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CN-121987839-A - Medical surgical suture and preparation method thereof

CN121987839ACN 121987839 ACN121987839 ACN 121987839ACN-121987839-A

Abstract

The invention belongs to the technical field of biomedical materials, and particularly relates to a medical surgical suture and a preparation method thereof. The preparation method of the medical surgical suture comprises the following steps of S1, dissolving alkenyl-terminated hyperbranched polylactic acid and benzoyl peroxide in an organic solvent to form a core spinning solution, S2, dissolving polyvinyl alcohol powder to obtain a polyvinyl alcohol solution, dissolving polyvinyl alcohol-styrylpyridinium salt to obtain a SbQ-PVA solution, mixing the polyvinyl alcohol solution and the SbQ-PVA solution, adding zinc oxide quantum dots to mix uniformly to obtain a skin spinning solution, S3, carrying out coaxial electrostatic spinning on the core spinning solution and the skin spinning solution to obtain a fiber film, carrying out post-treatment on the fiber film, cutting into strips, twisting and forming to obtain the medical surgical suture. The invention can obviously improve the breaking strength of the suture line and has excellent antibacterial rate.

Inventors

  • FAN HAIYANG
  • ZHANG QIWEI
  • ZHANG JUNHANG
  • LI YUN
  • SHI DONGLEI
  • HU LIU

Assignees

  • 中山大学附属第七医院(深圳)

Dates

Publication Date
20260508
Application Date
20260202

Claims (10)

  1. 1. A preparation method of a medical surgical suture is characterized in that, Coaxially and electrostatically spinning the prepared core spinning solution and the prepared skin spinning solution to obtain a fiber membrane, performing aftertreatment on the fiber membrane, cutting into strips, twisting and forming to obtain a medical surgical suture; The preparation method of the core spinning solution comprises the steps of dissolving alkenyl-terminated hyperbranched polylactic acid and benzoyl peroxide in an organic solvent to form the core spinning solution; Firstly, preparing hyperbranched polylactic acid by taking DL-lactic acid and glycerol as raw materials, and then, carrying out alkenylation treatment on the hyperbranched polylactic acid by using acryloyl chloride to obtain the terminal alkenyl hyperbranched polylactic acid; The preparation method of the cortex spinning solution comprises the steps of dissolving polyvinyl alcohol powder to obtain a polyvinyl alcohol solution, dissolving polyvinyl alcohol-styrylpyridinium salt to obtain a SbQ-PVA solution, mixing the polyvinyl alcohol solution and the SbQ-PVA solution, adding zinc oxide quantum dots, and uniformly mixing to obtain the cortex spinning solution.
  2. 2. The method for preparing a surgical suture as claimed in claim 1, wherein, The hyperbranched polylactic acid is prepared by the steps of pre-polymerizing 80-100 parts by weight of DL-lactic acid at 110-120 ℃ for 120-180 min, adding 3-5 parts by weight of glycerol, 0.32-0.36 part by weight of stannous chloride and 0.32-0.36 part by weight of p-toluenesulfonic acid, heating to 140-150 ℃ for reaction for 3-4 h, heating to 170-180 ℃ for reaction for 2-4 h, and steaming with dichloromethane dissolved products after the reaction is completed to obtain the hyperbranched polylactic acid.
  3. 3. The preparation method of the medical surgical suture line according to claim 1 or 2 is characterized in that the alkenyl treatment comprises the steps of dissolving 70-80 parts by weight of hyperbranched polylactic acid in 400-500 parts by weight of methylene dichloride, adding 10-12 parts by weight of triethylamine under the ice bath condition, then dropwise adding a mixed solution of 10-12 parts by weight of acryloyl chloride and 20-24 parts by weight of methylene dichloride, carrying out alkenyl treatment for 12-16 hours under the condition of 30-40 ℃, carrying out suction filtration, separating liquid, and carrying out rotary evaporation on an organic phase to obtain the alkenyl-terminated hyperbranched polylactic acid.
  4. 4. The method for preparing a surgical suture as claimed in claim 1, wherein, The preparation method of the polyvinyl alcohol solution comprises the steps of adding 20-30 parts by weight of polyvinyl alcohol powder into 90-100 parts by weight of deionized water, stirring for 2-4 hours at 80-90 ℃, and cooling to obtain the polyvinyl alcohol solution.
  5. 5. The method for preparing a surgical suture as claimed in claim 1, wherein, The preparation method of the SbQ-PVA solution comprises the steps of uniformly mixing 20-24 parts of glacial acetic acid and 90-100 parts of deionized water by weight, adding 10-15 parts of polyvinyl alcohol-styrylpyridinium salt, and stirring for 4-6 hours to obtain the SbQ-PVA solution.
  6. 6. The method for preparing a medical surgical suture according to claim 1, wherein the zinc oxide quantum dot is a rare earth doped zinc oxide quantum dot; The preparation method of the rare earth doped zinc oxide quantum dot comprises the steps of adding zinc acetate and rare earth salt into absolute ethyl alcohol, mixing and stirring, and then adding lithium hydroxide for stirring reaction to obtain the rare earth doped zinc oxide quantum dot.
  7. 7. The method for preparing a surgical suture as claimed in claim 6, wherein, The preparation method of the rare earth doped zinc oxide quantum dot specifically comprises the steps of adding 2.2-2.6 parts by weight of zinc acetate and 0.11-0.13 part by weight of rare earth salt into 100-120 parts by weight of absolute ethyl alcohol, and carrying out reflux stirring for 100-120 min at 70-80 ℃ to obtain zinc acetate mixed solution; Adding 0.22-0.24 part of lithium hydroxide into 140-150 parts of absolute ethyl alcohol, refluxing and stirring for 100-120 min at 75-85 ℃, cooling to room temperature, dropwise adding the zinc acetate mixed solution, stirring and reacting for 8-10 h under the ice bath condition, adding 40-50 parts of n-hexane for precipitation after the reaction is completed, centrifuging, and vacuum drying to obtain the rare earth doped zinc oxide quantum dots.
  8. 8. The method for preparing a surgical suture as claimed in claim 7, wherein, The rare earth salt is selected from one or more of lanthanum nitrate, neodymium nitrate and terbium nitrate.
  9. 9. The method for preparing a surgical suture as claimed in claim 1, wherein, The post-treatment comprises the steps of immersing the fiber membrane in a constant-temperature water bath at 80-90 ℃ for 4-6 hours under the nitrogen atmosphere, and taking out and drying.
  10. 10. A medical surgical suture prepared by the preparation method of any one of claims 1 to 9.

