CN-122003183-A - Composition for improving vascular endothelial function

Abstract

In one embodiment, the problem to be solved by the present invention is to provide a novel means for improving vascular endothelial function. In one embodiment, the present invention provides a composition for improving vascular endothelial function comprising bifidobacteria and a water-soluble dietary fiber.

Inventors

• DONG ZHISHU
• SAITO YASUO
• NISHIBE TOMOHIKO
• NISHIHIRA TAKASHI
• Motozai Naoyuki
• Choyada Akane
• TOYAMA Masayo

Assignees

• 江崎格力高株式会社

Dates

Publication Date

20260508

Application Date

20240924

Priority Date

20230925

Claims (20)

1. 1. A composition for improving vascular endothelial function comprising bifidobacteria (bifidobacteria) and a water-soluble dietary fiber.
2. 2. The composition of claim 1, wherein the improving vascular endothelial function comprises lowering blood LDL-c levels or lowering PAI-1 levels, or both.
3. 3. A composition for maintaining flexibility or elasticity of blood vessels, or preventing their decline, comprising bifidobacteria and a water-soluble dietary fiber.
4. 4. A composition for preventing arteriosclerosis comprising bifidobacteria and a water-soluble dietary fiber.
5. 5. A composition for improving renal function comprising bifidobacteria and water-soluble dietary fiber.
6. 6. The composition of any one of claims 1 to 5, wherein the water-soluble dietary fiber comprises inulin.
7. 7. The composition according to any one of claims 1 to 5, wherein the bifidobacteria have the ability to proliferate in the gut.
8. 8. The composition according to any one of claims 1 to 5, wherein the bifidobacterium has an antimetabolite syndrome effect.
9. 9. The composition according to any one of claims 1 to 5, which is a food product.
10. 10. The composition of any one of claims 1-5, further comprising arginine.
11. 11. Use of bifidobacteria and water-soluble dietary fibre in the manufacture of a composition for improving vascular endothelial function.
12. 12. The use of claim 11, wherein the improving vascular endothelial function comprises lowering blood LDL-c levels or lowering PAI-1 levels, or both.
13. 13. Use of bifidobacteria and water-soluble dietary fibre in the manufacture of a composition for maintaining vascular flexibility or elasticity, or preventing the decline thereof.
14. 14. Use of bifidobacteria and water-soluble dietary fibre in the manufacture of a composition for preventing arteriosclerosis.
15. 15. Use of bifidobacteria and water-soluble dietary fibre in the manufacture of a composition for improving renal function.
16. 16. Use of a water-soluble dietary fiber in the manufacture of a composition for improving vascular endothelial function, the composition comprising bifidobacteria.
17. 17. The use of claim 16, wherein the improving vascular endothelial function comprises lowering blood LDL-c levels or lowering PAI-1 levels, or both.
18. 18. Use of a water-soluble dietary fibre in the manufacture of a composition for maintaining flexibility or elasticity of blood vessels, or preventing their decline, said composition comprising bifidobacteria.
19. 19. Use of water-soluble dietary fibres in the manufacture of a composition for preventing arteriosclerosis, said composition comprising bifidobacteria.
20. 20. Use of water-soluble dietary fibres in the manufacture of a composition for improving renal function, the composition comprising bifidobacteria.

