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CN-121991301-A - Silicon hydrogel lens and preparation method and application thereof

CN121991301ACN 121991301 ACN121991301 ACN 121991301ACN-121991301-A

Abstract

The invention provides a silicon hydrogel lens, a preparation method and application thereof, and belongs to the technical field of contact lenses. The invention takes the organic silicon monomer as a main body, adopts a composite formula system of a high oxygen-permeable silicon-based skeleton and a hydrophilic functional monomer, realizes dual advantage fusion by a physical mixing process, has accurate occupation ratio of each core component, obtains a product system with oxygen permeability and comfort level, and provides safe, comfortable and healthy vision correction selection for consumers.

Inventors

  • HAO XIAOXIA
  • TANG YUXI
  • CHEN LINGLING

Assignees

  • 甘肃天后光学科技有限公司

Dates

Publication Date
20260508
Application Date
20260305

Claims (10)

  1. 1. The silica hydrogel lens is characterized in that the preparation raw materials comprise, by mass, 20-60% of hydrophilic monomers, 30-70% of organosilicon monomers, 0.1-2% of cross-linking agents, 0.1-2% of initiators and 5-20% of auxiliary agents; the hydrophilic monomer comprises at least two of 2-hydroxyethyl methacrylate, N-vinyl pyrrolidone, N-dimethylacrylamide, methacrylic acid and 2-methacryloyloxyethyl phosphorylcholine; The organic silicon monomer comprises at least two of hydroxyl modified silicon monomer, low molecular weight silicon monomer and high molecular weight silicon monomer.
  2. 2. The silicone hydrogel lens of claim 1, wherein the hydroxy-modified silicone monomer comprises one or more of trimethylsilanol, hydroxypropyl-terminated polydimethylsiloxane, (3-methacryloxy-2-hydroxypropoxy) propylbis (trimethylsiloxy) methylsilane, and 2- (trimethylsiloxy) ethyl methacrylate; the low molecular weight silicon monomer comprises one or more of methacrylic acyloxypropyl mono-terminated polydimethylsiloxane, allyl trimethyl silane, vinyl trimethoxy silane, vinyl triethoxy silane and triisopropyl silicon-based methacrylate; The high molecular weight silicon monomer is one or more of methacrylic acyloxypropyl double-end-capped polydimethylsiloxane, methacrylic acyloxypropyl tri (trimethylsiloxy) silane and 3-acetoxy-2-hydroxy propoxypropyl end-capped polydimethylsiloxane.
  3. 3. The silicone hydrogel lens of claim 1, wherein the crosslinking agent comprises at least one of ethylene glycol dimethacrylate, triethylene glycol dimethacrylate, N' -methylenebisacrylamide, and trimethylolpropane trimethacrylate.
  4. 4. The silicone hydrogel lens of claim 1, wherein the initiator comprises at least one of azobisisobutyronitrile, azobisisoheptonitrile, benzoyl peroxide, and 2,2' -azobis (2-methylpropionamidine) dihydrochloride.
  5. 5. The silicone hydrogel lens of claim 1, wherein the adjuvant comprises one or more of an antioxidant, a moisturizing lubricant, an anti-deposition moisturizing adjuvant, and a wetting anti-deposition adjuvant.
  6. 6. The silicone hydrogel lens of claim 5, wherein the antioxidant comprises 2, 6-di-t-butyl-p-cresol, the humectant slip agent comprises sodium hyaluronate, the anti-deposition humectant aid comprises polyvinylpyrrolidone, and the wetting anti-deposition aid comprises polyethylene glycol 400.
  7. 7. The method for preparing the silicon hydrogel lens of any one of claims 1 to 6, comprising the steps of: mixing hydrophilic monomer, organosilicon monomer, cross-linking agent, initiator and auxiliary agent, and forming after polymerization reaction to obtain lens forming body; After the lens molded body is subjected to plasma treatment, the obtained lens is extracted in purified water to obtain a silicon hydrogel lens.
  8. 8. The method according to claim 1, wherein the polymerization reaction is carried out at a temperature of 80-130 ℃ for 1-3 hours, and the plasma treatment conditions comprise oxygen gas, 100-300W power, 0.5-5.0 Pa pressure and 60-180 s time.
  9. 9. The method according to claim 1, wherein the extraction temperature is 90-95 ℃ and the extraction time is 1-3 hours.
  10. 10. Use of a silicone hydrogel lens as claimed in any one of claims 1 to 5 or a silicone hydrogel lens as produced by the method of any one of claims 6 to 8 as a contact lens.

