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CN-121987942-A - Alternating electric field device of three-dimensional magnetic ring

CN121987942ACN 121987942 ACN121987942 ACN 121987942ACN-121987942-A

Abstract

The invention relates to the field of medical equipment, and discloses an alternating electric field device of a three-dimensional magnetic ring, which comprises at least one group of three closed magnetic rings or magnetic chains (1) fixed on a frame, wherein the central axes of each group of three magnetic rings or magnetic chains are respectively positioned in three planes of a three-dimensional coordinate system XYZ and are intersected at the origin of the three-dimensional coordinate system XYZ, at least one metal coil (2) is wound on each magnetic ring or magnetic chain, two ends of each metal coil respectively form a closed loop with one alternating signal generating circuit, each alternating signal generating circuit circularly loads preset alternating current on each metal coil in turn, each preset alternating current circularly generates preset alternating electric fields with centers pointing to the origin in each magnetic ring or magnetic chain, and when in use, carriers of cells which are dividing rapidly are positioned at the origin. The device can remove tumor cells which are rapidly dividing from different directions and angles as far as possible, does not have electrodes, does not need to be clung to the skin for use, and has higher comfort level.

Inventors

  • YANG JUNZHI

Assignees

  • 昆仑智鼎(北京)医疗技术有限公司

Dates

Publication Date
20260508
Application Date
20210726

Claims (12)