Description

Medical surgical suture and preparation method thereof Technical Field The invention belongs to the technical field of biomedical materials, and particularly relates to a medical surgical suture and a preparation method thereof. Background The surgical suture has a key role in closing damaged tissues and promoting wound healing after operation. With the development of minimally invasive and refined medical technology and surgery, the clinical requirements on surgical sutures are also increasing. Foreign body reactions and excessive fibrosis may occur after surgical suture implantation, resulting in inflammatory reactions of the wound surface, delaying the wound healing process. In addition, bacterial infection of the wound surface after surgery may limit the suturing effect. Therefore, the innovative surgical suture should be adapted to the biological properties of tissue healing, have better biocompatibility, higher strength, lower risk of infection and stronger healing repair capability. In recent years, development of novel surgical sutures has been significantly advanced in the fields of materials, structures, functional and intelligent designs, and the like. Bioactive components and drugs have been applied to surgical sutures to achieve antimicrobial, inflammatory regulation, scar elimination, etc. functions by surface coating, directional loading, and other means to modify the surgical suture. With the continuous progress of the chemical industry, the development and processing level of polymers are gradually improved, and the research progress of synthetic sutures is promoted. In the last 30 th century, the first synthetic suture derived from polyvinyl alcohol was developed, and the 50 th polyester suture was synthesized for the first time. After that, a series of sutures based on fiber materials such as polylactic acid, polyamide, polypropylene, polyglycolide, etc. are successively introduced, and synthetic materials are becoming mainstream products due to their good stability and biocompatibility relative to natural materials. The polylactic acid is widely applied to medical surgical suture lines, but the polylactic acid-based surgical suture lines in the prior art have the problems of insufficient mechanical property and to-be-improved antibacterial property. Therefore, a medical surgical suture is urgently needed, and not only can the breaking strength of the suture be remarkably improved, but also the medical surgical suture has excellent antibacterial efficiency. Disclosure of Invention Aiming at the defects of the prior art, the invention aims to provide a medical surgical suture and a preparation method thereof, wherein the suture is prepared by designing components, introducing functional components such as antibacterial nano particles and the like and matching with an electrostatic spinning technology, so that the breaking strength of the suture can be remarkably improved, and the antibacterial efficiency is excellent. The invention prepares the sheath-core structure fiber material through coaxial electrostatic spinning, wherein the core layer material is alkenyl-terminated hyperbranched polylactic acid, the sheath layer material contains rare earth doped zinc oxide quantum dots, polyvinyl alcohol and polyvinyl alcohol-styrylpyridinium salt, then the sheath layer material and the core layer material are subjected to a post-treatment procedure of constant-temperature water bath, free radical polymerization is initiated, a micro-nano rough structure is constructed on the surface, and finally the sheath layer material is cut into strips and twisted to form, so that the medical surgical suture with good mechanical property and antibacterial property is obtained. In a first aspect of the invention, a preparation method of a medical surgical suture is provided, wherein a pre-prepared core spinning solution and a pre-prepared skin spinning solution are subjected to coaxial electrostatic spinning to obtain a fiber membrane, the fiber membrane is subjected to post-treatment, and then cut into strips and twisted to form the medical surgical suture; The preparation method of the core spinning solution comprises the steps of dissolving alkenyl-terminated hyperbranched polylactic acid and benzoyl peroxide in an organic solvent to form the core spinning solution; Firstly, preparing hyperbranched polylactic acid by taking DL-lactic acid and glycerol as raw materials, and then, carrying out alkenylation treatment on the hyperbranched polylactic acid by using acryloyl chloride to obtain the terminal alkenyl hyperbranched polylactic acid; The preparation method of the cortex spinning solution comprises the steps of dissolving polyvinyl alcohol powder to obtain a polyvinyl alcohol solution, dissolving polyvinyl alcohol-styrylpyridinium salt to obtain a SbQ-PVA solution, mixing the polyvinyl alcohol solution and the SbQ-PVA solution, adding zinc oxide quantum dots, and uniformly mixing to obtain the cortex spi