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CN-121995285-A - Magnetic resonance chemical exchange saturation transfer imaging method, device, equipment, product and storage medium

CN121995285ACN 121995285 ACN121995285 ACN 121995285ACN-121995285-A

Abstract

The application is suitable for the technical field of magnetic resonance chemical exchange saturation transfer imaging, and provides a magnetic resonance chemical exchange saturation transfer imaging method, a device, equipment, a product and a storage medium. The introduction of the wave control coding can reduce the scanning time. Because the wave control coding sampling efficiency is high, larger matrix size can be supported in the same time, thereby realizing high resolution imaging, being beneficial to reducing partial volume effect and improving CEST quantitative accuracy.

Inventors

  • WU KEN
  • Xie Zhuocheng
  • WANG HAIFENG

Assignees

  • 深圳先进技术研究院
  • 中国科学院深圳先进技术研究院

Dates

Publication Date
20260508
Application Date
20260408

Claims (10)

  1. 1. A method of magnetic resonance chemical exchange saturation transfer imaging, the method comprising: Acquiring saturated water molecule signals by adopting a gradient echo sequence, and storing the acquired water molecule signals into a K space, wherein in a data reading time window for reading gradient GRO and keeping on, the in-layer phase encoding GSPE direction and the in-layer phase encoding GPE direction are both on; and reconstructing a CEST image based on the water molecule signals of the K space.
  2. 2. The method of claim 1, wherein the K space is filled in a manner that the acquisition times of water molecule signals corresponding to each frequency offset in the K space is greater than or equal to 2, and filling is sequentially performed to the periphery of the K space from the center point of the K space in each acquisition process.
  3. 3. A method according to claim 1 or 2, characterized in that, In each acquisition process, acquiring water molecule signals corresponding to each frequency offset in the K space in a key hole part acquisition mode.
  4. 4. The method of claim 1 or 2, wherein reconstructing a CEST image based on the K-space water molecule signals comprises: And reconstructing a CEST image based on the water molecule signals in the K space by adopting compressed sensing.
  5. 5. The method of claim 1, wherein the GSPE and the GPE vary according to a sine wave waveform.
  6. 6. The method of claim 5, wherein the GSPE is turned on 0.5 cycles more than the GPE, wherein the GSPE is turned on 0.25 cycles earlier than the GPE, and wherein the GPE is turned on when GRO reaches a plateau.
  7. 7. A magnetic resonance chemical exchange saturation transfer imaging apparatus, comprising at least one module for performing the method of any one of claims 1 to 6.
  8. 8. An electronic device comprising at least one processor, and A memory storing a computer program executable on the processor, the processor executing the method of any one of claims 1 to 6 when the computer program is executed.
  9. 9. A program product, characterized in that the program product, when run on a computing node, causes the at least one computing node to perform the method of any of claims 1 to 6.
  10. 10. A computer readable storage medium comprising a program or instructions which when executed by a processor of a computing node implements the method of any of claims 1 to 6.

Description

Magnetic resonance chemical exchange saturation transfer imaging method, device, equipment, product and storage medium Technical Field The present application relates to the field of magnetic resonance chemical exchange saturation transfer imaging technology, and in particular, to a magnetic resonance chemical exchange saturation transfer imaging method, apparatus, device, product, and storage medium. Background Chemical exchange saturation transfer (Chemical Exchange Saturation Transfer, CEST) is a molecular imaging technique based on magnetic resonance imaging. Information about these low concentrations of macromolecules or metabolites is indirectly detected by selectively saturating (counteracting) the magnetization of exchangeable protons (e.g., -OH, -NH 2) in specific molecules (e.g., proteins, metabolites) in the body, and then transferring this "saturated" state to the free water by chemical exchange of these protons with surrounding free water molecules. However, in three-dimensional (3D) or high-resolution imaging, a large number of signals are often required to be acquired, which results in too long scanning time and affects clinical application. Due to the influence of radio frequency saturation pulses, CEST images have limited signal to noise ratio, so that the image resolution is not high, the quantitative accuracy is easily influenced by volume effect, and further, the range or activity of lesions is erroneously estimated. Disclosure of Invention The application provides a magnetic resonance chemical exchange saturation transfer imaging method, a device, equipment, a product and a storage medium, which can reduce the acquisition time of data in a K space and improve the image resolution of an image. In order to achieve the above purpose, the application adopts the following technical scheme: In a first aspect, a chemical exchange saturation transfer imaging method is provided, the method comprising: Acquiring saturated water molecule signals by adopting a gradient echo sequence, and storing the acquired water molecule signals into a K space, wherein a readout gradient in a readout direction GRO, a phase encoding GSPE direction in a layer selection direction and a wave encoding gradient in a phase encoding GPE direction in the layer are all started; and reconstructing a CEST image based on the water molecule signals of the K space. Optionally, the filling mode of the K space comprises the steps that the collection times of water molecule signals corresponding to each frequency offset position in the K space are more than or equal to 2, and filling is carried out to the periphery of the K space sequentially from the center point of the K space in each collection process. Optionally, the number of acquisitions is determined based on the size of the K-space. Optionally, in each collecting process, collecting the water molecule signal corresponding to each frequency offset in the K space by a key hole part collecting mode. Optionally, reconstructing the CEST image based on the water molecule signal of the K space comprises reconstructing the CEST image based on the water molecule signal of the K space by adopting compressed sensing. Optionally, the reconstructing the CEST image based on the water molecule signal of the K-space using compressed sensing includes: And reconstructing a CEST image based on the water molecule signals in the K space by adopting compressed sensing of L1 regular constraint. Optionally, the GSPE and the GPE vary according to a sine wave waveform. Optionally, the GSPE is 0.5 period more than the GPE, the GSPE is started 0.25 period earlier than the GPE, and the GPE is started when the GRO reaches the platform stage. In a second aspect, a chemical exchange saturated transfer imaging device is provided, comprising at least one module for performing the method according to any of the embodiments of the first aspect. In a third aspect, there is provided an electronic device comprising a memory, a processor and a computer program stored in the memory and executable on the processor, the processor implementing the steps of the chemical exchange saturation transfer imaging method as in any of the alternative implementations of the first aspect when the computer program is executed. In a fourth aspect, there is provided a computer readable storage medium storing a computer program which when executed by a processor implements the steps of the chemical exchange saturation transfer imaging method of any one of the first aspects. In a fifth aspect, there is provided a computer program product comprising a computer program which, when executed by a processor, implements the steps of the chemical exchange saturation transfer imaging method of any one of the first aspects. The magnetic resonance chemical exchange saturation transfer imaging method provided by the embodiment of the application has the following effective effects that a gradient echo sequence is adopted to collect saturated