CN-121994429-A - Self-checking device, equipment and method for immunohistochemical waste liquid system

CN121994429ACN 121994429 ACN121994429 ACN 121994429ACN-121994429-A

Abstract

The invention provides a self-checking device, equipment and a method of an immunohistochemical waste liquid system, wherein the self-checking device comprises a waste liquid system, a pressure source, a detection branch, a valve component and a control unit; the detection branch is connected with a pressure source and a vacuum tank of the waste liquid system, the detection branch is provided with a pressure collector, the valve component is arranged on the liquid suction pipeline, the liquid discharge pipeline and the detection branch, and the pressure source, the pressure collector and the valve component are electrically connected with the control unit. According to the invention, the opening and closing states of the valve assembly are regulated and controlled by the control unit, so that the pressure source can be respectively communicated with the liquid suction branch and the liquid discharge branch through the detection branch, the pressure value under different communication states is obtained by combining the pressure collector, the smoothness of each branch and the air tightness of the detection branch can be judged based on the pressure value, the differential diagnosis of the states of each functional section of the waste liquid system and the early warning of faults are realized, the dependence of manual maintenance is greatly reduced, the fault detection efficiency is improved, and the stable operation of the immunohistochemical equipment is practically ensured.

Inventors

CHEN HUALIANG
CHEN JINZHI
YANG LIYONG
YANG SHUJIE
CHEN ZHOU
LIU RUI

Assignees

深圳达盟生物科技有限公司

Dates

Publication Date: 20260508
Application Date: 20260225

Claims (10)

