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CN-121987945-A - Flexible miniature electric stimulator capable of being wound and adhered to peripheral nerve bundles and preparation method and application thereof

CN121987945ACN 121987945 ACN121987945 ACN 121987945ACN-121987945-A

Abstract

The invention discloses a flexible miniature electric stimulator capable of being wound and adhered to peripheral nerve bundles, and a preparation method and application thereof, and relates to the technical field of intersection of nerve engineering, bioelectronics and medical instruments. The invention is assembled layer by a first insulating layer, a first friction electrode layer, an intermediate isolation layer, a second friction electrode layer and a second insulating layer, wherein the first insulating layer and the second insulating layer are self-adhesion polyurethane layers, the first insulating layer and the second insulating layer encapsulate the first friction electrode layer, the intermediate isolation layer and the second friction electrode layer, the first friction electrode layer is gold foil, PEDOT formed by 3, 4-ethylenedioxythiophene monomer and polystyrene sulfonate is electroplated on the surface of the gold foil, and the second friction electrode layer is gold foil or aluminum foil. The invention realizes macroscopic contact-separation type friction power generation through ultrasonic drive, and has good output performance, long-term stability and nerve stimulation effect.

Inventors

  • LUO ZHIQIANG
  • YANG YONGHAO

Assignees

  • 华中科技大学

Dates

Publication Date
20260508
Application Date
20260317

Claims (8)

  1. 1. A flexible miniature electric stimulator capable of being wound and adhered to peripheral nerve bundles and a preparation method and application thereof are characterized by being formed by assembling a first insulating layer, a first friction electrode layer, an intermediate isolation layer, a second friction electrode layer and a second insulating layer by layer, wherein the first insulating layer and the second insulating layer are self-adhesive polyurethane layers, the first friction electrode layer, the intermediate isolation layer and the second friction electrode layer are packaged in the first insulating layer and the second insulating layer, the first friction electrode layer is gold foil, PEDOT formed by 3, 4-ethylenedioxythiophene monomers and polystyrene sulfonate is electroplated on the surface of the gold foil, and the second friction electrode layer is a PSS coating or an aluminum foil.
  2. 2. The flexible micro-electro-stimulator attachable to a peripheral nerve bundle by winding according to claim 1, wherein the first insulating layer and the first frictional electrode layer are led out, the second frictional electrode layer and the second insulating layer are led out, and the led-out portions of the first insulating layer and the first frictional electrode layer are symmetrically arranged with the led-out portions of the second frictional electrode layer and the second insulating layer.
  3. 3. The flexible micro-electro-stimulator capable of winding and adhering to peripheral nerve bundles according to claim 2, wherein the second friction electrode layer is gold foil, and the surface of the led-out part is electroplated with a PEDOT: PSS plating formed of 3, 4-ethylenedioxythiophene monomer and polystyrene sulfonate.
  4. 4. A flexible micro-electro-stimulator attachable to a peripheral nerve bundle in a wrapping manner according to claim 1 or 2, wherein the intermediate isolation layer is polytetrafluoroethylene or polyurethane.
  5. 5. A method of manufacturing a flexible micro-electro-stimulator attachable to a peripheral nerve bundle by wrapping according to any one of claims 1 to 4, comprising the steps of: (1) Dissolving isophorone diisocyanate and dibutyltin dilaurate in an organic solvent to obtain a mixed solution; under the condition of non-oxidizing protective gas, adding the mixed solution into dried polytetrahydrofuran glycol for reaction, then adding dimethylglyoxime, and adding a diluent after the reaction is finished to obtain an elastomer solution; (2) 3, 4-ethylenedioxythiophene monomer and polystyrene sulfonate are dissolved in deionized water to form a uniform mixed solution, then gold foil is used as a working electrode, and PEDOT (polyether-ether-ketone) PSS conducting layer is deposited on the surface of the gold foil in a constant current electrochemical polymerization mode; (3) The method comprises the steps of attaching gold foil or aluminum foil to the surface of a first self-adhesive polyurethane insulating layer, attaching an isolation layer gasket to the surface of the gold foil or aluminum foil, attaching gold foil plated with PEDOT (packet data) PSS (packet data service) plating to the surface of a second self-adhesive polyurethane insulating layer, aligning and attaching two self-adhesive polyurethane insulating layers, and packaging by utilizing the adhesive characteristic of self-adhesive polyurethane.
  6. 6. The method of manufacturing a flexible micro-electro-stimulator capable of winding and adhering to peripheral nerve bundles according to claim 5, wherein the first self-adhesive polyurethane insulation layer and the gold foil or aluminum foil on the surface of the first self-adhesive polyurethane insulation layer are led out, the second self-adhesive polyurethane insulation layer and the gold foil on the surface of the second self-adhesive polyurethane insulation layer, which is electroplated with a PEDOT: PSS plating layer, are led out, and the led-out structures of the two parts are symmetrically arranged.
  7. 7. The method for manufacturing a flexible micro-electro-stimulator capable of winding and adhering to peripheral nerve bundles according to claim 6, wherein the gold foil is adhered to the surface of the first self-adhesive polyurethane insulation layer, and the portion of the gold foil led out of the surface of the first self-adhesive polyurethane insulation layer is electroplated with a PEDOT: PSS plating.
  8. 8. Use of a flexible micro-electro-stimulator attachable to a peripheral nerve bundle in a wound form according to any one of claims 1-4, wherein the first and second friction electrode layers produce a contact-separation triboelectric effect under ultrasound driving, thereby achieving wireless energy conversion and nerve stimulation.

