CN-121990990-A - Antifungal isoquinoline derivative

Abstract

The invention belongs to the technical field of pesticides and plant disease control, and provides an antifungal isoquinoline derivative: can inhibit various fungal diseases on rice, tobacco and white lotus. The derivative can also be compounded with difenoconazole or pyraclostrobin to prevent and treat rice and tobacco fungal diseases, and has good development prospect.

Inventors

• CHENG CHUANYING
• ZHANG XIANPENG
• ZHANG XIAOPING
• ZHANG XINGLEI

Assignees

• 东华理工大学

Dates

Publication Date

20260508

Application Date

20260104

Claims (9)

1. 1. The application of isoquinoline derivatives in controlling plant pathogenic bacteria is characterized in that the isoquinoline derivatives have the structural formula: ; The plant pathogenic bacteria are selected from the group consisting of Coriolus (Thanatephorus cucumeris), alternaria alternata (ALTERNARIA ALTERNATE), rhizoctonia solani (Rhizoctonia solani), pyricularia oryzae (Magnaporthe oryzae) and Fusarium oxysporum (Fusarium oxysporum).
2. 2. A pesticidal composition characterized by comprising the following active ingredients 。
3. 3. A pesticidal composition according to claim 2, further comprising other pesticidal active ingredients or/and inert adjuvants.
4. 4. A pesticidal composition according to claim 3, wherein the pesticidal active ingredient is a fungicide.
5. 5. A pesticide composition as set forth in claim 3, characterized in that the pesticide active ingredient is difenoconazole or pyraclostrobin.
6. 6. The pesticidal composition according to claim 5, wherein the mass ratio of the isoquinoline derivative and the difenoconazole is 1:9 to 9:1, and the mass ratio of the isoquinoline derivative and the pyraclostrobin is 1:9 to 9:1.
7. 7. The pesticidal composition according to claim 5, wherein the mass ratio of the isoquinoline derivative and the difenoconazole is 1:9 or 7:3, and the mass ratio of the isoquinoline derivative and the pyraclostrobin is 1:9.
8. 8. The pesticide composition according to claim 2, wherein the control subjects of the pesticide composition are leatherleaf ara (Thanatephorus cucumeris), alternaria alternata (ALTERNARIA ALTERNATE), rhizoctonia solani (Rhizoctonia solani), rice blast bacteria (Magnaporthe oryzae) and fusarium oxysporum (Fusarium oxysporum).
9. 9. The pesticidal composition of claim 2, wherein the control disease is tobacco target spot, brown spot, rice sheath blight, rice blast, and white lotus rot.

Description

Antifungal isoquinoline derivative Technical Field The invention belongs to the technical field of pesticides and plant disease control, and relates to application of isoquinoline derivatives in controlling plant pathogenic bacteria. Background This background information is disclosed to enhance an understanding of the general background of the invention and is not necessarily to be considered an admission or any form of suggestion that this information constitutes prior art already known to a person of ordinary skill in the art. Rice is one of the main food crops worldwide, and is a staple food source for nearly 30 hundred million people worldwide. Therefore, stabilizing the quality and yield of rice plays an important role in guaranteeing the grain safety. The tobacco can be used as an industrial raw material, has medical effect and has wide application. Rice and tobacco are threatened by various pathogens in the growing period, such as rice blast, rice sheath blight, tobacco target spot, tobacco brown spot and the like, and the occurrence of the fungal diseases seriously affects the quality and the yield of crops. Therefore, controlling different diseases in the growth and development processes of crops such as rice, tobacco and the like becomes an important point of modern agricultural research. At present, the prevention and control measures are mainly chemical prevention and control, and the effects of preventing disease spreading, helping crop yield to be steadily improved and the like are always exerted. However, it should be ignored that the usage amount of pesticides is continuously increased in recent years, the usage intensity is also continuously increased, meanwhile, the situation of irregular usage frequently occurs, which not only causes the pathogenic bacteria to generate drug resistance, but also causes further influence on the environment and the human health due to excessive usage, and brings serious challenges to the agricultural ecological environment and the quality safety of agricultural products. Therefore, the development of novel, efficient and environment-friendly lead compounds is of great importance for the control of plant fungal diseases. Isoquinoline and its derivatives are an important class of nitrogen-containing heterocyclic compounds, which are widely found in alkaloid structures of natural origin. For example, papaverine extracted from Papaveraceae plant with spasmolytic effect, berberine extracted from Coptidis rhizoma, and tetrahydropalmatine derived from rhizoma corydalis with tranquilizing and analgesic effects. Therefore, the isoquinoline and the derivative thereof have great development and utilization values in chemical and biological medicines due to the characteristics of wide distribution in nature, complex and various structures, wide physiological activity and the like, and have wide medical activity and a certain report in agriculture. For example, sanguinarine isolated from macleaya cordata, chelerythrine isolated from celandine plants, have dactylogyrus killing activity. However, the research of the compounds on the aspect of controlling plant fungal diseases is relatively limited at present, and a large expansion space still exists. Disclosure of Invention Aiming at the problems in the prior art, the invention provides application of isoquinoline derivatives in preventing and treating plant pathogenic bacteria, which can inhibit the occurrence and development of various fungal diseases on rice, tobacco and white lotus. In order to achieve the above purpose, the present invention adopts the following technical scheme. An application of isoquinoline derivatives in preventing and treating plant pathogenic bacteria, wherein the isoquinoline derivatives have the structural formula: abbreviated Ntic. The plant pathogenic bacteria are selected from the group consisting of Coriolus (Thanatephorus cucumeris), alternaria alternata (ALTERNARIA ALTERNATE), rhizoctonia solani (Rhizoctonia solani), pyricularia oryzae (Magnaporthe oryzae) and Fusarium oxysporum (Fusarium oxysporum). The fusarium oxysporum is preferably fusarium oxysporum lotus specialization. A pesticide composition contains the isoquinoline derivatives as effective components. The pesticide composition also comprises other pesticide active ingredients or/and inert auxiliary materials. The pesticide active ingredient is preferably a bactericide. More preferably, the pesticide active ingredient is difenoconazole or pyraclostrobin. In the pesticide composition, the mass ratio of the isoquinoline derivative to the difenoconazole is 1:9-9:1. The mass ratio of the isoquinoline derivative to the pyraclostrobin is 1:9-9:1. Preferably, in the pesticide composition, the mass ratio of the isoquinoline derivative to the difenoconazole is 1:9 or 7:3. The mass ratio of the isoquinoline derivative to the pyraclostrobin is 1:9. The control objects of the pesticide composition are leather melon fungus (Thanatephorus c