CN-121992260-A - Magnesium alloy porous anorectal drainage tube and preparation method thereof

Abstract

The invention discloses a magnesium alloy porous anorectal drainage tube and a preparation method thereof, wherein the chemical expression general formula of the drainage tube is Mg-xLi-yM, M represents one of Ca, zn, ti, sr, x and y represent mass fractions of Li and M, x is more than or equal to 4 and less than or equal to 20, y is more than or equal to 1 and less than or equal to 10, and the balance is Mg, the drainage tube is subjected to vacuum arc melting to prepare a magnesium alloy cast ingot, then the cast ingot is subjected to hot extrusion to obtain a bar with the diameter of 2-10 mm, the bar is subjected to multi-pass drawing annealing to prepare a wire with the diameter of 0.2-1 mm, then the wire is woven into a porous tube, and finally the porous tube is subjected to laser treatment forming.

Inventors

• PENG QIUMING
• ZOU GUODONG
• YANG SEN
• WANG JINMING
• SUN YONG

Assignees

• 燕山大学

Dates

Publication Date

20260508

Application Date

20260210

Claims (9)

1. 1. The magnesium alloy porous anorectal drainage tube is characterized by comprising a chemical composition expression of Mg-xLi-yM, wherein M represents one of Ca, zn, ti, sr, x and y represent mass fractions of Li and M, x is more than or equal to 4 and less than or equal to 20, y is more than or equal to 1 and less than or equal to 10, and the balance is Mg, the magnesium alloy porous anorectal drainage tube is of a double-layer structure, an outer layer is of a coarse-grain tissue structure, an inner layer is of a fine-grain tissue structure, the ratio of coarse grains to fine grains is 1:1, 3:2 or 3:7, the diameter of the magnesium alloy porous anorectal drainage tube is 0.5-2.0 cm, the length of the magnesium alloy porous anorectal drainage tube is 8-15 cm, and the mesh diameter of the magnesium alloy porous anorectal drainage tube is 100-300 mu M.
2. 2. The method for preparing the magnesium alloy porous anorectal drainage tube according to claim 1, which is characterized by comprising the following steps in sequence: s1, weighing raw materials according to a proportion, placing pure magnesium into a vacuum arc melting furnace, igniting an electric arc under the protection of vacuum or high-purity argon, melting the pure magnesium to form a stable molten pool, then adding Li and M elements in batches, and realizing component homogenization by means of electric arc stirring to obtain a magnesium alloy cast ingot; S2, turning the magnesium alloy cast ingot, removing oxide skin on the surface and at the two ends, and then performing hot extrusion to obtain a magnesium alloy bar with the diameter of 2-10 mm; S3, performing multi-pass cold drawing on the magnesium alloy bar, and performing annealing treatment between every two adjacent processing passes to obtain a magnesium alloy wire with the diameter of 0.2-1 mm; S4, weaving the magnesium alloy wire into a compact porous tube, and then carrying out annealing shaping treatment under vacuum or high-purity argon to obtain the magnesium alloy porous tube; S5, fixing the magnesium alloy porous tube on a platform, performing laser treatment, and enabling the laser beam to perform linear scanning along the axial direction of the wire, and repeating the scanning for a plurality of times to obtain the magnesium alloy porous drainage tube.
3. 3. The method for preparing the magnesium alloy porous anorectal drainage tube according to claim 2, wherein in the step S1, the vacuum degree is 10 -3 Pa or 10 -4 Pa, the voltage is 25-35V, the current is 100-200A, and the arc heating time is 3-10 min during vacuum arc melting.
4. 4. The method for preparing the magnesium alloy porous anorectal drainage tube according to claim 2, wherein in the step S2, the temperature of hot extrusion is 200-500 ℃ and the speed is 0.2-1 mm/min.
5. 5. The method for preparing a magnesium alloy porous anorectal drainage tube according to claim 2, wherein in the step S3, the single-pass deformation is 5-20% during the multi-pass cold drawing.
6. 6. The method for preparing the magnesium alloy porous anorectal drainage tube according to claim 2, wherein in the step S3, the annealing temperature is 200-500 ℃ and the time is 5-20 min.
7. 7. The method for preparing the magnesium alloy porous anorectal drainage tube according to claim 2, wherein in the step S4, the annealing and shaping temperature is 200-400 ℃ and the annealing and shaping time is 10-60 min.
8. 8. The method for preparing the magnesium alloy porous anorectal drainage tube according to claim 2, wherein in the step S5, the diameter of a laser spot is 0.2-0.8 mm during the laser treatment, and the surface temperature of the magnesium alloy porous tube is 300-500 ℃.
9. 9. The method for preparing the magnesium alloy porous anorectal drainage tube according to claim 2, wherein in the step S5, the scanning speed of the laser beam during the linear scanning along the axial direction of the wire is 100-300 mm/S, the wire is rotated by 90 ° after the single-pass axial scanning, and the scanning process is repeated for 4-10 times in total.