Description

Flexible miniature electric stimulator capable of being wound and adhered to peripheral nerve bundles and preparation method and application thereof Technical Field The invention relates to the technical field of intersection of nerve engineering, bioelectronics and medical appliances, and discloses a flexible miniature electric stimulator capable of being wound and adhered to peripheral nerve bundles, and a preparation method and application thereof. Background The nerve stimulation technology is an important means in the field of nerve regulation, and has become a key method for treating nervous system diseases and recovering nerve functions. By applying controllable electric stimulation to specific nerve targets, nerve signal transduction can be effectively regulated, and the therapeutic effect is remarkable in the treatment of various diseases such as parkinsonism, epilepsy, chronic pain, heart failure, depression and the like. In terms of device structure, obvious mechanical mismatch (the elastic modulus difference is several orders of magnitude) exists between the traditional rigid nerve stimulator and soft nerve tissue, and tissue inflammation, fiber wrapping and electrode performance degradation are easy to cause. In recent years, the development of a thin film type nerve stimulator is promoted by the progress of flexible electronic technology, and the device can be attached to a nerve curved surface, so that mechanical damage is effectively reduced. However, existing flexible stimulators still rely on external wired power or built-in batteries, limiting their long-term autonomous working capabilities in the body. Friction nano generators (TENG) are an emerging energy harvesting technology capable of converting mechanical energy into electrical energy, providing self-powered solutions for implantable devices. The TENG based on the contact-separation working mode has the advantages of simple structure, high output voltage, flexible material selection and the like. However, the existing TENG-type nerve stimulator mostly adopts rigid or semi-rigid structural design, is difficult to adapt to dynamic deformation of nerve tissues, and meanwhile, has limited charge injection capability between a stimulating electrode and a nerve interface, and restricts stimulation efficiency and biosafety. Disclosure of Invention Aiming at the defects and improvement demands of the prior art, the invention aims to provide a flexible micro-electro-stimulator which can be wound and adhered to peripheral nerve bundles, a preparation method and application thereof, and a preparation method and application thereof, wherein the flexible micro-electro-stimulator is assembled by a first insulating layer, a first friction electrode layer, an intermediate isolating layer, a second friction electrode layer and a second insulating layer by layer, the first insulating layer and the second insulating layer are self-adhered polyurethane layers, the first friction electrode layer, the intermediate isolating layer and the second friction electrode layer are encapsulated in the first insulating layer and the second insulating layer, the first friction electrode layer is gold foil, the surface of the gold foil is electroplated with PEDOT PSS plating formed by a 3, 4-ethylenedioxythiophene monomer and polystyrene sulfonate, and the second friction electrode layer is gold foil or aluminum foil. Under the drive of ultrasound, the two friction electrode layers generate a contact-separation type friction electrification effect, so that wireless energy conversion and nerve stimulation are realized. The stimulator has the remarkable advantages of small volume, low modulus, ultrasonic wireless driving energy supply, high charge injection capacity, long-term stability and the like. According to the first aspect of the invention, the flexible miniature electric stimulator capable of being wound and adhered to peripheral nerve bundles, the preparation method and the application thereof are provided, the flexible miniature electric stimulator is formed by assembling a first insulating layer, a first friction electrode layer, an intermediate isolation layer, a second friction electrode layer and a second insulating layer one by one, the first insulating layer and the second insulating layer are self-adhered polyurethane layers, the first friction electrode layer, the intermediate isolation layer and the second friction electrode layer are packaged in the first insulating layer and the second insulating layer, the first friction electrode layer is gold foil, the surface of the gold foil is electroplated with PEDOT formed by 3, 4-ethylenedioxythiophene monomers and polystyrene sulfonate, and the second friction electrode layer is gold foil or aluminum foil. Preferably, the first insulating layer and the first friction electrode layer are led out, the second friction electrode layer and the second insulating layer are led out, and the led-out parts of the