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CN-121987834-A - Composite function degradable optical fiber and preparation method and application thereof

CN121987834ACN 121987834 ACN121987834 ACN 121987834ACN-121987834-A

Abstract

The invention relates to the technical field of medical implantable optical and electrical integrated devices, in particular to a composite function degradable optical fiber and a preparation method and application thereof. The composite function degradable optical fiber provided by the invention has the characteristics of biodegradability and high flexibility, can avoid permanent foreign body reaction, and greatly improves biocompatibility. The composite function degradable optical fiber provided by the invention realizes the PBM and PDT internal cooperative treatment driven by a single near infrared light source based on the unique physical characteristics of the up-conversion nano particles. The composite function degradable optical fiber integrates a 'treatment-feedback' closed loop system architecture of minimally invasive monitoring, and provides a good hardware basis for realizing self-adaptive treatment. The composite functional degradable optical fiber provided by the invention can be used in the field of medical implantation instruments, the field of nerve engineering or the field of biological materials, and particularly can be used in brain implantation materials or brain degenerative disease self-adaptive treatment systems.

Inventors

  • SHI XIN
  • WANG TIANHUA
  • Wolfgang Newberg

Assignees

  • 浙江赛瑞欧光电有限公司

Dates

Publication Date
20260508
Application Date
20260318

Claims (10)

  1. 1. The composite functional degradable optical fiber is characterized by comprising a minimally invasive conductive monitoring core and a functional outer cladding coated on the surface of the minimally invasive conductive monitoring core; The minimally invasive conductive monitoring core comprises a gold wire; the functional outer cladding comprises polylactic acid, a plasticizer and up-conversion luminescent nano particles with polyethylene glycol-silicon dioxide composite materials modified on the surfaces; The surface is modified with up-conversion luminescent nano particles of polyethylene glycol-silicon dioxide composite materials, and the up-conversion luminescent nano particles, silicon dioxide coated on the surfaces of the up-conversion luminescent nano particles and polyethylene glycol coated on the surfaces of the silicon dioxide are sequentially included from inside to outside.
  2. 2. The composite function degradable optical fiber of claim 1, wherein the diameter of the gold wire is 50-80 μm, and the purity is not lower than 99.99%; The number of the gold wires is 1; The gold wire is medical gold wire.
  3. 3. The composite function degradable optical fiber of claim 1, wherein the polylactic acid has a crystallinity of less than 1%; The polylactic acid is racemized polylactic acid; the weight average molecular weight of the polylactic acid is 8-10 ten thousand.
  4. 4. The composite function degradable optical fiber of claim 1, wherein the plasticizer is medical grade tributyl citrate; the plasticizer accounts for 5-8wt% of the functional outer wrapping layer.
  5. 5. The composite function degradable optical fiber of claim 1, wherein in the upconversion luminescent nanoparticle with polyethylene glycol-silica composite material modified on the surface, the upconversion luminescent nanoparticle is NaYF 4 :Yb 3+ ,Tm 3+ nanoparticle; The excitation wavelength of the up-conversion luminescence nano particles is 808nm, and the emission wavelength is 450-480 nm; The particle size of the up-conversion luminescence nano particles with the surface modified by the polyethylene glycol-silicon dioxide composite material is 50-80 nm; the up-conversion luminescent nano particles with the surface modified by the polyethylene glycol-silicon dioxide composite material account for 1-3wt% of the functional outer cladding.
  6. 6. The composite functional degradable optical fiber of claim 1, wherein the mass ratio of the minimally invasive conductive monitoring core to the functional outer cladding is 1:8-20; the outer diameter of the composite function degradable optical fiber is 200-250 mu m.
  7. 7. The method for preparing the composite functional degradable optical fiber according to any one of claims 1 to 6, which is characterized by comprising the following steps: (1) Mixing up-conversion luminescent nano particles with surfaces modified by polyethylene glycol-silicon dioxide composite materials and part of polylactic acid for the first time to obtain master batch; (2) Shearing, melting and mixing the master batch, the plasticizer and the rest polylactic acid to obtain a molten material; (3) And extruding and coating the molten material on the minimally invasive conductive monitoring core, and shaping to obtain the composite function degradable optical fiber.
  8. 8. The method of claim 7, wherein the shaping is followed by annealing; The annealing temperature is 45-55 ℃, and the annealing time is 10-30 minutes.
  9. 9. The use of a composite functional degradable optical fiber according to any one of claims 1 to 6 or the composite functional degradable optical fiber obtained by the preparation method according to claim 8 in the field of medical implantation instruments, in the field of nerve engineering or in the field of biological materials.
  10. 10. A multi-functional implantable optical fiber system comprising an implant unit and an external unit connected to the implant unit; The implantation unit comprises the composite function degradable optical fiber of any one of claims 1-6 or the composite function degradable optical fiber obtained by the preparation method of any one of claims 7-8; The external unit comprises a near infrared laser source, a signal processing module and a control unit, and the control unit adjusts the output parameters of the near infrared laser source according to signal feedback acquired by the minimally invasive conductive monitoring core; the composite function degradable optical fiber is respectively connected with the near infrared laser source and the signal processing module, the signal processing module is connected with one end of the control unit, and the other end of the control unit is connected with the near infrared laser source.

