CN-121988414-A - Production equipment and process for composite membrane soft-base microfluidic chip

CN121988414ACN 121988414 ACN121988414 ACN 121988414ACN-121988414-A

Abstract

The invention discloses a production device and a production process of a composite membrane soft foundation micro-fluidic chip, wherein the production device comprises a feeding mechanism and a feeding mechanism of a bottom membrane, a liquid medicine adding mechanism, a cotton filter placing device and a guiding converging mechanism are arranged along the conveying direction of the feeding mechanism of the bottom membrane, a first heat sealing device, a second heat sealing device, a pre-cutting device, a cutting device and a blanking device are arranged on one side of the guiding converging mechanism, the production process comprises the steps that the liquid medicine adding mechanism drops the liquid medicine onto the bottom membrane, the cotton filter placing device punches out single small pieces of cotton filter and places the single small pieces of cotton filter into the set position of the bottom membrane, and after the upper membrane and the bottom membrane are converged, the first heat sealing device and the second heat sealing device respectively perform heat sealing actions to form the micro-fluidic chip with two paths of flow channels. The invention integrates modules of film feeding, liquid medicine coating, on-line blanking and mounting of filter cotton, graded heat sealing, precise cutting and the like, and realizes high-efficiency, large-batch and high-consistency production of microfluidic chips.

Inventors

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Assignees

苏州万贵源精密科技有限公司

Dates

Publication Date: 20260508
Application Date: 20260410

Claims (10)

