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CN-121992529-A - Porous chitosan derivative fiber and preparation method and application thereof

CN121992529ACN 121992529 ACN121992529 ACN 121992529ACN-121992529-A

Abstract

The invention belongs to the field of medical materials, and relates to a porous chitosan derivative fiber, and a preparation method and application thereof. The preparation method comprises the following steps of S1, taking chitosan solution as spinning solution, performing wet spinning molding, adopting a freeze drying process with temperature programmed to prepare porous chitosan fibers with the diameter of 15-25 mu m, S2, adding the porous chitosan fibers into an organic solvent, and adding an acid solution under the stirring condition for reaction to obtain the porous chitosan derivative fibers. The porous chitosan derivative fiber prepared by the preparation method has higher porosity and specific surface area, and has excellent hydrophilicity and antibacterial property, and can be widely applied to medical materials.

Inventors

  • YANG YUMIN
  • Wu shouying
  • ZHANG LUZHONG
  • LIU MENGKE

Assignees

  • 南通大学

Dates

Publication Date
20260508
Application Date
20251231

Claims (10)

  1. 1. A method for preparing porous chitosan derivative fibers, which is characterized by comprising the following steps: S1, taking chitosan solution as spinning solution, performing wet spinning molding, and adopting a freeze drying process with programmed temperature rise to prepare porous chitosan fibers with the diameter of 15-25 mu m; S2, adding the porous chitosan fibers into an organic solvent, and adding an acid solution under the stirring condition to react to obtain the porous chitosan derivative fibers.
  2. 2. The method of claim 1, wherein the chitosan solution has a concentration of 3wt% to 7wt%.
  3. 3. The method of claim 1, wherein the chitosan solution is a chitosan acetic acid solution.
  4. 4. The preparation method according to claim 1, wherein the temperature-programmed freeze-drying process is characterized in that the temperature is maintained at-200 ℃ to-150 ℃ for 1-10min, then the temperature is maintained at-100 ℃ to-70 ℃ for 1-5h, and finally the final drying is completed at-60 ℃ to-30 ℃.
  5. 5. The method according to claim 1, wherein the organic solvent is isopropyl alcohol.
  6. 6. The method according to claim 1, wherein the acid solution is one of acetic acid solution, lactic acid solution and hydrochloric acid solution.
  7. 7. The method according to claim 1, wherein the acid solution is used in an amount of 0.003 to 0.017mol of H + per g of the porous chitosan fiber in the step S2.
  8. 8. The method according to claim 1, wherein in step S2, the reaction temperature is room temperature and the reaction time is 1 to 5 hours.
  9. 9. The porous chitosan derivative fiber prepared by the preparation method according to any one of claims 1 to 8.
  10. 10. Use of the porous chitosan derivative fiber of claim 9 in biomedical materials.

Description

Porous chitosan derivative fiber and preparation method and application thereof Technical Field The invention belongs to the field of medical materials, and relates to a porous chitosan derivative fiber, and a preparation method and application thereof. Background Effective, rapid and safe hemostasis is a primary challenge in wound healing, especially in battlefield environments, severe wounds and surgical procedures. Although the traditional hemostatic materials and modern hemostatic agents are widely applied, the partially synthesized polymer materials have the problems of poor biocompatibility, possibility of in-vivo retention of degradation products, initiation of inflammatory reaction and the like. Therefore, development of a novel hemostatic material which has high hemostatic performance, excellent biocompatibility, good biodegradability and convenient use is an urgent need in the current field of wound treatment. Chitosan, which is a natural polymer obtained by deacetylation of chitin, has abundant active amino groups and hydroxyl groups on the molecular chain, has excellent biocompatibility, biodegradability and broad-spectrum antibacterial property, and is regarded as a polymer biological material with great application potential. However, chitosan has poor solubility in physiologically neutral or weakly alkaline environments, limited swelling capacity and antibacterial capacity, and severely restricts its practical application as a hemostatic material. In addition, although the processing of chitosan into a fiber form is helpful for expanding the application range, the fiber obtained by the conventional preparation method is compact in structure and small in specific surface area, so that the liquid absorption rate and the hemostatic performance are not ideal. Aiming at the problems, the swelling capacity and the antibacterial performance of chitosan in a physiological environment are improved through chemical modification, and the porous structure design is combined to enhance the blood absorption performance of the chitosan, so that the chitosan has important significance in improving the hemostatic performance and widening biomedical application of the chitosan. Disclosure of Invention The invention aims to provide a porous chitosan derivative fiber, a preparation method and application thereof, wherein the porous chitosan derivative fiber has better swelling performance and antibacterial performance. In a first aspect, the present invention provides a method for preparing a porous chitosan derivative fiber, comprising the steps of: S1, taking chitosan solution as spinning solution, performing wet spinning molding, and adopting a freeze drying process with programmed temperature rise to prepare porous chitosan fibers with the diameter of 15-25 mu m; s2, adding the porous chitosan fibers into an organic solvent, and adding an acid solution under the stirring condition to react to obtain the porous chitosan derivative fibers. Further, the chitosan solution has a concentration of 3wt% to 7wt%. Further, the chitosan solution is chitosan acetic acid solution. Further, the temperature-programmed freeze-drying process specifically comprises the steps of maintaining at-200 ℃ to-150 ℃ for 1-10min, then freeze-drying at-100 ℃ to-70 ℃ for 1-5h, and finally finishing final drying at-60 ℃ to-30 ℃ for 12-36h. Further, the organic solvent is isopropyl alcohol. Further, the acid solution is one of acetic acid solution, lactic acid solution and hydrochloric acid solution. Further, in the step S2, the acid solution is used in an amount of 0.003-0.017mol H + per g of the porous chitosan fibers. Further, in step S2, the reaction temperature is room temperature, and the reaction time is 1-5h. In a second aspect, the invention provides a porous chitosan derivative fiber prepared by the preparation method. In a third aspect, the invention provides an application of the porous chitosan derivative fiber in biomedical materials. Compared with the prior art, the porous chitosan fiber is obtained by heating and freeze-drying the chitosan fiber obtained by wet spinning, so that the fiber has higher porosity and specific surface area, and then the porous chitosan fiber is modified by adopting organic acid or inorganic acid, so that the hydrophilicity of the chitosan fiber can be effectively improved, and meanwhile, the antibacterial performance of the material is improved by increasing the protonation degree of amino groups in chitosan molecular chains. Drawings These and/or other aspects and advantages of the present invention will become apparent and readily appreciated from the following description of the preferred embodiments, taken in conjunction with the accompanying drawings, in which: FIG. 1 shows a scanning electron microscope image of a sample of example 1 and samples of comparative examples 1 and 2 Fig. 2 shows the antibacterial properties of the samples of examples 1, 2, 5 and the samples of comparative example