CN-121987946-A - Electromagnetic synchronous stimulation control device, method, equipment, medium and program product

CN121987946ACN 121987946 ACN121987946 ACN 121987946ACN-121987946-A

Abstract

The device comprises a target point information generation module, a stimulation parameter configuration module, a synchronous control instruction generation module and a stimulation execution and feedback module, wherein the target point information generation module is used for generating target point position information, the stimulation parameter configuration module is used for generating a combined stimulation scheme data packet based on a stimulation parameter template and the target point position information, the synchronous control instruction generation module is used for analyzing the combined stimulation scheme data packet to generate a first time sequence control signal and a second time sequence control signal, and the stimulation execution and feedback module is used for driving a transcranial direct current stimulation unit and a repeated transcranial magnetic stimulation unit to synchronously apply physical stimulation to the target point position through the first time sequence control signal and the second time sequence control signal, and simultaneously collecting brain electrical signals of a target object in real time and generating a stimulation execution log. The electromagnetic synchronous stimulation is applied to the same target point and at the same time, and the physiological addition and synergistic effect of the electric field and the magnetic field is utilized, so that the effects are remarkable in the aspects of reducing the seizure frequency and the electroencephalogram epileptic discharge.

Inventors

SHEN WENWEN
LIN YICONG
ZHANG LIPING

Assignees

首都医科大学宣武医院

Dates

Publication Date: 20260508
Application Date: 20260317

Claims (10)

1. An electromagnetic synchronous stimulation control device, characterized by comprising: The target information generation module is configured to acquire multi-mode data of neuroelectrophysiology and images of a target object, perform fusion analysis on the multi-mode data through a preset positioning algorithm, determine the spatial position of an initial source region of an epileptogenic focus in a cerebral cortex, map the spatial position to a scalp coordinate system and generate target position information; The stimulation parameter configuration module is configured to acquire a preset individualized stimulation parameter template, and generate a combined stimulation scheme data packet containing a cathode stimulation electrode placement position, a magnetic field stimulation coil focusing position, transcranial direct current stimulation parameters and repeated transcranial magnetic stimulation parameters based on the stimulation parameter template and the target point position information; The synchronous control instruction generation module is configured to analyze the combined stimulation scheme data packet, generate a first time sequence control signal for controlling the transcranial direct current stimulation unit and a second time sequence control signal for controlling the repeated transcranial magnetic stimulation unit, and enable the first time sequence control signal and the second time sequence control signal to be synchronously overlapped on a time axis; The stimulation execution and feedback module is configured to send the first time sequence control signal to the transcranial direct current stimulation unit, send the second time sequence control signal to the repeated transcranial magnetic stimulation unit, drive the transcranial direct current stimulation unit and the repeated transcranial magnetic stimulation unit to synchronously apply physical stimulation to the target point position, simultaneously collect brain electrical signals of the target object in real time and generate a stimulation execution log.
2. The apparatus of claim 1, wherein the target information generation module is specifically configured to: preliminarily judging the brain area range of the epileptic focus based on the video electroencephalogram; Determining an initial source region of a epileptogenic focus from within the brain region based on the brain structure magnetic resonance imaging data; based on the brain magnetic map source analysis and the structural image fusion, the initial source region of the epileptogenic focus is mapped to the individualized scalp coordinates.
3. The apparatus of claim 1, wherein the stimulation parameter configuration module is specifically configured to: Calling a preset transcranial direct current stimulation parameter table and a repeated transcranial magnetic stimulation parameter table; generating a first driving control word according to the target scalp coordinate data and the transcranial direct current stimulation parameter table, wherein the first driving control word comprises cathode electrode channel selection, target current intensity value, stimulation duration and electrode polarity configuration; Generating a second driving control word according to the target scalp coordinate data and the repeated transcranial magnetic stimulation parameter table, wherein the second driving control word comprises magnetic stimulation coil channel selection, pulse frequency, pulse quantity and stimulation intensity percentage information; encapsulating the first drive control word and the second drive control word in the same time frame, and attaching a time synchronization stamp; the first driving control word and the second driving control word with the time synchronization stamp are output to the corresponding stimulation driver.
4. The apparatus according to claim 1, wherein the synchronization control instruction generation module is specifically configured to: controlling the first time sequence control signal to be the same as the starting time and the ending time of the second time sequence control signal; Or alternatively, the first and second heat exchangers may be, And controlling the first time sequence control signal and the second time sequence control signal to have a completely coincident time window in duration.
5. The apparatus of claim 1, wherein the stimulus execution and feedback module is specifically configured to: and extracting epileptiform discharge characteristics in the electroencephalogram signals, and automatically generating a stimulation suspension or parameter down-regulation instruction in response to the discharge frequency exceeding a preset threshold.
6. The apparatus of claim 1, wherein the neuro-electrophysiologic and imaging multi-modal data includes at least one of: inter-seizure video electroencephalogram, skull structure magnetic resonance imaging, and magnetoencephalography source localization data.
7. An electromagnetic synchronous stimulation control method, characterized by comprising the following steps: acquiring multi-modal data of neuroelectrophysiology and images of a target object, performing fusion analysis on the multi-modal data through a preset positioning algorithm, determining the spatial position of an initial source region of an epileptogenic focus in a cerebral cortex, mapping the spatial position to a scalp coordinate system, and generating target position information; Acquiring a preset individualized stimulation parameter template, and generating a combined stimulation scheme data packet containing a cathode stimulation electrode placement position, a magnetic field stimulation coil focusing position, transcranial direct current stimulation parameters and repeated transcranial magnetic stimulation parameters based on the stimulation parameter template and the target point position information; Analyzing the combined stimulation scheme data packet, generating a first time sequence control signal for controlling the transcranial direct current stimulation unit and a second time sequence control signal for controlling the repeated transcranial magnetic stimulation unit, and enabling the first time sequence control signal and the second time sequence control signal to be synchronously overlapped on a time axis; And sending the first time sequence control signal to the transcranial direct current stimulation unit, sending the second time sequence control signal to the repeated transcranial magnetic stimulation unit, driving the transcranial direct current stimulation unit and the repeated transcranial magnetic stimulation unit to synchronously apply physical stimulation to the target point position, simultaneously collecting the brain electrical signals of the target object in real time, and generating a stimulation execution log.
8. An electronic device comprising a memory, a processor and a computer program stored on the memory, the processor executing the computer program to perform the steps of the method of claim 7.
9. A computer readable storage medium, having stored thereon a computer program/instruction which, when executed by a processor, implements the steps of the method of claim 7.
10. A computer program product comprising computer programs/instructions which, when executed by a processor, implement the steps of the method of claim 7.

