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CN-121991609-A - High-moisture-permeability solvent type medical acrylate pressure-sensitive adhesive and preparation method thereof

CN121991609ACN 121991609 ACN121991609 ACN 121991609ACN-121991609-A

Abstract

The invention belongs to the technical field of adhesives, and in particular relates to a high-moisture-permeability solvent type medical acrylic pressure-sensitive adhesive and a preparation method thereof, wherein the acrylic pressure-sensitive adhesive is prepared by initiating soft monomers, hard monomers and the like to carry out free radical polymerization by using an initiator, then mixing the soft monomers, the hard monomers and the like with a modifier and the like, the prepared modifier has an aerogel state, the porous structure can form a ventilation and moisture-permeable passage inside the pressure-sensitive adhesive film, so that the ventilation and moisture-permeable performance of the pressure-sensitive adhesive is greatly enhanced, and meanwhile, the modifier structure contains a large number of quaternary ammonium cation structures, so that the pressure-sensitive adhesive can be endowed with good antibacterial performance, and the functional improvement of the pressure-sensitive adhesive is realized.

Inventors

  • XU CUN
  • HUANG JUNDA
  • ZHANG HONGXIA

Assignees

  • 昆山石梅新材料科技有限公司

Dates

Publication Date
20260508
Application Date
20260226

Claims (10)

  1. 1. The high-moisture-permeability solvent type medical acrylate pressure-sensitive adhesive is characterized by comprising the following raw materials in parts by weight: 32-38 parts of soft monomer, 8-12 parts of hard monomer, 2-4 parts of functional monomer, 0.1-0.2 part of initiator, 60-85 parts of organic solvent, 1-3.5 parts of modifier and 0.3-0.5 part of curing agent; the modifier is tamarind gum aerogel containing quaternary ammonium cations.
  2. 2. The high-moisture-permeability solvent type medical acrylate pressure-sensitive adhesive according to claim 1, wherein the soft monomer is at least one of ethyl acrylate, butyl acrylate or isooctyl acrylate, the hard monomer is at least one of vinyl acetate, butyl methacrylate or methyl acrylate, the functional monomer is at least one of hydroxyethyl methacrylate, glycidyl methacrylate or methacrylic acid, the initiator is azobisisobutyronitrile or azobisisoheptonitrile, and the organic solvent is ethyl acetate.
  3. 3. The high-moisture-permeability solvent type medical acrylate pressure-sensitive adhesive according to claim 1, wherein the modifier is prepared by the following method: Adding tamarind gum into a mixed solution of acetone and deionized water, uniformly stirring, adding a functionalization reagent and an accelerator into the formed uniform mixed solution, heating to 30-40 ℃ after the addition, keeping the temperature for 4-8 hours, stopping heating, filtering out a product, and washing and drying in vacuum to obtain the modified tamarind gum; Adding the modified tamarind gum into a mixed solution of deionized water, starting stirring, continuously adding the bis (2-hydroxyethyl) dimethyl ammonium chloride and the catalyst after the uniform mixed solution is formed, starting heating after the addition, heating to 60-70 ℃, keeping the temperature for 8-12 hours, stopping heating, pouring the product into a mould, gelatinizing, transferring to a freeze dryer for freeze drying treatment, and finally grinding and sieving with a 100-200-mesh sieve.
  4. 4. The high moisture vapor transmission solvent type medical acrylate pressure sensitive adhesive according to claim 3, wherein the functionalizing agent is prepared by the following method: Adding succinyl chloride into acetone, stirring, mixing, adding glycidol and promoter under ice bath condition, removing ice bath, stirring at 30-40deg.C for 3-6 hr, evaporating to remove solvent, collecting crude product, and purifying.
  5. 5. The high moisture vapor transmission solvent type medical acrylate pressure sensitive adhesive according to claim 4, wherein the molar ratio of succinyl chloride to glycidol is 1:1.
  6. 6. The high moisture vapor transmission solvent type medical acrylate pressure sensitive adhesive according to claim 4, wherein the accelerator is triethylamine or pyridine.
  7. 7. The high moisture permeability solvent type medical acrylate pressure sensitive adhesive according to claim 3, wherein the catalyst is boron trifluoride diethyl ether complex.
  8. 8. The high-moisture-permeability solvent type medical acrylate pressure-sensitive adhesive according to claim 3, wherein the mass ratio of the modified tamarind gum to the bis (2-hydroxyethyl) dimethyl ammonium chloride is 1:0.15-0.3.
  9. 9. The high moisture permeability solvent type medical acrylate pressure sensitive adhesive according to claim 1, wherein the curing agent is isocyanate curing agent.
  10. 10. The method for preparing the high-moisture-permeability solvent type medical acrylate pressure-sensitive adhesive as claimed in claim 1, which is characterized by comprising the following steps: Firstly, weighing and preparing all raw materials according to parts by weight; Adding the soft monomer, the hard monomer, the functional monomer and the initiator into an organic solvent, mechanically stirring until a uniform mixed solution is formed, introducing nitrogen for protection, starting heating, raising the temperature to 72-76 ℃, continuously preserving heat for 6-9 hours, stopping heating, cooling and discharging to form an acrylic ester polymerization solution; And thirdly, adding the modifier into the acrylic ester polymerization liquid, stirring and mixing uniformly, then adding the curing agent, and stirring and mixing uniformly at room temperature after the addition.

