Search

CN-121994569-A - Tumor isolated sample preprocessing device

CN121994569ACN 121994569 ACN121994569 ACN 121994569ACN-121994569-A

Abstract

The invention belongs to the technical field of medical equipment, and particularly relates to a tumor in-vitro sample pretreatment device which comprises a mounting shell, wherein a cleaning part, a rotating part and a dehydrating part are sequentially arranged in the mounting shell from top to bottom, the cleaning part can wash a sample at a low temperature to remove substances on the surface of the sample, the sample can be automatically discharged into the dehydrating part after the sample is washed, the upper end of the dehydrating part is matched with a discharge port of the cleaning part, the dehydrating part can drive the sample to rotate to adsorb residual moisture on the outer edge of the sample after the sample is discharged by the cleaning part, and the rotating part drives the dehydrating part to rotate to discharge the sample after the sample is dehydrated. According to the invention, through the matching of the overflow prevention groove of the cleaning part and the liquid supply groove, accurate liquid control and impurity removal can be realized, the worm gear and worm transmission and the arc track of the rotating part can ensure stable unfolding, the elastic structure of the dewatering part can absorb water efficiently and be dynamically adapted to discharge, and the whole process of sample pretreatment can be realized efficiently and reliably.

Inventors

  • WANG ZIHAN
  • LI SHUANG
  • DONG SHUAI
  • XU HAOBIN
  • ZHU MEI
  • LV PENGJU
  • Jiang Yarui

Assignees

  • 哈尔滨医科大学大庆分校

Dates

Publication Date
20260508
Application Date
20260306

Claims (10)

