CN-121987857-A - Pure magnesium surface modified material, preparation method and application thereof in tooth GBR membrane

Abstract

The invention relates to a pure magnesium surface modified material, a preparation method and application thereof in a tooth GBR membrane, wherein the pure magnesium surface modified material comprises the following components in percentage by weight: the magnesium/gallium bimetallic polyphenol coating comprises a pure magnesium matrix and a magnesium/gallium bimetallic polyphenol network coating generated on the surface of the pure magnesium matrix in situ, wherein the coating contains magnesium ions, gallium ions and quercetin. The invention realizes a multifunctional integrated degradable magnesium-based bone regeneration material which has controllable degradation, high-efficiency antibacterial property and active bone promotion and angiogenesis promotion, a preparation method and application thereof.

Inventors

• LIU XUANYONG
• Xue kui
• QIU JIAJUN
• XING MIN
• QIAN WENHAO

Assignees

• 国科大杭州高等研究院
• 中国科学院上海硅酸盐研究所
• 上海市徐汇区口腔医院(上海市徐汇区牙病防治所)

Dates

Publication Date

20260508

Application Date

20251224

Claims (9)

1. 1. The application of the pure magnesium surface modification material in the tooth GBR membrane is characterized in that the pure magnesium surface modification material comprises a pure magnesium matrix and a magnesium/gallium bimetal polyphenol network coating generated on the surface of the pure magnesium matrix in situ, wherein the coating contains magnesium ions, gallium ions and quercetin.
2. 2. The use according to claim 1, wherein the magnesium/gallium bimetallic polyphenol network coating is a nanoscale coating, a dense structure of nanoscale particle stacks.
3. 3. A pure magnesium surface modified material, comprising: A pure magnesium matrix; The magnesium/gallium bimetallic polyphenol network coating is combined on the surface of the pure magnesium matrix in situ, and the coating is formed by coordination of magnesium ions and gallium ions and deprotonated quercetin.
4. 4. The pure magnesium surface modified material of claim 3, wherein said magnesium/gallium bimetallic polyphenol network coating is generated in situ on said pure magnesium substrate by a hydrothermal process.
5. 5. The method for preparing a surface-modified pure magnesium material according to claim 3 or 4, comprising the steps of: Providing a pure magnesium substrate subjected to surface pretreatment; placing the pure magnesium matrix in an alkaline hydrothermal reaction solution containing a gallium source and a polyphenol compound; And carrying out hydrothermal reaction to generate the magnesium/gallium bimetallic polyphenol network coating on the surface of the pure magnesium base in situ.
6. 6. The method of claim 5, wherein the gallium source is gallium nitrate and the polyphenol compound is quercetin.
7. 7. The method according to claim 5, wherein a mixed aqueous solution containing a gallium source at a concentration of 1 to 5 g/L and quercetin at a concentration of 0.5 to 3 g/L is prepared; adjusting the pH value of the mixed aqueous solution to 8-11 by using an alkaline solution; Immersing the pure magnesium matrix subjected to surface pretreatment into the mixed aqueous solution, and placing the mixed aqueous solution in a closed reaction container; Carrying out hydrothermal reaction for 6-24 hours at 80-150 ℃; And after the reaction is finished, taking out the pure magnesium matrix, cleaning and drying to obtain the material with the magnesium/gallium bimetallic polyphenol network coating on the surface.
8. 8. The preparation method according to claim 7, wherein the gallium source is gallium nitrate nonahydrate, the concentration of which in the mixed aqueous solution is 2g/L, the concentration of quercetin is 1 g/L, the pH value is 9, the hydrothermal reaction temperature is 100 ℃, and the reaction time is 12 hours.
9. 9. The method according to claim 7, wherein the alkaline solution is sodium hydroxide solution.

Description

Pure magnesium surface modified material, preparation method and application thereof in tooth GBR membrane Technical Field The invention belongs to the technical field of preparation of tooth guided bone regeneration membrane materials, and particularly relates to a pure magnesium surface modification material, a preparation method and application thereof in a tooth GBR membrane. Background Insufficient alveolar bone mass often makes oral implant repair a dilemma, and guiding bone regeneration GBR is a treatment technique that can be used for horizontal or vertical bone augmentation. Bone implant guiding bone regeneration membrane material is a key biological material used in oral implant, orthopaedics and maxillofacial surgery. Its core function is to guide and promote the regeneration of bone tissue of human body in specific area, and to block the overgrowth of soft tissue, so as to create a protected stable space for the growth and repair of bone cells. Among these, the barrier membrane is a key component of GBR technology, and can separate soft tissue from bone defect areas. The ideal bone implantation guiding bone regeneration film material firstly requires good biocompatibility, is not repelled by a human body, is not harmful to the human body, and secondly has excellent mechanical properties, and has elastic modulus similar to bone tissue, good corrosion resistance, fatigue resistance and the like. The GBR films at present are mainly classified into non-degradable films (polytetrafluoroethylene, titanium mesh, etc.) and degradable films (collagen films, magnesium alloys, zinc alloys, etc.). The non-degradable film needs to be taken out for the second time, so that the experimental cost is increased. The mechanical properties of the degradable collagen film are crossed, the sufficient supporting performance is difficult to ensure, and the polylactic acid material is easy to cause inflammation due to degradation acidity. The degradable metal material is distinguished by the excellent mechanical property and the low toxicity of degradation products. The degradable pure magnesium is a metal material with extremely high ductility, the elastic modulus is 35GPa, the tensile strength is 165-205MPa, the yield strength is 0.2MPa, the degradation performance is good, and the degradation product magnesium ion is a human body macroelement. Compared with degradable materials such as collagen, polylactic acid-glycolic acid and the like, the collagen-polylactic acid-glycolic acid composite material has the advantages of good biocompatibility, mechanical property approaching human bones and the like. Degradable pure magnesium materials are currently applied to the fields of bone nails, bone plates, degradable closure clips and the like, but the degradable pure magnesium materials still have some problems in practical application. Research shows that the problem of pH surge, mechanical function reduction and difficult cell adhesion caused by too high degradation speed of pure magnesium is still an important factor for limiting the development of magnesium alloy. Most of the surface is wrapped by fiber instead of mineralized tissue, which easily leads to loosening of the implant. Meanwhile, the surface of pure magnesium has poor antibacterial effect in vivo, and bacteria are easy to fix values on the surface of the pure magnesium, so that implantation failure is caused. Therefore, the surface modification of the pure magnesium, the improvement of the osteogenesis and the antibacterial property of the pure magnesium, and the promotion of the clinical application of the pure magnesium are of great significance. In the bone defect healing process, a vascular remodeling process is indispensable. Therefore, in preparing the bone regeneration guiding membrane material, the membrane has positive significance in endowing good angiogenesis promoting capability. Therefore, how to solve the problems of too high degradation speed and poor antibacterial performance of the existing medical pure magnesium material as a tooth guiding bone regeneration film material, which may cause postoperative infection, implantation failure and the like, and provide a pure magnesium surface modification material to meet the clinical requirements on the bone formation and anti-infection of the pure magnesium material is a technical problem to be solved urgently by the technicians in the field. Disclosure of Invention The invention provides application of a pure magnesium surface modification material in a dental GBR membrane, aiming at the problems that the medical pure magnesium material in the prior art is used as a dental guiding bone regeneration membrane material, the degradation speed is too high, the antibacterial performance is poor, postoperative infection and implantation failure can be caused, and the like, so as to meet the clinical requirements on the bone formation and anti-infection of the pure magnesium material. For this purpose, th