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CN-121991451-A - Liquid composition for contact lens and contact lens product

CN121991451ACN 121991451 ACN121991451 ACN 121991451ACN-121991451-A

Abstract

The invention discloses a liquid composition for contact lenses and a contact lens product, which comprises the following components: a first hydrophilic component, a second hydrophilic component, inorganic salts, and liquid water. The first hydrophilic component is present in an amount of no greater than 1% by weight. The first hydrophilic component is a polymer having phosphorylcholine (phosphorylcholine) groups and has a first weight average molecular weight of not less than 4,000 da. The second hydrophilic component is present in an amount of no greater than 1% by weight. The second hydrophilic component is a hyaluronic acid or salt thereof and has a second weight-average molecular weight of no greater than 10,000 da.

Inventors

  • ZHANG HANYI
  • CHEN JUNHAN
  • KE YANJUN
  • WU YAWEN
  • HUANG MINYANG
  • YE WEIAN

Assignees

  • 晶硕光学股份有限公司

Dates

Publication Date
20260508
Application Date
20241108

Claims (13)

  1. 1. A liquid composition for a contact lens, characterized in that the liquid composition for a contact lens comprises: A first hydrophilic component in an amount of no greater than 1 wt%, and the first hydrophilic component is a polymer having phosphorylcholine groups and has a first weight average molecular weight of no less than 4,000 da; A second hydrophilic component in an amount no greater than 1% by weight, and the second hydrophilic component is a hyaluronic acid or salt thereof and has a second weight average molecular weight no greater than 10,000 da; An inorganic salt in an amount of not more than 5% by weight, and A liquid water in an amount of not less than 80% by weight.
  2. 2. The liquid composition for a contact lens according to claim 1, wherein the first hydrophilic component is at least one of a homopolymer and a copolymer having a phosphorylcholine group.
  3. 3. The liquid composition for a contact lens according to claim 2, wherein the homopolymer having a phosphorylcholine group is poly (2-methacryloyloxyethyl phosphorylcholine), and the copolymer having a phosphorylcholine group is formed by copolymerizing 2-methacryloyloxyethyl phosphorylcholine with a methacrylate, wherein the methacrylate is an alkyl methacrylate having a C2 to C12 alkyl group or a hydroxyalkyl methacrylate having a C2 to C12 hydroxyalkyl group.
  4. 4. The liquid composition for a contact lens according to claim 1, wherein the first weight average molecular weight of the first hydrophilic component is from 4,000da to 1,000,000da, the second weight average molecular weight of the second hydrophilic component is less than the first weight average molecular weight, and the second weight average molecular weight is not more than 5,000da.
  5. 5. The liquid composition for a contact lens according to claim 4, wherein the first weight average molecular weight of the first hydrophilic component is between 100,000da and 1,000,000da, and the second weight average molecular weight of the second hydrophilic component is not more than 3,000da.
  6. 6. The liquid composition for a contact lens according to claim 1, wherein the second hydrophilic component is sodium salt of hyaluronic acid or potassium salt of hyaluronic acid.
  7. 7. The liquid composition for a contact lens according to claim 6, wherein the second hydrophilic component is sodium salt of hyaluronic acid and the second weight average molecular weight of the second hydrophilic component is not more than 1,000da.
  8. 8. The liquid composition for a contact lens according to claim 7, wherein the second hydrophilic component is sodium hyaluronate or hydrolyzed sodium hyaluronate of small molecules.
  9. 9. The liquid composition for a contact lens according to claim 1, wherein the content of the first hydrophilic component is 0.005 to 1% by weight, the content of the second hydrophilic component is 0.005 to 1% by weight, the content of the inorganic salt is 0.01 to 5% by weight, and the content of the liquid water is not less than 90% by weight, based on 100% by weight of the total weight of the liquid composition for a contact lens.
  10. 10. The liquid composition for a contact lens according to claim 9, wherein the content of the first hydrophilic component is from 0.05 to 1% by weight, and the content of the second hydrophilic component is from 0.01 to 0.08% by weight.
  11. 11. The liquid composition for a contact lens according to claim 1, wherein a first weight molar concentration of the first hydrophilic component is between 1 x 10 -8 mol/liter and 2.5 x 10 -4 mol/liter, and a second weight molar concentration of the second hydrophilic component is between 5 x 10 -7 mol/liter and 6 x 10 -5 mol/liter.
  12. 12. The liquid composition for a contact lens according to claim 1, wherein the inorganic salt comprises a chloride salt and a buffer salt, wherein the chloride salt comprises at least one of sodium chloride (NaCl), potassium chloride (KCl), and magnesium chloride (MgCl 2 ), and wherein the buffer salt comprises at least one of boric acid or a salt thereof, phosphoric acid or a salt thereof, carbonic acid or a salt thereof, and citric acid or a salt thereof.
  13. 13. A contact lens product, the contact lens product comprising: A packaging container; The liquid composition for a contact lens according to any one of claims 1 to 12, which is filled in the packaging container, and A contact lens immersed in the liquid composition for contact lens, wherein the contact lens is a hydrogel lens or a silicone hydrogel lens.

