CN-121988226-A - Quick material changing system for chemical synthesis automation platform

Abstract

The invention discloses a quick material changing system for a chemical synthesis automation platform, and relates to the technical field of chemical synthesis. The system comprises a multi-channel material inlet module, a switching executing mechanism, a public outlet module, a cleaning and purging unit and a control system. The multi-channel material inlet module is provided with a plurality of independent material inlets, and the switching actuating mechanism comprises one or more switching valve groups and is used for selectively communicating any material inlet to a public outlet. The cleaning and blowing unit integrates a solvent flushing channel and an inert gas blowing interface and is used for cleaning and blowing the switched flow path. The control system is communicated with the upper computer, receives the switching instruction and controls each unit to execute actions. The invention realizes the rapid switching of materials and the automatic cleaning of a flow path, has the advantages of high switching efficiency, low cross contamination, high modularization degree, safety, reliability and the like, and can be widely applied to the field of chemical synthesis automation.

Inventors

• CHEN XIAOYI
• ZENG WENGUI
• HUANG KAIJUN
• SUN FENG

Assignees

• 宁波兴博元智能技术有限公司

Dates

Publication Date

20260508

Application Date

20260306

Claims (10)

1. 1. A rapid reloading system for a chemical synthesis automation platform, comprising: The multichannel material inlet module is provided with N independent material inlets, wherein N is more than or equal to 2 and is used for connecting a reagent storage tank; the switching execution mechanism comprises one or more switching valve groups and is used for selectively communicating any material inlet in the multichannel material inlet module to a public outlet; a common outlet module connected to the downstream reactor or feed pump; The cleaning and blowing unit is integrated with a solvent flushing channel and an inert gas blowing interface and is used for cleaning and blowing the switched flow path; and the control system is in communication connection with the upper computer and is used for receiving the switching instruction and controlling the execution actions of the switching execution mechanism and the cleaning and purging unit.
2. 2. A quick-change material system for a chemical synthesis automation platform according to claim 1, wherein the material inlet and the common outlet are each configured as a quick-plug interface.
3. 3. A quick-change material system for a chemical synthesis automation platform according to claim 1, wherein the switching valve in the switching valve block is a zero dead volume diaphragm valve or a piezo-electrically driven micro valve.
4. 4. The rapid tooling change system for a chemical synthesis automation platform of claim 1, wherein the switch actuator has an integrally formed valve seat structure with a valve core disposed therein, the valve core is made of a corrosion resistant material, and each material passage meets a single outlet at the valve core such that the physical dead volume is less than 5 μl.
5. 5. The rapid tooling change system for a chemical synthesis automation platform of claim 4, wherein the valve core is a ceramic-PFA composite structure having a PFA coating on the surface of the ceramic substrate.
6. 6. A quick-change system for a chemical synthesis automation platform according to claim 1, wherein the common outlet module is provided with a one-way valve or solenoid valve for preventing backflow of material.
7. 7. A rapid tooling change system for a chemical synthesis automation platform according to claim 1, wherein the control system has a material compatibility database built-in for controlling the switching path or/and issuing an alarm based on material compatibility information.
8. 8. The rapid tooling change system for a chemical synthesis automation platform of claim 1 or 7, wherein the control system is integrated with a machine learning module for dynamically adjusting the flush time, purge intensity and switching timing based on historical operational data and real-time sensor feedback.
9. 9. A rapid reloading system for a chemical synthesis automation platform according to claim 1, wherein the control system is further connected with a pressure sensor and/or a flow meter for monitoring the pipeline status in real time and stopping operation and giving an alarm when an abnormality is detected.
10. 10. A rapid tooling change system for chemical synthesis automation platforms according to claim 1, wherein the system is a fully closed flow path structure.

Description

Quick material changing system for chemical synthesis automation platform Technical Field The invention relates to the technical field of chemical synthesis, in particular to a quick material changing system for a chemical synthesis automation platform. Background With the development of chemical synthesis to high throughput and automation, higher requirements are put on material switching efficiency and cross-contamination control of a synthesis platform. When the traditional chemical synthesis equipment processes various reagents, a manual replacement or simple valve group switching mode is generally adopted, so that the problems of complex operation, low efficiency, serious cross contamination and the like exist, and the requirements of modern laboratories on high-throughput experiments are difficult to meet. In particular, where radiopharmaceutical synthesis or hazardous chemical handling is involved, conventional equipment suffers from inadequate containment and presents a safety hazard. In view of the above problems, there are some improvements in the prior art. For example, CN109173951a discloses a microfluidic technology-based PET imaging agent modularized integrated synthesis device, which utilizes the cooperation of a syringe pump and a multi-position selection valve to realize a complex synthesis process, but has limitation in the range of synthesizable drugs, and is difficult to meet the synthesis requirements of different types of drugs. CN106824006a provides a multi-reagent sequential liquid inlet device for preventing cross contamination, which adopts a multi-layer structure design to effectively avoid reagent residues, but the fluid control and mixing effects thereof are still to be optimized, and the structure is complex and maintenance is inconvenient. In addition, the existing automatic liquid supply equipment has the problems of insufficient measuring precision, single function, lack of modularized design concept and the like, is high in price and low in running speed, and is difficult to adapt to the changes of different experimental conditions and requirements. Disclosure of Invention Aiming at the technical problems in the related art, the invention provides a quick material changing system for a chemical synthesis automation platform, which can overcome the defects in the prior art. In order to achieve the technical purpose, the technical scheme of the invention is realized as follows: a rapid reloading system for a chemical synthesis automation platform; the quick-change material system for the chemical synthesis automation platform comprises: The multichannel material inlet module is provided with N independent material inlets, wherein N is more than or equal to 2 and is used for connecting a reagent storage tank; the switching execution mechanism comprises one or more switching valve groups and is used for selectively communicating any material inlet in the multichannel material inlet module to a public outlet; a common outlet module connected to the downstream reactor or feed pump; The cleaning and blowing unit is integrated with a solvent flushing channel and an inert gas blowing interface and is used for cleaning and blowing the switched flow path; and the control system is in communication connection with the upper computer and is used for receiving the switching instruction and controlling the execution actions of the switching execution mechanism and the cleaning and purging unit. Further, the material inlet and the public outlet are designed by adopting a quick-plug interface. Further, the switching valve in the switching valve group is a zero dead volume diaphragm valve or a piezoelectric driven micro valve. Further, the switching actuating mechanism is provided with an integrally formed valve seat structure, a valve core is arranged in the valve seat and made of corrosion-resistant materials, and all material channels are intersected at a single outlet at the valve core, so that the physical dead volume is smaller than 5 mu L. Further, the valve core is of a ceramic-PFA composite structure, and a PFA coating is arranged on the surface of a ceramic matrix. Further, the common outlet module is provided with a one-way valve or a solenoid valve for preventing backflow of materials. Further, a material compatibility database is arranged in the control system and is used for controlling a switching path or/and giving an alarm according to the compatibility information of the materials. Further, the control system is integrated with a machine learning module for dynamically adjusting the flushing time, the purging strength and the switching time sequence according to historical operation data and real-time sensor feedback. Further, the control system is also connected with a pressure sensor and/or a flowmeter, and is used for monitoring the pipeline state in real time, stopping running and giving an alarm when an abnormality is detected. Further, the system is a fully closed flo