CN-121990934-A - Preparation method and application of magnesium lysine

Abstract

The invention relates to the technical field of preparation of organic metal compounds, in particular to a preparation method and application of magnesium lysine, comprising the following steps of taking L-lysine hydrochloride, adding deionized water, heating and stirring until the L-lysine hydrochloride is completely dissolved, and regulating the pH value of a solution to 9.0-10.0 by using an alkali reagent to obtain a lysine solution; the invention can realize the improvement of quality and the remarkable reduction of the dissolution pH dependence, can keep stable and efficient dissolution state in different gastrointestinal tract environments such as simulated gastric fluid, intestinal fluid and the like, can fully adapt to various crowds with insufficient gastric acid secretion, normal secretion and higher intestinal pH, thoroughly solves the core problems of unstable dissolution and limited applicable crowds of the existing magnesium supplement, and provides more reliable magnesium supplement selection for users with different physiological conditions.

Inventors

• ZHANG SHENG
• Xi rixin
• LI JIASHENG
• JIAN JIKANG
• WANG JIAQI

Assignees

• 浙江天启生化股份有限公司

Dates

Publication Date

20260508

Application Date

20260409

Claims (10)

1. 1. The preparation method of the magnesium lysine is characterized by comprising the following steps of: Adding deionized water into L-lysine hydrochloride, heating and stirring until the L-lysine hydrochloride is completely dissolved, and regulating the pH value of the solution to 9.0-10.0 by using an alkali reagent to obtain a lysine solution; taking magnesium salt which can be dissolved in dilute acetic acid, adding dilute acetic acid with the pH value of 4.0-5.0 for dissolution, and then optionally filtering for impurity removal to obtain magnesium salt solution; Dropwise adding a magnesium salt solution into a lysine solution at the rate of 8-12mL/min, adding the alkali reagent in the dropwise adding process to maintain the pH value of the solution to be 9.0-10.0, and keeping the temperature at 50-70 ℃ and stirring for 1-3 hours until the conductivity of the solution is stable; Concentrating, crystallizing, washing and drying the reaction liquid to obtain magnesium lysine.
2. 2. The method according to claim 1, wherein the magnesium salt is one or more selected from magnesium carbonate, magnesium sulfate heptahydrate, and anhydrous magnesium chloride.
3. 3. The method according to claim 1, wherein the alkaline agent is one or more selected from sodium hydroxide, potassium hydroxide and lithium hydroxide.
4. 4. The process according to claim 1, wherein the molar ratio of L-lysine hydrochloride in step (1) to Mg 2+ in step 2) is 1.8:1 to 2.5:1.
5. 5. The method of claim 1, wherein the magnesium salt is a mixed magnesium salt consisting of magnesium carbonate and magnesium sulfate heptahydrate.
6. 6. The method of claim 1, wherein the alkaline agent is a mixed alkaline agent consisting of sodium hydroxide and potassium hydroxide.
7. 7. The process according to claim 1, wherein in the step (4), the concentration is carried out by distillation under reduced pressure to 1/3 of the volume of the raw reaction solution.
8. 8. The preparation method according to claim 1, wherein in the step (4), the crystallization is carried out at 0 ℃ for 12 hours, the washing is carried out by adopting 80% cold ethanol until the filtrate ninhydrin reaction is negative, and the drying is carried out at 50 ℃ for 12 hours.
9. 9. The preparation method according to claim 5, wherein the mass ratio of magnesium carbonate to magnesium sulfate heptahydrate in the mixed magnesium salt is 15:19.
10. 10. Magnesium lysine, characterized in that it is prepared by the preparation method according to any one of claims 1 to 9.

Description

Preparation method and application of magnesium lysine Technical Field The invention relates to the technical field of preparation of organic metal compounds, in particular to a preparation method and application of magnesium lysine. Background The magnesium element is a mineral substance necessary for human body, participates in various physiological metabolic processes, and has important significance for maintaining normal physiological functions of the organism. With the rising health consciousness of people, the market demand of magnesium supplements is growing, and the existing magnesium supplements are mainly divided into inorganic magnesium and organic magnesium, but have obvious performance defects. Although the inorganic magnesium supplement has lower cost of raw materials, the dissolution characteristic is obviously affected by the pH of the gastrointestinal tract, the dissolution efficiency in the intestinal environment is low, the inorganic magnesium supplement is difficult to be effectively absorbed by human bodies, applicable people are limited, and the requirements of special people with insufficient gastric acid secretion and the like cannot be met. The organic magnesium supplement has improved dissolution performance, but most products still have the problem of insufficient adaptability to gastrointestinal tract environment, and have poor dissolution stability under different gastric acid levels or intestinal tract pH conditions. Aiming at the organic metal compounds with nutrition and functionality such as magnesium lysine, the prior preparation process has a plurality of limitations. On one hand, the selection range of raw materials is narrow, the suitability of magnesium salt and alkali reagent is not systematically optimized, partial process even directly uses raw materials which are not pretreated, so that the reaction is incomplete and more impurities remain, on the other hand, the process parameters lack scientific regulation and control, and the key parameter settings such as temperature, pH value, raw material proportion and the like are unreasonable, so that the product purity and yield are difficult to be compatible, and the performance attenuation easily occurs in the storage process. In addition, some of the prior art attempts to improve performance by simply mixing different magnesium salts, but the combination mode fails to solve the problem of synergy among the components, but rather leads to large dissolution fluctuation, easy separation of the components during storage, and further affects the stability and the use effect of the product. In the whole, the existing magnesium supplement and magnesium lysinate preparation process have obvious defects in the aspects of dissolution performance, environment suitability, storage stability, product purity, bioavailability and the like, and are difficult to meet the requirements of personalized supplement requirements of different people and the requirements of industrial production on quality stability and process reliability, so that an optimized preparation technology is needed to break through the bottleneck. Disclosure of Invention The invention aims at providing a preparation method and application of magnesium lysine. The invention further aims to provide a preparation method of magnesium lysine, which comprises the following steps: Adding deionized water into L-lysine hydrochloride, heating and stirring until the L-lysine hydrochloride is completely dissolved, and regulating the pH value of the solution to 9.0-10.0 by using an alkali reagent to obtain a lysine solution; taking magnesium salt which can be dissolved in dilute acetic acid, adding dilute acetic acid with the pH value of 4.0-5.0 for dissolution, and then optionally filtering for impurity removal to obtain magnesium salt solution; Dropwise adding a magnesium salt solution into a lysine solution at the rate of 8-12mL/min, adding the alkali reagent in the dropwise adding process to maintain the pH value of the solution to be 9.0-10.0, and keeping the temperature at 50-70 ℃ and stirring for 1-3 hours until the conductivity of the solution is stable; Concentrating, crystallizing, washing and drying the reaction liquid to obtain magnesium lysine. Preferably, the magnesium salt is selected from one or more of magnesium carbonate, magnesium sulfate heptahydrate and anhydrous magnesium chloride. Preferably, the alkali agent is selected from one or more of sodium hydroxide, potassium hydroxide and lithium hydroxide. Preferably, the molar ratio of L-lysine hydrochloride in step (1) to Mg 2+ in step 2) is 1.8:1 to 2.5:1. Preferably, the magnesium salt is a mixed magnesium salt consisting of magnesium carbonate and magnesium sulfate heptahydrate. Preferably, the alkali agent is a mixed alkali agent, and the mixed alkali agent consists of sodium hydroxide and potassium hydroxide. Preferably, in the step (4), the concentration is performed by distillation under reduced pressur