Description

High-moisture-permeability solvent type medical acrylate pressure-sensitive adhesive and preparation method thereof Technical Field The invention belongs to the technical field of adhesives, and particularly relates to a high-moisture-permeability solvent type medical acrylate pressure-sensitive adhesive and a preparation method thereof. Background Medical pressure sensitive adhesives are used as key interface materials between medical devices and human skin or tissue, and their properties directly affect the safety, effectiveness and patient comfort of medical products. Acrylic pressure-sensitive adhesives are the mainstream choice in the medical pressure-sensitive adhesive field due to their excellent biocompatibility, stable chemical properties and adjustable adhesion characteristics. Traditional medical acrylic ester pressure-sensitive adhesives are mainly divided into three categories, namely solvent type, water-based type and hot melt type. Among them, the solvent type acrylic acid ester pressure-sensitive adhesive plays an important role in the application of high-end medical dressing, transdermal drug delivery system, electrocardiogram electrode and the like with strict requirements on performance due to the characteristics of excellent film forming performance, strong initial adhesive force and the like. However, with the development of modern medical technology and the increasing demand for patient experience, medical pressure-sensitive adhesives face new challenges, namely skin health problems during long-term application are becoming increasingly interesting. Problems such as skin overhydration, dipping, itching and even infection caused by the occlusive dressing, and problems such as infection and the like are easy to be caused by the problem of insufficient antibacterial property, so that researchers are promoted to develop a pressure-sensitive adhesive system with higher moisture permeability and antibacterial property. Disclosure of Invention Aiming at the defects of the prior art, the invention aims to provide a solvent type medical acrylic pressure-sensitive adhesive with high moisture permeability and a preparation method thereof. The invention provides a high-moisture-permeability solvent type medical acrylate pressure-sensitive adhesive, which comprises the following raw materials in parts by weight: 32-38 parts of soft monomer, 8-12 parts of hard monomer, 2-4 parts of functional monomer, 0.1-0.2 part of initiator, 60-85 parts of organic solvent, 1-3.5 parts of modifier and 0.3-0.5 part of curing agent; the modifier is tamarind gum aerogel containing quaternary ammonium cations. According to the preferable technical scheme, the soft monomer is at least one of ethyl acrylate, butyl acrylate or isooctyl acrylate, the hard monomer is at least one of vinyl acetate, butyl methacrylate or methyl acrylate, the functional monomer is at least one of hydroxyethyl methacrylate, glycidyl methacrylate or methacrylic acid, the initiator is azobisisobutyronitrile or azobisisoheptonitrile, and the organic solvent is ethyl acetate. As a preferred technical scheme of the invention, the modifier is prepared by adopting the following method: Adding tamarind gum into a mixed solution of acetone and deionized water, uniformly stirring, adding a functionalization reagent and an accelerator into the formed uniform mixed solution, heating to 30-40 ℃ after the addition, keeping the temperature for 4-8 hours, stopping heating, filtering out a product, and washing and drying in vacuum to obtain the modified tamarind gum; Adding the modified tamarind gum into a mixed solution of deionized water, starting stirring, continuously adding the bis (2-hydroxyethyl) dimethyl ammonium chloride and the catalyst after the uniform mixed solution is formed, starting heating after the addition, heating to 60-70 ℃, keeping the temperature for 8-12 hours, stopping heating, pouring the product into a mould, gelatinizing, transferring to a freeze dryer for freeze drying treatment, and finally grinding and sieving with a 100-200-mesh sieve. As a preferred technical scheme of the invention, the functionalizing agent is prepared by the following method: Adding succinyl chloride into acetone, stirring, mixing, adding glycidol and promoter under ice bath condition, removing ice bath, stirring at 30-40deg.C for 3-6 hr, evaporating to remove solvent, collecting crude product, and purifying. As a preferable technical scheme of the invention, the molar ratio of the succinyl chloride to the glycidol is 1:1. As a preferable technical scheme of the invention, the accelerator is triethylamine or pyridine. As a preferable technical scheme of the invention, the catalyst is boron trifluoride diethyl etherate. As a preferable technical scheme of the invention, the mass ratio of the modified tamarind gum to the bis (2-hydroxyethyl) dimethyl ammonium chloride is 1:0.15-0.3. As a preferable technical scheme of the invention, the curing agent is isocyan