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CN-121994573-A - Calibration piece for calibrating collagen content measurement and method and system for measuring collagen content

CN121994573ACN 121994573 ACN121994573 ACN 121994573ACN-121994573-A

Abstract

The invention relates to a calibration piece for calibrating collagen content measurement and a method and a system for measuring the collagen content. The method comprises the steps of carrying out energy scanning on a measuring object containing collagen through an energy CT device to obtain CT scanning data of the measuring object, and extracting collagen scanning content from the CT scanning data based on characteristic parameters of the collagen and characteristic parameters of pure matters possibly contained in the measuring object. The calibration component comprises a plurality of sets of a mixture of collagen-pure components, each pure component comprising a pure substance, and for each pure component there are at least two sets of a mixture of collagen-pure components having different collagen contents from each other. When the calibration piece is scanned by energy CT equipment, obtaining a corresponding relation between the collagen scanning content and the actual collagen content for the mixture of at least two groups of collagen-pure matter components with the same pure matter components, and obtaining the actual collagen content based on the extracted collagen scanning content and the corresponding relation.

Inventors

  • ZHANG KUN

Assignees

  • 湖南中医药大学

Dates

Publication Date
20260508
Application Date
20260331

Claims (19)

  1. 1. A calibration part for calibrating a collagen content measurement comprises a plurality of sets of a mixture of collagen-pure components, each pure component comprising a pure substance, at least two sets of a mixture of collagen-pure components having different collagen contents from each other for each pure component, When the calibration piece is scanned by energy CT equipment, at least two sets of CT scanning data are obtained for the mixture of at least two sets of collagen-pure matter components with the same pure matter component, the collagen scanning content is respectively extracted from the at least two sets of CT scanning data based on the characteristic parameters of the collagen and the characteristic parameters of the pure matter in the pure matter component, and the corresponding relation between the collagen scanning content and the actual collagen content is obtained based on the extracted collagen scanning content and the collagen content of the mixture of the at least two sets of collagen-pure matter components.
  2. 2. The calibration element of claim 1, wherein the calibration element comprises a mixed solution of a phantom and a collagen-neat component.
  3. 3. The calibration element of claim 2, wherein the phantom comprises a plurality of regions, each region having disposed thereon a body of collagen-pure composition material, each pure composition comprising a pure substance, and at least two sets of collagen-pure composition material having different collagen contents from each other for each pure composition.
  4. 4. A method for measuring collagen content, comprising the steps of: a) Energy scanning a measurement object containing collagen by an energy CT apparatus to obtain CT scan data of the measurement object, and B) Extracting a collagen scan content of the measurement object from CT scan data of the measurement object based on the characteristic parameters of collagen and the characteristic parameters of the purities possibly contained in the measurement object.
  5. 5. The method of claim 4, wherein the characteristic parameters are determined by modeling collagen as a chemical formula.
  6. 6. The method of claim 5, wherein the chemical formula is any one of C M ; C 5M H 9M N M O 3M ; C 6M H 14M N 2M O 3M ; C 169858M H 990099M N 29979M O 403125M Na 870M P 323M S 624M Cl 846M K 256M or C 82431M H 950495M N 15703M O 465000M Na 2175M P 7104M S 2807M Cl 846M , Wherein M >0.
  7. 7. The method of claim 4, wherein the collagen parameters have corresponding ranges of intervals at different energy voltages [ characteristic parameters min , characteristic parameters max ], Wherein 0< feature parameter min <1,0< feature parameter max <1, feature parameter min < feature parameter max , As the energy voltage increases, the characteristic parameter min and the characteristic parameter max each monotonically decrease.
  8. 8. The method of claim 7, wherein the characteristic parameter min is in the range of 0.20750-0.13740 and the characteristic parameter max is in the range of 0.28324-0.15214 when the energy voltage is in the range of 40 kev-140 kev.
  9. 9. The method of any of claims 4-8, further comprising the step of: c) Performing an energy scan of the calibration piece according to any one of claims 1-3 by means of the energy CT apparatus to obtain CT scan data of a mixture of at least two sets of collagen-pure matter components having different collagen contents from each other for pure matter possibly contained in the measurement object; d) Extracting collagen scan contents from the at least two sets of CT scan data, respectively, based on the characteristic parameters of collagen and the characteristic parameters of the purities possibly included in the measurement object; e) Obtaining a collagen scanning content-collagen actual content correspondence based on the extracted collagen scanning content and the collagen content of each of the mixture of the at least two groups of collagen-pure components, and F) Obtaining the actual content of collagen in the measured object based on the corresponding relation between the scanned content of collagen and the actual content of collagen in the measured object extracted in the step b).
  10. 10. The method of claim 9, wherein the relationship between the scanned collagen content and the actual collagen content is y=kx+b, where y is the actual collagen content and x is the scanned collagen content.
  11. 11. A system for measuring collagen content, comprising: An energy CT apparatus configured to perform energy scanning on a measurement object containing collagen to obtain CT scan data of the measurement object, and And a calculation unit configured to extract a collagen scanning content of the measurement object from CT scanning data of the measurement object based on the characteristic parameters of collagen and the characteristic parameters of a pure object possibly contained in the measurement object.
  12. 12. The system of claim 11, wherein the computing unit determines the characteristic parameters by modeling collagen as a chemical formula.
  13. 13. The system of claim 12, wherein the chemical formula is any one of C M ; C 5M H 9M N M O 3M ; C 6M H 14M N 2M O 3M ; C 169858M H 990099M N 29979M O 403125M Na 870M P 323M S 624M Cl 846M K 256M or C 82431M H 950495M N 15703M O 465000M Na 2175M P 7104M S 2807M Cl 846M , Wherein M >0.
  14. 14. The system of claim 11, wherein the collagen parameters have corresponding ranges of intervals at different energy voltages [ characteristic parameters min , characteristic parameters max ], Wherein 0< feature parameter min <1,0< feature parameter max <1, feature parameter min < feature parameter max , As the energy voltage increases, the characteristic parameter min and the characteristic parameter max each monotonically decrease.
  15. 15. The system of claim 14, wherein the characteristic parameter min is in the range of 0.20750 to 0.13740 and the characteristic parameter max is in the range of 0.28324 to 0.15214 when the energy voltage is in the range of 40kev to 140 kev.
  16. 16. The system of any one of claim 11 to 15, The energy CT apparatus is further configured to: an energy scan of a calibration phantom according to any of the claims 1-3, for obtaining CT scan data of a mixture of at least two collagen-pure components with different collagen contents from each other for pure substances possibly contained in the measuring object, and The computing unit is further configured to: Extracting collagen scan contents from the at least two sets of CT scan data, respectively, based on the characteristic parameters of collagen and the characteristic parameters of the purities possibly included in the measurement object; Obtaining a collagen scanning content-collagen actual content correspondence based on the extracted collagen scanning content and the collagen content of each of the mixture of the at least two groups of collagen-pure components, and And obtaining the actual content of the collagen in the measured object based on the extracted corresponding relation between the collagen scanning content of the measured object and the actual content of the collagen.
  17. 17. The system of claim 16, wherein the relationship between the scanned collagen content and the actual collagen content is y=kx+b, where y is the actual collagen content and x is the scanned collagen content.
  18. 18. A computer readable storage medium having encoded thereon instructions that, when executed, implement the method of any of claims 4-10.
  19. 19. A computer program product comprising a computer program which, when executed, implements the method of any of claims 4-10.