  1. 1. The alternating electric field device of the three-dimensional magnetic ring is characterized by comprising at least one group of three closed magnetic rings or magnetic links (1) fixed on a frame, wherein the central axes of the three magnetic rings or magnetic links (1) are respectively positioned in three planes of a three-dimensional coordinate system XYZ and are intersected with the origin of the three-dimensional coordinate system XYZ, the distances from the center of each magnetic ring or magnetic link (1) to the origin of the three-dimensional coordinate system XYZ are equal in each group, at least one metal coil (2) is wound on each magnetic ring or magnetic link (1), a closed loop is formed between two ends of each metal coil (2) and one alternating signal generating circuit, preset alternating current is circularly loaded on each metal coil in turn, and each preset alternating current is circularly arranged in each magnetic ring or magnetic link to generate a preset alternating electric field with the center pointing to the origin; The alternating signal generating circuits are any one of a constant amplitude sine wave generator circuit, a amplitude reduction sine wave generator circuit, an amplitude amplification sine wave generator circuit, an amplitude first amplification sine wave generator circuit and a sine wave circuit with the frequency continuously changing between a maximum value and a minimum value, wherein the inductance in each sine wave generator circuit is the metal coil (2); The device is provided with a similar 'sequential shift register' circuit and electric control switches with the same number as the magnetic rings or magnetic links, so that each alternating signal generating circuit circularly loads preset alternating current on each metal coil in turn, each alternating signal generating circuit loads preset alternating current with the signal frequency of 30-300 kHz of a current waveform on each metal coil (2), the preset alternating current can enable a preset alternating magnetic field to be generated in the corresponding magnetic ring or magnetic link (1), and the preset alternating magnetic field can form a preset alternating electric field with the intensity of 0.1-10V/cm, which is used for destroying or inhibiting tumor cells which are rapidly dividing in the carrier and has no effect on normal cells, in the direction perpendicular to the corresponding magnetic ring or magnetic link (1).
  2. 2. The alternating electric field device of the three-dimensional magnetic ring as claimed in claim 1, wherein each of the electric control switches is connected between a VDD power supply and an input terminal of each of the alternating signal generating circuits, and an input terminal of each of the electric control switches is connected to an output terminal of the similar "sequential shift register" circuit, and an input terminal of the similar "sequential shift register" circuit is connected to an output terminal of the random/periodic signal generating circuit.
  3. 3. The alternating electric field device of a three-dimensional magnetic ring according to claim 1, further comprising at least one magnetic ring or flux linkage with a center coordinate of (x 1, y1, z 1) in the three-dimensional plane, wherein x1 noteq0, y1 noteq0, z1 noteq0, wherein the magnetic ring or flux linkage with a center coordinate of (x 1, y1, z 1) and the magnetic ring or flux linkage in three planes of the three-dimensional coordinate system XYZ form a closed loop between two ends of each metal coil (2) and one alternating signal generating circuit, respectively, and each preset alternating current generates a preset alternating electric field with a center pointing to the origin in each magnetic ring or flux linkage.
  4. 4. An alternating electric field device of a three-dimensional magnetic ring as claimed in claim 3, characterized in that the center coordinates of a set of three of the magnetic rings or flux linkages lying in three planes of the three-dimensional coordinate system XYZ are (x 2, 0), (0, y2, 0) and (0, z 2), respectively, wherein x2+.0, y2+.0, z2+.0; the center coordinates of the other set of three magnetic rings or flux linkages located in three planes of the three-dimensional coordinate system XYZ are (x 3, y3, 0), (x 3,0, z 3) and (0, y3, z 3), respectively, wherein x3+.0, y3+.0, z3+.0.
  5. 5. The alternating electric field device of the three-dimensional magnetic ring as recited in claim 4, wherein x1=y1=z1, x2=y2=z2, x3=y3=z3, and 。
  6. 6. The alternating electric field device of the three-dimensional magnetic ring according to any one of claims 1 to 5, wherein the number of the constant amplitude sine wave generator circuits is equal to the number of the magnetic rings or magnetic chains (1), each constant amplitude sine wave generator circuit is a clar wave oscillating circuit or a schler wave oscillating circuit, and the output current waveform of the preset alternating current is a constant amplitude sine wave, a constant amplitude sine wave with a plurality of groups of periodic time intervals or a constant amplitude sine wave with a plurality of groups of random time intervals.
  7. 7. The alternating electric field device of the three-dimensional magnetic ring according to any one of claims 1 to 5, wherein the constant amplitude sine wave generator circuit mainly comprises sawtooth wave generators and voltage-controlled oscillators with the same number as the magnetic ring or the magnetic chain (1), sawtooth wave voltages generated by the sawtooth wave generators control the voltage-controlled oscillators, and the current waveform of the output preset alternating current is similar to frequency modulation continuous FMCW waves, FMCW waves with multiple groups of periodic time intervals or FMCW waves with multiple groups of random time intervals.
  8. 8. The alternating electric field device of a three-dimensional magnetic ring according to any one of claims 1 to 5, characterized in that the constant amplitude sine wave generator circuit mainly comprises triangular wave generators and voltage controlled oscillators equal in number to the magnetic ring or flux linkage (1), each voltage controlled oscillator being connected with one of the metal coils (2) as a load; The triangular wave voltage generated by the triangular wave generator controls each voltage-controlled oscillator, and the current waveform of the output preset alternating current is similar to frequency modulation continuous FMCW wave, FMCW wave with a plurality of groups of periodic time intervals or FMCW wave with a plurality of groups of random time intervals.
  9. 9. The alternating electric field device of a three-dimensional magnetic ring according to any one of claims 1 to 5, characterized in that the constant amplitude sine wave generator circuit mainly comprises sine wave generators and voltage controlled oscillators equal in number to the magnetic ring or flux linkage (1), each voltage controlled oscillator being connected with one of the metal coils (2) as a load; The sine wave voltage generated by the sine wave generator controls each voltage-controlled oscillator, and the current waveform of the output preset alternating current is similar to frequency modulation continuous FMCW wave, FMCW wave with a plurality of groups of periodic time intervals or FMCW wave with a plurality of groups of random time intervals.
  10. 10. The alternating electric field device of a three-dimensional magnetic ring according to any one of claims 1 to 5, wherein the number of the damped sine wave generator circuits is equal to the number of the magnetic rings or magnetic chains (1), each damped sine wave generator circuit is an LC oscillator circuit, and the current waveform of the output preset alternating current is a continuous damped sine wave, a damped sine wave with a plurality of groups of periodic time intervals, or a damped sine wave with a plurality of groups of random time intervals.
  11. 11. The alternating electric field device of a three-dimensional magnetic ring according to any one of claims 1 to 5, characterized in that the amplified sine wave generator circuit mainly comprises a high frequency sine wave generator, a sawtooth wave generator and an equal number of analog multiplier circuits as the magnetic ring or flux linkage (1), each of the analog multiplier circuits being connected to one of the metal coils (2) as a load; and multiplying the high-frequency sine wave generated by the high-frequency sine wave circuit with the sawtooth wave generated by the sawtooth wave generator, wherein the current waveform of the output preset alternating current is a continuous amplified sine wave, an amplified sine wave with a plurality of groups of periodic time intervals or an amplified sine wave with a plurality of groups of random time intervals.
  12. 12. The alternating electric field device of a three-dimensional magnetic ring according to any one of claims 1 to 5, characterized in that the amplitude-first-increase-then-decrease sine wave generator circuit mainly comprises a high-frequency sine wave generator, a low-frequency sine wave generator or a triangular wave generator and an analog multiplier circuit equal in number to the magnetic ring or the magnetic chain (1), each analog multiplier circuit being connected with one of the metal coils (2) as a load; And multiplying the high-frequency sine wave generated by the high-frequency sine wave generator by the low-frequency sine wave generated by the low-frequency sine wave generator or the low-frequency triangular wave generated by the triangular wave generator, wherein the output current waveform of the preset alternating current is a continuous sine wave with the amplitude increased and then reduced firstly, and a sine wave with the amplitude increased and then reduced firstly or a sine wave with the amplitude increased and then reduced firstly at a plurality of groups of random time intervals.