Description

Liquid composition for contact lens and contact lens product Technical Field The present invention relates to a liquid composition, and more particularly, to a liquid composition for contact lenses and a contact lens product. Background In the prior art, liquid compositions for contact lenses generally contain hydrophilic ingredients to improve the wettability of the lenses. However, these compositions often have difficulty effectively maintaining the wetting of the lens surface during extended wear, resulting in dryness and discomfort to the wearer. The hydrophilic components added in the liquid compositions in the market at present can provide a certain moisturizing effect in a short time, but the moisturizing effect gradually weakens with the lapse of time, so that the needs of long-term wearing cannot be met. Furthermore, the prior art fails to provide an effective combination of ingredients to enhance both wettability and water-locking effects. Accordingly, there is a need to develop an improved liquid composition that can permanently maintain the wettability and comfort of the lens during extended wear of the contact lens, reducing the occurrence of dry eye problems. Disclosure of Invention The invention aims to solve the technical problem of providing a liquid composition for contact lenses and a contact lens product aiming at the defects of the prior art. In order to solve the above problems, one of the technical solutions adopted in the present invention is to provide a liquid composition for contact lenses, which comprises a first hydrophilic component with a content of not more than 1 wt%, wherein the first hydrophilic component is a polymer with phosphorylcholine (phosphorylcholine) group and has a first weight average molecular weight of not less than 4,000Da, a second hydrophilic component with a content of not more than 1 wt%, wherein the second hydrophilic component is hyaluronic acid or a salt thereof and has a second weight average molecular weight of not more than 10,000Da, an inorganic salt with a content of not more than 5 wt%, and liquid water with a content of not less than 80 wt%. Optionally, the first hydrophilic component is at least one of a homopolymer and a copolymer having a phosphorylcholine group. Alternatively, the homopolymer having a phosphorylcholine group is poly (2-methacryloyloxyethyl phosphorylcholine), and the copolymer having a phosphorylcholine group is formed by copolymerizing 2-methacryloyloxyethyl phosphorylcholine with a methacrylate ester, wherein the methacrylate ester is an alkyl methacrylate having a C2 to C12 alkyl group or a hydroxyalkyl methacrylate having a C2 to C12 hydroxyalkyl group. Optionally, the first weight average molecular weight of the first hydrophilic component is between 4,000da and 1,000,000da, the second weight average molecular weight of the second hydrophilic component is less than the first weight average molecular weight, and the second weight average molecular weight is no greater than 5,000da. Optionally, the first weight average molecular weight of the first hydrophilic component is between 100,000da and 1,000,000da, and the second weight average molecular weight of the second hydrophilic component is no greater than 3,000da. Optionally, the second hydrophilic component is a sodium salt of hyaluronic acid or a potassium salt of hyaluronic acid. Optionally, the second hydrophilic component is a sodium salt of hyaluronic acid and the second weight average molecular weight of the second hydrophilic component is not greater than 1,000da. Optionally, the second hydrophilic component is small molecule sodium hyaluronate or hydrolyzed sodium hyaluronate. Alternatively, the content of the first hydrophilic component is from 0.005 to 1% by weight, the content of the second hydrophilic component is from 0.005 to 1% by weight, the content of the inorganic salt is from 0.01 to 5% by weight, and the content of the liquid water is not less than 90% by weight, based on 100% by weight of the total weight of the liquid composition for a contact lens. Alternatively, the content of the first hydrophilic component is between 0.05 wt% and 1 wt%, and the content of the second hydrophilic component is between 0.01 wt% and 0.08 wt%. Optionally, a first weight molar concentration of the first hydrophilic component is between 1×10 -8 moles/liter and 2.5×10 -4 moles/liter, and a second weight molar concentration of the second hydrophilic component is between 5×10 -7 moles/liter and 6×10 -5 moles/liter. Optionally, the inorganic salt comprises a chloride salt and a buffer salt, wherein the chloride salt comprises at least one of sodium chloride (NaCl), potassium chloride (KCl) and magnesium chloride (MgCl 2), and the buffer salt comprises at least one of boric acid or salt thereof, phosphoric acid or salt thereof, carbonic acid or salt thereof and citric acid or salt thereof. In order to solve the above-mentioned problems, another technical solution adopted