CN-121987859-A - Preparation method and application of multifunctional liquid metal-based drug-loaded microsphere

Abstract

The invention discloses a preparation method of a multifunctional liquid metal-based drug-loaded microsphere, which comprises the following steps of (1) preparing a gel prepolymer solution and a crosslinking solution, wherein the crosslinking solution comprises a gel crosslinking agent, a surface functional material and a drug, and (2) taking liquid metal as an inner shaft of a coaxial injector and placing the gel prepolymer solution on an outer shaft of the coaxial injector, uniformly extruding the gel prepolymer solution and the liquid metal-based drug-loaded microsphere, and dripping the gel prepolymer solution and the gel prepolymer solution into the crosslinking solution to obtain the uniform and stable liquid metal-loaded microsphere. The invention also discloses the multifunctional liquid metal-based drug-loaded microsphere prepared by the preparation method and application thereof.

Inventors

• WANG XINPENG
• FAN YUBO
• MIAO JINLAI
• HE YINGYING
• MENG ZIXUAN

Assignees

• 康复大学

Dates

Publication Date

20260508

Application Date

20260116

Priority Date

20250515

Claims (8)

1. 1. The preparation method of the multifunctional liquid metal-based drug-loaded microsphere is characterized by comprising the following steps of: (1) Preparing a gel prepolymer solution and a crosslinking solution, wherein the crosslinking solution comprises a gel crosslinking agent, a surface functionalization material and a drug; (2) And (3) placing the liquid metal on the inner shaft of the coaxial injector and the gel prepolymer solution on the outer shaft of the coaxial injector, uniformly extruding the liquid metal and the gel prepolymer solution, and dripping the liquid metal and the gel prepolymer solution into the crosslinking liquid to obtain uniform and stable liquid metal drug-carrying microspheres.
2. 2. The preparation method according to claim 1, wherein the extrusion speed of the liquid metal is 0.1 to 0.5ml/min and the extrusion speed of the gel prepolymer solution is 1 to 2ml/min.
3. 3. The preparation method of the gel according to claim 2, wherein the concentration of the gel prepolymer solution is 0.1 mM-100 mM, and the gel prepolymer is sodium alginate or polyvinyl alcohol.
4. 4. The method for preparing the ball according to claim 2, wherein the surface functional material is at least one selected from the group consisting of dopamine, chitosan, tannic acid and benzalkonium bromide, and the gel cross-linking agent is calcium chloride.
5. 5. The method of claim 2, wherein the liquid metal is a metal or alloy that assumes a liquid state below 300 ℃.
6. 6. A multifunctional liquid metal-based drug-loaded microsphere prepared by the method of claim 1.
7. 7. The use of the multi-functional liquid metal-based drug-loaded microsphere of claim 6 for the preparation of an in vivo drug-loaded motor.
8. 8. The use of the multi-functional liquid metal-based drug-loaded microsphere of claim 6 in the preparation of a wound dressing.

Description

Preparation method and application of multifunctional liquid metal-based drug-loaded microsphere Technical Field The invention relates to the technical field of liquid metal functionalization, in particular to a preparation method and application of a multifunctional liquid metal-based drug-loaded microsphere. Background As a novel material with both metallic and liquid fluidity, liquid metal has been reported to have good biocompatibility, and can be used in various fields of biomedical engineering, but the liquid metal has large surface tension and is not easy to form, so how to better convert practical application by utilizing the excellent characteristics of the liquid metal is still a problem to be solved. By exploring the interface characteristics, the functional modification of the liquid metal is realized, so that the multifunctional flexible metal is favorable for meeting more application requirements, expanding and promoting the development and innovation of the multifunctional flexible application. The physical doping and surface modification modes of the liquid metal are simple and effective methods for preparing the liquid metal matrix composite material, and the prepared composite material is favorable for further forming, functionalization and application expansion, but can weaken the ductility, conductivity or biocompatibility of the liquid metal to a certain extent. In the prior art, liquid metal microspheres have been reported, wherein the surface modification methods commonly used for preparing the liquid metal microspheres at present comprise ultrasonic and magnetic stirring. However, the liquid metal microspheres prepared by the method have poor uniformity, and further functionalization process needs to be transferred to other environments to control the functionalization environment because ultrasonic and magnetic stirring can damage the functionalization process. The above problems not only affect the application effect of the liquid metal microsphere, such as the uniform controllability of drug loading/release, the conductivity and stretchability of the flexible circuit, but also are unfavorable for mass production. In addition, the liquid metal microspheres prepared by the method are difficult to recycle and are easy to polymerize. Disclosure of Invention The invention aims at providing a preparation method of a multifunctional liquid metal-based drug-carrying microsphere, which is used for preparing the liquid metal microsphere with good uniformity, thereby being beneficial to ensuring the uniform controllability of drug carrying/drug release. The second object of the present invention is to provide a multifunctional liquid metal-based drug-carrying microsphere prepared by the above preparation method. The invention also aims to provide application of the multifunctional liquid metal-based drug-loaded microsphere. In order to achieve the above purpose, the present invention adopts the following technical scheme. The preparation method of the multifunctional liquid metal-based drug-loaded microsphere comprises the following steps: (1) Preparing a gel prepolymer solution and a crosslinking solution, wherein the crosslinking solution comprises a gel crosslinking agent, a surface functionalization material and a drug; (2) And (3) placing the liquid metal on the inner shaft of the coaxial injector and the gel prepolymer solution on the outer shaft of the coaxial injector, uniformly extruding the liquid metal and the gel prepolymer solution, and dripping the liquid metal and the gel prepolymer solution into the crosslinking liquid to obtain uniform and stable liquid metal drug-carrying microspheres. The liquid metal and gel prepolymer solution are coaxially printed into the crosslinking liquid by utilizing a coaxial injector, and the liquid metal drug-carrying microsphere with uniform size can be obtained under the inner diameter and extrusion speed of a fixed dropping liquid metal needle head. In other words, the liquid metal drug-carrying microsphere with the required size can be obtained by controlling the inner diameter of the liquid metal needle head and the extrusion speed of the liquid metal. The invention performs surface functionalization on the liquid metal drug-carrying microsphere while preparing the liquid metal drug-carrying microsphere by coaxial printing, which not only can obtain uniform and stable liquid metal drug-carrying microsphere, but also can endow the liquid metal drug-carrying microsphere with more functionality. The liquid metal-based drug-carrying microsphere prepared by the invention can carry drugs, can realize surface functionalization by utilizing a surface functionalization material, so that the liquid metal-based drug-carrying microsphere can obtain antibacterial property, adhesiveness, hemostasis and the like, and further, based on good electric conduction and thermal conduction of liquid metal, the liquid metal-based microsphere can carry drugs and re