CN-121987949-A - Transcranial direct current closed-loop regulation and control method based on near infrared brain oxygen real-time feedback

CN121987949ACN 121987949 ACN121987949 ACN 121987949ACN-121987949-A

Abstract

The invention relates to the technical field of nerve rehabilitation, in particular to a transcranial direct current closed-loop regulation and control method based on near infrared brain oxygen real-time feedback, which comprises the following steps of collecting brain oxygen baseline signals of all brain regions, calculating the mean value and standard deviation of all brain regions, and establishing a whole brain blood oxygen regulation and control threshold matrix of the regional and parameter; the method comprises the steps of dynamically adjusting a core target brain region, adjusting sampling frequency and single detection duration according to fluctuation frequency of oxygenated hemoglobin concentration of the core target brain region, continuously adapting detection parameters according to signal fluctuation frequency, optimizing transcranial direct current regulation parameters by combining core characteristic parameters with a whole brain blood oxygen regulation threshold matrix comparison result, and outputting optimized data, and dynamically adapting the detection parameters and signal fluctuation characteristics to improve regulation cooperativity.

Inventors

Sun Nianyi
XU ZHONGYAN
ZHAO YINUO
Guo Kangxiang
ZHANG ANREN

Assignees

上海市第四人民医院(同济大学附属上海市第四人民医院)

Dates

Publication Date: 20260508
Application Date: 20260127

Claims (10)

1. A transcranial direct current closed-loop regulation and control method based on near infrared brain oxygen real-time feedback is characterized by comprising the following steps: Collecting brain oxygen baseline signals of all brain regions, calculating the mean value and standard deviation of all brain regions, and establishing a whole brain blood oxygen regulation threshold matrix of the sub-regions and parameters; dynamically adjusting a core target brain region, and adjusting a sampling frequency and a single detection time length according to the fluctuation frequency of the concentration of the oxyhemoglobin in the core target brain region; And continuously adapting the detection parameters according to the signal fluctuation frequency, and optimizing the transcranial direct current regulation parameters by combining the core characteristic parameters with the comparison result of the whole brain blood oxygen regulation threshold matrix, and outputting optimized data.
2. The transcranial direct current closed-loop regulation and control method based on near infrared brain oxygen real-time feedback according to claim 1, wherein in the step of collecting brain oxygen baseline signals of all brain regions, calculating the mean value and standard deviation of all brain regions and establishing a brain blood oxygen regulation and control threshold matrix of the sub-regions and parameters: synchronously acquiring brain oxygen baseline signals of all brain regions by adopting a near infrared probe array, wherein the signal types comprise blood oxygen saturation and deoxyhemoglobin concentration; Respectively calculating the mean value and standard deviation of the blood oxygen saturation and the deoxyhemoglobin concentration of each brain region; And distributing corresponding blood oxygen saturation and deoxyhemoglobin concentration threshold value intervals for each brain region, and constructing a whole brain blood oxygen regulation threshold value matrix of the subareas and parameters.
3. The transcranial direct current closed loop control method based on near infrared brain oxygen real-time feedback according to claim 2, wherein before the step of calculating the mean and standard deviation of blood oxygen saturation and deoxyhemoglobin concentration of each brain region respectively: And screening and denoising the acquired brain oxygen baseline signals of all the areas of the whole brain, and removing abnormal fluctuation data.
4. The transcranial direct current closed-loop control method based on near infrared brain oxygen real-time feedback according to claim 3, wherein after the step of calculating the mean and standard deviation of blood oxygen saturation and deoxyhemoglobin concentration of each brain region, respectively: And setting constraint conditions, monitoring a blood oxygen saturation concentration threshold of a core target brain region, and setting an associated brain region abnormal response early warning line.
5. The transcranial direct current closed-loop control method based on near infrared brain oxygen real-time feedback according to claim 1, wherein in the step of dynamically adjusting the core target brain region and adjusting the sampling frequency and the single detection duration according to the fluctuation frequency of the concentration of oxygenated hemoglobin in the core target brain region: determining an initial core target brain region and an associated brain region based on the regulatory targets and the electroencephalogram positioning; Continuously acquiring a blood oxygen saturation concentration real-time signal of a core target brain region subjected to transcranial direct current stimulation by adopting a near infrared probe array, and recording a signal acquisition time sequence; continuously analyzing the blood oxygen saturation concentration real-time signal of the core target brain region, judging the change times of the signal in unit time, and determining the fluctuation frequency of the signal; And adjusting the detection parameters according to a preset fluctuation threshold.
6. The transcranial direct current closed loop control method based on near infrared brain oxygen real time feedback according to claim 5, wherein in the step of determining an initial core target brain region and associated brain regions based on control targets and electroencephalogram localization: and dynamically switching to the functionally associated alternative brain region when no effective response is found in the monitoring of the core target brain region signal.
7. The transcranial direct current closed-loop control method based on near infrared brain oxygen real-time feedback according to claim 5, wherein in the step of adjusting the detection parameters according to a preset fluctuation threshold: when the fluctuation frequency exceeds the upper limit of the threshold value, the sampling frequency is increased, and the single detection duration is prolonged to capture the complete signal track; When the fluctuation frequency is lower than the threshold lower limit, reducing the sampling frequency and shortening the single detection time length to reduce the data redundancy; When the fluctuation frequency is in the threshold value interval, the current detection parameters are maintained and checked regularly.
8. The method for closed loop regulation and control of transcranial direct current based on near infrared brain oxygen real-time feedback according to claim 1, wherein in the steps of continuously adapting detection parameters according to signal fluctuation frequency, and combining core characteristic parameters with a whole brain blood oxygen regulation and control threshold matrix comparison result, optimizing transcranial direct current regulation and control parameters, and outputting optimized data: continuously monitoring the fluctuation frequency of the blood oxygen saturation concentration of the core target brain region, and dynamically adapting the sampling frequency and the single detection duration; Processing the whole brain blood oxygen real-time signal, and extracting core characteristic parameters; Comparing the extracted core characteristic parameters with a whole brain blood oxygen regulation threshold matrix, and judging whether the core target brain region parameters are in a threshold interval or not and whether abnormal response exists in the associated brain region or not; optimizing transcranial direct current regulation parameters according to the comparison result; recording the optimized detection parameters, the optimized regulation parameters and the corresponding whole brain blood oxygen characteristic data, forming complete parameter regulation track and effect data and outputting the complete parameter regulation track and effect data.
9. The transcranial direct current closed-loop control method based on near infrared brain oxygen real-time feedback according to claim 8, wherein in the step of processing the whole brain blood oxygen real-time signal, the extracted core characteristic parameters are as follows: The method comprises the steps of removing signal cross interference by adopting multichannel independent component analysis, removing motion artifact and ambient light interference by self-adaptive filtering, and extracting core characteristic parameters, wherein the core characteristic parameters comprise a core target brain region blood oxygen saturation/deoxyhemoglobin concentration change value, whole brain blood oxygen distribution uniformity and associated brain region blood oxygen response delay time.
10. The transcranial direct current closed loop control method based on near infrared brain oxygen real-time feedback according to claim 9, wherein in the step of optimizing transcranial direct current control parameters according to the comparison result: when the core target brain region parameter exceeds the upper threshold value, the stimulation intensity is reduced, the duration of the next period is shortened or the stimulation polarity is switched; When the core target brain region parameter is lower than the threshold lower limit, the stimulation intensity is improved and the duration is prolonged; And when the associated brain region responds abnormally, the parameters are synchronously fine-tuned.