Description

Electromagnetic synchronous stimulation control device, method, equipment, medium and program product Technical Field The present disclosure relates to the technical field of medical devices, and in particular, to an electromagnetic synchronous stimulation control device, method, device, medium, and program product. Background This section is intended to provide a background or context for embodiments of the present disclosure. The description herein is not admitted to be prior art by inclusion in this section. Epilepsy is a common chronic neurological disease that severely affects the quality of life of patients. Although most patients can control seizures through drugs, a fraction of patients develop drug refractory seizures. For drug-refractory epilepsy of focal origin, the surgical treatment is effective, but has the limitations of traumatism, high risk, inapplicability of partial patients because the epileptogenic focus is located in a functional area, high economic cost and the like. Therefore, developing a novel nerve control device which can achieve higher stimulation efficacy, better therapeutic effect and is safe and noninvasive is a technical problem to be solved in the field. Disclosure of Invention To at least partially solve one of the technical problems in the related art, the present disclosure provides an electromagnetic synchronous stimulation control apparatus, method, device, medium, and program product. In view of the above object, a first aspect of exemplary embodiments of the present disclosure provides an electromagnetic synchronous stimulation control device, including: The target information generation module is configured to acquire multi-mode data of neuroelectrophysiology and images of a target object, perform fusion analysis on the multi-mode data through a preset positioning algorithm, determine the spatial position of an initial source region of an epileptogenic focus in a cerebral cortex, map the spatial position to a scalp coordinate system and generate target position information; The stimulation parameter configuration module is configured to acquire a preset individualized stimulation parameter template, and generate a combined stimulation scheme data packet containing a cathode stimulation electrode placement position, a magnetic field stimulation coil focusing position, transcranial direct current stimulation parameters and repeated transcranial magnetic stimulation parameters based on the stimulation parameter template and the target point position information; The synchronous control instruction generation module is configured to analyze the combined stimulation scheme data packet, generate a first time sequence control signal for controlling the transcranial direct current stimulation unit and a second time sequence control signal for controlling the repeated transcranial magnetic stimulation unit, and enable the first time sequence control signal and the second time sequence control signal to be synchronously overlapped on a time axis; The stimulation execution and feedback module is configured to send the first time sequence control signal to the transcranial direct current stimulation unit, send the second time sequence control signal to the repeated transcranial magnetic stimulation unit, drive the transcranial direct current stimulation unit and the repeated transcranial magnetic stimulation unit to synchronously apply physical stimulation to the target point position, simultaneously collect brain electrical signals of the target object in real time and generate a stimulation execution log. In some exemplary embodiments, the target information generation module is specifically configured to: preliminarily judging the brain area range of the epileptic focus based on the video electroencephalogram; Determining an initial source region of a epileptogenic focus from within the brain region based on the brain structure magnetic resonance imaging data; based on the brain magnetic map source analysis and the structural image fusion, the initial source region of the epileptogenic focus is mapped to the individualized scalp coordinates. In some exemplary embodiments, the stimulation parameter configuration module is specifically configured to: Calling a preset transcranial direct current stimulation parameter table and a repeated transcranial magnetic stimulation parameter table; generating a first driving control word according to the target scalp coordinate data and the transcranial direct current stimulation parameter table, wherein the first driving control word comprises cathode electrode channel selection, target current intensity value, stimulation duration and electrode polarity configuration; Generating a second driving control word according to the target scalp coordinate data and the repeated transcranial magnetic stimulation parameter table, wherein the second driving control word comprises magnetic stimulation coil channel selection, pulse frequency, pulse