-aging effect. The invention solves the technical problems by adopting the following technical scheme: The composition comprises, by mass, 10-50 parts of SOD yeast powder, 5-30 parts of epigallocatechin gallate, 10-60 parts of Pleurotus citrinopileatus concentrate powder and 10-40 parts of phyllanthus emblica extract. The SOD yeast powder is a key speed limiting enzyme for eliminating superoxide anion free radicals in organisms, and can be used as a carrier to improve the bioavailability of SOD and block aging-related reactions such as lipid peroxidation, DNA oxidative damage, protein crosslinking and the like caused by the free radicals. The epigallocatechin gallate is a core active ingredient of green tea polyphenol, has strong reducibility and multi-target binding capacity, can directly remove various ROS such as hydroxyl radicals and singlet oxygen, induces the expression of endogenous antioxidant enzymes such as CAT, GSH-Px and the like, can inhibit the activity reduction of telomerase and the expression of beta-galactosidase (SA-beta-gal) related to cell aging, and can delay the replicative aging of cells. The Pleurotus citrinopileatus concentrate powder is a medicinal and edible fungi, can activate immunocyte activities such as macrophages and NK cells, enhance the capability of an organism to clear aging-related pathogens, promote cell mitochondrial function repair, promote ATP generation efficiency and improve energy metabolism disorder of aging cells. The phyllanthus emblica extract can remove intracellular ROS, promote the activity of DNA repair enzyme, reduce the probability of gene mutation caused by free radicals, and delay cell aging. The composition has excellent anti-aging effect by combining the raw materials, and the composition respectively plays roles in anti-aging core channels such as oxidative stress removal, cell damage repair, metabolism regulation and control, immune enhancement and the like, realizes the synergistic effect of anti-aging by the way of channel complementation, target point coordination and function amplification, and effectively improves the anti-aging effect. The application relates to a preferred embodiment, which comprises, by mass, 20-40 parts of SOD yeast powder, 10-25 parts of epigallocatechin gallate, 20-50 parts of Pleurotus citrinopileatus concentrate powder and 15-35 parts of phyllanthus emblica extract. As a preferred embodiment of the present application, the preparation method of the phyllanthus emblica extract comprises: (1) Pulverizing phyllanthus emblica to 50-400 meshes to obtain phyllanthus emblica powder; (2) Adding phyllanthus emblica powder into water, and then adding cellulase, papain and neutral protease for ultrasonic enzymolysis to obtain enzymolysis liquid; (3) Ultrafiltering the enzymolysis liquid with ultrafilter membrane with molecular weight cut-off of 500Da and ultrafilter membrane with molecular weight cut-off of 5000Da to obtain fructus Phyllanthi extract. As a preferred embodiment of the application, the mass ratio of the phyllanthus emblica powder to the water is 1 (2-10). As a preferred embodiment of the application, the mass ratio of the phyllanthus emblica powder to the cellulase to the papain to the neutral protease is 1 (0.008-0.012): 0.005-0.01): 0.