1. The production equipment of the composite membrane soft-base micro-fluidic chip is characterized by comprising the following components: The upper film feeding mechanism is used for supplying upper films; the bottom film feeding mechanism is used for supplying a bottom film; a chemical liquid adding mechanism arranged along the conveying direction of the carrier film feeding mechanism and used for adding chemical liquid to a set position of the carrier film; the filter cotton placing device is arranged behind the liquid medicine adding mechanism along the conveying direction of the basement membrane feeding mechanism and comprises a filter cotton feeding mechanism for placing sheet filter cotton and a blanking conveying mechanism for blanking single small filter cotton from the sheet filter cotton on the filter cotton feeding mechanism and placing the small filter cotton on the basement membrane; The guiding and converging mechanism is used for converging the upper membrane on the upper membrane feeding mechanism with the bottom membrane after guiding, and the small filter cotton quilt is restrained between the bottom membrane and the upper membrane; The first heat sealing device, the second heat sealing device, the pre-cutting device, the cutting device and the blanking device are sequentially arranged on one side of the guiding converging mechanism, the filter cotton placing device is positioned on the other side of the guiding converging mechanism, the first heat sealing device is configured to form a first channel between the bottom film and the upper film, and the second heat sealing device is configured to form a second channel between the bottom film and the upper film.
2. The production device of the composite membrane material soft-base micro-fluidic chip as claimed in claim 1, wherein the upper membrane feeding mechanism comprises an upper membrane feeding roll, a first deviation rectifying assembly and a plurality of first guide shafts, and the bottom membrane feeding mechanism comprises a bottom membrane feeding roll, a second deviation rectifying assembly and a plurality of second guide shafts.
3. The production equipment of the composite membrane soft foundation micro-fluidic chip is characterized in that the liquid medicine adding mechanism comprises a support, a sliding table cylinder arranged on the support, a first supporting plate driven by the sliding table cylinder to move up and down, a first mounting frame arranged on the first supporting plate in a sliding manner up and down, and a plurality of liquid dropping heads vertically arranged on the first mounting frame, wherein a plurality of liquid outlets extend from the outer Zhou Shuxiang of the bottom of the liquid dropping head and are circumferentially distributed, and liquid flow channels communicated with the liquid outlets are arranged inside the liquid dropping heads.
4. The production equipment of the composite membrane soft foundation micro-fluidic chip is characterized in that the filter cotton feeding mechanism comprises a second mounting frame and a feeding plate arranged on the second mounting frame, a plurality of containing grooves are formed in the feeding plate, a material pressing plate is arranged in the containing grooves, a plurality of avoiding holes are uniformly distributed in the material pressing plate, the feeding plate is driven by a first driving piece to move along the conveying direction of a bottom membrane, and limiting columns are arranged at two ends of the second mounting frame.
5. The soft basic micro-fluidic chip production equipment of composite membrane material as set forth in claim 1, wherein the blanking and carrying mechanism comprises an XYZ driving module, a second supporting plate connected to the movable end of the XYZ driving module, a moving plate arranged on the second supporting plate in a sliding manner, and a blanking and adsorbing assembly and a cutting assembly which are arranged on the moving plate and are mutually matched to realize blanking and adsorbing actions.
6. The device for producing the composite membrane soft-base micro-fluidic chip according to claim 1, wherein the guiding and converging mechanism comprises a third guiding shaft and a guiding module arranged on one side of the third guiding shaft, the guiding module comprises a supporting roller, a pressing roller and a gap adjusting assembly for adjusting a gap between the supporting roller and the pressing roller, and a detection camera is arranged between the guiding module and the first heat sealing device.
7. The soft basic micro-fluidic chip production equipment of composite membrane material is characterized in that the first heat sealing device and the second heat sealing device comprise a bottom plate, a second driving piece arranged on the bottom plate, a lifting frame driven by the second driving piece to move up and down, a lower forming die arranged on the lifting frame, an upper forming die arranged right above the lower forming die and matched with the lower forming die, and a third driving piece for driving the upper forming die to move up and down, wherein the third driving piece is arranged at the top of the lifting frame, and the upper forming die is connected with a heating plate.
8. The soft basic micro-fluidic chip production equipment of composite membrane material is characterized in that the pre-cutting device comprises a first cutting die, a first cutting upper die and a first cutting driving piece for driving the first cutting upper die to conduct lifting motion, the cutting device comprises a second cutting die, a second cutting upper die and a second cutting driving piece for driving the second cutting upper die to conduct lifting motion, a waste recycling device is arranged above the cutting device, and the waste recycling device comprises a material collecting shaft and a plurality of fourth guide shafts.
9. The production device of the composite membrane soft foundation micro-fluidic chip of claim 6, wherein the blanking device comprises a blanking conveying line and a guide assembly arranged at one end of the blanking conveying line, a pressing assembly is arranged between the pre-cutting device and the cutting device, and the pressing assembly and the guide module are arranged between the second heat sealing device and the pre-cutting device.
10. The production process of the composite membrane soft-base microfluidic chip is characterized by being completed based on the production equipment of the composite membrane soft-base microfluidic chip, which is disclosed by any one of claims 1-9, and comprises the following steps of: S1, releasing an upper membrane by the upper membrane feeding mechanism, releasing a bottom membrane by the bottom membrane feeding mechanism, and placing sheet filter cotton on the filter cotton feeding mechanism; S2, conveying the bottom film on the bottom film feeding mechanism to the liquid medicine adding mechanism, dropwise adding the liquid medicine to a set position of the bottom film by the liquid medicine adding mechanism, and adhering the dropwise added liquid medicine to the bottom film after evaporating redundant solvent; S3, blanking a single small piece of filter cotton from the piece-shaped filter cotton by the blanking conveying mechanism and placing the small piece of filter cotton at a set position of the basement membrane; S4, guiding an upper membrane on the upper membrane feeding mechanism through the guiding converging mechanism, converging the upper membrane with a bottom membrane, superposing the upper membrane right above the bottom membrane, and restraining the small filter cotton between the upper membrane and the bottom membrane; s5, conveying the converged bottom film, the small filter cotton and the upper film to the first heat sealing device together, performing a first heat sealing action by the first heat sealing device, and hot-pressing the bottom film and the upper film together, wherein a channel is formed between the bottom film and the upper film according to design requirements; S6, continuously conveying the micro-fluidic chip to the second heat sealing device, performing a second heat sealing action by the second heat sealing device, and forming another channel between the bottom film and the upper film according to design requirements to obtain a micro-fluidic chip with two channels; s7, the pre-cutting device performs pre-cutting action on the micro-fluidic chip; and S8, the cutting device cuts the micro-fluidic chip completely, and the cut micro-fluidic chip falls onto the blanking device.

