CN-121987959-A - Atmospheric pressure low temperature plasma bladder perfusion treatment system and application thereof

Abstract

The invention provides an atmospheric pressure low temperature plasma bladder perfusion treatment system and application thereof, relating to the technical field of plasma medical appliances, the system comprises a main control and parameter setting module, a working air source module, a gas flow regulating module, a pulse high-voltage power supply matching module, a CAP generator device, a flexible delivery catheter device and a CAP treatment module in the bladder cavity. The flexible delivery catheter device comprises an inner catheter and an outer sleeve, wherein the inner catheter is used for conveying plasma, the outer sleeve is sleeved outside the inner catheter, and an annular clearance channel is formed between the inner catheter and the outer sleeve and used for maintaining pressure balance in the bladder. According to the invention, the atmospheric pressure low-temperature plasma is accurately delivered into the bladder through the urethra cannula, so that the safe and accurate delivery of the plasma is realized, and a new technical scheme is provided for medical equipment in the field of bladder cancer treatment.

Inventors

• JING WEIQIANG
• SHI BENKANG
• WANG XIAOLONG
• WANG GANYU

Assignees

• 山东大学齐鲁医院

Dates

Publication Date

20260508

Application Date

20260407

Claims (10)

1. 1. An atmospheric pressure cryogenic plasma bladder perfusion treatment system, comprising: The main control and parameter setting module is used for controlling the operation of the system and adjusting the output parameters of the plasmas; the working gas source module is used for providing working gas; The gas flow regulating module is connected with the working gas source module and used for regulating the gas flow; The pulse high-voltage power supply matching module is used for providing power supply required by high-voltage discharge; The CAP generator device is respectively connected with the gas flow regulating module and the pulse high-voltage power supply matching module and is used for ionizing working gas to generate atmospheric pressure low-temperature plasma; a flexible delivery catheter device connected to the CAP generator device for delivering the plasma into the bladder; And the bladder cavity CAP treatment module is connected with the flexible delivery catheter device and is used for applying plasma to the focus of the bladder.
2. 2. The system of claim 1, further comprising a monitoring feedback unit coupled to the intravesical CAP therapy module and the master and parameter setting module for feeding back detection data during therapy to the master and parameter setting module.
3. 3. The system of claim 1, further comprising an exhaust treatment unit coupled to the intravesical CAP treatment module for collecting and treating exhaust gases generated during treatment.
4. 4. The system of claim 1, further comprising an anesthesia and support assistance unit that cooperates with the intravesical CAP treatment module for providing anesthesia, insulation and operational support during treatment.
5. 5. The system of claim 1, wherein the CAP generator device comprises a power supply portion, a gas input interface, and a CAP generator body, the gas input interface being coupled to the CAP generator body, the CAP generator body being coupled to the flexible delivery catheter device.
6. 6. The system of claim 5, wherein the CAP generator body comprises a high voltage electrode, a dielectric insulating tube, a return electrode, and a discharge chamber, the high voltage electrode and the return electrode forming a discharge structure within the dielectric insulating tube, the discharge chamber being energized to produce an atmospheric pressure low temperature plasma.
7. 7. The system of claim 1, wherein the flexible delivery conduit means comprises an inner conduit as the plasma delivery channel and an outer sleeve sleeved outside the inner conduit, the outer sleeve and the inner conduit forming an annular gap channel therebetween for backflow, exhaust and pressure equalization.
8. 8. The system of claim 1, further comprising an anti-tumor drug.
9. 9. The system of claim 8, wherein the anti-tumor drug comprises a PD-1 antibody.
10. 10. Use of the atmospheric pressure cryogenic plasma bladder perfusion treatment system according to any one of claims 1 to 9 in the manufacture of a bladder cancer treatment device.

Description

Atmospheric pressure low temperature plasma bladder perfusion treatment system and application thereof Technical Field The invention relates to the technical field of plasma medical appliances, in particular to an atmospheric pressure low temperature plasma bladder perfusion treatment system and application thereof. Background Atmospheric pressure low temperature plasma (Cold Atmospheric Plasma, CAP) is a partially ionized gas generated by high pressure discharge at atmospheric pressure, whose macroscopic temperature can be maintained between room temperature and 40 ℃, and has received wide attention in biomedical fields in recent years. The existing research shows that CAP can selectively induce apoptosis of tumor cells by inducing oxidative stress of the tumor cells, and has obvious effect in superficial tumor treatment. While CAP has shown great potential in superficial tumor treatment, its use in deep organ tumors still faces many challenges. The bladder is a hollow organ that is accessible through the natural lumen (urethra) and is ideally suited for local perfusion therapy. However, current CAP studies on bladder cancer are limited to in vitro cell experiments. The existing plasma generating device has large volume, the electrode structure is difficult to adapt to the long and narrow bending environment in the urethra, and the potential safety hazard of thermal effect and air pressure change is difficult to realize accurate delivery of plasma to the inside of the bladder in the treatment process. Disclosure of Invention In order to solve the technical problem that accurate delivery of plasma to the inside of a bladder is difficult to realize in the prior art, the invention provides an atmospheric pressure low temperature plasma bladder perfusion treatment system, which comprises: The main control and parameter setting module is used for controlling the operation of the system and adjusting the output parameters of the plasmas; the working gas source module is used for providing working gas; The gas flow regulating module is connected with the working gas source module and used for regulating the gas flow; The pulse high-voltage power supply matching module is used for providing power supply required by high-voltage discharge; The CAP generator device is respectively connected with the gas flow regulating module and the pulse high-voltage power supply matching module and is used for ionizing working gas to generate atmospheric pressure low-temperature plasma; a flexible delivery catheter device connected to the CAP generator device for delivering the plasma into the bladder; And the bladder cavity CAP treatment module is connected with the flexible delivery catheter device and is used for applying plasma to the focus of the bladder. Further, the system also comprises a monitoring feedback unit, wherein the monitoring feedback unit is connected with the CAP treatment module in the bladder cavity and the master control and parameter setting module and is used for feeding back detection data in the treatment process to the master control and parameter setting module. Further, the system also comprises an exhaust gas treatment unit, wherein the exhaust gas treatment unit is connected with the CAP treatment module in the bladder cavity and is used for collecting and treating the tail gas generated in the treatment process. Further, the system also includes an anesthesia and support aid unit that cooperates with the intravesical CAP treatment module for providing anesthesia, thermal insulation, and operational support during treatment. Further, the CAP generator device comprises a power supply portion, a gas input interface, and a CAP generator body, the gas input interface being connected with the CAP generator body, the CAP generator body being connected with the flexible delivery catheter device. Further, the CAP generator main body comprises a high-voltage electrode, a dielectric insulation tube, a loop electrode and a discharge cavity, wherein the high-voltage electrode and the loop electrode form a discharge structure in the dielectric insulation tube, and the discharge cavity is internally excited to generate atmospheric pressure low-temperature plasma. Further, the flexible delivery catheter device comprises an inner catheter as a plasma delivery channel and an outer sleeve sleeved outside the inner catheter, an annular gap channel is formed between the outer sleeve and the inner catheter, and the annular gap channel is used for backflow, exhaust and pressure balance. Further, the system also comprises an anti-tumor drug, preferably the anti-tumor drug comprises a PD-1 antibody. The invention also provides application of the atmospheric pressure low-temperature plasma bladder perfusion treatment system in preparation of bladder cancer treatment equipment. Compared with the prior art, the atmospheric pressure low-temperature plasma bladder perfusion treatment system and the application thereof have th