  1. 1. The tumor in-vitro sample pretreatment device is characterized by comprising a mounting shell (1), wherein a cleaning part (2), a rotating part (3) and a dehydrating part (4) are sequentially arranged in the mounting shell (1) from top to bottom; the cleaning part (2) can perform low-temperature flushing on the sample to remove substances on the surface of the sample, and can automatically discharge the sample into the dehydration part (4) after the sample flushing is finished; The upper end of the dehydration part (4) is matched with the discharge port of the cleaning part (2), and the dehydration part (4) can drive the sample to rotate to adsorb residual moisture on the outer edge of the sample after the sample is discharged by the cleaning part (2); after the sample is dehydrated, the rotating part (3) drives the dehydrating part (4) to rotate so as to discharge the sample; The cleaning part (2) comprises a bearing seat (201), a bearing cover (202), a guide seat (203), a sliding seat (204), a driving screw (205) and a driving motor (206), wherein the bearing seat (201) is fixedly connected with the inside of a mounting shell (1), the bearing cover (202) is arranged at the lower end of the bearing seat (201), the guide seat (203) is fixedly connected with the inside of the mounting shell (1), the sliding seat (204) is slidably arranged at the outer edge of the guide seat (203), the inside of the guide seat (203) and the sliding seat (204) are slidably connected with the two sides of the bearing cover (202), the driving screw (205) is rotatably arranged inside the sliding seat (204), the inside of the sliding seat (204) is fixedly connected with the outer edge of the driving screw (205), and the driving motor (206) is fixedly connected with the inside of the mounting shell (1), and the output end of the driving motor (206) is fixedly connected with one end of the driving screw (205).
  2. 2. The tumor in-vitro sample pretreatment device according to claim 1, wherein an anti-overflow groove (2011) is formed in one side of the bearing seat (201), a liquid supply groove (2012) is formed in the other side of the bearing seat (201), and the liquid supply groove (2012) corresponds to the anti-overflow groove (2011) horizontally.
  3. 3. The device for pretreating tumor in-vitro samples according to claim 1, wherein a carrying net (2021) is arranged at the upper end inside the carrying cover (202), a discharge hopper (2022) is arranged at the lower end of the carrying cover (202), and the discharge outlet inside the discharge hopper (2022) has a discharge flow smaller than the liquid supply flow of the liquid supply tank (2012).
  4. 4. The device for pretreating tumor in-vitro samples according to claim 1, wherein limit rods (2023) are fixedly arranged on two sides of the bearing cover (202), and the limit rods (2023) are arranged in a mode of being higher and lower.
  5. 5. The tumor in-vitro sample pretreatment device according to claim 1, wherein a first guide groove (2031) and a second guide groove (2032) are formed in the guide seat (203), the first guide groove (2031) is in sliding connection with a limiting rod (2023) located at a high position, a vertical section and an inclined moving section are sequentially formed in the first guide groove (2031) from top to bottom, the second guide groove (2032) is in sliding connection with the limiting rod (2023) located at a low position, and a vertical section, an inclined moving section and an arc-shaped rotating section are sequentially formed in the second guide groove (2032) from top to bottom.
  6. 6. The tumor in-vitro sample pretreatment device according to claim 1, wherein a first extrusion groove (2041) and a second extrusion groove (2042) are formed in the sliding seat (204), a vertical limiting section and an inclined pushing section are sequentially formed in the first extrusion groove (2041) from top to bottom, the first extrusion groove (2041) is slidably connected with a high limiting rod (2023), the second extrusion groove (2042) is obliquely arranged, and the second extrusion groove (2042) is slidably connected with a low limiting rod (2023).
  7. 7. The tumor in-vitro sample pretreatment device according to claim 1, wherein the rotating part (3) comprises a rotating frame (301), a sliding frame (302), a guide plate (303), a driving worm wheel (304), a driving worm (305) and a torque motor (306), one end of the rotating frame (301) is rotationally connected with the inside of the installation shell (1), one end of the sliding frame (302) is in sliding connection with the inside of the rotating frame (301), the guide plate (303) is fixedly connected with the inside of the installation shell (1), the inside of the guide plate (303) is in sliding connection with the other end of the sliding frame (302), the driving worm wheel (304) is fixedly connected with one end of the rotating frame (301), the outer edge of the driving worm (305) is meshed with the driving worm wheel (304), the torque motor (306) is fixedly connected with the inside of the installation shell (1), and the output end of the torque motor (306) is fixedly connected with the driving worm (305).
  8. 8. The device for pretreating tumor in-vitro samples according to claim 7, wherein a spreading groove (3031) is formed in the guide plate (303), the whole spreading groove (3031) is arc-shaped, and the inner part of the spreading groove (3031) is in sliding connection with the sliding frame (302).
  9. 9. The tumor in-vitro sample pretreatment device according to claim 1, wherein the dewatering part (4) comprises a mounting box (401), a follow-up box (402), a guide roller (403), a connecting plate (404), a connecting bridge (405), a feeding seat (406), a coiling seat (407) and a coiling motor (408), wherein the mounting box (401) is arranged inside the rotating frame (301), the follow-up box (402) is arranged inside the sliding frame (302), the follow-up box (402) and the mounting box (401) are in sliding connection, the guide roller (403) is respectively and rotatably arranged inside the mounting box (401) and the follow-up box (402), two ends of the connecting plate (404) are respectively and fixedly connected with the mounting box (401) and the follow-up box (402), the connecting bridge (405) is arranged at the lower part of the connecting plate (404), two ends of the connecting bridge (405) are respectively and slidably connected with the mounting box (401) and the follow-up box (402), the feeding seat (406) is rotatably arranged inside the sliding frame (302), the water absorbing seat (406) is fixedly connected with the coiling seat (402), the water absorbing seat (406) and the water absorbing material passing through the connecting plate (407) and the connecting plate (404), the winding motor (408) is fixedly arranged in the follow-up box (402), and the output end of the winding motor (408) is fixedly connected with the winding seat (407).
  10. 10. The device for pretreating tumor in-vitro samples according to claim 9, wherein the whole of the connecting plate (404) and the connecting bridge (405) is arc-shaped, the arc direction points to the inside of the mounting box (401) and the follower box (402), and the whole of the connecting plate (404) and the connecting bridge (405) is made of elastic materials.