Description

Production equipment and process for composite membrane soft-base microfluidic chip Technical Field The invention belongs to the technical field of manufacturing of microfluidic chips, and particularly relates to production equipment and process of a composite membrane soft-base microfluidic chip. Background The microfluidic chip technology integrates basic operation units of sample preparation, reaction, separation, detection and the like in biological, chemical and medical analysis processes onto a micron-scale chip, and automatically completes the whole analysis process. The microfluidic chip can realize the transmission, mixing, reaction and detection of samples in a micro space, and has the remarkable advantages of high flux, low sample consumption, high reaction speed and the like. With the rapid development of In Vitro Diagnostics (IVD) and point of care testing (POCT) technologies, higher demands are being placed on the mass manufacturing capability and uniformity of microfluidic chips. The traditional microfluidic chip comprises a bottom plate and a cover plate, is formed in an injection molding mode, for example, a production line of the microfluidic chip disclosed in China patent application publication No. CN116214837A comprises a forming die and injection molding equipment for carrying out injection molding on the forming die, and the microfluidic chip formed in the injection molding mode has the main defects that (1) the curing period is long, continuous high-efficiency production is difficult to realize, (2) the chip thickness is large, 90% or more of materials are invalid supporting structures, waste is serious, the cost of a single piece is high, (3) the function integration capability is weak, the on-line completion of built-in compounding of multiple materials such as liquid medicine dispensing, filter cotton and the like is difficult, the bonding process is complex, the alignment difficulty is high, the yield is limited due to plasma treatment, and (5) the consistency between batches is obviously influenced by curing shrinkage and manual operation fluctuation, so that the microfluidic chip formed in an injection molding mode is not suitable for industrialized scenes of the microfluidic chip with low cost, large quantity and high consistency. In order to solve the above-mentioned problems, a batch processing technology for obtaining a soft-base microfluidic chip by composite film forming is designed in the prior art, for example, a batch processing technology for a microfluidic chip is disclosed in chinese patent application publication No. CN121134678a, in which at least two polymer coiled materials are provided, namely, a first coiled material for forming a microchannel structure and a second coiled material for sealing a microchannel, continuous compression molding processing is performed on the surface of the first coiled material by a roll-to-roll processing platform, and by a roll-to-roll continuous process, the microchannel compression molding, functional deposition, precise para-thermal sealing and online cutting are integrated into a whole to realize the production of the microfluidic chip. In the prior art, a thin film micro-channel laser welding device and a laser welding method thereof disclosed in the patent grant publication number CN116852725B of China comprise a laser machine, a thin film feeding machine and a thin film compression joint clamp, wherein the scheme mainly shows two thin film feeding and laser welding related devices, but in actual production of a micro-fluidic chip, functional components such as medicines, filter cotton or other surface modification materials are required to be placed in a channel of the chip, and the devices are not provided with structures related to the functional components, so that the actions cannot be completed. Therefore, there is a need to design a production device capable of obtaining a soft-base microfluidic chip through composite membrane material molding, and the production device is required to automatically complete actions such as film feeding, medicament placement, filter cotton placement, runner molding, cutting and blanking, and the like, and is required to be capable of producing microfluidic chips with good consistency in a high-efficiency and large-scale manner. Therefore, it is necessary to provide a production device and a process for a composite membrane soft-base microfluidic chip to solve the above technical problems. Disclosure of Invention The invention mainly aims to provide the production equipment for the composite membrane soft-base microfluidic chip, which integrates modules such as membrane feeding, liquid medicine coating, on-line blanking and mounting of filter cotton, graded heat sealing, precise cutting and the like, realizes high-efficiency, large-batch and high-consistency production of the microfluidic chip, and remarkably improves the composite capability and process stability of a multi-element ma