CN-122003406-A - Amide compound, preparation method and agronomic application thereof

Abstract

Relates to the field of pesticide chemistry, and provides an amide compound, a preparation method thereof, agronomic application and a biostimulant, wherein the compound has a structure shown in a formula (I). The compound can effectively promote the germination of seeds, improve the yield of crops, regulate the growth of plants, strengthen the disease resistance of the plants and manage the abiotic stress of the plants.

Inventors

• XI ZHEN
• WANG DAWEI
• WU HAIXIANG

Assignees

• 南开大学

Dates

Publication Date

20260508

Application Date

20240919

Priority Date

20230928

Claims (12)

1. An amide compound is characterized in that the compound has a structure shown in a formula (I), Wherein, in the formula (I), R 1 and R 2 are each independently selected from H, substituted or unsubstituted C 1-12 alkyl, substituted or unsubstituted C 3-12 cycloalkyl, A substituted or unsubstituted heterocyclic ring of C 1-8 containing a heteroatom selected from at least one of N, O and S, wherein R 7 、R 8 、R 9 、R 10 and R 11 are each independently selected from H, halogen, nitro, cyano, phenyl, benzyl, alkyl of C 1-6 , cycloalkyl of C 3-6 , C 1-6 alkyl substituted with 1-9 halogens, alkoxy of C 1-6 , C 1-6 alkoxy substituted with 1-9 halogens, alkylthio of C 1-6 , alkyl of C 1-6 alkylthio of-COO-C 1-6 and alkyl of-S (O) 2 -C 1-6 , or any adjacent two of R 7 、R 8 、R 9 、R 10 、R 11 are cyclic together to form a 3-8 membered cyclic structure; And each of the substituents optionally present on R 1 and R 2 is independently selected from alkyl of C 1-12 , phenyl; R 3 、R 4 、R 5 and R 6 are each independently selected from the group consisting of alkyl of H, C 1-12 and cycloalkyl of C 3-12 ; n is 0,1, 2, 3 or 4; X is O, S, -S (O) -or-S (O) 2 -, and Y is O, NH, S, CH 2 or-N (CH 3 ) -.
2. The compound of claim 1, wherein in formula (I), X and Y are not both O.
3. The compound according to claim 2, wherein, in formula (I), R 1 and R 2 are each independently selected from H, C 1-6 alkyl, - (CH 2 ) z -phenyl, unsaturated five-membered ring group containing hetero atom selected from group B, saturated four-membered ring group containing hetero atom of group B, unsaturated six-membered ring group containing hetero atom of group B, saturated cycloalkyl of C 4-8 , benzothiazolyl, benzoxazolyl, benzopyrazolyl, benzothienyl, N-methyl-benzopyrrolyl, Z is an integer from 1 to 6, each of said class B heteroatoms is independently selected from at least one of O, S, N, and optionally, said class B heteroatoms having C 1-3 alkyl as a substituent; Wherein R 7 、R 8 、R 9 、R 10 and R 11 are each independently selected from H, halogen, nitro, cyano, phenyl, benzyl, C 1-6 alkyl, C 3-6 cycloalkyl, C 1-6 alkyl substituted with 1-6 halogens, C 1-6 alkoxy, C 1-6 alkoxy substituted with 1-6 halogens, alkylthio of C 1-6 , C 1-6 alkylthio substituted with 1-3 halogens, -COO-C 1-6 alkyl and-S (O) 2 -C 1-6 alkyl, or any adjacent two of R 7 、R 8 、R 9 are cyclic together to form a saturated cycloalkyl structure of C 3-6 with or without an O atom, or any adjacent two of R 7 、R 8 、R 9 are cyclic together to form an unsaturated cycloalkyl structure of C 3-6 with or without a class A heteroatom selected from at least one of O, S, N, and optionally, the alkyl of C 1-3 on the class A heteroatom is used as a substituent; R 3 、R 4 、R 5 and R 6 are each independently selected from the group consisting of alkyl of H, C 1-6 and cycloalkyl of C 3-6 ; n is 0,1, 2 or 3; X is S, -S (O) -or-S (O) 2 -; Y is O, NH, -CH 2 -or-N (CH 3 ) -.
4. A compound according to claim 2 or 3, wherein, in formula (I), R 1 is Wherein R 7 、R 8 、R 9 、R 10 and R 11 are each independently selected from H, halogen, nitro, cyano, phenyl, benzyl, C 1-6 alkyl, C 3-6 cycloalkyl, C 1-6 alkyl substituted with 1-6 halogens, C 1-6 alkoxy, C 1-6 alkoxy substituted with 1-6 halogens, alkylthio of C 1-6 , C 1-6 alkylthio substituted with 1-3 halogens, -COO-C 1-6 alkyl and-S (O) 2 -C 1-6 alkyl, or any adjacent two of R 7 、R 8 、R 9 are cyclic together to form a saturated cycloalkyl structure of C 3-6 with or without an O atom, or any adjacent two of R 7 、R 8 、R 9 are cyclic together to form an unsaturated cycloalkyl structure of C 3-6 with or without a class A heteroatom selected from at least one of O, S, N, and optionally, the alkyl of C 1-3 on the class A heteroatom is used as a substituent; R 2 、R 5 and R 6 are each independently selected from H, methyl, ethyl, n-propyl, isopropyl, tert-butyl, or R 2 is phenyl; R 3 and R 4 are both H; n is 0, 1 or 2; X is S, -S (O) -or-S (O) 2 -; Y is O, NH, -CH 2 -or-N (CH 3 ) -.
5. The compound according to claim 4, wherein the compound represented by formula (I) has a structure of a compound represented by formula (I-a): wherein the substitution in formula (I-A) ,n、X、Y、R 2 、R 3 、R 4 、R 5 、R 6 、R 7 、R 8 、R 9 、R 10 、R 11 is as follows: The compound 1 is characterized in that n is 0, X is S, Y is O, R 6 is Me,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 , and H is H; The compound 2 is that n is 0, X is S, Y is O, R 6 is Me, R 7 is F, and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; Compound 3:n is 0, x is S, Y is O, R 6 is Me, R 8 is F, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are both H; Compound 4:n is 0, x is S, Y is O, R 6 is Me, R 9 is F, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are both H; compound 5:n is 0, x is S, Y is O, R 6 is Me, R 7 is Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are both H; compound 6:n is 0, x is S, Y is O, R 6 is Me, R 8 is Cl, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are both H; compound 7:n is 0, x is S, Y is O, R 6 is Me, R 9 is Cl, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are both H; compound 8:n is 0, x is S, Y is O, R 6 is Me, R 7 is Br, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are all H; compound 9:n is 0, x is S, Y is O, R 6 is Me, R 8 is Br, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are all H; The compound 10 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 9 is Br, and R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; The compound 11 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 7 is I, and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; the compound 12 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 8 is I, and R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; the compound 13 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 9 is I, and R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; The compound 14 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 7 is NO 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H; the compound 15 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 8 is NO 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and H; the compound 16 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 9 is NO 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and H; the compound 17 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 7 is CF 3 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and both are H; the compound 18 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 8 is CF 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and both are H; the compound 19 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 9 is CF 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and both are H; the compound 20 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 7 is OCF 3 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H is H; the compound 21 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 8 is OCF 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and H is H; the compound 22 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 9 is OCF 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and H is H; the compound 23 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 7 is OCHF 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H is H; the compound 24 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 8 is OCHF 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and H is H; the compound 25 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 9 is OCHF 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and H is H; the compound 26 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 9 is SCF 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and H is H; compound 27: n is 0, x is S, Y is O, R 6 is Me, R 7 is OCH 3 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are both H; the compound 28 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 8 is OCH 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and H is H; the compound 29 is that n is 0, X is S, Y is O, R 6 is Me, R 9 is OCH 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and H is the same as the compound; The compound 30 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 9 is COOC 2 H 5 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and H is H; the compound 31 is that n is 0, X is S, Y is O, R 6 is Me, R 7 is CN, and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; the compound 32 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 8 is CN, and R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; The compound 33 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 9 is CN, and R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; compound 34: n is 0, x is S, Y is O, R 6 and R 7 are Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are both H; The compound 35 is that n is 0, X is S, Y is O, R 6 and R 8 are Me, and R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; the compound 36 is characterized in that n is 0, X is S, Y is O, R 6 and R 9 are Me, and R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; the compound 37 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 7 is CH 3 SO 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H is H; The compound 38 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 8 is CH 3 SO 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and H is H; the compound 39 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 9 is CH 3 SO 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and H is H; the compound 40 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 7 is C 2 H 5 SO 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H is H; The compound 874 is that n is 0, X is S, Y is O, R 6 is Me, R 7 is CO 2 CH 3 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H is the same as the compound; the compound 875 is that n is 0, X is S, Y is O, R 6 is Me, R 8 is CO 2 CH 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and both are H; The compound 876 is that n is 0, X is S, Y is O, R 6 is Me, R 9 is CO 2 CH 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and H is the same as the compound; The compound 877:n is 0, X is S, Y is O, R 6 is Me, R 7 is Ph, and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; The compound 878:n is 0, X is S, Y is O, R 6 is Me, R 8 is Ph, and R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; the compound 879:n is 0, X is S, Y is O, R 6 is Me, R 9 is Ph, and R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; the compound 880 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 7 is Bn, and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; the compound 881:n is 0, X is S, Y is O, R 6 is Me, R 8 is Bn, and R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; The compound 882: n is 0, x is S, Y is O, R 6 is Me, R 9 is Bn, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are both H; The compound 41 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 7 and R 8 are Cl, and R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; the compound 42 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 7 and R 9 are Cl, and R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 are H; the compound 43 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 7 and R 10 are Cl, and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 11 are H; the compound 44 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 7 and R 11 are Cl, and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 are H; the compound 45 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 8 and R 9 are Cl, and R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; The compound 46 is that n is 0, X is S, Y is O, R 6 and R 7 are Me, R 9 is Cl, and R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 are H; The compound 47 is that n is 0, X is S, Y is O, R 6 、R 7 、R 8 is Me, and R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 is H; The compound 48 is characterized in that n is 0, X is S, Y is O, R 6 、R 7 、R 9 is Me, and R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 is H; the compound 49 is characterized in that n is 0, X is S, Y is O, R 6 、R 7 、R 10 is Me, and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 11 is H; the compound 50 is characterized in that n is 0, X is S, Y is O, R 6 、R 7 、R 11 is Me, and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 is H; the compound 51 is characterized in that n is 0, X is S, Y is O, R 6 、R 7 、R 8 、R 11 is Me, and R 2 、R 3 、R 4 、R 5 、R 9 、R 10 is H; the compound 52 is characterized in that n is 0, X is S, Y is O, R 6 、R 7 、R 9 、R 11 is Me, and R 2 、R 3 、R 4 、R 5 、R 8 、R 10 is H; the compound 53 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 7 、R 9 is CF 3 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 and H; The compound 54 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 8 、R 10 is CF 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 11 and H; the compound 55 is that n is 0, X is S, Y is O, R 6 is Me, R 2 、R 3 、R 4 、R 5 is H, and R 7 、R 8 、R 9 、R 10 、R 11 is F; The compound 56 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 7 is CH 3 CH 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H is H; the compound 57 is that n is 0, X is S, Y is O, R 6 is Me, R 8 is CH 3 CH 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and H is the same as the compound; The compound 58 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 9 is CH 3 CH 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and H is H; The compound 59 is that n is 0, X is S, Y is O, R 6 is Me, R 7 is CH(CH 3 ) 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H is the same as the compound; The compound 60 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 8 is CH(CH 3 ) 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and H is H; The compound 61 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 9 is CH(CH 3 ) 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and H is H; The compound 62 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 7 is CH 3 (CH 2 ) 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H is H; The compound 63 is 0, X is S, Y is O, R 6 is Me, R 7 is R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; The compound 64 is that n is 0, X is S, Y is O, R 6 is Me, R 7 is R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; the compound 65 is characterized in that n is 0, X is S, Y is O, R 6 is Me, R 7 is CO 2 CH 3 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H is H; the compound 66 is formed by cyclization of n is 0, X is S, Y is O, R 6 is Me, R 7 and R 8 R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; The compound 67 is formed by cyclization of n is 0, X is S, Y is O, R 6 is Me, R 8 and R 9 R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; The compound 68 is formed by cyclization of n is 0, X is S, Y is O, R 6 is Me, R 8 and R 9 R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; The compound 69 is formed by cyclization of n is 0, X is S, Y is O, R 6 is Me, R 7 and R 8 R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; The compound 70 is formed by cyclization of n is 0, X is S, Y is O, R 6 is Me, R 8 and R 9 R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; The compound 71 is formed by cyclization of n is 0, X is S, Y is O, R 6 is Me, R 8 and R 9 R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 is H; The compound 72 is formed by cyclization of n is 0, X is S, Y is O, R 6 is Me, R 7 and R 8 R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; The compound 73:n is 0, X is S, Y is O, R 6 is Me, R 7 and R 8 are cyclized to form R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; The compound 74 is formed by cyclization of n is 0, X is S, Y is O, R 6 is Me, R 8 and R 9 R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; The compound 75:n is 0, X is S, Y is O, R 6 is Me, R 8 and R 9 are cyclized to form R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; The compound 76 is formed by cyclization of n is 0, X is S, Y is O, R 6 is Me, R 8 and R 9 R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; The compound 77 is characterized in that n is 0, X is S, Y is O, R 5 is Me,R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 9 、R 10 、R 11 , and H is H; The compound 78 is characterized in that n is 0, X is S, Y is O, R 5 is Me, R 7 is F, and R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 are H; The compound 79 is characterized in that n is 0, X is S, Y is O, R 5 is Me, R 8 is F, and R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 are H; The compound 80 is characterized in that n is 0, X is S, Y is O, R 5 is Me, R 9 is F, and R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 are H; The compound 81 is characterized in that n is 0, X is S, Y is O, R 5 is Me, R 7 is Cl, and R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 are H; The compound 82 is characterized in that n is 0, X is S, Y is O, R 5 is Me, R 8 is Cl, and R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 are H; The compound 83 is that n is 0, X is S, Y is O, R 5 is Me, R 9 is Cl, and R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 are H; the compound 84 is that n is 0, X is S, Y is O, R 5 is Me, R 7 is Br, and R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 are H; the compound 85 is characterized in that n is 0, X is S, Y is O, R 5 is Me, R 8 is Br, and R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 are H; The compound 86 is characterized in that n is 0, X is S, Y is O, R 5 is Me, R 9 is Br, and R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 are H; The compound 87 is characterized in that n is 0, X is S, Y is O, R 5 is Me, R 7 is I, and R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 are H; The compound 88 is characterized in that n is 0, X is S, Y is O, R 5 is Me, R 8 is I, and R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 are H; the compound 89 is characterized in that