Description

Magnesium alloy porous anorectal drainage tube and preparation method thereof Technical Field The invention belongs to the field of medical material preparation, and relates to a magnesium alloy porous anorectal drainage tube and a preparation method thereof. Background With the increasing popularity of anorectal surgery (such as hemorrhoidectomy, anal fistula repair, radical rectal cancer treatment, etc.), postoperative drainage has become a key link for preventing infection and promoting wound healing. Due to the special anatomical characteristics of the anorectal part, the problems of effusion, infection, delayed healing and the like are very easy to occur after operation, so that drainage intervention is naturally required. A plurality of loose connective tissue gaps are distributed around anorectum, postoperative wound surfaces are lacunar/complicated wound surfaces (such as fistula of anal fistula and pus cavities of perianal abscess), blood, pus and exudates are difficult to naturally drain by gravity and are easy to accumulate in the cavity to cause infection, meanwhile, operation positions are close to anus, excrement and bacteria easily pollute the wound surfaces during postoperative defecation, if the accumulated liquid and the pus cannot be timely drained, the bacteria can be greatly propagated to directly cause wound surface infection and suppuration, even inflammation diffusion, in addition, anorectal distal blood supply is derived from lower rectal artery, the blood flow speed is low, the nutrition supply is relatively insufficient, and if the wound surfaces are soaked by the effusion or are stimulated by infection for a long time, granulation tissue edema and necrosis can be caused, so that the healing period is greatly prolonged, and chronic ulcer, anastomotic fistula and other refractory complications can be formed in serious cases. The traditional anorectal drainage tube is mostly made of silica gel, polyvinyl chloride (PVC) or rubber and other inert materials, and has a certain drainage effect, but has a plurality of defects. These materials are often non-degradable and require removal by secondary surgery or instruments, adding to the pain and medical costs of the patient. In addition, inert materials such as silica gel, polyvinyl chloride (PVC) or rubber have limited biocompatibility and are easy to cause local inflammatory reaction or tissue adhesion after long-term retention. In recent years, degradable medical materials (such as polylactic acid-glycolic acid copolymer and PLGA) are gradually applied to drainage tube preparation, but the problems of insufficient mechanical strength, excessively strong acidity of degradation products and the like limit clinical popularization. The metal drainage tubes on the market at present are mainly divided into non-degradable stainless steel/titanium alloy drainage tubes and degradable magnesium alloy urethra/vascular stents. The degradable magnesium alloy stent has the advantages that the supporting force of the non-degradable metal drainage tube is too high, the non-degradable metal drainage tube is free from degradability, the mucosa is easy to compress after the non-degradable metal drainage tube is implanted into anorectal, necrosis is caused, secondary surgery is needed to take out, the risk of complications is high, the degradation period of the degradable magnesium alloy stent is designed according to the urethra/blood vessel environment, the degradation rate is out of control in the environment with changeable anorectal (pH=6.0-9.0), the supporting force is lost in advance, the structure has no drainage anti-blocking function, and the requirements after anorectal surgery cannot be met. The related art of related anorectal abscess drainage also has obvious short plates, application number 202220214701.5 discloses a drainage tube for treating perianal abscess, the drainage tube is attached to an anatomical structure and can take multiple pus cavities into consideration, but only has a single drainage function, the drainage tube cannot be biodegraded, secondary operation is required to be taken out, wound healing is difficult to promote, complications are reduced, chinese patent application number 201410331301.2 discloses a multifunctional anorectal drainage tube which is provided with a structure such as an anti-falling elastic balloon and the like, but has poor sealing effect, and literature ' Annals of MEDICINE AND Surgery ' 11 (2016) 42e46 ' discloses a study for evaluating perianal abscess postoperative corrugated rubber drainage, the corrugated rubber drainage tube used in the literature can realize drainage by means of pressure difference and gravity, but the rubber material of the corrugated rubber drainage tube can cause strong tissue reaction, the healing time of a drainage track is prolonged, and the open drainage port is easy to become an entrance of pathogen invasion, nursing is improper and perianal abscess, cellulitis and the