Description

Silicon hydrogel lens and preparation method and application thereof Technical Field The invention relates to the technical field of contact lenses, in particular to a silicon hydrogel lens, a preparation method and application thereof. Background Contact lenses are a widely used vision correction tool, and the development of materials has undergone an evolution from rigid gas permeable lenses to hydrogel lenses to the currently prevailing silicone hydrogel lenses. The oxygen permeability of conventional hydrogel lenses depends on the moisture content of the material, and oxygen dissolved in the aqueous phase diffuses to the cornea according to henry's law. However, there is a theoretical limit to the oxygen permeability coefficient, and it is generally difficult to satisfy the physiological oxygen demand in the long-term eye-closing state of the cornea, which may lead to corneal hypoxia, and complications such as edema and neovascularization. The silicone hydrogel material achieves breakthrough of the oxygen permeation mechanism by introducing an organosiloxane component into the hydrogel polymer network. The siloxane chain segment can form a high-efficiency oxygen diffusion channel due to extremely low oxygen transmission resistance, so that the oxygen permeability coefficient of the material is improved by a plurality of times compared with that of the traditional hydrogel, the physiological metabolism requirement of cornea is supported, and the long wearing of the lens is possible even overnight wearing. However, despite the remarkable advantages of silicone hydrogels in oxygen permeability, there is still a sharp contradiction between their inherent material properties and the physiological environment of the ocular surface, constituting a long-standing technical bottleneck in this field, mainly in three aspects: First, high oxygen permeability contradicts surface wettability. To achieve high oxygen permeability, the material needs to contain a sufficient proportion of hydrophobic silicone components. However, hydrophobic surfaces result in poor tear wettability of the lens, large contact angles, acceleration of tear film rupture, and initiation of dry feel and visual fluctuations in wear. Meanwhile, the hydrophobic surface is more likely to adsorb biological macromolecules such as proteins and lipids in tears, and forms precipitates, which affect visual clarity and may irritate the ocular surface. The prior art has used surface modification treatments (e.g., plasma oxidation, hydrophilic polymer coatings) to improve hydrophilicity. For example, hydrophilic groups such as hydroxyl groups, carboxyl groups and the like are introduced on the surface of the lens through oxygen plasma treatment, or polyvinylpyrrolidone coating is grafted to improve the surface wettability. However, these surface modifying layers have durability problems, and abrasion or degradation may occur during wear, under the flushing of eye drops, resulting in deterioration of hydrophilic properties over time, which cannot guarantee long-lasting comfort. Second, the modulus of the material contradicts the wearing comfort. High levels of silicone and the crosslink density required to maintain lens morphology often result in a silicone hydrogel lens with a relatively high elastic modulus (typically >0.8 MPa). Higher modulus means that the lens is stiffer, potentially increasing its mechanical irritation to the cornea and eyelid, resulting in a foreign body sensation, especially for sensitive eye patients. Meanwhile, the dynamic adaptability of the high modulus lens to the curvature of the cornea is poor. Although there have been attempts to reduce the modulus by introducing long-chain flexible siloxane monomers (such as TRIS-VC) or using lactone monomers, it has been difficult to achieve a desirable balance between low modulus, high strength and efficient oxygen permeation, often accompanied by problems of reduced material strength, poor processability or impaired oxygen permeation. Therefore, the development of a novel silicone hydrogel material that achieves unification of oxygen permeability, wearing comfort, and long-term stability has become an urgent technical need in the art. Disclosure of Invention The invention aims to provide a silicon hydrogel lens, a preparation method and application thereof, which have high oxygen permeability and comfort, are accurate in size and can be worn stably for a long time. In order to achieve the above object, the present invention provides the following technical solutions: The invention provides a silicon hydrogel lens, which comprises, by mass, 20-60% of hydrophilic monomers, 30-70% of organic silicon monomers, 0.1-2% of cross-linking agents, 0.1-2% of initiator and 5-20% of auxiliary agents; the hydrophilic monomer comprises at least two of 2-hydroxyethyl methacrylate, N-vinyl pyrrolidone, N-dimethylacrylamide, methacrylic acid and 2-methacryloyloxyethyl phosphorylcholine; The organic silicon