n is 0, X is S, Y is O, R 5 is Me, R 9 is I, and R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 are H; the compound 90 is characterized in that n is 0, X is S, Y is O, R 5 is Me, R 7 is NO 2 ,R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 and H; the compound 91 is characterized in that n is 0, X is S, Y is O, R 5 is Me, R 8 is NO 2 ,R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 and H is the same as the above; the compound 92 is that n is 0, X is S, Y is O, R 5 is Me, R 9 is NO 2 ,R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 and H is the same as the above; the compound 93 is that n is 0, X is S, Y is O, R 5 is Me, R 7 is CF 3 ,R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 and both are H; The compound 94 is characterized in that n is 0, X is S, Y is O, R 5 is Me, R 8 is CF 3 ,R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 and both are H; The compound 95:n is 0, X is S, Y is O, R 5 is Me, R 9 is CF 3 ,R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 and both are H; the compound 96 is that n is 0, X is S, Y is O, R 5 is Me, R 7 is OCF 3 ,R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 and H is the same as that of the compound; the compound 97 is characterized in that n is 0, X is S, Y is O, R 5 is Me, R 8 is OCF 3 ,R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 and H is H; the compound 98:n is 0, X is S, Y is O, R 5 is Me, R 9 is OCF 3 ,R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 and H is the same as the above; the compound 99 is characterized in that n is 0, X is S, Y is O, R 5 is Me, R 7 is OCHF 2 ,R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 and H is H; The compound 100 is characterized in that n is 0, X is S, Y is O, R 5 is Me, R 8 is OCHF 2 ,R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 and H is H; the compound 101 is characterized in that n is 0, X is S, Y is O, R 5 is Me, R 9 is OCHF 2 ,R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 and H is H; The compound 102 is characterized in that n is 0, X is S, Y is O, R 5 is Me, R 9 is SCF 3 ,R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 and H is H; the compound 103 is characterized in that n is 0, X is S, Y is O, R 5 is Me, R 7 is OCH 3 ,R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 and H is H; the compound 104 is characterized in that n is 0, X is S, Y is O, R 5 is Me, R 8 is OCH 3 ,R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 and H is H; The compound 105 is that n is 0, X is S, Y is O, R 5 is Me, R 9 is OCH 3 ,R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 and H is the same as the compound; the compound 106 is characterized in that n is 0, X is S, Y is O, R 5 is Me, R 9 is OC 2 H 5 ,R 2 、R 3 、R 4 、R 6 、R 8 、R 7 、R 10 、R 11 and H is H; the compound 107 is characterized in that n is 0, X is S, Y is O, R 5 is Me, R 7 is CN, and R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 are H; The compound 108 is characterized in that n is 0, X is S, Y is O, R 5 is Me, R 8 is CN, and R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 are H; the compound 109 is characterized in that n is 0, X is S, Y is O, R 5 is Me, R 9 is CN, and R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 are H; The compound 110 is characterized in that n is 0, X is S, Y is O, R 5 and R 7 are Me, and R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 are H; The compound 111 is characterized in that n is 0, X is S, Y is O, R 5 and R 8 are Me, and R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 are H; The compound 112 is that n is 0, X is S, Y is O, R 5 and R 9 are Me, and R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 are H; The compound 113 is characterized in that n is 0, X is S, Y is O, R 5 is Me, R 7 is CH 3 SO 2 ,R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 and H is H; The compound 114 is characterized in that n is 0, X is S, Y is O, R 5 is Me, R 8 is CH 3 SO 2 ,R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 and H is H; The compound 115 is that n is 0, X is S, Y is O, R 5 is Me, R 9 is CH 3 SO 2 ,R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 and H is the same as that of the compound; The compound 116 is characterized in that n is 0, X is S, Y is O, R 5 is Me, R 7 is C 2 H 5 SO 2 ,R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 and H is H; the compound 117 is characterized in that n is 0, X is S, Y is O, R 5 is Me, R 7 and R 8 are Cl, and R 2 、R 3 、R 4 、R 6 、R 9 、R 10 、R 11 are H; the compound 118 is characterized in that n is 0, X is S, Y is O, R 5 is Me, R 7 and R 9 are Cl, and R 2 、R 3 、R 4 、R 6 、R 8 、R 10 、R 11 are H; the compound 119 is characterized in that n is 0, X is S, Y is O, R 5 is Me, R 7 and R 10 are Cl, and R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 11 are H; the compound 120 is characterized in that n is 0, X is S, Y is O, R 5 is Me, R 7 and R 11 are Cl, and R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 are H; the compound 121 is characterized in that n is 0, X is S, Y is O, R 5 is Me, R 8 and R 9 are Cl, and R 2 、R 3 、R 4 、R 6 、R 7 、R 10 、R 11 are H; compound 122: n is 0, x is S, Y is O, R 5 and R 7 are Me, R 9 is Cl, R 2 、R 3 、R 4 、R 6 、R 8 、R 10 、R 11 are both H; The compound 123 is that n is 0, X is S, Y is O, R 5 、R 7 、R 8 is Me, and R 2 、R 3 、R 4 、R 6 、R 9 、R 10 、R 11 is H; The compound 124 is that n is 0, X is S, Y is O, R 5 、R 7 、R 9 is Me, R 2 、R 3 、R 4 、R 6 、R 8 、R 10 、R 11 is H; The compound 125 is characterized in that n is 0, X is S, Y is O, R 5 、R 7 、R 10 is Me, and R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 11 is H; The compound 126 is characterized in that n is 0, X is S, Y is O, R 5 、R 7 、R 11 is Me, and R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 is H; The compound 127:n is 0, X is S, Y is O, R 5 、R 7 、R 8 、R 11 is Me, and R 2 、R 3 、R 4 、R 6 、R 9 、R 10 is H; The compound 128 is characterized in that n is 0, X is S, Y is O, R 5 、R 7 、R 9 、R 11 is Me, and R 2 、R 3 、R 4 、R 6 、R 8 、R 10 is H; The compound 129 is 0, X is S, Y is O, R 5 is Me, R 7 、R 9 is CF 3 ,R 2 、R 3 、R 4 、R 6 、R 8 、R 10 、R 11 is H; the compound 130 is that n is 0, X is S, Y is O, R 5 is Me, R 8 、R 10 is CF 3 ,R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 11 is H; the compound 131 is that n is 0, X is S, Y is O, R 5 is Me, R 2 、R 3 、R 4 、R 6 is H, and R 7 、R 8 、R 9 、R 10 、R 11 is F; The compound 132 is characterized in that n is 0, X is S, Y is O, R 5 is Me, R 7 is CH 3 CH 2 ,R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 and H is H; The compound 133 is that n is 0, X is S, Y is O, R 5 is Me, R 8 is CH 3 CH 2 ,R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 and both are H; The compound 134 is characterized in that n is 0, X is S, Y is O, R 5 is Me, R 9 is CH 3 CH 2 ,R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 and H is H; The compound 135 is that n is 0, X is S, Y is O, R 5 is Me, R 7 is CH(CH 3 ) 2 ,R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 and both are H; The compound 136 is characterized in that n is 0, X is S, Y is O, R 5 is Me, R 8 is CH(CH 3 ) 2 ,R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 and H is H; The compound 137:n is 0, X is S, Y is O, R 5 is Me, R 9 is CH(CH 3 ) 2 ,R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 and both are H; the compound 138 is that n is 0, X is S, Y is O, R 5 is Me, R 7 is CH 3 (CH 2 ) 2 ,R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 and H is H; The compound 139 is that n is 0, X is S, Y is O, R 5 is Me, R 7 is R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 are H; The compound 140 is that n is 0, X is S, Y is O, R 5 is Me, R 7 is R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 are H; The compound 141 is characterized in that n is 0, X is S, Y is O, R 5 is Me, R 7 is CO 2 CH 3 ,R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 and H is H; the compound 142 is formed by cyclization of n is 0, X is S, Y is O, R 5 is Me, R 7 and R 8 R 2 、R 3 、R 4 、R 6 、R 9 、R 10 、R 11 are H; The compound 143 is that n is 0, X is S, Y is O, R 5 is Me, R 8 and R 9 are cyclized to form R 2 、R 3 、R 4 、R 6 、R 7 、R 10 、R 11 are H; The compound 144 is formed by cyclization of n is 0, X is S, Y is O, R 5 is Me, R 8 and R 9 R 2 、R 3 、R 4 、R 6 、R 7 、R 10 、R 11 are H; the compound 145 is formed by cyclization of n is 0, X is S, Y is O, R 5 is Me, R 7 and R 8 R 2 、R 3 、R 4 、R 6 、R 9 、R 10 、R 11 are H; The compound 146 is formed by cyclization of n is 0, X is S, Y is O, R 5 is Me, R 8 and R 9 R 2 、R 3 、R 4 、R 6 、R 7 、R 10 、R 11 are H; Compounds 147 are formed by cyclization of n is 0, X is S, Y is O, R 5 is Me, R 7 and R 8 R 2 、R 3 、R 4 、R 6 、R 9 、R 10 、R 11 are H; The compound 148 is formed by cyclization of n is 0, X is S, Y is O, R 5 is Me, R 7 and R 8 R 2 、R 3 、R 4 、R 6 、R 9 、R 10 、R 11 are H; Compounds 149:n is 0, X is S, Y is O, R 5 is Me, R 7 and R 8 are cyclized to form R 2 、R 3 、R 4 、R 6 、R 9 、R 10 、R 11 are H; Compounds 150:n is 0, X is S, Y is O, R 5 is Me, R 7 and R 8 are cyclized to form R 2 、R 3 、R 4 、R 6 、R 9 、R 10 、R 11 are H; the compound 151:n is 0, X is S, Y is O, R 5 is Me, R 7 and R 8 are cyclized to form R 2 、R 3 、R 4 、R 6 、R 9 、R 10 、R 11 are H; The compound 152 is formed by cyclization of n is 0, X is S, Y is O, R 5 is Me, R 8 and R 9 R 2 、R 3 、R 4 、R 6 、R 7 、R 10 、R 11 are H; The compound 153 is characterized in that n is 0, X is S, Y is O, R 5 、R 6 is Me, and R 2 、R 3 、R 4 、R 7 、R 8 、R 9 、R 10 、R 11 is H; the compound 154 is characterized in that n is 0, X is S, Y is O, R 5 、R 6 is Me, R 7 is F, and R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 is H; the compound 155 is characterized in that n is 0, X is S, Y is O, R 5 、R 6 is Me, R 8 is F, and R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 is H; the compound 156 is that n is 0, X is S, Y is O, R 5 、R 6 is Me, R 9 is F, and R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 is H; The compound 157 is that n is 0, X is S, Y is O, R 5 、R 6 is Me, R 7 is Cl, and R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 is H; the compound 158 is characterized in that n is 0, X is S, Y is O, R 5 、R 6 is Me, R 8 is Cl, and R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 is H; the compound 159 is characterized in that n is 0, X is S, Y is O, R 5 、R 6 is Me, R 9 is Cl, and R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 is H; The compound 160 is characterized in that n is 0, X is S, Y is O, R 5 、R 6 is Me, R 7 is Br, and R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 is H; the compound 161 is characterized in that n is 0, X is S, Y is O, R 5 、R 6 is Me, R 8 is Br, and R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 is H; the compound 162 is characterized in that n is 0, X is S, Y is O, R 5 、R 6 is Me, R 9 is Br, and R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 is H; The compound 163 is characterized in that n is 0, X is S, Y is O, R 5 、R 6 is Me, R 7 is I, and R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 is H; the compound 164 is characterized in that n is 0, X is S, Y is O, R 5 、R 6 is Me, R 8 is I, and R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 is H; The compound 165 is characterized in that n is 0, X is S, Y is O, R 5 、R 6 is Me, R 9 is I, and R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 is H; compound 166: n is 0, x is S, Y is O, R 5 、R 6 is Me, R 7 is NO 2 ,R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 is H; the compounds 167:n are 0, X is S, Y is O, R 5 、R 6 is Me, R 8 is NO 2 ,R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 and H; the compounds 168 are 0 in n, S in X, O in Y, me in R 5 、R 6 , NO 2 ,R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 in R 9 ; the compound 169 is that n is 0, X is S, Y is O, R 5 、R 6 is Me, R 7 is CF 3 ,R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 is H; The compound 170 is characterized in that n is 0, X is S, Y is O, R 5 、R 6 is Me, R 8 is CF 3 ,R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 and H; The compound 171 is that n is 0, X is S, Y is O, R 5 、R 6 is Me, R 9 is CF 3 ,R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 is H; The compound 172 is that n is 0, X is S, Y is O, R 5 、R 6 is Me, R 7 is OCF 3 ,R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 is H; the compound 173 is that n is 0, X is S, Y is O, R 5 、R 6 is Me, R 8 is OCF 3 ,R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 is H; The compound 174 is characterized in that n is 0, X is S, Y is O, R 5 、R 6 is Me, R 9 is OCF 3 ,R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 and H; The compound 175 is characterized in that n is 0, X is S, Y is O, R 5 、R 6 is Me, R 7 is OCHF 2 ,R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 is H; The compound 176 is that n is 0, X is S, Y is O, R 5 、R 6 is Me, R 8 is OCHF 2 ,R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 is H; Compound 177: n is 0, x is S, Y is O, R 5 、R 6 is Me, R 9 is OCHF 2 ,R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 is H; the compound 178 is characterized in that n is 0, X is S, Y is O, R 5 、R 6 is Me, R 9 is SCF 3 ,R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 is H; The compound 179 is that n is 0, X is S, Y is O, R 5 、R 6 is Me, R 7 is OCH 3 ,R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 is H; the compound 180 is characterized in that n is 0, X is S, Y is O, R 5 、R 6 is Me, R 8 is OCH 3 ,R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 and H; the compound 181 is characterized in that n is 0, X is S, Y is O, R 5 、R 6 is Me, R 9 is OCH 3 ,R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 and H; the compound 182 is characterized in that n is 0, X is S, Y is O, R 5 、R 6 is Me, R 9 is OC 2 H 5 ,R 2 、R 3 、R 4 、R 8 、R 7 、R 10 、R 11 and H; the compound 183 is characterized in that n is 0, X is S, Y is O, R 5 、R 6 is Me, R 7 is CN, and R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 is H; The compound 184 is that n is 0, X is S, Y is O, R 5 、R 6 is Me, R 8 is CN, and R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 is H; the compound 185 is characterized in that n is 0, X is S, Y is O, R 5 、R 6 is Me, R 9 is CN, and R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 is H; Compound 186: n is 0, x is S, Y is O, R 5 、R 6 and R 7 are Me, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 are both H; compound 187: n is 0, x is S, Y is O, R 5 、R 6 and R 8 are Me, R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 are both H; the compound 188 is characterized in that n is 0, X is S, Y is O, R 5 、R 6 and R 9 are Me, and R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 are H; The compound 189 is that n is 0, X is S, Y is O, R 5 、R 6 is Me, R 7 is CH 3 SO 2 ,R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 is H; the compound 190 is that n is 0, X is S, Y is O, R 5 、R 6 is Me, R 8 is CH 3 SO 2 ,R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 is H; the compound 191 is characterized in that n is 0, X is S, Y is O, R 5 、R 6 is Me, R 9 is CH 3 SO 2 ,R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 and H; The compound 192 is that n is 0, X is S, Y is O, R 5 、R 6 is Me, R 7 is C 2 H 5 SO 2 ,R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 and H; Compounds 193 to n are 0, X is S, Y is O, R 5 、R 6 are Me, R 7 and R 8 are Cl, and R 2 、R 3 、R 4 、R 9 、R 10 、R 11 are H; The compound 194 is characterized in that n is 0, X is S, Y is O, R 5 、R 6 is Me, R 7 and R 9 are Cl, and R 2 、R 3 、R 4 、R 8 、R 10 、R 11 is H; The compound 195:n is 0, X is S, Y is O, R 5 、R 6 is Me, R 7 and R 10 are Cl, and R 2 、R 3 、R 4 、R 8 、R 9 、R 11 is H; The compound 196 is characterized in that n is 0, X is S, Y is O, R 5 、R 6 is Me, R 7 and R 11 are Cl, and R 2 、R 3 、R 4 、R 8 、R 9 、R 10 is H; Compound 197: n is 0, x is S, Y is O, R 5 、R 6 are both Me, R 8 and R 9 are both Cl, R 2 、R 3 、R 4 、R 7 、R 10 、R 11 are both H; The compound 198 is characterized in that n is 0, X is S, Y is O, R 5 、R 6 and R 7 are Me, R 9 is Cl, and R 2 、R 3 、R 4 、R 8 、R 10 、R 11 are H; The compound 199:n is 0, X is S, Y is O, R 5 、R 6 、R 7 、R 8 is Me, and R 2 、R 3 、R 4 、R 9 、R 10 、R 11 is H; the compound 200 is characterized in that n is 0, X is S, Y is O, R 5 、R 6 、R 7 、R 9 is Me, and R 2 、R 3 、R 4 、R 8 、R 10 、R 11 is H; The compound 201 is characterized in that n is 0, X is S, Y is O, R 5 、R 6 、R 7 、R 10 is Me, and R 2 、R 3 、R 4 、R 8 、R 9 、R 11 is H; the compound 202 is characterized in that n is 0, X is S, Y is O, R 5 、R 6 、R 7 、R 11 is Me, and R 2 、R 3 、R 4 、R 8 、R 9 、R 10 is H; The compound 203 is characterized in that n is 0, X is S, Y is O, R 5 、R 6 、R 7 、R 8 、R 11 is Me, and R 2 、R 3 、R 4 、R 9 、R 10 is H; The compound 204 is characterized in that n is 0, X is S, Y is O, R 5 、R 6 、R 7 、R 9 、R 11 is Me, and R 2 、R 3 、R 4 、R 8 、R 10 is H; compound 205:0, x is S, Y is O, R 5 、R 6 are both Me, R 7 、R 9 are both CF 3 ,R 2 、R 3 、R 4 、R 8 、R 10 、R 11 are both H; the compound 206:0, X is S, Y is O, R 5 、R 6 is Me, R 8 、R 10 is CF 3 ,R 2 、R 3 、R 4 、R 7 、R 9 、R 11 is H; compound 207:0, X is S, Y is O, R 5 、R 6 is Me, R 2 、R 3 、R 4 is H, and R 7 、R 8 、R 9 、R 10 、R 11 is F; compound 208:0, x is S, Y is O, R 5 、R 6 are both Me, R 7 are CH 3 CH 2 ,R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 are both H; compound 209:0, x is S, Y is O, R 5 、R 6 is Me, R 8 is CH 3 CH 2 ,R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 is H; Compound 210:0, x is S, Y is O, R 5 、R 6 are both Me, R 9 are CH 3 CH 2 ,R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 are both H; compound 211:0, x is S, Y is O, R 5 、R 6 are both Me, R 7 are both CH(CH 3 ) 2 ,R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 are both H; compound 212:0, x is S, Y is O, R 5 、R 6 are both Me, R 8 are both CH(CH 3 ) 2 ,R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 are both H; The compound 213:0, X is S, Y is O, R 5 、R 6 is Me, R 9 is CH(CH 3 ) 2 ,R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 is H; The compound 214:0, X is S, Y is O, R 5 、R 6 is Me, R 7 is CH 3 (CH 2 ) 2 ,R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 is H; compound 215:0, x is S, Y is O, R 5 、R 6 is Me, R 7 is C(CH 3 ) 3 ,R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 is H; Compounds 216:0, X is S, Y is O, R 5 、R 6 is Me, R 7 is R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 are H; Compounds 217:0, X is S, Y is O, R 5 、R 6 is Me, R 7 is R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 are H; Compound 218:0, x is S, Y is O, R 5 、R 6 are both Me, R 7 are CO 2 CH 3 ,R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 are both H; The compound 219:n is 0, X is S, Y is O, R 5 、R 6 is Me, R 7 and R 8 are cyclized to form R 2 、R 3 、R 4 、R 9 、R 