Description

Alternating electric field device of three-dimensional magnetic ring The application discloses a divisional application of a Chinese patent application of an alternating electric field device of a three-dimensional magnetic ring, which is filed by Chinese patent office at the year 2021 and the month 07 and the day 26, and has the application number 202110843574.5. Technical Field The invention relates to the field of medical equipment, in particular to an alternating electric field device of a three-dimensional magnetic ring. Background It is well known that tumors, particularly malignant tumors or cancers, have uncontrolled proliferation of cell division, rapid growth, low cell differentiation, and wettability and diffusivity (migration) as compared to normal tissues. As mentioned above, the rapid growth of tumors in general (and malignant tumors in particular) is a result of relatively frequent cell division or proliferation compared to normal tissue cells. The frequent cell division of cancer cells relative to normal cells is the basis for the effectiveness of existing cancer therapies, such as radiation therapy and the use of a wide variety of chemotherapeutic agents. Such treatments are based on the fact that cells undergoing division are more sensitive to radiation and chemotherapeutic agents than non-dividing cells. Because tumor cells divide more frequently than normal cells, it is possible to selectively damage or destroy tumor cells by radiation therapy and/or chemotherapy to some extent. The actual sensitivity of a cell to radiation, therapeutic agents, etc. also depends on the specific characteristics of different types of normal or malignant cell types. Thus, unfortunately, tumor cells are not significantly more sensitive than many types of normal tissue. This makes it less easy to distinguish between tumor cells and normal cells, and thus existing typical treatment regimens for cancer can also cause significant damage to normal cells, thereby limiting the therapeutic efficacy of such treatments. Furthermore, the inevitable damage to other tissues makes the treatment very damaging to the patient, and the patient often cannot recover from seemingly successful treatments. Moreover, some types of tumors are not sensitive at all to existing treatments. Other methods exist for destroying cells that do not rely on radiation therapy or chemotherapy alone. For example, methods using ultrasound or electrical disruption of tumor cells may be substituted for conventional treatments. Electric fields and currents have been used for medical purposes for many years. It is most common to maintain a potential difference between the conductive electrodes by means of a pair of conductive electrodes, and to generate an electric current in the human or animal body by applying an electric field in the human or animal body. These currents are either used to exert their special effect, i.e. to stimulate excitable tissue, or to generate heat by forming currents in the body, since the body can be equivalently resistive. Examples of the first type of application include cardiac defibrillators, peripheral nerve and muscle stimulators, brain stimulators, and the like. Examples of the use of electrical current to generate heat include tumor ablation, ablation of malfunctioning heart or brain tissue, cauterization, relief of muscle rheumatalgia or other pain, and the like. Other applications of electric fields for medical purposes include the use of high frequency oscillating fields emitted from sources emitting e.g. radio frequency electric waves or microwave sources directed to a site of interest in the body. In these examples, there is no conduction of electrical energy between the source and the body, but rather energy is transferred to the body by radiation or induction. More particularly, the electrical energy generated by the source reaches the vicinity of the body via conductors and is transferred from that location to the human body by air or some other electrically insulating material. In conventional electrical methods, electrical current is delivered to a target tissue region through electrodes placed in contact with the patient's body. The applied current will destroy substantially all cells in the vicinity of the target tissue. Thus, this type of electrical method does not distinguish between different types of cells within the target tissue and results in destruction of both tumor cells and normal cells. Patent application 200580048335.X entitled a device for selectively destroying or inhibiting growth of rapidly dividing tumor cells located within a target region of a patient, the device comprising at least two pairs of insulated electrodes (1620,1630), wherein each electrode (1620,1630) has a surface configured for placement against the patient's body, and an AC voltage source having at least two sets of outputs, wherein the at least two sets of outputs are phase shifted and each electrically connected to on