Description

Transcranial direct current closed-loop regulation and control method based on near infrared brain oxygen real-time feedback Technical Field The invention relates to the technical field of nerve rehabilitation, in particular to a transcranial direct current closed-loop regulation and control method based on near-infrared brain oxygen real-time feedback. Background Transcranial direct current stimulation (tDCS) is widely applied to the fields of cerebral dysfunction rehabilitation (such as cerebral apoplexy motor function recovery), cognitive function enhancement, mental disease adjuvant therapy (such as depression) and the like. The existing tDCS closed-loop regulation and control method still has the defect that the detection parameters are stiff and the dynamic characteristics of the signals cannot be adapted. The parameters such as sampling frequency, single detection duration and the like of the existing method are mostly preset fixed values, and are not linked with the fluctuation characteristics of brain oxygen signals. When the blood oxygen signal of the core target brain region fluctuates severely (such as the early regulation stage or the rapid change stage of the brain function state), the fixed low sampling frequency can lead to the loss of key characteristics and the failure of capturing the complete signal track, and when the signal tends to be stable, the fixed high sampling frequency can lead to the data redundancy, increase the transmission and processing load of the system and even cause the regulation delay. The selection of the core target brain region lacks a dynamic adaptation mechanism, and if the initial target brain region has no effective response due to individual differences, the initial target brain region cannot be switched to the functionally associated alternative brain region in time, so that the regulation and control pertinence is insufficient. Therefore, it is necessary to provide a transcranial direct current closed-loop control method for dynamically adapting detection parameters and signal fluctuation characteristics and improving control cooperativity. Disclosure of Invention The invention aims to provide a transcranial direct current closed-loop regulation and control method based on near infrared brain oxygen real-time feedback, aiming at achieving the effects of dynamically adapting detection parameters and signal fluctuation characteristics and improving regulation and control cooperativity. In order to achieve the purpose, the transcranial direct current closed-loop regulation and control method based on near-infrared brain oxygen real-time feedback comprises the following steps: Collecting brain oxygen baseline signals of all brain regions, calculating the mean value and standard deviation of all brain regions, and establishing a whole brain blood oxygen regulation threshold matrix of the sub-regions and parameters; dynamically adjusting a core target brain region, and adjusting a sampling frequency and a single detection time length according to the fluctuation frequency of the concentration of the oxyhemoglobin in the core target brain region; And continuously adapting the detection parameters according to the signal fluctuation frequency, and optimizing the transcranial direct current regulation parameters by combining the core characteristic parameters with the comparison result of the whole brain blood oxygen regulation threshold matrix, and outputting optimized data. Wherein, in the step of collecting brain oxygen baseline signals of all brain regions, calculating the mean value and standard deviation of all brain regions and establishing a brain blood oxygen regulation threshold matrix of the sub-regions and parameters: synchronously acquiring brain oxygen baseline signals of all brain regions by adopting a near infrared probe array, wherein the signal types comprise blood oxygen saturation and deoxyhemoglobin concentration; Respectively calculating the mean value and standard deviation of the blood oxygen saturation and the deoxyhemoglobin concentration of each brain region; And distributing corresponding blood oxygen saturation and deoxyhemoglobin concentration threshold value intervals for each brain region, and constructing a whole brain blood oxygen regulation threshold value matrix of the subareas and parameters. Wherein, before the step of calculating the mean value and standard deviation of the blood oxygen saturation and the deoxyhemoglobin concentration of each brain region respectively: And screening and denoising the acquired brain oxygen baseline signals of all the areas of the whole brain, and removing abnormal fluctuation data. Wherein, after the step of calculating the mean value and standard deviation of the blood oxygen saturation and the deoxyhemoglobin concentration of each brain region, respectively: And setting constraint conditions, monitoring a blood oxygen saturation concentration threshold of a core target brain region, and settin