10 、R 11 are H; The compound 220 is formed by cyclization of n is 0, X is S, Y is O, R 5 、R 6 is Me, R 8 and R 9 R 2 、R 3 、R 4 、R 7 、R 10 、R 11 are H; compounds 221:n is 0, X is S, Y is O, R 5 、R 6 is Me, R 8 and R 9 are cyclized to form R 2 、R 3 、R 4 、R 7 、R 10 、R 11 are H; compounds 222:n is 0, X is S, Y is O, R 5 、R 6 is Me, R 7 and R 8 are cyclized to form R 2 、R 3 、R 4 、R 9 、R 10 、R 11 are H; The compound 223 is formed by cyclization of n is 0, X is S, Y is O, R 5 、R 6 is Me, R 8 and R 9 R 2 、R 3 、R 4 、R 7 、R 10 、R 11 are H; The compound 224 is formed by cyclization of n is 0, X is S, Y is O, R 5 、R 6 is Me, R 7 and R 8 R 2 、R 3 、R 4 、R 9 、R 10 、R 11 are H; The compound 225 is formed by cyclization of n is 0, X is S, Y is O, R 5 、R 6 is Me, R 7 and R 8 R 2 、R 3 、R 4 、R 9 、R 10 、R 11 are H; The compound 226 is formed by cyclization of n being 0, X being S, Y being O, R 5 、R 6 being Me, R 7 and R 8 R 2 、R 3 、R 4 、R 9 、R 10 、R 11 are H; The compound 227 is formed by cyclization of n is 0, X is S, Y is O, R 5 、R 6 is Me, R 7 and R 8 R 2 、R 3 、R 4 、R 9 、R 10 、R 11 are H; The compound 228 is that n is 0, X is S, Y is O, R 5 、R 6 is Me, R 7 and R 8 are cyclized to form R 2 、R 3 、R 4 、R 9 、R 10 、R 11 are H; The compound 229 is formed by cyclization of n 0, X is S, Y is O, R 5 、R 6 is Me, R 8 and R 9 R 2 、R 3 、R 4 、R 7 、R 10 、R 11 are H; compound 230: n is 0, x is S, Y is CH 2 ,R 6 is Me,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 , both are H; The compound 231 is characterized in that n is 0, X is S, Y is CH 2 ,R 6 , me, R 7 is F, and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; The compound 232 is characterized in that n is 0, X is S, Y is CH 2 ,R 6 , me, R 8 is F, and R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; The compound 233:n is 0, X is S, Y is CH 2 ,R 6 is Me, R 9 is F, and R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; The compound 234 is that n is 0, X is S, Y is CH 2 ,R 6 is Me, R 7 is Cl, and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; The compound 235 is characterized in that n is 0, X is S, Y is CH 2 ,R 6 , me, R 8 is Cl, and R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; the compound 236 is characterized in that n is 0, X is S, Y is CH 2 ,R 6 , me, R 9 is Cl, and R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; The compound 237 is characterized in that n is 0, X is S, Y is CH 2 ,R 6 , me, R 7 is Br, and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; The compound 238 is that n is 0, X is S, Y is CH 2 ,R 6 is Me, R 8 is Br, and R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; the compound 239 is 0, X is S, Y is CH 2 ,R 6 , me, R 9 is Br, and R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; the compound 240 is that n is 0, X is S, Y is CH 2 ,R 6 is Me, R 7 is I, and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; The compound 241 is characterized in that n is 0, X is S, Y is CH 2 ,R 6 , me, R 8 is I, and R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; the compound 242 is that n is 0, X is S, Y is CH 2 ,R 6 is Me, R 9 is I, and R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; the compound 243 is 0, X is S, Y is CH 2 ,R 6 is Me, R 7 is NO 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H; The compound 244 is that n is 0, X is S, Y is CH 2 ,R 6 is Me, R 8 is NO 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and H is H; the compound 245 n is 0, X is S, Y is CH 2 ,R 6 is Me, R 9 is NO 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and H is H; compound 246 n is 0, x is S, Y is CH 2 ,R 6 is Me, R 7 is CF 3 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 , both are H; the compound 247 is characterized in that n is 0, X is S, Y is CH 2 ,R 6 , me, R 8 is CF 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and H; The compound 248 is that n is 0, X is S, Y is CH 2 ,R 6 is Me, R 9 is CF 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and both are H; the compound 249:n is 0, X is S, Y is CH 2 ,R 6 is Me, R 7 is OCF 3 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and both are H; the compound 250 is that n is 0, X is S, Y is CH 2 ,R 6 , me, R 8 is OCF 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 , and H is H; The compound 251 is characterized in that n is 0, X is S, Y is CH 2 ,R 6 , me, R 9 is OCF 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 , and H is H; the compound 252 is characterized in that n is 0, X is S, Y is CH 2 ,R 6 , me, R 7 is OCHF 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 , and H is H; the compound 253 is characterized in that n is 0, X is S, Y is CH 2 ,R 6 , me, R 8 is OCHF 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 , and H is H; compound 254: n is 0, x is S, Y is CH 2 ,R 6 is Me, R 9 is OCHF 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 , both are H; the compound 255 is that n is 0, X is S, Y is CH 2 ,R 6 is Me, R 9 is SCF 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and both are H; 256:n is 0, X is S, Y is CH 2 ,R 6 is Me, R 7 is OCH 3 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H is H; the compound 257 is characterized in that n is 0, X is S, Y is CH 2 ,R 6 , me, R 8 is OCH 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 , and H is H; The compound 258 is that n is 0, X is S, Y is CH 2 ,R 6 is Me, R 9 is OCH 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and H is H; the compound 259 is that n is 0, X is S, Y is CH 2 ,R 6 and Me, R 9 is OC 2 H 5 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 , and H is H; the compound 260 is characterized in that n is 0, X is S, Y is CH 2 ,R 6 , me, R 7 is CN, and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; Compound 261: n is 0, x is S, Y is CH 2 ,R 6 is Me, R 8 is CN, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are both H; Compound 262:n is 0, x is S, Y is CH 2 ,R 6 is Me, R 9 is CN, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are both H; compound 263: n is 0, x is S, Y is CH 2 ,R 6 and R 7 is Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are both H; compound 264:n is 0, x is S, Y is CH 2 ,R 6 and R 8 is Me, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are both H; Compound 265: n is 0, x is S, Y is CH 2 ,R 6 and R 9 is Me, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are both H; Compound 266: n is 0, x is S, Y is CH 2 ,R 6 is Me, R 7 is CH 3 SO 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are both H; compounds 267:n is 0, X is S, Y is CH 2 ,R 6 is Me, R 8 is CH 3 SO 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and both are H; the compound 268 n is 0, X is S, Y is CH 2 ,R 6 is Me, R 9 is CH 3 SO 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and H is H; The compound 269 is characterized in that n is 0, X is S, Y is CH 2 ,R 6 , me, R 7 is C 2 H 5 SO 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 , and H is H; the compound 270 is characterized in that n is 0, X is S, Y is CH 2 ,R 6 , me, R 7 and R 8 are Cl, and R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; The compound 271 is that n is 0, X is S, Y is CH 2 ,R 6 is Me, R 7 and R 9 are Cl, and R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 are H; the compound 272 is that n is 0, X is S, Y is CH 2 ,R 6 is Me, R 7 and R 10 are Cl, and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 11 are H; the compound 273 is that n is 0, X is S, Y is CH 2 ,R 6 is Me, R 7 and R 11 are Cl, and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 are H; The compound 274 is characterized in that n is 0, X is S, Y is CH 2 ,R 6 , me, R 8 and R 9 are Cl, and R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; Compound 275: n is 0, x is S, Y is CH 2 ,R 6 and R 7 is Me, R 9 is Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 are both H; Compound 276: n is 0, x is S, Y is CH 2 ,R 6 、R 7 、R 8 , both are Me, R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 both are H; the compound 277 is characterized in that n is 0, X is S, Y is CH 2 ,R 6 、R 7 、R 9 , me and R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 are H; the compound 278:n is 0, X is S, Y is CH 2 ,R 6 、R 7 、R 10 , me and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 11 are H; the compounds 279 are respectively 0, S, CH 2 ,R 6 、R 7 、R 11 and Me, and H are respectively R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 ; the compound 280:n is 0, X is S, Y is CH 2 ,R 6 、R 7 、R 8 、R 11 , me and R 2 、R 3 、R 4 、R 5 、R 9 、R 10 are H; the compounds 281:n are 0, X is S, Y is CH 2 ,R 6 、R 7 、R 9 、R 11 , me and R 2 、R 3 、R 4 、R 5 、R 8 、R 10 are H; compound 282: n is 0, x is S, Y is CH 2 ,R 6 is Me, R 7 、R 9 is CF 3 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 is H; compound 283: n is 0, x is S, Y is CH 2 ,R 6 is Me, R 8 、R 10 is CF 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 11 is H; Compound 284: n is 0, x is S, Y is CH 2 ,R 6 is Me, R 2 、R 3 、R 4 、R 5 are both H, R 7 、R 8 、R 9 、R 10 、R 11 are both F; the compound 285 is that n is 0, X is S, Y is CH 2 ,R 6 , me, R 7 is CH 3 CH 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 , and H is the same as the compound; the compound 286 is that n is 0, X is S, Y is CH 2 ,R 6 is Me, R 8 is CH 3 CH 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and H is H; The compound 287:n is 0, X is S, Y is CH 2 ,R 6 is Me, R 9 is CH 3 CH 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and H is H; the compound 288 is characterized in that n is 0, X is S, Y is CH 2 ,R 6 , me, R 7 is CH(CH 3 ) 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 , and H is H; compound 289: n is 0, x is S, Y is CH 2 ,R 6 is Me, R 8 is CH(CH 3 ) 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are both H; the compound 290 is characterized in that n is 0, X is S, Y is CH 2 ,R 6 , me, R 9 is CH(CH 3 ) 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 , and H is the same as the above; The compound 291 is characterized in that n is 0, X is S, Y is CH 2 ,R 6 , me, R 7 is CH 3 (CH 2 ) 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 , and H is H; compound 292: n is 0, x is S, Y is CH 2 ,R 6 is Me, R 7 is C(CH 3 ) 3 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are both H; The compound 293:n is 0, X is S, Y is CH 2 ,R 6 is Me, R 7 is R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; Compounds 294:n is 0, X is S, Y is CH 2 ,R 6 is Me, R 7 is R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; the compound 295 is that n is 0, X is S, Y is CH 2 ,R 6 is Me, R 7 is CO 2 CH 3 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H is H; the compound 296:n is 0, X is S, Y is CH 2 ,R 6 is Me, R 7 and R 8 are cyclized to form R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; compounds 297 n is 0, X is S, Y is CH 2 ,R 6 is Me, R 8 and R 9 are cyclized to form R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; The compound 298 n is 0, X is S, Y is CH 2 ,R 6 is Me, R 8 and R 9 are cyclized to form R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; compounds 299 n is 0, X is S, Y is CH 2 ,R 6 is Me, R 7 and R 8 are cyclized to form R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; The compound 300 is formed by cyclization of n is 0, X is S, Y is CH 2 ,R 6 is Me, R 8 and R 9 R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; The compound 300 is formed by cyclization of n is 0, X is S, Y is CH 2 ,R 6 is Me, R 8 and R 9 R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; The compound 301 is formed by cyclization of n is 0, X is S, Y is CH 2 ,R 6 is Me, R 7 and R 8 R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; The compound 302 is formed by cyclization of n is 0, X is S, Y is CH 2 ,R 6 is Me, R 7 and R 8 R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; Compounds 303:n is 0, X is S, Y is CH 2 ,R 6 is Me, R 7 and R 8 are cyclized to form R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; The compound 304 is formed by cyclization of n is 0, X is S, Y is CH 2 ,R 6 is Me, R 7 and R 8 R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; The compound 305 is formed by cyclization of n is 0, X is S, Y is CH 2 ,R 6 is Me, R 7 and R 8 R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; The compound 306 is that n is 0, X is S, Y is CH 2 ,R 6 , me, R 8 and R 9 are cyclized to form R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; Compound 307: n is 0, x is S, Y is NMe, R 6 is Me,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 , both are H; the compound 308 is that n is 0, X is S, Y is NMe, R 6 is Me, R 7 is F, and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; the compound 309 is n is 0, X is S, Y is NMe, R 6 is Me, R 8 is F, and R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; The compound 310 is characterized in that n is 0, X is S, Y is NMe, R 6 is Me, R 9 is F, and R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; The compound 311 is characterized in that n is 0, X is S, Y is NMe, R 6 is Me, R 7 is Cl, and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; the compound 312 is characterized in that n is 0, X is S, Y is NMe, R 6 is Me, R 8 is Cl, and R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; the compound 313 is that n is 0, X is S, Y is NMe, R 6 is Me, R 9 is Cl, and R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; the compound 314 is characterized in that n is 0, X is S, Y is NMe, R 6 is Me, R 7 is Br, and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; The compound 315 is characterized in that n is 0, X is S, Y is NMe, R 6 is Me, R 8 is Br, and R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; The compound 316 is characterized in that n is 0, X is S, Y is NMe, R 6 is Me, R 9 is Br, and R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; The compound 317 is 0 in n, S in X, NMe in Y, me in R 6 , I in R 7 and H in R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 ; The compound 318 is characterized in that n is 0, X is S, Y is NMe, R 6 is Me, R 8 is I, and R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; The compound 319 is characterized in that n is 0, X is S, Y is NMe, R 6 is Me, R 9 is I, and R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; the compound 320 is characterized in that n is 0, X is S, Y is NMe, R 6 is Me, R 7 is NO 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H; the compound 321 is characterized in that n is 0, X is S, Y is NMe, R 6 is Me, R 8 is NO 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and H; Compound 322: n is 0, x is S, Y is NMe, R 6 is Me, R 9 is NO 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 is H; the compound 323 is characterized in that n is 0, X is S, Y is NMe, R 6 is Me, R 7 is CF 3 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and both are H; The compound 324 is that n is 0, X is S, Y is NMe, R 6 is Me, R 8 is CF 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and both are H; the compound 325 is that n is 0, X is S, Y is NMe, R 6 is Me, R 9 is CF 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and both are H; compound 326: n is 0, x is S, Y is NMe, R 6 is Me, R 7 is OCF 3 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are both H; the compounds 327: n is 0, x is S, Y is NMe, R 6 is Me, R 8 is OCF 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are both H; compound 328, n is 0, x is S, Y is NMe, R 6 is Me, R 9 is OCF 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 , all are H; the compound 329 is 0, X is S, Y is NMe, R 6 is Me, R 7 is OCHF 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H; compound 330: n is 0, x is S, Y is NMe, R 6 is Me, R 8 is OCHF 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are both H; compound 331: n is 0, x is S, Y is NMe, R 6 is Me, R 9 is OCHF 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are both H; the compound 332 is characterized in that n is 0, X is S, Y is NMe, R 6 is Me, R 9 is SCF 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and H is H; compound 333: n is 0, x is S, Y is NMe, R 6 is Me, R 7 is OCH 3 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are both H; the compound 334 is characterized in that n is 0, X is S, Y is NMe, R 6 is Me, R 8 is OCH 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and H is the same as the compound; compound 335 n is 0, x is S, Y is NMe, R 6 is Me, R 9 is OCH 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are both H; the compound 336 is characterized in that n is 0, X is S, Y is NMe, R 6 is Me, R 9 is OC 2 H 5 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and H is H; the compound 337 is that n is 0, X is S, Y is NMe, R 6 is Me, R 7 is CN, and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; the compound 338 is characterized in that n is 0, X is S, Y is NMe, R 6 is Me, R 8 is CN, and R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; the compound 339:n is 0, X is S, Y is NMe, R 6 is Me, R 9 is CN, and R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; the compound 340 is characterized in that n is 0, X is S, Y is NMe, R 6 is Me, R 7 is CH 3 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and both are H; the compound 341 is characterized in that n is 0, X is S, Y is NMe, R 6 is Me, R 8 is CH 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and both are H; Compound 342: n is 0, x is S, Y is NMe, R 6 is Me, R 9 is CH 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 , all are H; The compound 343 is characterized in that n is 0, X is S, Y is NMe, R 6 is Me, R 7 is CH 3 SO 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H is the same as the compound; compound 344: n is 0, x is S, Y is NMe, R 6 is Me, R 8 is CH 3 SO 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are both H; the compound 345 is characterized in that n is 0, X is S, Y is NMe, R 6 is Me, R 9 is CH 3 SO 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and H is H; The compound 346 is characterized in that n is 0, X is S, Y is NMe, R 6 is Me, R 7 is C 2 H 5 SO 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H is the same as that of the compound; compounds 347 n is 0, X is S, Y is NMe, R 6 is Me, R 7 and R 8 are both Cl, R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are both H; Compound 348: n is 0, x is S, Y is NMe, R 6 is Me, R 7 and R 9 are both Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 are both H; the compound 349 is that n is 0, X is S, Y is NMe, R 6 is Me, R 7 and R 10 are Cl, and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 11 are H; The compound 350 is characterized in that n is 0, X is S, Y is NMe, R 6 is Me, R 7 and R 11 are Cl, and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 are H; Compound 351: n is 0, x is S, Y is NMe, R 6 is Me, R 8 and R 9 are both