Search

CN-121990256-A - Biological sample collection and liquid nitrogen storage transfer system

CN121990256ACN 121990256 ACN121990256 ACN 121990256ACN-121990256-A

Abstract

The invention discloses a biological sample collection and liquid nitrogen storage transfer system which comprises a material taking vehicle, a storage transfer vehicle and at least one transfer tray, wherein a liquid supply cavity for containing liquid nitrogen and a storage area which is positioned above the liquid supply cavity and communicated with the liquid supply cavity are arranged in the transfer tray, the liquid nitrogen in the liquid supply cavity enters the storage area through a gas phase, a cover plate is arranged on the transfer tray corresponding to the storage area, and both a first liquid supply unit and a second liquid supply unit can be selectively communicated with the liquid supply cavity of the transfer tray so as to supplement the liquid nitrogen to the liquid supply cavity. Through setting up a plurality of independent storage chambers and transporting the tray to adopt the mode of dividing the storage area with the tray, make when carrying out batch sample operation, operating personnel can open target transportation tray or storage area alone, access single batch sample, and other samples still are in the inclosed low temperature environment, thereby avoided temperature violent fluctuation and cross contamination problem, greatly promoted biological sample's survival rate and storage quality.

Inventors

  • ZHENG LIDAN
  • BAO XIAODONG
  • YU ZHIJIE
  • YE JU
  • HUANG XIAOYING
  • CHEN QUBO

Assignees

  • 温州医科大学附属第一医院

Dates

Publication Date
20260508
Application Date
20260109

Claims (10)

  1. 1. A biological sample collection and liquid nitrogen storage transfer system comprising: The device comprises a material taking vehicle (1), wherein the material taking vehicle (1) comprises a first vehicle body (4), a photographing unit (6) arranged on the first vehicle body (4), a first liquid supply unit (9) arranged inside the first vehicle body (4) and a plurality of mutually independent first storage cavities (7); A storage transfer vehicle (2), wherein the storage transfer vehicle (2) comprises a second vehicle body (22), a second liquid supply unit arranged inside the second vehicle body (22), and a plurality of mutually independent second storage cavities; -at least one transfer tray (3), the transfer tray (3) being selectively receivable within the first storage cavity (7) or the second storage cavity; The transfer tray (3) is internally provided with a liquid supply cavity (23) for containing liquid nitrogen and a storage area (24) which is positioned above the liquid supply cavity (23) and communicated with the liquid supply cavity (23), the liquid nitrogen in the liquid supply cavity (23) enters the storage area (24) through a gas phase, and the transfer tray (3) is provided with a cover plate (25) corresponding to the storage area (24); the first liquid supply unit (9) and the second liquid supply unit can be selectively communicated with a liquid supply cavity (23) of the transfer tray (3) so as to supplement liquid nitrogen to the liquid supply cavity (23).
  2. 2. Biological sample collection and liquid nitrogen storage transfer system according to claim 1, characterized in that the transfer tray (3) is provided with a lifting basket (26) for holding a sample rack (27) corresponding to the storage area (24), a plurality of ventilation holes (29) are formed in the bottom of the lifting basket (26), and handles (30) are arranged on two sides of the lifting basket (26) in an outward extending mode.
  3. 3. A biological sample collection and liquid nitrogen storage transfer system according to claim 1, wherein a porous adsorption unit (31) is fixedly arranged in the liquid supply cavity (23).
  4. 4. A biological sample collection and liquid nitrogen storage transfer system according to claim 1, characterized in that the transfer tray (3) is provided with a liquid inlet (33) corresponding to the liquid supply cavity (23), and a sealing plate (34) driven by an elastic piece to normally close the liquid inlet (33) is arranged at the liquid inlet (33); The first liquid supply unit (9) and the second liquid supply unit comprise liquid supply pipes (35) for conveying liquid nitrogen, and an ejection mechanism (36) is arranged at the end part of each liquid supply pipe (35); when the transfer tray (3) is pushed into a preset position in the storage cavity of the material taking vehicle (1) or the storage transfer vehicle (2), the pushing mechanism (36) can push the sealing plate (34) to open the liquid inlet (33), so that the liquid supply pipe (35) is communicated with the liquid supply cavity (23).
  5. 5. A biological sample collection and liquid nitrogen storage transfer system according to claim 1, wherein the first liquid supply unit (9) and the second liquid supply unit comprise a storage tank (17), a liquid supply pipe (35) path (18), a pumping means (19) and a control valve (20) arranged on the liquid supply pipe (35) path (18); a sensor for detecting the liquid nitrogen state is arranged in a liquid supply cavity (23) of the transfer tray (3); The automatic fluid infusion device further comprises a control module which is in communication connection with the sensor, the pumping component (19) and the control valve (20) and is configured to control the opening and closing of the pumping component (19) and the control valve (20) according to signals of the sensor so as to realize automatic fluid infusion of the designated transfer tray (3).
  6. 6. Biological sample collection and liquid nitrogen storage transfer system according to claim 1, characterized in that the camera unit (6) comprises a camera (10) and a connecting rod (11), the camera (10) being connected to the upper end of the first vehicle body (4) by means of the connecting rod (11).
  7. 7. The biological sample collection and liquid nitrogen storage transfer system according to claim 6, wherein the sampling vehicle (1) is further provided with a code scanner (12) for identifying sample marks.
  8. 8. The biological sample collection and liquid nitrogen storage transfer system according to claim 1, wherein a display module (39) and a communication module are arranged on the material taking vehicle (1) and the storage transfer vehicle (2), and the display module (39) is used for displaying system state information and performing data interaction with external equipment through the communication module.
  9. 9. Biological sample collection and liquid nitrogen storage transfer system according to claim 1, characterized in that the first vehicle body (4) and the second vehicle body (22) are provided with liquid filling interfaces (21) on one side.
  10. 10. A biological sample collection and liquid nitrogen storage transfer system according to claim 1, characterized in that said first body (4) is provided with at least one drawer (16).

