CN-122003269-A - Guide wire

Abstract

The purpose of the present invention is to provide a guide wire which, even when a hydrophilic coating is in contact with a liquid such as a body fluid, can suppress an increase in frictional resistance with a combined device caused by swelling of the hydrophilic coating and can improve the rotational response of the guide wire. The guide wire (1) comprises a core shaft (11), a coil body (21), a wire (w) of which is wound so as to cover the outer periphery of the front end portion of the core shaft (11), a first portion (41) formed by a hydrophilic coating (411) and a hydrophobic coating (412), the hydrophilic coating (411) being arranged on the surface on the outer peripheral surface of the wire (w) on the outer side in the radial direction, the hydrophobic coating (412) being formed on the hydrophilic coating (411) at a second portion (51) which is a portion on the outer side in the radial direction than the axis of the wire (w), and which is formed by a hydrophilic coating (511), the hydrophilic coating (511) being arranged so as to fill a recess between wires (w, w) adjacent in the longitudinal direction.

Inventors

• FUJIWARA SOICHIRO
• Xi Ancheng
• SUGITA Rio

Assignees

• 朝日英达科株式会社

Dates

Publication Date

20260508

Application Date

20240909

Priority Date

20231004

Claims (4)

1. 1. A guide wire is characterized in that, the guide wire includes: A mandrel; a coil body in which a wire is wound so as to cover the outer periphery of the distal end portion of the mandrel; a first portion formed of a hydrophilic coating layer disposed on a surface on the outer circumferential surface of the wire that is located radially outward, and a hydrophobic coating layer formed on the outer circumferential surface of the hydrophilic coating layer; and a second portion which is a portion radially outside of the axial center of the wire and is formed of a hydrophilic coating layer configured to fill the concave portion between the wires adjacent in the long axis direction.
2. 2. The guidewire of claim 1, wherein a distance between the outer peripheral surface of the second location and the central axis of the mandrel is less than a distance between the outer peripheral surface of the first location and the central axis of the mandrel when the hydrophilic coating is dried.
3. 3. The guidewire of claim 1, wherein a distance between the outer peripheral surface of the second location and the central axis of the mandrel is approximately equal to a distance between the outer peripheral surface of the first location and the central axis of the mandrel when the hydrophilic coating is in contact with a liquid.
4. 4. A guide wire, which is used for guiding a patient, characterized by comprising the following steps: A mandrel; a coil body in which a wire is wound so as to cover the outer periphery of the distal end portion of the mandrel; A first portion formed of a hydrophobic coating layer disposed on a surface on the outer circumferential surface of the wire, the surface being located radially outward; and a second portion which is a portion radially outside of the axial center of the wire and is formed of a hydrophilic coating layer configured to fill the concave portion between the wires adjacent in the long axis direction.

Description

Guide wire Technical Field The present invention relates to a guidewire. Background For example, when a therapeutic device such as a catheter (a combination device) is inserted into a body cavity such as a blood vessel, a guide wire is inserted into the body cavity before the device is used to guide the combination device to a therapeutic site. For example, after the tip portion is shaped in a substantially J-shape in advance, the guide wire is inserted into the body cavity. At the site where the branching occurs in the body cavity, the guide wire is rotated appropriately so that the distal end portion of the guide wire is directed toward the desired branched lumen, and the distal end portion of the guide wire is advanced to the site of treatment. For such a guidewire, in order to enable it to reach the site of treatment quickly, the following technique is proposed. For example, a technique of reducing frictional resistance with a combined device by reducing a contact area of a guide wire with a wall surface (for example, see patent document 1), or a technique of providing a hydrophilic coating on a surface of a guide wire with a wall surface, absorbing moisture when in contact with body fluid, and forming a liquid film on the outermost surface, thereby reducing frictional resistance with a combined device (for example, see patent document 2). Prior art literature Patent literature Patent document 1, japanese patent application laid-open No. 2011-152211. Patent document 2, japanese patent application laid-open No. 2012-70979. Disclosure of Invention Problems to be solved by the invention However, even in the case where a liquid film is formed on the outermost surface using a hydrophilic coating, if the hydrophilic coating is excessively swelled due to absorption of moisture, for example, a gap between the hydrophilic coating and a combined apparatus abutting against the outer peripheral surface becomes small. Therefore, when the distal end portion of the guide wire is rotated by the proximal rotation operation, the frictional resistance with the combined device increases, and the rotational response of the guide wire may be deteriorated. The present invention has been made in view of the above circumstances, and an object thereof is to provide a guide wire capable of suppressing an increase in frictional resistance with a combined device caused by swelling of a hydrophilic coating layer even when the hydrophilic coating layer is in contact with a liquid such as a body fluid, and capable of improving a rotational response of the guide wire. Solution to the problem Some embodiments of the present disclosure are shown below: (1) A guidewire, comprising: A mandrel; a coil body in which a wire is wound so as to cover the outer periphery of the distal end portion of the mandrel; A first portion formed of a hydrophilic coating layer disposed on a surface on the outer circumferential surface of the wire that is located radially outward, and a hydrophobic coating layer formed on the outer circumferential surface of the hydrophilic coating layer; the second portion, which is a portion radially outward of the axial center of the wire, is formed of a hydrophilic coating configured to fill the concave portion between the wires adjacent in the long axis direction. (2) The guidewire according to embodiment (1), wherein the distance between the outer peripheral surface of the second portion and the central axis of the mandrel is smaller than the distance between the outer peripheral surface of the first portion and the central axis of the mandrel when the hydrophilic coating is dried. (3) The guidewire of embodiment (1), wherein the distance between the outer peripheral surface of the second location and the central axis of the mandrel is approximately equal to the distance between the outer peripheral surface of the first location and the central axis of the mandrel when the hydrophilic coating is in contact with the liquid. (4) A guidewire, comprising: A mandrel; a coil body in which a wire is wound so as to cover the outer periphery of the tip end portion of the mandrel; a first portion formed of a hydrophobic coating layer disposed on a surface on the outer circumferential surface of the wire, the surface being located radially outward; the second portion, which is a portion radially outward of the axial center of the wire, is formed of a hydrophilic coating configured to fill the concave portion between the wires adjacent in the long axis direction. In the present specification, the term "distal end side" refers to a direction along the longitudinal direction of the guide wire, and refers to a direction toward the insertion of a deeper portion (distal end) of the body cavity. The "proximal end side" is a direction along the longitudinal direction of the guide wire, and means a direction opposite to the "distal end side". The "tip" means a tip-side end portion of any component or site, and the "base" means a base-side