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CN-121994749-A - Novel nanometer laser sensing mechanism with ultrahigh sensitivity and resolution

CN121994749ACN 121994749 ACN121994749 ACN 121994749ACN-121994749-A

Abstract

The invention discloses a sensing mechanism and a sensing method based on nanometer laser, which comprise (1) selection and matching of luminescent materials, namely a marker which can be used for luminescence sensing and can be used as a gain medium of a nanometer laser, (2) energy level matching and optimization of luminescent molecules used in traditional sensing based on luminescence signal intensity change as the nanometer laser gain medium and a surface plasmon structure, (3) obtaining nanometer laser signals based on a surface plasmon array and a luminescent material system, and (4) sensing based on the nanometer laser signals has higher sensitivity and resolution than traditional sensing based on luminescence signal intensity change. The intensity of the nano laser in the patent of the invention is influenced by the intensity of the luminescent substance. Compared with the traditional luminous intensity sensing, the nano laser has the ultra-narrow linewidth, so that the nano laser has high sensitivity and resolution, and plays an important role in the future optical sensing technology.

Inventors

  • LIU BOWEN
  • HE BAOYING

Assignees

  • 兰州大学

Dates

Publication Date
20260508
Application Date
20241104

Claims (7)

  1. 1. The novel ultra-high-sensitivity and resolution nano laser sensing mechanism is characterized by comprising the following steps of: (1) The selection and matching of the luminescent materials are required to be satisfied, and the luminescent materials are not only a marker for luminescence sensing, but also can be used as a gain medium of a nano laser; (2) All luminescent molecules used in the traditional sensing based on the change of the luminous signal intensity are used as the energy level matching and optimization between the nano laser gain medium and the surface plasmon structure; (3) Obtaining a nanometer laser signal based on the surface plasmon array and the luminescent material system; (4) The sensing based on the nanometer laser signal has higher sensitivity and resolution than the traditional sensing based on the change of the luminous signal intensity.
  2. 2. The method of claim 1, wherein in step (1, 2), the luminescent molecules include, but are not limited to, all conventional luminescent molecules in the ultraviolet, visible and near infrared bands of 190-1000 nm.
  3. 3. The method of preparing as claimed in claim 1, wherein in the steps (2, 3), the method as the nano laser gain medium comprises spin coating, drop coating, surface self-assembly, specific binding, adsorption of surface potential and hydrophobicity on the surface of the plasmonic nano-array structure, and attaching the gain medium fixed on other substrates on the surface of the plasmonic nano-array structure using the refractive index matching solution.
  4. 4. The method of claim 1, wherein in the step (2, 3), the surface plasmon nanoarray comprises gold and silver nanoarray structures prepared by holographic lithography, nanoimprint lithography, nanosphere lithography, and electron beam and focused ion beam etching methods.
  5. 5. The method of claim 1, wherein in step (3), the nano laser signal acquisition device comprises a pump source, an optical filter, a polarizer and a signal acquisition device.
  6. 6. The method according to claim 1, wherein in the step (3, 4), the nano laser signal includes intensity, displacement, half-width and threshold, and the sensing of the substance to be measured includes sensing of properties such as concentration, structural change, dynamic detection, etc.
  7. 7. A novel nano laser sensing mechanism with ultrahigh sensitivity and resolution as claimed in claims 1-6 is characterized in that the process of converting photoluminescence signals into nano laser signals comprises the stimulated radiation light amplification process caused by a surface plasmon nano optical resonant cavity, so that the sensitivity is higher than that of the traditional luminous intensity detection method, and the signals of laser are only a few nanometers, are obviously superior to fluorescent luminous peak shapes of tens or tens of nanometers, and have higher resolution. The sensor technology has brand new performance and excellent performance, and plays an important role in the fields of life science, biological medicine, food safety, environmental safety and the like.

Description

Novel nanometer laser sensing mechanism with ultrahigh sensitivity and resolution Technical Field The invention belongs to the technical fields of nano optics, analytical chemistry, life medicine and the like, and particularly relates to a novel sensing mechanism based on a nano laser, which has ultrahigh sensitivity and resolution. Background The development of fluorescence sensing technology can be traced to the 19 th century, but until the 20 th century, with the advent of fluorescence detection methods and the progress of instrumentation technology, fluorescence sensing technology has not been increasingly used. Early, fluorescence was mainly observed by the naked eye, but this method has limited sensitivity. In 1928, jette and West developed the first photo-fluorometer, ending the era of visual inspection. Subsequently, zworykin and Rajchman of the photomultiplier invented in 1939 further improve the sensitivity and resolution of the fluorometer, and bring important breakthrough to the development of a fluorescence detection method. Fluorescence sensing suffers from significant drawbacks such as being susceptible to interference from environmental factors, limited selectivity, sensitivity limitations, stability problems, biocompatibility problems, operational complexity, and quantum yield limitations. The plasmon nanometer laser is a coherent light source on the nanometer scale with the nanometer optical cavity provided by the plasmon structure as optical feedback. We have found that almost all biomarkers for luminescence analysis can be used as gain medium for nanolasers. This means that the conventional luminescence-based analytical sensing technology can use the nano-laser excited signal to perform the sensing analysis. It is important that the nanolaser signal will provide higher sensitivity and resolution. However, an important premise of this technique is that the threshold for nanolasing is reached. Indeed, scientists in the world are trying to solve the nanolaser threshold problem in various ways. Continuous optically pumped nano-lasing at room temperature has been achieved in recent years. The development of a nano laser which can be excited by a common light source of incoherent light such as an LED is realized through optimizing a nano optical cavity. This is an important research foundation based on nano laser signal sensing proposed by the invention. Disclosure of Invention Aiming at the defects pointed out in the background technology and the existing research basis, the invention provides a novel mechanism based on nanometer laser sensing with ultra-high sensitivity and resolution, and aims to solve the problems in the prior art in the background technology. In order to achieve the above purpose, the invention adopts the following technical scheme: A novel ultra-high-sensitivity and resolution nano laser sensing mechanism comprises the following steps: (1) The selection and matching of the luminescent materials are required to be satisfied, and the luminescent materials are not only a marker for luminescence sensing, but also can be used as a gain medium of a nano laser; (2) All luminescent molecules used in the traditional sensing based on the change of the luminous signal intensity are used as the energy level matching and optimization between the nano laser gain medium and the surface plasmon structure; (3) Obtaining a nanometer laser signal based on the surface plasmon array and the luminescent material system; (4) The sensing based on the nanometer laser signal has higher sensitivity and resolution than the traditional sensing based on the change of the luminous signal intensity. Optionally, in step (1), the light emitting range of the light emitting molecule may be 190-1000nm, but is not strictly limited; optionally, in the step (2), the method used as the nano laser gain medium may be spin coating, drop coating, surface self-assembly, specific binding, surface potential and hydrophilic-hydrophobic adsorption on the surface of the plasmonic nanostructure, and attaching the gain medium fixed on other substrates to the surface of the plasmonic nanostructure by using an index matching liquid; Optionally, in the step (2, 3), the surface plasmon array includes gold and silver nano array structures prepared by holographic lithography, nanoimprint lithography, nanosphere lithography, and electron beam and focused ion beam etching methods; Optionally, in step (3), the pump light source in the nano laser acquisition may be continuous laser and pulse laser; optionally, in the step (3), the collection angle and the rotation angle range in the nano laser collection may be 0-360 °; optionally, in the step (3, 4), the properties of the nano laser signal may be intensity, displacement, half-width and threshold; alternatively, different detection systems may be mapped by changing the luminescent molecule or by changing the mechanism of specific binding. The invention has the following advantages b