Description

Biological sample collection and liquid nitrogen storage transfer system Technical Field The invention relates to the technical field of biological sample processing equipment, in particular to a system integrating the functions of sample collection, temporary storage, transportation and storage in biological sample collection and liquid nitrogen storage transportation. Background In the field of biological sample collection and long-term low-temperature preservation, a common biological sample low-temperature storage operation flow is as follows, the collected biological sample is divided into a plurality of freezing storage tubes, and then the freezing storage tubes are intensively placed on a sample rack. For convenient batch management, a plurality of sample racks can be further and intensively accommodated in a large-scale frame or basket which can be integrally lifted, and finally the frame is integrally immersed in a large-scale liquid nitrogen storage tank for storage. However, the above storage method has a remarkable disadvantage in actual operation that when an operator needs to store or take out a certain lot or a certain area of samples from the storage tank, the entire frame must be taken out of the liquid nitrogen tank and completely exposed to the room temperature environment before the operation of the target samples can be performed on the frame. This procedure means that a large number of other samples stored in the same frame, not the target of this operation, are also inevitably brought out of the liquid nitrogen environment with the frame, undergoing severe temperature fluctuations and thermal shocks, even from cryogenic temperatures to room temperature, once or more. Repeated temperature impact can seriously affect the activity and quality of biological samples, and can cause the problems of damage to cell structures, protein denaturation, nucleic acid degradation and the like of ice crystal recrystallization. In addition, frequent opening and closing of the integral frame also increases the risk of external pollutants entering the storage environment, aggravates unnecessary volatilization of liquid nitrogen, and increases the use cost and potential safety hazard, so that the method needs to be improved. Disclosure of Invention Aiming at the problems that in the prior art, non-target biological samples repeatedly experience temperature fluctuation, thermal shock and pollution risk increase due to integral access operation, the invention aims to provide a biological sample sampling, storing and transporting system. Through the modularized and independent design, the whole process from the sampling point to the storage point is accurately, separately and continuously managed at low temperature, so that each batch of samples can be independently processed without affecting other samples, and unnecessary temperature interference is eliminated. In order to achieve the above purpose, the present invention provides the following technical solutions: a biological sample collection and liquid nitrogen storage transfer system comprising: The material taking vehicle comprises a first vehicle body, a photographing unit arranged on the first vehicle body, a first liquid supply unit arranged in the first vehicle body and a plurality of mutually independent first storage cavities; The storage transfer trolley comprises a second trolley body, a second liquid supply unit and a plurality of mutually independent second storage cavities, wherein the second liquid supply unit is arranged in the second trolley body; At least one transfer tray selectively receivable within the first storage cavity or the second storage cavity; The transfer tray is internally provided with a liquid supply cavity for containing liquid nitrogen and a storage area which is positioned above the liquid supply cavity and communicated with the liquid supply cavity, the liquid nitrogen in the liquid supply cavity enters the storage area through a gas phase, and the transfer tray is provided with a cover plate corresponding to the storage area; The first liquid supply unit and the second liquid supply unit can be selectively communicated with a liquid supply cavity of the transfer tray so as to supplement liquid nitrogen to the liquid supply cavity. As a further improvement of the invention, the transfer tray is provided with a lifting basket for carrying the sample rack corresponding to the storage area, the bottom of the lifting basket is provided with a plurality of air holes, and the two sides of the lifting basket are outwards extended and provided with lifting handles. As a further improvement of the invention, the liquid supply cavity is fixedly provided with a porous adsorption unit. As a further improvement of the invention, the transfer tray is provided with a liquid inlet corresponding to the liquid supply cavity, and a sealing plate driven by an elastic piece to normally close the liquid inlet is arranged at the liquid in