Description

Composite function degradable optical fiber and preparation method and application thereof Technical Field The invention relates to the technical field of medical implantable optical and electrical integrated devices, in particular to a composite function degradable optical fiber and a preparation method and application thereof. Background Currently, medical implantable optical and electrical integrated devices, particularly brain implantable devices, mainly suffer from the following drawbacks: the function is single, lack of synergy, that is, the existing brain implantable device only supports a single mode (such as only electrical stimulation or optical stimulation), the time sequence and space synergy of photo-biological regulation (PBM) and photodynamic therapy (PDT) can not be realized, and the treatment effect is limited; The material has insufficient biocompatibility, the main brain implantable device adopts non-degradable silicon-based or glass-based materials (such as composite glass optical fiber disclosed in Chinese patent CN 113900185A) as permanent foreign matters, chronic inflammation and colloid scars are easy to cause after long-term implantation, and the rigidity and soft brain tissue are mechanically mismatched; Most of brain implantable devices are open loop systems, and the treatment parameters cannot be dynamically adjusted according to the real-time physiological response of brain tissues, so that the risk of insufficient treatment or damage to normal tissues exists; The system is complex, and in order to realize multi-mode treatment, a complex external system with multiple light sources and multiple channels is often needed, so that the system is large in volume and high in cost. Therefore, how to realize the functions of diversity cooperation, good biocompatibility and synchronous treatment and monitoring on the premise of avoiding complex systems is a problem to be solved urgently by the technicians in the field. Disclosure of Invention In view of the above, the invention provides a composite-function degradable optical fiber, a preparation method and application thereof, and the composite-function degradable optical fiber provided by the invention has the advantages of various and synergistic functions, good biocompatibility, synchronous treatment and monitoring and capability of simplifying the system to a great extent. The invention provides a composite functional degradable optical fiber which comprises a minimally invasive conductive monitoring core and a functional outer cladding coated on the surface of the minimally invasive conductive monitoring core, wherein the minimally invasive conductive monitoring core comprises gold wires, the components of the functional outer cladding comprise polylactic acid, a plasticizer and up-conversion luminescent nanoparticles with polyethylene glycol-silicon dioxide composite materials modified on the surfaces, and the up-conversion luminescent nanoparticles with the polyethylene glycol-silicon dioxide composite materials modified on the surfaces sequentially comprise the up-conversion luminescent nanoparticles, silicon dioxide coated on the surfaces of the up-conversion luminescent nanoparticles and polyethylene glycol coated on the surfaces of the silicon dioxide from inside to outside. Preferably, the diameter of the gold wire is 50-80 mu m, the purity is not lower than 99.99%, the number of the gold wires is 1, and the gold wire is medical gold wire. Preferably, the crystallinity of the polylactic acid is less than 1%, the polylactic acid is racemized polylactic acid, and the weight average molecular weight of the polylactic acid is 8-10 ten thousand. Preferably, the plasticizer is medical tributyl citrate, and the plasticizer accounts for 5-8wt% of the functional outer wrapping layer. Preferably, in the up-conversion luminescent nano particles with the surface modified polyethylene glycol-silicon dioxide composite material, the up-conversion luminescent nano particles are NaYF 4:Yb3+,Tm3+ nano particles, the excitation wavelength of the up-conversion luminescent nano particles is 808nm, the emission wavelength of the up-conversion luminescent nano particles is 450-480 nm, the particle size of the up-conversion luminescent nano particles with the surface modified polyethylene glycol-silicon dioxide composite material is 50-80 nm, and the mass ratio of the up-conversion luminescent nano particles with the surface modified polyethylene glycol-silicon dioxide composite material to the functional outer cladding is 1-3wt%. The emission wavelength of the up-conversion luminescent nanoparticle corresponds to blue light. Preferably, the mass ratio of the minimally invasive conductive monitoring core to the functional outer cladding is 1:8-20, and the outer diameter of the composite functional degradable optical fiber is 200-250 mu m. The invention also provides a preparation method of the composite functional degradable optical fiber, which com