1. The utility model provides an immunity group ization waste liquid system self-checking device, includes the waste liquid system, the waste liquid system is including reaction chamber, imbibition pipeline, vacuum tank, flowing back pipeline and the waste liquid collecting vessel that connects gradually, reaction chamber, imbibition pipeline and vacuum chamber form the imbibition branch road, vacuum tank, flowing back pipeline and waste liquid collecting vessel form exhaust branch road, its characterized in that still includes: a pressure source for providing negative pressure to the liquid suction branch and positive pressure to the liquid discharge branch; the detection branch is connected with the pressure source and the vacuum tank, and is provided with a pressure collector; The valve component is arranged on the liquid suction pipeline, the liquid discharge pipeline and the detection branch and is used for switching on or switching off the liquid suction branch, the liquid discharge branch and the detection branch; The control unit is configured to enable the pressure source to be communicated with the liquid suction branch or the liquid discharge branch through the detection branch by controlling the opening and closing state of the valve assembly, and judge the smoothness of the liquid suction branch, the smoothness of the liquid discharge branch or the air tightness state of the detection branch based on pressure values obtained by the pressure collector in different communication states.
2. The self-test device of the immunohistochemical waste liquid system according to claim 1, wherein the valve assembly comprises a three-way joint, and three ends of the three-way joint are respectively connected with a positive pressure end of the pressure source, a negative pressure end of the pressure source and the pressure collector.
3. The device of claim 2, wherein the valve assembly further comprises a first solenoid valve and a second solenoid valve disposed between the pressure source and the three-way connector, the first solenoid valve being connected to a positive pressure end of the pressure source and one end of the three-way connector, the first solenoid valve being configured to communicate the positive pressure end of the pressure source with the three-way connector when detecting the fluid discharge branch and the air tightness of the detection branch, the second solenoid valve being connected to a negative pressure end of the pressure source and one end of the three-way connector, the second solenoid valve being configured to communicate the negative pressure end of the pressure source with the three-way connector when detecting the fluid suction branch and the air tightness of the detection branch.
4. The self-test device of an immunohistochemical waste liquid system according to claim 1, wherein the valve assembly comprises a third electromagnetic valve and a fourth electromagnetic valve, wherein two ends of the third electromagnetic valve are respectively connected with the reaction cavity and the vacuum tank, the third electromagnetic valve is opened when detecting the smoothness of the liquid suction branch so as to communicate the reaction cavity and the vacuum tank, two ends of the fourth electromagnetic valve are respectively connected with the vacuum tank and the waste liquid collecting container, and the fourth electromagnetic valve is opened when detecting the smoothness of the liquid discharge branch so as to communicate the vacuum tank and the waste liquid collecting container.
5. The self-test device of an immunohistochemical waste liquid system according to claim 1, wherein the valve assembly comprises a pressure relief valve, and the pressure relief valve is arranged between the pressure collector and the vacuum tank.
6. A self-test device for an immunohistochemical waste liquid system, comprising at least one self-test apparatus for an immunohistochemical waste liquid system according to any one of claims 1 to 5.
7. The self-test device for the immunohistochemical waste liquid system according to claim 6, wherein the number of the self-test devices for the immunohistochemical waste liquid system is two or more, all the self-test devices for the immunohistochemical waste liquid system are mutually connected in parallel, and the self-test devices for the immunohistochemical waste liquid system which are mutually connected in parallel share the same reaction chamber and waste liquid collecting container.
8. A self-test method of an immunohistochemical waste liquid system, applied to the self-test device of the immunohistochemical waste liquid system according to any one of claims 1 to 5 or the self-test equipment of the immunohistochemical waste liquid system according to any one of claims 6 to 7, characterized by comprising: Controlling the valve assembly to enable the waste liquid system and the detection branch to be communicated with the atmosphere, acquiring an initial pressure value P 0 acquired by a pressure acquisition device, and judging that the pressure acquisition device fails if |P 0 | is larger than or equal to a first preset threshold value alpha; Controlling the valve assembly to isolate the waste liquid system from the detection branch and the atmosphere, starting the pressure source to obtain the pressure drop rate of the pressure collector, judging that the detection branch has leakage if the pressure drop rate is greater than or equal to a preset leakage threshold value, and otherwise judging that the gas tightness of the detection branch meets the standard; Controlling the valve component to be communicated with the liquid suction branch, and to be communicated with a negative pressure end of the pressure source, the pressure collector and the vacuum tank, controlling the pressure source to provide negative pressure, obtaining a first pressure value P v2 collected by the pressure collector, judging that the liquid suction branch is completely blocked if the first pressure value P v2 is less than or equal to a first blocking threshold value beta, and judging that the liquid suction branch is locally blocked if the first blocking threshold value beta is less than or equal to a second blocking threshold value theta and is less than or equal to a first pressure value P v2 ; The valve component is controlled to be communicated with the liquid discharge branch, the positive pressure end of the pressure source, the pressure collector and the vacuum tank are controlled to provide positive pressure, a second pressure value P v8 collected by the pressure collector is obtained, if the second pressure value P v8 is more than or equal to a third blockage threshold gamma, the liquid discharge branch is judged to be completely blocked, and if the fourth blockage threshold delta is less than the second pressure value P v8 and less than or equal to the third blockage threshold gamma, the liquid discharge branch is judged to be locally blocked.
9. The method according to claim 8, wherein the controlling the valve assembly to isolate the waste liquid system from the detecting branch and from the atmosphere, starting the pressure source, and obtaining a pressure drop rate of the pressure collector, wherein if the pressure drop rate is greater than or equal to a preset leakage threshold, determining that the detecting branch has leakage, otherwise determining that the air tightness of the detecting branch meets the standard comprises: Controlling the valve assembly to isolate the waste liquid system from the detection branch and the atmosphere, and communicating a negative pressure end of the pressure source, a pressure collector and a vacuum tank; Controlling the pressure source to vacuumize to a preset negative pressure value P S1 , and maintaining the pressure for a first preset time T 1 ; acquiring the pressure drop rate of the pressure collector in a first preset time T 1 ; If the pressure drop rate is larger than or equal to a preset early warning value, judging that leakage exists in the detection branch, otherwise, judging that the air tightness of the detection branch meets the standard.
10. The method according to claim 8, wherein the controlling the valve assembly to isolate the waste liquid system from the detecting branch and from the atmosphere, starting the pressure source, and obtaining a pressure drop rate of the pressure collector, wherein if the pressure drop rate is greater than or equal to a preset leakage threshold, determining that the detecting branch has leakage, otherwise determining that the air tightness of the detecting branch meets the standard comprises: Controlling the valve assembly to isolate the waste liquid system from the detection branch and the atmosphere, and communicating the positive pressure end of the pressure source, the pressure collector and the vacuum tank; Controlling the pressure source to pressurize to a preset positive pressure value P S2 , and maintaining the pressure for a second preset time T 2 ; Acquiring the pressure drop rate of the pressure collector in a second preset time T 2 ; If the pressure drop rate is larger than or equal to a preset early warning value, judging that leakage exists in the detection branch, otherwise, judging that the air tightness of the detection branch meets the standard.