Cl, R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are both H; compound 352: n is 0, x is S, Y is NMe, R 6 and R 7 are Me, R 9 is Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 are both H; Compound 353 n is 0, x is S, Y is NMe, R 6 、R 7 and R 8 are Me, R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are both H; Compound 354: n is 0, x is S, Y is NMe, R 6 、R 7 and R 9 are Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 are both H; The compound 355 is characterized in that n is 0, X is S, Y is NMe, R 6 、R 7 and R 10 are Me, and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 11 are H; compound 356: n is 0, x is S, Y is NMe, R 6 、R 7 and R 11 are Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 are both H; Compound 357: n is 0, x is S, Y is NMe, R 6 、R 7 、R 8 and R 11 are Me, R 2 、R 3 、R 4 、R 5 、R 9 、R 10 are both H; Compound 358 n is 0, x is S, Y is NMe, R 6 、R 7 、R 9 and R 11 are Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 are both H; Compound 359: n is 0, x is S, Y is NMe, R 6 is Me, R 7 and R 9 are both CF 3 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 and H; Compound 360: n is 0, x is S, Y is NMe, R 6 is Me, R 8 and R 10 are both CF 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 11 and H; The compound 361 is characterized in that n is 0, X is S, Y is NMe, R 6 is Me, R 2 、R 3 、R 4 、R 5 is H, and R 7 、R 8 、R 9 、R 10 、R 11 is F; the compound 362 is characterized in that n is 0, X is S, Y is NMe, R 6 is Me, R 7 is CH 3 CH 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H is the same as the above; The compound 363 is that n is 0, X is S, Y is NMe, R 6 is Me, R 8 is CH 3 CH 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and both are H; compound 364:n is 0, x is S, Y is NMe, R 6 is Me, R 9 is CH 3 CH 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are both H; the compound 365 is characterized in that n is 0, X is S, Y is NMe, R 6 is Me, R 7 is CH(CH 3 ) 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H is H; compound 366: n is 0, x is S, Y is NMe, R 6 is Me, R 8 is CH(CH 3 ) 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are both H; the compound 367 is characterized in that n is 0, X is S, Y is NMe, R 6 is Me, R 9 is CH(CH 3 ) 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and H is the same as the compound; the compound 368 is n is 0, X is S, Y is NMe, R 6 is Me, R 7 is CH 3 (CH 2 ) 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H is the same as the compound; Compound 369: n is 0, x is S, Y is NMe, R 6 is Me, R 7 is C(CH 3 ) 3 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 , both are H; The compound 370 is 0, X is S, Y is NMe, R 6 is Me, R 7 is R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; The compound 371:n is 0, X is S, Y is NMe, R 6 is Me, R 7 is R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; the compounds 372 are respectively H, wherein n is 0, X is S, Y is NMe, R 6 is Me, R 7 is CO 2 CH 3 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 ; Compounds 373:n is 0, X is S, Y is NMe, R 6 is Me, R 7 and R 8 are cyclized to form R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; The compound 374 is formed by cyclization of n is 0, X is S, Y is NMe, R 6 is Me, R 8 and R 9 R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; compounds 375:n is 0, X is S, Y is NMe, R 6 is Me, R 8 and R 9 are cyclized to form R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; The compound 376:n is 0, X is S, Y is NMe, R 6 is Me, R 7 and R 8 are cyclized to form R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; Compounds 377:n is 0, X is S, Y is NMe, R 6 is Me, R 8 and R 9 are cyclized to form R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; compounds 378: n is 0, X is S, Y is NMe, R 6 is Me, R 7 and R 8 are cyclized to form R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; The compound 379 is formed by cyclization of n is 0, X is S, Y is NMe, R 6 is Me, R 7 and R 8 R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; The compound 380 is that n is 0, X is S, Y is NMe, R 6 is Me, R 7 and R 8 are cyclized to form R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; compounds 381 n is 0, X is S, Y is NMe, R 6 is Me, R 7 and R 8 are cyclized to form R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; Compounds 382 n is 0, X is S, Y is NMe, R 6 is Me, R 7 and R 8 are cyclized to form R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; compounds 383:n is 0, X is S, Y is NMe, R 6 is Me, R 8 and R 9 are cyclized to form R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; The compound 873 is that n is 0, X is S, Y is NH, R 6 is Me,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 , and H is H; The compound 883 is characterized in that n is 0, X is S, Y is S, R 6 is Me,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 , and H is H; The compound 384:n is 0, X is S, Y is O, R 2 、R 6 is Me, and R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 are H; compound 385:n is 0, X is S, Y is O, R 2 、R 6 is Me, R 7 is F, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; the compound 386 is that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 8 is F, and R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; The compound 387 is that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 9 is F, and R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; Compound 388:n is 0, X is S, Y is O, R 2 、R 6 is Me, R 7 is Cl, and R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; the compound 389 is that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 8 is Cl, and R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; The compound 390 is characterized in that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 9 is Cl, and R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; the compound 391 is characterized in that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 7 is Br, and R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; the compound 392 is characterized in that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 8 is Br, and R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; the compound 393 is that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 9 is Br, and R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; Compounds 394:n is 0, X is S, Y is O, R 2 、R 6 is Me, R 7 is I, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; the compound 395 is that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 8 is I, and R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; the compound 396 n is 0, X is S, Y is O, R 2 、R 6 is Me, R 9 is I, and R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; The compound 397:n is 0, X is S, Y is O, R 2 、R 6 is Me, R 7 is NO 2 ,R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and both are H; the compound 398 is characterized in that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 8 is NO 2 ,R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and H is the same as that of the compound; compounds 399:n is 0, X is S, Y is O, R 2 、R 6 is Me, R 9 is NO 2 ,R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and H; the compound 400 is characterized in that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 7 is CF 3 ,R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and both are H; The compound 401 is characterized in that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 8 is CF 3 ,R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and both are H; The compound 402 is characterized in that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 9 is CF 3 ,R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and both are H; the compound 403 is that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 7 is OCF 3 ,R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H; the compound 404 is characterized in that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 8 is OCF 3 ,R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and H; The compound 405 is that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 9 is OCF 3 ,R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and H; the compound 406 is that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 7 is OCHF 2 ,R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H; the compound 407 is that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 8 is OCHF 2 ,R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and H; the compound 408 is characterized in that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 9 is OCHF 2 ,R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and H; the compound 409 is 0 in n, X is S, Y is O, R 2 、R 6 is Me, R 9 is SCF 3 ,R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and H; the compound 410 is characterized in that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 7 is OCH 3 ,R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H; the compound 411 is characterized in that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 8 is OCH 3 ,R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and H; The compound 412 is that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 9 is OCH 3 ,R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and H; The compound 413 is 0, X is S, Y is O, R 2 、R 6 is Me, R 9 is OC 2 H 5 ,R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and H; the compound 414 is that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 7 is CN, and R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; the compound 415 is that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 8 is CN, and R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; the compound 416 is that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 9 is CN, and R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; the compound 417 is characterized in that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 7 is CH 3 ,R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and both are H; the compound 418 is characterized in that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 8 is CH 3 ,R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and both are H; The compound 419 is characterized in that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 9 is CH 3 ,R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and both are H; the compound 420 is characterized in that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 7 is CH 3 SO 2 ,R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and both are H; the compound 421 is characterized in that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 8 is CH 3 SO 2 ,R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and both are H; the compound 422 is characterized in that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 9 is CH 3 SO 2 ,R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and both are H; Compound 423: n is 0, x is S, Y is O, R 2 、R 6 is Me, R 7 is C 2 H 5 SO 2 ,R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are both H; compound 424: n is 0, x is S, Y is O, R 2 、R 6 is Me, R 7 and R 8 are both Cl, R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are both H; Compound 425: n is 0, x is S, Y is O, R 2 、R 6 is Me, R 7 and R 9 are both Cl, R 3 、R 4 、R 5 、R 8 、R 10 、R 11 are both H; The compound 426 is characterized in that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 7 and R 10 are Cl, and R 3 、R 4 、R 5 、R 8 、R 9 、R 11 are H; the compound 427:n is 0, X is S, Y is O, R 2 、R 6 is Me, R 7 and R 11 are Cl, and R 3 、R 4 、R 5 、R 8 、R 9 、R 10 are H; the compound 428 is that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 8 and R 9 are Cl, and R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; The compound 429 is that n is 0, X is S, Y is O, R 2 、R 6 and R 7 are Me, R 9 is Cl, and R 3 、R 4 、R 5 、R 8 、R 10 、R 11 are H; compound 430: n is 0, x is S, Y is O, R 2 、R 6 、R 7 and R 8 are Me, R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are both H; compound 431: n is 0, x is S, Y is O, R 2 、R 6 、R 7 and R 9 are Me, R 3 、R 4 、R 5 、R 8 、R 10 、R 11 are both H; the compound 432 is that n is 0, X is S, Y is O, R 2 、R 6 、R 7 and R 10 are Me, and R 3 、R 4 、R 5 、R 8 、R 9 、R 11 are H; compound 433: n is 0, x is S, Y is O, R 2 、R 6 、R 7 and R 11 are Me, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 are both H; compound 434: n is 0, x is S, Y is O, R 2 、R 6 、R 7 、R 8 and R 11 are Me, R 3 、R 4 、R 5 、R 9 、R 10 are both H; Compound 435 n is 0, x is S, Y is O, R 2 、R 6 、R 7 、R 9 and R 11 are Me, R 3 、R 4 、R 5 、R 8 、R 10 are both H; Compound 436: n is 0, x is S, Y is O, R 2 、R 6 is Me, R 7 and R 9 are both CF 3 ,R 3 、R 4 、R 5 、R 8 、R 10 、R 11 and H; compound 437 is 0, X is S, Y is O, R 2 、R 6 is Me, R 8 and R 10 are CF 3 ,R 3 、R 4 、R 5 、R 7 、R 9 、R 11 and H; the compound 438:n is 0, X is S, Y is O, R 2 、R 6 is Me, R 3 、R 4 、R 5 is H, and R 7 、R 8 、R 9 、R 10 、R 11 is F; The compound 439 is that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 7 is CH 3 CH 2 ,R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and both are H; the compound 440 is that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 8 is CH 3 CH 2 ,R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and both are H; the compound 441:n is 0, X is S, Y is O, R 2 、R 6 is Me, R 9 is CH 3 CH 2 ,R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and both are H; The compound 442:n is 0, X is S, Y is O, R 2 、R 6 is Me, R 7 is CH(CH 3 ) 2 ,R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and both are H; The compound 443 is that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 8 is CH(CH 3 ) 2 ,R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and H is the same as that of the compound; compound 444: n is 0, x is S, Y is O, R 2 、R 6 is Me, R 9 is CH(CH 3 ) 2 ,R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are both H; the compound 445:n is 0, X is S, Y is O, R 2 、R 6 is Me, R 7 is CH 3 (CH 2 ) 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H is the same as that of the compound; The compound 446 is characterized in that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 7 is C(CH 3 ) 3 ,R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H is H; Compound 447:n is 0, X is S, Y is O, R 2 、R 6 is Me, R 7 is R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; Compounds 448: n is 0, X is S, Y is O, R 2 、R 6 is Me, R 7 is R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; the compound 449 is characterized in that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 7 is CO 2 CH 3 ,R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H is the same as the compound; Compounds 450:n is 0, X is S, Y is O, R 2 、R 6 is Me, R 7 and R 8 are cyclized to form R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; Compounds 451: n is 0, X is S, Y is O, R 2 、R 6 is Me, R 8 and R 9 are cyclized to form R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; compounds 452 n is 0, X is S, Y is O, R 2 、R 6 is Me, R 8 and R 9 are cyclized to form R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; Compounds 453 are prepared in such a way that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 7 and R 8 are cyclized to form R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; The compound 454 is that n is 0, X is S, Y is O, R 2 、R 6 is Me, R 8 and R 9 are cyclized to form R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; The compound 455 is formed by cyclization of n 0, X is S, Y is O, R 2 、R 6 is Me, R 8 and R 9 R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; The compound 456:n is 0, X is S, Y is O, R 2 、R 6 is Me, R 7 and R 8 are cyclized to form R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; compounds 457:n is 0, X is S, Y is O, R 2 、R 6 is Me, R 7 and R 8 are cyclized to form R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; The compound 458 is formed by cyclization of n of 0, X of S, Y of O, R 2 、R 6 of Me, R 7 and R 8 R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; Compounds 459:n is 0, X is S, Y is O, R 2 、R 6 is Me, R 7 and R 8 are cyclized to form R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; The compound 460 is formed by cyclization of n is 0, X is S, Y is O, R 2 、R 6 is Me, R 8 and R 9 R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; Compound 461: n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 are H; Compound 462: n is 0, x is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 7 is F, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are both H; Compound 463: n is 0, x is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 8 is F, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are both H; Compound 464: n is 0, x is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 9 is F, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are both H; The compound 465 is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 7 is Cl, and R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; the compound 466 is characterized in that n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 8 is Cl, and R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; compound 467: n is 0, x is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 9 is Cl, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are both H; the compound 468 is characterized in that n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 7 is Br, and R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; compound 469: n is 0, x is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 8 is Br, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are both H; the compound 470 is that n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 9 is Br, and R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; the compound 471 is characterized in that n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 7 is I, and R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; the compound 472 is characterized in that n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 8 is I, and R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; the compound 473:n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 9 is I, and R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; The compound 474 is characterized in that n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 7 is NO 2 ,R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and both are H; compound 475: n is 0, x is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 8 is NO 2 ,R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 , all are H; Compounds 476: n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 9 is NO 2 ,R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; Compounds 