Description

Calibration piece for calibrating collagen content measurement and method and system for measuring collagen content Technical Field The present invention relates to the field of medical testing, and more particularly to a calibration piece for calibrating a collagen content measurement and a method and system for measuring collagen content. Background Collagen (also known as collagen), which is very important for the living body. Particularly, in the human body, collagen is a protein with the largest content in the human body, is an extremely important structural protein component of connective tissues such as skin, bone and cartilage, teeth, tendons, ligaments and blood vessels throughout each organ of human tissues, and is involved in physiological actions such as morphological composition, proliferation, differentiation, adhesion, migration, development of individuals, reproduction, information transmission, coagulation, tissue repair and the like of cells, and is also involved in the prevention and treatment of skin aging and the occurrence of certain diseases. Therefore, in clinical testing, it is highly desirable to measure the collagen content in humans. Various analytical methods commonly used in biochemistry and analytical chemistry are cumbersome, although quantification of collagen can be performed. Another type of high pressure liquid chromatography not only requires the provision of specialized equipment and adds complexity, but also has significant limitations. Moreover, these methods cannot detect living bodies, and require that an ex-vivo sample be obtained and then detected. In addition, there are often other elements in the body (e.g., calcium in bone and possibly iron in liver) in addition to collagen, which further increases the difficulty in accurately determining the collagen content of each site. Therefore, a new technology is needed to conveniently and accurately measure the collagen content of an object. Disclosure of Invention The present invention is directed to overcoming the above and/or other problems in the art. By means of the method and system for measuring the collagen content, the measured object containing the collagen and other pure matters is subjected to energy scanning by means of an energy CT (computed tomography) device, and the collagen content of the measured object can be directly extracted from the obtained CT scanning data, which cannot be realized by any prior art. By scanning the calibration piece for calibrating the measurement of the collagen content, which is provided by the invention, the measurement accuracy of the method and the system for measuring the collagen content can be further improved. According to a first aspect of the present invention, a method for measuring collagen content is provided, which may comprise the steps of a) energy scanning a measurement object containing collagen by means of an energy CT apparatus to obtain CT scan data of the measurement object, and b) extracting the collagen scan content of the measurement object from the CT scan data of the measurement object based on characteristic parameters of collagen and characteristic parameters of pure substances possibly contained in the measurement object. According to a second aspect of the invention, there is accordingly provided a system for measuring collagen content, which may comprise an energy CT device and a calculation unit. The energy CT apparatus may be configured to perform an energy scan of a measurement object comprising collagen to obtain CT scan data of the measurement object. The calculation unit may be configured to extract a collagen scan content of the measurement object from CT scan data of the measurement object based on the characteristic parameters of collagen and the characteristic parameters of pure objects that may be contained in the measurement object. Collagen has not been able to determine its characteristic parameters because it is not pure. However, the inventors have calculated characteristic parameters of collagen for the first time through a great number of experiments and calculations, and this breakthrough progress makes it possible to obtain the collagen content in the measured object through an energy CT apparatus. The energy CT apparatus has a multi-level energy such that CT scan data obtained by energy scanning of the measurement object through the energy CT apparatus may contain energy scan data corresponding to a plurality of energy levels, the energy scan data being associated with characteristic parameters and contents of components in the measurement object. Thus, the collagen content can be derived from the CT scan data based on the characteristic parameters of collagen and the characteristic parameters of other known purities, which are also referred to herein as "collagen scan content" because they are obtained directly from CT scan data. As mentioned above, since collagen is not pure, it does not have a truly corresponding chemical