Description

Self-checking device, equipment and method for immunohistochemical waste liquid system Technical Field The invention relates to the technical field of waste liquid system detection, in particular to an immunohistochemical waste liquid system self-checking device, equipment and a method. Background The immunohistochemical equipment is one of core automation equipment of hospital pathology department, it needs frequent processing DAB developer, hematoxylin, high viscosity antibody and multiple chemical reagents such as washing liquid in sample detection process, and these reagents possess high stickness, easy crystallization, strong corrosivity and easily produce chemical deposition's characteristic, after the equipment long-term operation, parts such as liquid waste system's pipeline, solenoid valve in the immunohistochemical equipment extremely easily appear blockking up the problem, still easily take place the condition that sealing performance descends simultaneously, and then cause equipment trouble such as liquid waste leakage, drawing liquid is unusual, flowing back is unusual, seriously influences the normal operating of equipment. At present, the existing waste liquid system monitoring means is single, and the state monitoring of the waste liquid system is generally realized only through the liquid level detection of a waste liquid barrel, the operation state monitoring of a vacuum pump or a simple flow judgment mode, and the monitoring mode cannot accurately conduct differential diagnosis on different functional sections such as liquid suction and liquid discharge in the waste liquid system, and cannot provide effective early warning for potential abnormal risks before equipment faults occur. When the waste liquid system of the immune grouping equipment breaks down, professional after-sales personnel are often required to go up to check the liquid path section by section, so that the equipment maintenance efficiency is low, the pathological sample dyeing failure is easy to cause in the experimental process, and adverse effects are brought to pathological detection work. Therefore, there is a need for an immunohistochemical waste liquid system self-test scheme capable of automatically completing the state detection of the waste liquid system and performing individual state detection on different liquid path functional sections. Disclosure of Invention The invention aims to overcome the defects of the prior art, and provides a self-checking device, equipment and a method for an immunohistochemical waste liquid system, so as to solve the technical problems that the existing immunohistochemical waste liquid system cannot be diagnosed in a partitioning mode and is dependent on manual section-by-section checking. In order to achieve the above purpose, the present invention adopts the following technical scheme: in a first aspect, the present invention provides an immunohistochemical waste liquid system self-test apparatus comprising: The waste liquid system comprises a reaction cavity, a liquid suction pipeline, a vacuum tank, a liquid discharge pipeline and a waste liquid collecting container which are sequentially connected, wherein the reaction cavity, the liquid suction pipeline and the vacuum cavity form a liquid suction branch, and the vacuum tank, the liquid discharge pipeline and the waste liquid collecting container form an exhaust branch; a pressure source for providing negative pressure to the liquid suction branch and positive pressure to the liquid discharge branch; the detection branch is connected with the pressure source and the vacuum tank, and is provided with a pressure collector; The valve component is arranged on the liquid suction pipeline, the liquid discharge pipeline and the detection branch and is used for switching on or switching off the liquid suction branch, the liquid discharge branch and the detection branch; The control unit is configured to enable the pressure source to be communicated with the liquid suction branch or the liquid discharge branch through the detection branch by controlling the opening and closing state of the valve assembly, and judge the smoothness of the liquid suction branch, the smoothness of the liquid discharge branch or the air tightness state of the detection branch based on pressure values obtained by the pressure collector in different communication states. In one embodiment, the valve assembly comprises a three-way joint, wherein three ends of the three-way joint are respectively connected with the positive pressure end of the pressure source, the negative pressure end of the pressure source and the pressure collector. In one embodiment, the valve assembly further comprises a first electromagnetic valve and a second electromagnetic valve, wherein the first electromagnetic valve and the second electromagnetic valve are arranged between the pressure source and the three-way connector, the first electromagnetic valve is connected with the positive