477:n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 7 is CF 3 ,R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are all H; compounds 478 n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 8 is CF 3 ,R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and both are H; Compounds 479:n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 9 is CF 3 ,R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are all H; Compound 480: n is 0, x is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 7 is OCF 3 ,R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are both H; compound 481: n is 0, x is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 8 is OCF 3 ,R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are both H; Compound 482:n is 0, x is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 9 is OCF 3 ,R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are both H; The compound 483 is characterized in that n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 7 is OCHF 2 ,R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H; Compound 484 n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 8 is OCHF 2 ,R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and H; The compound 485 is characterized in that n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 9 is OCHF 2 ,R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and H; Compound 486 n is 0, x is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 9 is SCF 3 ,R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 is H; the compound 487 is characterized in that n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 7 is OCH 3 ,R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H; Compound 488: n is 0, x is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 8 is OCH 3 ,R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are both H; the compound 489 is characterized in that n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 9 is OCH 3 ,R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and H; Compound 490: n is 0, x is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 9 is OC 2 H 5 ,R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are both H; the compound 491:n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 7 is CN, and R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; the compound 492 n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 8 is CN, and R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; the compound 493 is that n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 9 is CN, and R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; compounds 494:n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 7 is CH 3 ,R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and both are H; compounds 495:n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 8 is CH 3 ,R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and both are H; compounds 496:n are 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 9 is CH 3 ,R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; compounds 497:n are 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 7 is CH 3 SO 2 ,R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and all are H; Compound 498: n is 0, x is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 8 is CH 3 SO 2 ,R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are all H; Compounds 499:n are 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 9 is CH 3 SO 2 ,R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and both are H; The compound 500 is characterized in that n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 7 is C 2 H 5 SO 2 ,R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and both are H; The compound 501 is characterized in that n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 , me, R 7 and R 8 are Cl, and R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; the compound 502 is characterized in that n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 , me, R 7 and R 9 are Cl, and R 3 、R 4 、R 5 、R 8 、R 10 、R 11 are H; the compound 503 is characterized in that n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 , me, R 7 and R 10 are Cl, and R 3 、R 4 、R 5 、R 8 、R 9 、R 11 are H; The compound 504 is that n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 7 and R 11 are Cl, and R 3 、R 4 、R 5 、R 8 、R 9 、R 10 are H; Compound 505: n is 0, x is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 8 and R 9 are both Cl, R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are both H; Compound 506: n is 0, x is S, Y is O, R 2 is C 2 H 5 ,R 6 and R 7 is Me, R 9 is Cl, R 3 、R 4 、R 5 、R 8 、R 10 、R 11 are both H; compound 507: n is 0, x is S, Y is O, R 2 is C 2 H 5 ,R 6 、R 7 and R 8 is Me, R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are both H; the compound 508 is that n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 、R 7 and R 9 is Me, R 3 、R 4 、R 5 、R 8 、R 10 、R 11 are H; The compound 509 is n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 、R 7 and R 10 is Me, R 3 、R 4 、R 5 、R 8 、R 9 、R 11 are H; The compound 510 is that n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 7 and R 11 is Me, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 are H; compound 511: n is 0, x is S, Y is O, R 2 is C 2 H 5 ,R 6 、R 7 、R 8 and R 11 is Me, R 3 、R 4 、R 5 、R 9 、R 10 are both H; The compound 512 is that n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 、R 7 、R 9 and R 11 is Me, R 3 、R 4 、R 5 、R 8 、R 10 are H; Compound 513 wherein n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 7 and R 9 are CF 3 ,R 3 、R 4 、R 5 、R 8 、R 10 、R 11 are H; compound 514: n is 0, x is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 8 and R 10 are both CF 3 ,R 3 、R 4 、R 5 、R 7 、R 9 、R 11 and H; Compound 515: n is 0, x is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 3 、R 4 、R 5 are both H, R 7 、R 8 、R 9 、R 10 、R 11 are both F; Compound 516: n is 0, x is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 7 is CH 3 CH 2 ,R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are both H; the compound 517 is characterized in that n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 8 is CH 3 CH 2 ,R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and both are H; The compound 518 is characterized in that n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 9 is CH 3 CH 2 ,R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and both are H; compound 519, n is 0, x is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 7 is CH(CH 3 ) 2 ,R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are both H; the compound 520 is characterized in that n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 8 is CH(CH 3 ) 2 ,R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and both are H; Compound 521 is represented by formula n, X is represented by S, Y is represented by O, R 2 is represented by C 2 H 5 ,R 6 , R 9 is represented by CH(CH 3 ) 2 ,R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 , and H; Compound 522: n is 0, x is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 7 is CH 3 (CH 2 ) 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are both H; The compound 523 is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 7 is C(CH 3 ) 3 ,R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and both are H; The compound 524 is that n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 7 is R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; The compound 525 is characterized in that n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 7 is R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; The compound 526 is characterized in that n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 7 is CO 2 CH 3 ,R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and both are H; Compound 527: n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 7 and R 8 are cyclized to form R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; Compounds 528:n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 8 and R 9 are cyclized to form R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; The compound 529 is formed by cyclization of n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 8 and R 9 R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; The compound 530 is formed by cyclization of n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 7 and R 8 R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; Compound 531, n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 8 and R 9 are cyclized to form R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; The compound 532:n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 and Me, R 8 and R 9 are cyclized to form R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; The compound 533:n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 7 and R 8 are cyclized to form R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; The compound 534 is formed by cyclization of n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 7 and R 8 R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; Compounds 535: n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 7 and R 8 are cyclized to form R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; Compounds 536:n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 7 and R 8 are cyclized to form R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; Compounds 537:n is 0, X is S, Y is O, R 2 is C 2 H 5 ,R 6 is Me, R 8 and R 9 are cyclized to form R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; The compound 796:n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, and R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 are H; The compound 797:n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 7 is F, and R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are all H; The compound 798:n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 8 is F, and R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are all H; the compound 799:n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 9 is F, and R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are all H; the compound 800 is that n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 7 is Cl, and R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; The compound 801 is characterized in that n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 8 is Cl, and R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; The compound 802 is characterized in that n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 9 is Cl, and R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; The compound 803 is that n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 7 is Br, and R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; The compound 804 is that n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 8 is Br, and R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; the compound 805:n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 9 is Br, and R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; the compound 806:n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 7 is I, and R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are all H; Compound 807: n is 0, x is S, Y is O, R 2 is OMe, R 6 is Me, R 8 is I, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are both H; The compound 808 is that n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 9 is I, and R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; Compounds 809:n are 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 7 is NO 2 ,R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and both are H; The compound 810 is characterized in that n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 8 is NO 2 ,R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and H; Compound 811: n is 0, x is S, Y is O, R 2 is OMe, R 6 is Me, R 9 is NO 2 ,R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 , all are H; The compound 812 is that n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 7 is CF 3 ,R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and both are H; compound 813 n is 0, x is S, Y is O, R 2 is OMe, R 6 is Me, R 8 is CF 3 ,R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 , all are H; the compound 814 is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 9 is CF 3 ,R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and both are H; Compound 815 is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 7 is OCF 3 ,R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H; The compound 816 is characterized in that n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 8 is OCF 3 ,R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and H; the compound 817 is that n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 9 is OCF 3 ,R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and H; Compound 818 n is 0, x is S, Y is O, R 2 is OMe, R 6 is Me, R 7 is OCHF 2 ,R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are all H; The compounds 819:n are 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 8 is OCHF 2 ,R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and H; the compound 820 is characterized in that n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 9 is OCHF 2 ,R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and H; Compound 821: n is 0, x is S, Y is O, R 2 is OMe, R 6 is Me, R 9 is SCF 3 ,R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are all H; the compound 822 is that n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 7 is OCH 3 ,R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H; Compounds 823, wherein n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 8 is OCH 3 ,R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and H; The compound 824 is that n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 9 is OCH 3 ,R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and H; the compounds 825:n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 9 is OC 2 H 5 ,R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and all are H; The compound 826 is characterized in that n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 7 is CN, and R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; the compound 827 is characterized in that n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 8 is CN, and R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; compound 828, n is 0, x is S, Y is O, R 2 is OMe, R 6 is Me, R 9 is CN, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are both H; the compound 829 is characterized in that n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 7 is CH 3 ,R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and both are H; the compound 830 is characterized in that n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 8 is CH 3 ,R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and both are H; the compound 831 is characterized in that n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 9 is CH 3 ,R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and both are H; Compound 832 n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 7 is CH 3 SO 2 ,R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and both are H; the compound 833 is that n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 8 is CH 3 SO 2 ,R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and both are H; the compound 834 is that n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 9 is CH 3 SO 2 ,R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and both are H; compound 835 n is 0, x is S, Y is O, R 2 is OMe, R 6 is Me, R 7 is C 2 H 5 SO 2 ,R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are both H; compound 836: n is 0, x is S, Y is O, R 2 is OMe, R 6 is Me, R 7 and R 8 are both Cl, R 3 、R 4 、R 5 、R 9 、R 10 、R 11 is H; The compound 837 is that n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 7 and R 9 are Cl, and R 3 、R 4 、R 5 、R 8 、R 10 、R 11 is H; The compound 838 is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 7 and R 10 are Cl, and R 3 、R 4 、R 5 、R 8 、R 9 、R 11 are H; the compound 839 is that n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 7 and R 11 are Cl, and R 3 、R 4 、R 5 、R 8 、R 9 、R 10 is H; The compound 840 is characterized in that n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 8 and R 9 are Cl, and R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; The compound 841 is characterized in that n is 0, X is S, Y is O, R 2 is OMe, R 6 and R 7 are Me, R 9 is Cl, and R 3 、R 4 、R 5 、R 8 、R 10 、R 11 are H; Compound 842: n is 0, x is S, Y is O, R 2 is OMe, R 6 、R 7 and R 8 are Me, R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are both H; The compound 843:n is 0, X is S, Y is O, R 2 is OMe, R 6 、R 7 and R 9 are Me, and R 3 、R 4 、R 5 、R 8 、R 10 、R 11 are H; compound 844: n is 0, x is S, Y is O, R 2 is OMe, R 6 、R 7 and R 10 are Me, R 3 、R 4 、R 5 、R 8 、R 9 、R 11 are both H; the compound 845:n is 0, X is S, Y is O, R 2 is OMe, R 7 and R 11 are Me, and R 3 、R 4 、R 5 、R 8 、R 9 、R 10 are H; compound 846: n is 0, x is S, Y is O, R 2 is OMe, R 6 、R 7 、R 8 and R 11 are Me, R 3 、R 4 、R 5 、R 9 、R 10 are both H; the compound 847 is that n is 0, X is S, Y is O, R 2 is OMe, R 6 、R 7 、R 9 and R 11 are Me, and R 3 、R 4 、R 5 、R 8 、R 10 are H; The compound 848 is that n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 7 and R 9 are CF 3 ,R 3 、R 4 、R 5 、R 8 、R 10 、R 11 and H; the compound 849 is that n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 8 and R 10 are CF 3 ,R 3 、R 4 、R 5 、R 7 、R 9 、R 11 and H; The compound 850 is that n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 3 、R 4 、R 5 are H, and R 7 、R 8 、R 9 、R 10 、R 11 are F; The compound 851 is characterized in that n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 7 is CH 3 CH 2 ,R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and both are H; compounds 852:n are 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 8 is CH 3 CH 2 ,R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and both are H; The compound 853 is characterized in that n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 9 is CH 3 CH 2 ,R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and both are H; compound 854: n is 0, x is S, Y is O, R 2 is OMe, R 6 is Me, R 7 is CH(CH 3 ) 2 ,R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are both H; compounds 855: n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 8 is CH(CH 3 ) 2 ,R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; compound 856: n is 0, x is S, Y is O, R 2 is OMe, R 6 is Me, R 9 is CH(CH 3 ) 2 ,R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are both H; the compound 857 