Description

Tumor isolated sample preprocessing device Technical Field The invention belongs to the technical field of medical equipment, and particularly relates to a tumor in-vitro sample pretreatment device. Background Pretreatment of tumor in-vitro samples is a key pre-stage link of tumor pathology research, clinical diagnosis and molecular detection, and the treatment effect directly influences the accuracy of follow-up experimental data and the reliability of clinical decisions. In the field of tumor research, an isolated sample needs to undergo core steps such as cleaning (removing impurities such as blood and tissue scraps), dewatering (reducing liquid residues on the surface of the sample), transferring (safely transferring to a subsequent processing link), and the like, and the deviation of any link can cause sample pollution, morphological damage or loss of effective components, so that key analysis results such as pathological section observation, molecular marker detection and the like are affected. However, conventional means of pretreatment of tumor ex vivo samples have significant limitations. Firstly, the cleaning link depends on manual operation or a simple mechanical device, the control precision of the cleaning liquid amount is insufficient, the manual operation is easily influenced by the experience of an operator, excessive cleaning liquid can scatter samples or overflow to pollute the environment, the defect causes impurity residues, the mechanical device mostly adopts fixed flow liquid supply, the liquid cannot be dynamically adjusted according to the size and the type of the samples, and the cleaning requirements of different samples are difficult to meet. Secondly, the sample transferring link has potential safety hazards that the traditional device finishes transferring by dumping or mechanical pushing, and samples are easy to be detained on the inner wall of the device due to collision or splash caused by improper speed control, so that the samples are lost or cross-pollutes. Disclosure of Invention The invention aims to provide a tumor in-vitro sample pretreatment device, which can realize accurate liquid control and impurity removal through matching of an overflow prevention groove of a cleaning part and a liquid supply groove, ensure stable unfolding through worm and gear transmission and arc track of a rotating part, and realize efficient water absorption and dynamic adaptation discharge of an elastic structure of a dehydration part so as to realize the efficient and reliable whole flow of sample pretreatment. The technical scheme adopted by the invention is as follows: The tumor in-vitro sample pretreatment device comprises a mounting shell, wherein a cleaning part, a rotating part and a dehydrating part are sequentially arranged in the mounting shell from top to bottom; the cleaning part can perform low-temperature flushing on the sample to remove substances on the surface of the sample, and can automatically discharge the sample into the dehydration part after the sample flushing is completed; The upper end of the dehydration part is matched with the discharge port of the cleaning part, and the dehydration part can drive the sample to rotate to adsorb residual moisture on the outer edge of the sample after the sample is discharged by the cleaning part; The rotating part drives the dehydrating part to rotate after the sample is dehydrated to discharge the sample; The cleaning part comprises a bearing seat, a bearing cover, a guide seat, a sliding seat, a driving screw and a driving motor, wherein the bearing seat is fixedly connected with the inside of the installation shell, the bearing cover is arranged at the lower end of the bearing seat, the guide seat is fixedly connected with the inside of the installation shell, the sliding seat is arranged on the outer edge of the guide seat in a sliding mode, the inside of the guide seat and the sliding seat is slidably connected with the two sides of the bearing cover, the driving screw is rotationally arranged in the sliding seat, the inside of the sliding seat is in threaded connection with the outer edge of the driving screw, the driving motor is fixedly connected with the inside of the installation shell, and the output end of the driving motor is fixedly connected with one end of the driving screw. In a preferred scheme, one side of the bearing seat is provided with an anti-overflow groove, the other side of the bearing seat is provided with a liquid supply groove, and the liquid supply groove corresponds to the anti-overflow groove horizontally. In a preferred scheme, the upper end of the bearing cover is internally provided with a bearing net, the lower end of the bearing cover is provided with a discharge hopper, and the drainage flow of the discharge outlet in the discharge hopper is smaller than the liquid supply flow of the liquid supply tank. In a preferred scheme, limit rods are fixedly arranged on two sides of the bearing cover