Description

Composition for improving vascular endothelial function Technical Field The present invention relates to a composition for improving vascular endothelial function. Background Cardiovascular disease (CVD) has become a leading cause of death worldwide, with particularly dramatic effects in low and medium income countries. It was estimated that 1790 ten thousand deaths in 2019 were estimated to be due to CVD, representing 32% of all deaths worldwide. Despite current prophylactic and therapeutic strategies, the mortality rate of CVD in the next decade is expected to increase further. Arteriosclerosis is an inflammatory disease of the cardiovascular system characterized by arterial lumen stenosis due to plaque formation, the progression of which directly leads to the development of CVD. Vascular endothelial dysfunction leads to plaque formation and disease progression, leading to the development of atherosclerosis. Similarly, CVD has been widely reported to be associated with metabolic syndrome. Metabolic syndrome is a clinical condition associated with at least three of the metabolic risk factors of excess visceral fat (abdominal obesity), insulin resistance, hyperglycemia, hypertension, and dyslipidemia (i.e., high triglyceride and low High Density Lipoprotein (HDL) cholesterol). These metabolic syndrome components have been found to each impair endothelial function, and patients with metabolic syndrome are known to develop vascular endothelial dysfunction at a high frequency. Under these circumstances, there is a strong need to develop a novel means for improving vascular endothelial function. List of references Patent literature JP2021-169517A patent document 1 Patent document 2 JP 588801B Non-patent literature Non-patent document 1:J Biosci Bioeng.2012, 113:587-91. Non-patent document 2 Sci Rep.2017, 7: 43522. Non-patent document 3, food Sci Nutr.2019, 7, 1828-37. Non-patent document 4:Scientific Reports, volume 4, particle number 4548 (2014). Non-patent document 5: hypertension.2018; 72: 1060-71. Non-patent document 6:Biosci Microbiota Food Health, 2016, 35 (4): 163-171. Non-patent document 7, genome Biol 2022 Apr 14, 23 (1): 95. Non-patent document 8, microbiolome 2021 Apr 29, 9 (1): 95, doi 10.1186/s40168-021-01048-3. Non-patent literature 9：The Japanese Circulation Society and the Japanese Society for Vascular Failure (eds.), "Kekkan Fuzen no Seirigakuteki Shindan Shishin" [Physiological Diagnostic Guidelines for Vascular Failure], Life Science Publishing Co., Ltd., 2021. Non-patent literature 10:Am J Clin Nutr.2018; 107:965-83. Disclosure of Invention Technical problem The problem to be solved by the present invention is to provide a novel means for improving vascular endothelial function. Solution to the problem Under the above circumstances, the present inventors have conducted extensive studies and found that a combination of bifidobacteria (bifidobacteria) and a water-soluble dietary fiber can improve vascular endothelial function. The present invention is based on such new findings. Accordingly, the present invention provides the following items: Item 1. A composition for improving vascular endothelial function comprising bifidobacteria and water-soluble dietary fiber. Item 2. The composition of item 1, wherein improving vascular endothelial function comprises lowering blood LDL-c levels or lowering PAI-1 levels, or both. Item 3. A composition for maintaining vascular flexibility or elasticity, or preventing its decline, comprising bifidobacteria and a water-soluble dietary fiber. Item 4. A composition for preventing arteriosclerosis comprising bifidobacteria and a water-soluble dietary fiber. Item 5. A composition for improving renal function comprising bifidobacteria and water-soluble dietary fiber. Item 6 the composition of any one of items 1 to 5, wherein the water-soluble dietary fiber comprises inulin. Item 7 the composition according to any one of items 1 to 6, wherein the bifidobacteria have the ability to proliferate in the intestinal tract. Item 8 the composition according to any one of items 1 to 7, wherein the bifidobacteria have an antimetabolite syndrome effect. Item 9 the composition according to any one of items 1 to 8, which is a food product. Item 10 the composition according to any one of items 1 to 9, further comprising arginine. Item 11 use of bifidobacteria and water-soluble dietary fibre in the manufacture of a composition for improving vascular endothelial function. Item 12. The use of item 11, wherein improving vascular endothelial function comprises lowering blood LDL-c levels or lowering PAI-1 levels, or both. Item 13 use of bifidobacteria and water-soluble dietary fibre in the manufacture of a composition for maintaining vascular flexibility or elasticity, or preventing the decrease thereof. Use of bifidobacteria and water-soluble dietary fibre in the manufacture of a composition for preventing arteriosclerosis. Item 15 use of bifidobacteria and water-soluble dietary fi