is characterized in that n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 7 is CH 3 (CH 2 ) 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H is the same as that of the compound; compounds 858:n are 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 7 is C(CH 3 ) 3 ,R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; The compound 859 is that n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 7 is R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; The compound 860 is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 7 is R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; the compound 861 is characterized in that n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 7 is CO 2 CH 3 ,R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and both are H; Compounds 862 n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 7 and R 8 are cyclized to form R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; The compound 863:n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 8 and R 9 are cyclized to form R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; The compound 864 is formed by cyclization of n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 8 and R 9 R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; The compound 865 is formed by cyclization of n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 7 and R 8 R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; The compound 866 is formed by cyclization of n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 8 and R 9 R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; The compound 867 is formed by cyclization of n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 8 and R 9 R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; The compound 868 is formed by cyclization of n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 7 and R 8 R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; The compound 869 is formed by cyclization of n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 7 and R 8 R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; The compound 870 is formed by cyclization of n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 7 and R 8 R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; Compounds 871:n are 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 7 and R 8 are cyclized to form R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; Compounds 872:n is 0, X is S, Y is O, R 2 is OMe, R 6 is Me, R 8 and R 9 are cyclized to form R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; Compound 538:n is 0, X is SO, Y is O, R 6 is Me,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 and both are H; the compound 539:n is 0, X is SO, Y is O, R 6 is Me, R 7 is F, and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; the compound 540 is that n is 0, X is SO, Y is O, R 6 is Me, R 8 is F, and R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; The compound 541 is characterized in that n is 0, X is SO, Y is O, R 6 is Me, R 9 is F, and R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; The compound 542 is n is 0, X is SO, Y is O, R 6 is Me, R 7 is Cl, and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; the compound 543 is that n is 0, X is SO, Y is O, R 6 is Me, R 8 is Cl, and R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; the compound 544 is characterized in that n is 0, X is SO, Y is O, R 6 is Me, R 9 is Cl, and R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; the compound 545 is characterized in that n is 0, X is SO, Y is O, R 6 is Me, R 7 is Br, and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; The compound 546 is characterized in that n is 0, X is SO, Y is O, R 6 is Me, R 8 is Br, and R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; compound 547: n is 0, x is SO, Y is O, R 6 is Me, R 9 is Br, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are both H; the compound 548 is that n is 0, X is SO, Y is O, R 6 is Me, R 7 is I, and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; The compound 549 is that n is 0, X is SO, Y is O, R 6 is Me, R 8 is I, and R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; the compound 550 is characterized in that n is 0, X is SO, Y is O, R 6 is Me, R 9 is I, and R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; the compound 551 is characterized in that n is 0, X is SO, Y is O, R 6 is Me, R 7 is NO 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H is the same as the compound; Compound 552 n is 0, x is SO, Y is O, R 6 is Me, R 8 is NO 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and both are H; compound 553: n is 0, x is SO, Y is O, R 6 is Me, R 9 is NO 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are both H; Compounds 554 n is 0, X is SO, Y is O, R 6 is Me, R 7 is CF 3 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; The compound 555 is that n is 0, X is SO, Y is O, R 6 is Me, R 8 is CF 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and both are H; The compound 556 is that n is 0, X is SO, Y is O, R 6 is Me, R 9 is CF 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and both are H; Compound 557: n is 0, x is SO, Y is O, R 6 is Me, R 7 is OCF 3 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are both H; the compound 558 is that n is 0, X is SO, Y is O, R 6 is Me, R 8 is OCF 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and H is the same as that of the compound; compound 559: n is 0, x is SO, Y is O, R 6 is Me, R 9 is OCF 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are both H; the compound 560 is characterized in that n is 0, X is SO, Y is O, R 6 is Me, R 7 is OCHF 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H is H; Compound 561: n is 0, x is SO, Y is O, R 6 is Me, R 8 is OCHF 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are both H; compound 562 wherein n is 0, x is SO, Y is O, R 6 is Me, R 9 is OCHF 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 , and both are H; the compound 563 is that n is 0, X is SO, Y is O, R 6 is Me, R 9 is SCF 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and H is the same as that of the compound; the compound 564 is characterized in that n is 0, X is SO, Y is O, R 6 is Me, R 7 is OCH 3 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H is H; Compound 565: n is 0, x is SO, Y is O, R 6 is Me, R 8 is OCH 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are both H; compounds 566 n is 0, X is SO, Y is O, R 6 is Me, R 9 is OCH 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; The compound 567 is that n is 0, X is SO, Y is O, R 6 is Me, R 9 is OC 2 H 5 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and H is the same as that of the compound; Compound 568 n is 0, X is SO, Y is O, R 6 is Me, R 7 is CN, and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; the compound 569 is that n is 0, X is SO, Y is O, R 6 is Me, R 8 is CN, and R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; The compound 570 is characterized in that n is 0, X is SO, Y is O, R 6 is Me, R 9 is CN, and R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; Compounds 571 to n are 0, X is SO, Y is O, R 6 is Me, R 7 is CH 3 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and both are H; the compound 572 is that n is 0, X is SO, Y is O, R 6 is Me, R 8 is CH 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and both are H; The compound 573 is that n is 0, X is SO, Y is O, R 6 is Me, R 9 is CH 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and both are H; Compound 574, n is 0, X is SO, Y is O, R 6 is Me, R 7 is CH 3 SO 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and both are H; the compound 575 is characterized in that n is 0, X is SO, Y is O, R 6 is Me, R 8 is CH 3 SO 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and H is H; The compound 576:n is 0, X is SO, Y is O, R 6 is Me, R 9 is CH 3 SO 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and both are H; the compound 577 is characterized in that n is 0, X is SO, Y is O, R 6 is Me, R 7 is C 2 H 5 SO 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H is the same as that of the compound; Compound 578: n is 0, x is SO, Y is O, R 6 is Me, R 7 and R 8 are both Cl, R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are both H; The compound 579 is characterized in that n is 0, X is SO, Y is O, R 6 is Me, R 7 and R 9 are Cl, and R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 are H; The compound 580 is characterized in that n is 0, X is SO, Y is O, R 6 is Me, R 7 and R 10 are Cl, and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 11 are H; compound 581: n is 0, x is SO, Y is O, R 6 is Me, R 7 and R 11 are both Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 are both H; the compound 582 is that n is 0, X is SO, Y is O, R 6 is Me, R 8 and R 9 are Cl, and R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; Compound 583: n is 0, x is SO, Y is O, R 6 and R 7 are Me, R 9 is Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 are both H; the compound 584 is characterized in that n is 0, X is SO, Y is O, R 6 、R 7 and R 8 are Me, and R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; Compound 585: n is 0, x is SO, Y is O, R 6 、R 7 and R 9 are Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 are both H; Compound 586: n is 0, x is SO, Y is O, R 6 、R 7 and R 10 are Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 11 are both H; compound 587: n is 0, x is SO, Y is O, R 6 、R 7 and R 11 are Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 are both H; Compound 588: n is 0, x is SO, Y is O, R 6 、R 7 、R 8 and R 11 are Me, R 2 、R 3 、R 4 、R 5 、R 9 、R 10 are both H; compound 589: n is 0, x is SO, Y is O, R 6 、R 7 、R 9 and R 11 are Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 are both H; compound 590: n is 0, x is SO, Y is O, R 6 is Me, R 7 and R 9 are both CF 3 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 and H; Compound 591: n is 0, x is SO, Y is O, R 6 is Me, R 8 and R 10 are both CF 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 11 and H; The compound 592:n is 0, X is SO, Y is O, R 6 is Me, R 2 、R 3 、R 4 、R 5 is H, and R 7 、R 8 、R 9 、R 10 、R 11 is F; the compound 593:n is 0, X is SO, Y is O, R 6 is Me, R 7 is CH 3 CH 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H is H; the compounds 594:n are 0, X is SO, Y is O, R 6 is Me, R 8 is CH 3 CH 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and H; The compounds 595:n are 0, X is SO, Y is O, R 6 is Me, R 9 is CH 3 CH 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and H is the same as the above; the compound 596 is that n is 0, X is SO, Y is O, R 6 is Me, R 7 is CH(CH 3 ) 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H is the same as the compound; the compound 597 is that n is 0, X is SO, Y is O, R 6 is Me, R 8 is CH(CH 3 ) 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and H is the same as the compound; The compound 598 is that n is 0, X is SO, Y is O, R 6 is Me, R 9 is CH(CH 3 ) 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and H is the same as the compound; The compound 599 is that n is 0, X is SO, Y is O, R 6 is Me, R 7 is CH 3 (CH 2 ) 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H is the same as the compound; The compound 600 is characterized in that n is 0, X is SO, Y is O, R 6 is Me, R 7 is C(CH 3 ) 3 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H is H; The compound 601 is that n is 0, X is SO, Y is O, R 6 is Me, R 7 is R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; The compound 602 is that n is 0, X is SO, Y is O, R 6 is Me, R 7 is R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; Compound 603, n is 0, x is SO, Y is O, R 6 is Me, R 7 is CO 2 CH 3 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 , all are H; The compound 604 is formed by cyclization of n is 0, X is SO, Y is O, R 6 is Me, R 7 and R 8 R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; the compound 605 is formed by cyclization of n is 0, X is SO, Y is O, R 6 is Me, R 8 and R 9 R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; The compound 606 is formed by cyclization of n is 0, X is SO, Y is O, R 6 is Me, R 8 and R 9 R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; Compounds 607:n is 0, X is SO, Y is O, R 6 is Me, R 7 and R 8 are cyclized to form R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; The compound 608 is formed by cyclization of n is 0, X is SO, Y is O, R 6 is Me, R 8 and R 9 R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; Compounds 609:n is 0, X is SO, Y is O, R 6 is Me, R 7 and R 8 are cyclized to form R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; The compound 610 is formed by cyclization of n is 0, X is SO, Y is O, R 6 is Me, R 7 and R 8 R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; The compound 611 is formed by cyclization of n is 0, X is SO, Y is O, R 6 is Me, R 7 and R 8 R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; the compound 612 is formed by cyclization of n is 0, X is SO, Y is O, R 6 is Me, R 7 and R 8 R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; The compound 613 is formed by cyclization of n is 0, X is SO, Y is O, R 6 is Me, R 7 and R 8 R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; the compound 614 is formed by cyclization of n is 0, X is SO, Y is O, R 6 is Me, R 8 and R 9 R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; The compound 615 is characterized in that n is 0, X is SO 2 , Y is O, R 6 is Me,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 , and H is the same as that of the compound; the compound 616 is characterized in that n is 0, X is SO 2 , Y is O, R 6 is Me, R 7 is F, and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; The compound 617 is characterized in that n is 0, X is SO 2 , Y is O, R 6 is Me, R 8 is F, and R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; the compound 618 is characterized in that n is 0, X is SO 2 , Y is O, R 6 is Me, R 9 is F, and R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; the compound 619 is characterized in that n is 0, X is SO 2 , Y is O, R 6 is Me, R 7 is Cl, and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; The compound 620 is characterized in that n is 0, X is SO 2 , Y is O, R 6 is Me, R 8 is Cl, and R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; The compound 621 is characterized in that n is 0, X is SO 2 , Y is O, R 6 is Me, R 9 is Cl, and R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; The compound 622 is characterized in that n is 0, X is SO 2 , Y is O, R 6 is Me, R 7 is Br, and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; the compound 623 is n is 0, X is SO 2 , Y is O, R 6 is Me, R 8 is Br, and R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; compound 624: n is 0, x is SO 2 , Y is O, R 6 is Me, R 9 is Br, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are both H; Compound 625: n is 0, x is SO 2 , Y is O, R 6 is Me, R 7 is I, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are both H; Compound 626 n is 0, x is SO 2 , Y is O, R 6 is Me, R 8 is I, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are both H; the compound 627 is characterized in that n is 0, X is SO 2 , Y is O, R 6 is Me, R 9 is I, and R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; Compound 628: n is 0, x is SO 2 , Y is O, R 6 is Me, R 7 is NO 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 , all are H; The compound 629 is characterized in that n is 0, X is SO 2 , Y is O, R 6 is Me, R 8 is NO 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and both are H; Compound 630: n is 0, x is SO 2 , Y is O, R 6 is Me, R 9 is NO 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 , all are H; The compound 631 is characterized in that n is 0, X is SO 2 , Y is O, R 6 is Me, R 7 is CF 3 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and both are H; Compound 632: n is 0, x is SO 2 , Y is O, R 6 is Me, R 8 is CF 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 , all are H; Compounds 633:n is 0, X is SO 2 , Y is O, R 6 is Me, R 9 is CF 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and both are H; Compound 634: n is 0, x is SO 2 , Y is O, R 6 is Me, R 7 is OCF 3 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 , all are H; Compound 635: n is 0, x is SO 2 , Y is O, R 6 is Me, R 8 is OCF 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 , all are H; The compound 636 is characterized in that n is 0, X is SO 2 , Y is O, R 6 is Me, R 9 is OCF 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and both are H; Compound 637: n is 0, x is SO 2 , Y is O, R 6 is Me, R 7 is OCHF 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 , all are H; Compound 638, n is 0, x is SO 2 , Y is O, R 6 is Me, R 8 is OCHF 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 , all are H; Compound 639: n is 0, x is SO 2 , Y is O, R 6 is Me, R 9 is OCHF 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 , all are H; The compound 640 is characterized in that n is 0, X is SO 2 , Y is O, R 6 is Me, R 9 is SCF 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and both are H; The compound 641 is characterized in that n is 0, X is SO 2 , Y is O, R 6 is Me, R 7 is OCH 3 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and both are H; Compound 642 wherein n is 0, x is SO 2 , Y is O, R 6 is Me, R 8 is OCH 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 , and both are H; Compounds 643:n are 0, X is SO 2 , Y is O, R 6 is Me, R 9 is OCH 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and both are H; Compound 644:n is 0, x is SO 2 , Y is O, R 6 is Me, R 9 is OC 2 H 5 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 , all are H; the compound 645 is that n is 0, X is SO 2 , Y is O, R 6 is Me, R 7 is CN, and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; compound 646: n is 0, x is SO 2 , Y is O, R 6 is Me, R 8 is CN, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are both H; the compound 647 is that n is 0, X is SO 2 , Y is O, R 6 is Me, R 9 is CN, and R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; The compound 648 is characterized in that n is 0, X is SO 2 , Y is O, R 6 is Me, R 7 is CH 3 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and both are H; The compound 649 is characterized in that n is 0, X is SO 2 , Y is O, R 6 is Me, R 8 is CH 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and both are H; The compound 650 is characterized in that n is 0, X is SO 2 , Y is O, R 6 is Me, R 9 is CH 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and both are H; compound 651: n is 0, x is SO 2 , Y is O, R 6 is Me, R 7 is CH 3 SO 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 , both are H; compound 652: n is 0, x is SO 2 , Y is O, R 6 is Me, R 8 is CH 3 SO 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 , all are H; Compounds 653:n are 0, X is SO 2 , Y is O, R 6 is Me, R 9 is CH 3 SO 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and both are H; Compound 654: n is 0, x is SO 2 , Y is O, R 6 is Me, R 7 is C 2 H 5 SO 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 , both are H; compound 655: n is 0, x is SO 2 , Y is O, R 6 is Me, R 7 and R 8 are both Cl, R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are both H; compound 656: n is 0, x is SO 2 , Y is O, R 6 is Me, R 7 and R 9 are both Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 are both H; The compound 657 is characterized in that n is 0, X is SO 2 , Y is O, R 6 is Me, R 7 and R 10 are Cl, and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 11 are H; Compound 658:n is 0, X is SO 2 , Y is O, R 6 is Me, R 7 and R 11 are both Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 are both H; The compound 659 is characterized in that n is 0, X is SO 2 , Y is O, R 6 is Me, R 8 and R 9 are Cl, and R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; The compound 660 is characterized in that n is 0, X is SO 2 , Y is O, R 6 and R 7 are Me, R 9 is Cl, and R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 are H; the compound 661 is that n is 0, X is SO 2 , Y is O, R 6 、R 7 and R 8 are Me, and R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; the compound 662 is characterized in that n is 0, X is SO 2 , Y is O, R 6 、R 7 and R 9 are Me, and R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 are H; Compound 663: n is 0, x is SO 2 , Y is O, R 6 、R 7 and R 10 are Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 11 are both H; The compound 664 is characterized in that n is 0, X is SO 2 , Y is O, R 6 、R 7 and R 11 are Me, and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 are H; Compound 665: n is 0, x is SO 2 , Y is O, R 6 、R 7 、R 8 and R 11 are Me, R 2 、R 3 、R 4 、R 5 、R 9 、R 10 are both H; Compound 666: n is 0, x is SO 2 , Y is O, R 6 、R 7 、R 9 and R 11 are Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 are both H; Compound 667: n is 0, x is SO 2 , Y is O, R 6 is Me, R 7 and R 9 are both CF 3 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 and H; Compound 668 is characterized in that n is 0, X is SO 2 , Y is O, R 6 is Me, R 8 and R 10 are CF 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 11 and H; The compound 669 is characterized in that n is 0, X is SO 2 , Y is O, R 6 is Me, R 2 、R 3 、R 4 、R 5 are H, and R 7 、R 8 、R 9 、R 10 、R 11 are F; compound 670, n is 0, x is SO 2 , Y is O, R 6 is Me, R 7 is CH 3 CH 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 , all are H; The compound 671:n is 0, X is SO 2 , Y is O, R 6 is Me, R 8 is CH 3 CH 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and both are H; Compound 672 n is 0, x is SO 2 , Y is O, R 6 is Me, R 9 is CH 3 CH 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 , all are H; compound 673: n is 0, x is SO 2 , Y is O, R 6 is Me, R 7 is CH(CH 3 ) 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are both H; Compound 674 n is 0, x is SO 2 , Y is O, R 6 is Me, R 8 is CH(CH 3 ) 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 , all are H; the compound 675 is that n is 0, X is SO 2 , Y is O, R 6 is Me, R 9 is CH(CH 3 ) 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and both are H; The compounds 676:n are 0, X is SO 2 , Y is O, R 6 is Me, R 7 is CH 3 (CH 2 ) 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H; compound 677: n is 0, x is SO 2 , Y is O, R 6 is Me, R 7 is C(CH 3 ) 3 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are both H; The compound 678:n is 0, X is SO 2 , Y is O, R 6 is Me, R 7 is R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; The compound 679:n is 0, X is SO 2 , Y is O, R 6 is Me, R 7 is R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; compound 680: n is 0, x is SO 2 , Y is O, R 6 is Me, R 7 is CO 2 CH 3 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are both H; compounds 681:n is 0, X is SO 2 , Y is O, R 6 is Me, R 7 and R 8 are cyclized to form R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; Compounds 682: n is 0, X is SO 2 , Y is O, R 6 is Me, R 8 and R 9 are cyclized to form R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; Compounds 683:n is 0, X is SO 2 , Y is O, R 6 is Me, R 8 and R 9 are cyclized to form R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; The compound 684 is that n is 0, X is SO 2 , Y is O, R 6 is Me, R 7 and R 8 are cyclized to form R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; The compound 685 is formed by cyclization of n is 0, X is SO 2 , Y is O, R 6 is Me, R 8 and R 9 R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; Compounds 686:n is 0, X is SO 2 , Y is O, R 6 is Me, R 7 and R 8 are cyclized to form R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; Compounds 687:n is 0, X is SO 2 , Y is O, R 6 is Me, R 7 and R 8 are cyclized to form R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; The compound 688:n is 0, X is SO 2 , Y is O, R 6 is Me, R 7 and R 8 are cyclized to form R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; The compound 689 is that n is 0, X is SO 2 , Y is O, R 6 is Me, R 7 and R 8 are cyclized to form R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; Compounds 690:n is 0, X is SO 2 , Y is O, R 6 is Me, R 7 and R 8 are cyclized to form R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 are H; The compound 691:n is 0, X is SO 2 , Y is O, R 6 is Me, R 8 and R 9 are cyclized to form R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; the compounds 692:n are 1, X is S, Y is O, R 6 is Me,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 and H; The compound 693 is that n is 2, X is S, Y is O, R 6 is Me,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 and H is H; The compound 697:n is 0, X is S, Y is O, R 2 is R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 is H, and R 6 is CH 3 .
6. A compound according to claim 2 or 3, wherein, in formula (I), R 1 is selected from the group consisting of C 1-6 alkyl, - (CH 2 ) z -phenyl), an unsaturated five-membered ring group containing a heteroatom selected from the group consisting of B-type heteroatoms, a saturated four-membered ring group containing a heteroatom selected from the group consisting of B-type heteroatoms, an unsaturated six-membered ring group containing a heteroatom selected from the group consisting of B-type heteroatoms, C 4-8 saturated cycloalkyl, benzothiazolyl, benzoxazolyl, benzopyrazolyl, phenylpropylthiophene, N-methyl-benzopyrrolyl, and, Z is an integer from 1 to 6, each of said class B heteroatoms is independently selected from at least one of O, S, N, and optionally, said class B heteroatoms having C 1-3 alkyl as a substituent; R 2 is selected from H, n-butyl, -CH 2 -phenyl; R 3 、R 4 and R 5 are both H, R 6 is methyl, n is 0;X is S, Y is O.
7. The compound according to claim 6, wherein, in formula (I), N, X, Y, R 1 、R 2 、R 3 、R 4 、R 5 、R 6 substitution is as follows: the compound 694:n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; The compound 695:n is 0, X is S, Y is O, R 1 is R 2 is H, R 3 、R 4 、R 5 are H, and R 6 is CH 3 ; The compound 696:n is 0, X is S, Y is O, R 1 is R 2 is R 3 、R 4 、R 5 is H, R 6 is CH 3 ; The compounds 698:n are 0, X is S, Y is O, R 1 is CH 3 ,R 2 , CH 3 ,R 3 、R 4 、R 5 are H, and R 6 is CH 3 ; The compounds 699:n are 0, X is S, Y is O, R 1 is CH 3 CH 2 ,R 2 , CH 3 ,R 3 、R 4 、R 5 are H, and R 6 is CH 3 ; The compound 700 is characterized in that n is 0, X is S, Y is O, R 1 is CH 3 CH 2 ,R 2 , CH 3 CH 2 ,R 3 、R 4 、R 5 is H, and R 6 is CH 3 ; Compound 701: n is 0, x is S, Y is O, R 1 is (CH 3 ) 2 CH 2 ,R 2 is H, R 6 is CH 3 ; Compound 702 where n is 0, x is S, Y is O, R 1 is (CH 3 ) 2 CH 2 ,R 2 is CH 3 CH 2 ,R 3 、R 4 、R 5 both are H, R 6 is CH 3 ; Compound 703: n is 0, x is S, Y is O, R 1 is CH 3 CH 3 CH 2 ,R 2 is CH 3 CH 3 CH 2 ,R 3 、R 4 、R 5 is H, R 6 is CH 3 ; compound 704: n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; Compounds 705 n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; the compound 706:n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; Compounds 707 are each 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; Compounds 708:n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; compounds 709 are each 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; The compound 710 n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; Compounds 711: n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; compound 712:n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; Compounds 713:n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; The compound 714 is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; Compound 715 is represented by n, 0, X is represented by S, Y is represented by O, R 1 is represented by R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; The compound 716 is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; Compound 717 n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; the compound 718 is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; Compounds 719 are those wherein n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; The compound 720:n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; Compounds 721 n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; The compound 722 is that n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; The compound 723:n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; Compound 724 n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; Compound 725 n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; The compound 726:n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; The compound 727:n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; Compound 728 n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; Compound 729:n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; Compound 730, n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; The compound 731 is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; The compound 732 is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; The compound 733:n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; Compounds 734:n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; Compounds 735:n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; compounds 736 n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; The compound 737:n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; Compounds 738: n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; The compound 739:n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; the compound 740:n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; A compound 741 n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; Compounds 742:n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; The compound 743:n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; The compound 744:n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; Compounds 745:n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; Compounds 746 n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; the compound 747 is that n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; Compound 748 n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; the compound 749:n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; The compound 750:n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; The compound 751:n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; Compound 752, n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; Compound 753 n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; Compound 754: n is 0, x is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; Compounds 755 n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; Compound 756 having n of 0, X of S, Y of O, R 1 of R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; Compound 757:n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; Compounds 758:n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; Compound 759:n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; The compound 760 is 0 in n, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; The compound 761:n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; Compounds 762:n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; The compound 763:n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; The compound 764:n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; The compound 765 is that n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; The compound 766 is that n is 0, X is S, Y is O, R 1 is R 2 、R 3 、R 4 、R 5 is H, R 6 is CH 3 ; The compounds 767:n are 0, X is S, Y is O, R 1 is CH 3 (CH 2 ) 3 ,R 2 , CH 3 (CH 2 ) 3 ,R 3 、R 4 、R 5 are H, and R 6 is CH 3 .
8. The compound of claim 1, wherein in formula (I), X and Y are both O; Preferably, the compound represented by formula (I) has the structure of the compound represented by formula (I-A): wherein the substitution in formula (I-A) ,n、X、Y、R 2 、R 3 、R 4 、R 5 、R 6 、R 7 、R 8 、R 9 、R 10 、R 11 is as follows: The compound 768 is that n is 0, X is O, Y is O, R 6 is Me,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 and H is all; the compound 769 is that n is 0, X is O, Y is O, R 6 is Me, R 7 is F, and R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; The compound 770 is characterized in that n is 0, X is O, Y is O, R 6 is Me, R 8 is F, and R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; The compound 771:n is 0, X is O, Y is O, R 6 is Me, R 9 is F, and R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; Compound 772:n is 0, X is O, Y is O, R 6 is Me, R 7 is Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; the compound 773 is that n is 0, X is O, Y is O, R 6 is Me, R 8 is Cl, and R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; the compound 774 is that n is 0, X is O, Y is O, R 6 is Me, R 9 is Cl, and R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; The compound 775:n is 0, X is O, Y is O, R 6 is Me, R 7 is Br, and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; The compound 776 is that n is 0, X is O, Y is O, R 6 is Me, R 8 is Br, and R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are H; The compound 777 is that n is 0, X is O, Y is O, R 6 is Me, R 9 is Br, and R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; The compound 778 is that n is 0, X is O, Y is O, R 6 is Me, R 7 is NO 2 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and H is the same as the above; the compound 779 is that n is 0, X is O, Y is O, R 6 is Me, R 8 is NO 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and H is the same as the above; Compound 780: n is 0, x is O, Y is O, R 6 is Me, R 9 is NO 2 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 , all are H; The compound 781:n is 0, X is O, Y is O, R 6 is Me, R 7 is CF 3 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and both are H; The compound 782:n is 0, X is O, Y is O, R 6 is Me, R 8 is CF 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and both are H; the compound 783:n is 0, X is O, Y is O, R 6 is Me, R 9 is CF 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and both are H; the compound 784 is that n is 0, X is O, Y is O, R 6 is Me, R 7 is OCH 3 ,R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 and both are H; The compound 785 is that n is 0, X is O, Y is O, R 6 is Me, R 8 is OCH 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 and both are H; The compound 786 is that n is 0, X is O, Y is O, R 6 is Me, R 9 is OCH 3 ,R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 and both are H; the compound 787:n is 0, X is O, Y is O, R 6 and R 7 are Me, and R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 are H; the compound 788: n is 0, x is O, Y is O, R 6 and R 8 are Me, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 are both H; The compound 789:n is 0, X is O, Y is O, R 6 and R 9 are Me, and R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 are H; The compound 790 is that n is 0, X is O, Y is O, R 5 is Me, R 7 is CH 3 CH 2 ,R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 and both are H; the compound 791:n is 0, X is O, Y is O, R 5 is Me, R 8 is CH 3 CH 2 ,R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 and both are H; the compound 792:n is 0, X is O, Y is O, R 5 is Me, R 9 is CH 3 CH 2 ,R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 and H is the same; the compound 793:n is 0, X is O, Y is O, R 5 is Me, R 7 is CH(CH 3 ) 2 ,R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 and H is H; The compound 794 is that n is 0, X is O, Y is O, R 5 is Me, R 8 is CH(CH 3 ) 2 ,R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 and H is the same; The compounds 795:n are 0, X is O, Y is O, R 5 is Me, R 9 is CH(CH 3 ) 2 ,R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 and H.
9. A process for producing the amide-based compound according to any one of claims 1 to 8, which comprises contacting a compound represented by the formula (V-1) with a compound represented by the formula (V-2); Wherein the substitution of the substituents in the formulae (V-1) and (V-2) corresponds to the same substitution in the amide-based compound according to any one of claims 1 to 8, and one of Z 1 and Z 2 is-Br, the other is-XH, and the definition of X corresponds to the same as the definition in the amide-based compound according to any one of claims 1 to 8.
10. A process for producing the amide-based compound according to any one of claims 1 to 8, which comprises subjecting a compound represented by the formula (II) to a coupling reaction with a compound represented by the formula (III); Wherein the substitution of the substituents in the formula (III) and the formula (II) is correspondingly the same as the substitution in the amide-based compound according to any one of claims 1 to 8.
11. Use of an amide compound according to any one of claims 1-8 in agriculture; Preferably, the agronomic use is selected from at least one of increasing crop yield, managing abiotic stress on plants, regulating plant growth, enhancing plant disease resistance, promoting seed germination, regulating soil microbial population structure and increasing soil fertility.
12. A biostimulant comprising a plant growth regulating effective amount of at least one of the amide compounds of any one of claims 1-8, and optionally an adjuvant; Preferably, the content of the amide-based compound is 1 to 99.99wt%, or the content of the amide-based compound is 0.001ppm to 100ppm.

