CN-121991143-A - 2-Acetamido glucose potassium sulfate salt and preparation method and application thereof

Abstract

The invention discloses a 2-acetamido glucose potassium sulfate compound, a preparation method and application thereof. The compound has a structure shown in a formula I. The compound shown in the formula I has biological activity for preventing and/or treating tumors. I

Inventors

• HE XIANRAN
• LI SHAOLEI
• ZHONG MIN

Assignees

• 深圳福山生物科技有限公司

Dates

Publication Date

20260508

Application Date

20251229

Claims (6)

1. 1. A potassium salt of 2-acetamido glucose sulfate, or a stereoisomer, tautomer, hydrate, or solvate thereof, wherein the potassium salt has a structure represented by formula I: I 。
2. 2. A pharmaceutical composition comprising the potassium salt of 2-acetamido glucose sulfate of claim 1 or its stereoisomers, tautomers, hydrates or solvates, And at least one pharmaceutically acceptable carrier.
3. 3. A process for the preparation of a compound as claimed in claim 1 comprising the steps of: Reacting compound IV with 5-methylsulfonylaminoxime in the presence of N-chlorosuccinimide (NCS), pyridine and triethylamine to obtain compound III; reacting the compound III with a sulfur trioxide pyridine complex and an aqueous solution of potassium bicarbonate to obtain a compound II; reacting the compound II with ammonia methanol solution to obtain a compound I.
4. 4. The preparation method according to claim 3, wherein the equivalent ratio of the compound IV, 5-methylsulfonylmethane oxime and N-chlorosuccinimide is 1 (1-1.5): 1-1.5.
5. 5. Use of a compound according to claim 1 for the manufacture of a medicament for the prevention and/or treatment of tumors.
6. 6. The use according to claim 5, wherein the tumor is selected from colon cancer, breast cancer, prostate cancer, cervical cancer, liver cancer, blood cancer and lung cancer.

Description

2-Acetamido glucose potassium sulfate salt and preparation method and application thereof Technical Field The invention relates to the technical field of biological medicine, in particular to 2-acetamido glucose potassium sulfate and a preparation method and application thereof. Background Malignant tumors have become a prominent public health challenge worldwide today. The world health organization calls that on average 1 person dies of cancer in every 8 deaths worldwide, the number of deaths exceeds the sum of three diseases, aids, malaria and tuberculosis. According to the data published by the international cancer research Institute (IARC), the global new cancer cases were approximately 1090 tens of thousands and the death cases were approximately 670 tens of thousands in 2002. The institution further predicts that up to 1500 tens of thousands of new cancer patients will be worldwide annually by 2020. WHO statistics show that worldwide cancer new cases and death numbers have increased surprisingly in 2012, china is the top of the high house. The latest stage of analysis report of the onset and death of malignant tumor in China, which is issued by the national cancer center, shows that about 380.4 ten thousand malignant tumor cases and 229.6 ten thousand death cases are generated nationally in 2014. China accounts for about 21.8% and 27% of new and dead cases of malignant tumors worldwide, respectively, with mid-to-mid levels in 184 countries and regions. This means that on average 7 people per minute were diagnosed with cancer and 4 people died from cancer. Currently, cancer treatments mainly include surgery, radiation, chemotherapy, biological treatment, etc., and chemical drug treatment is still the main treatment mode. Currently, the main treatments for cancer include surgical excision, radiation therapy, chemical drug therapy, biological therapy, etc., and chemotherapy is still dominant. Cancer is essentially an abnormal proliferative disorder in living tissue that depends on host nutrition but is not regulated by the body to be hyperproliferative and cause damage to normal tissue. Human organs are composed of numerous cells, and cancer occurs from normal cells to abnormal cells, which divide and proliferate uncontrollably. While genetic factors play a major role in the development of cancer, environmental factors also have a significant impact on the pathogenesis of cancer. Cancer is particularly common in developed countries. Studies indicate that increased incidence of cancer may be associated with a variety of factors including food residues resulting from increased use of pesticides and insecticides, increased intake of processed foods containing additives (e.g., preservatives, pigments), increased water, soil and air pollution, increased pressure in modern life, decreased physical activity, obesity induced by high fat diets, and the like. Recent studies have also shown that abnormal normal cell signaling systems, oncogene activation or loss of oncogene function can trigger the onset of cancer. There are many methods of treating cancer, for example, surgery, radiation therapy, chemotherapy, and immunotherapy, and the combined use of several methods can increase survival. The transfer of cancer cells between organs is a problem faced by the treatment of cancer, however surgery and radiation therapy are limited to its treatment. Therefore, chemotherapy is mainly used. Chemotherapy is commonly performed using anticancer drugs, and many chemotherapeutic drugs have been reported. These antitumor drugs are classified into antitumor alkylating agents represented by cyclophosphamide, antitumor antimetabolites represented by 5-fluorouracil, antitumor antibiotics represented by doxorubicin hydrochloride, antitumor drugs derived from plants represented by vincristine and taxol, antitumor platinum complexes represented by cisplatin, and the like. However, it is known that toxicity of anticancer drugs acts not only on cancer cells but also on normal cells of patients, causing side effects. Thus, new anticancer drugs with higher cancer cell selectivity and as little toxicity as possible are to be developed. In view of the foregoing, there remains a need in the medical arts for novel antitumor compounds that are highly potent and safe. How to develop anticancer drugs with better effects has become a key scientific issue to be broken through in the field. Disclosure of Invention The inventor unexpectedly found in the research that a 2-acetylglucosamine potassium sulfate salt shown as a formula I has unexpected biological activity for preventing and/or treating tumors, and can be effectively used for preventing and/or treating various cancers. Based on this discovery, embodiments of the present invention provide a potassium 2-acetamido glucose sulfate or a stereoisomer, tautomer, hydrate, or solvate thereof, wherein the potassium 2-acetamido glucose sulfate has a structure represented by formula I: 。 The invent