Description

Amide compound, preparation method and agronomic application thereof Cross Reference to Related Applications The present application claims the benefit of chinese patent application 202311268630.2 filed on 28, 09, 2023, the contents of which are incorporated herein by reference. Technical Field The invention relates to the field of pesticide chemistry, in particular to an amide compound, a preparation method and agronomic application thereof. Background The global economic loss to grain production due to weed damage is up to $950 billion annually, while the vast seed pool in the soil is a direct cause of weed damage. Germination is a prerequisite for the vital activity of seed plants. Promoting seed germination can improve seed germination rate, reduce seed usage in agricultural production, improve herba cistanches and herba Cynomorii inoculation rate, and protect wild traditional Chinese medicine resources, and can control weeds by applying post-emergence herbicide to the weeds. Strigolactone is a natural product isolated from plants and containing alkenyl ether butenolide structural units. Research shows that the strigolactone compound can promote the germination of parasitic root weeds, such as broomrape, strigola and other seeds, and promote the germination of arbuscular mycorrhizal fungi spores and the branching of hyphae. In addition, the strigolactone compound can also regulate a plurality of processes of plant growth and development, such as inhibiting plant branching, controlling axillary bud germination, inhibiting plant lateral root growth, promoting main root elongation and the like, volume ("Strigolactones:plant hormones with promising features"(Bouwmeester,H.J.etc.,"Angew.Chem.Int.Ed.",2019,58, p12778-12786 as a newly discovered plant hormone. The existing strigolactone compounds are difficult to obtain and have poor stability, so that the application of the strigolactone compounds in agricultural growth is limited. "Tentative molecular mechanism for germination stimulation of striga and orobanche seeds by strigol and its synthetic analogs"(Mangnus,E.M.;Zwanenburg,B.;"J.Agric.Food Chem.",1992, Volume 40, p 1066-1070) indicates that the alkenyl ether butenolide building block in strigolactones is critical to maintaining the activity of the compound, which would result in a loss of activity if the enol ether linkage was replaced with a methylene group. At present, reported strigolactone analogues or mimics also contain alkenyl ether butenolide structural units with poor stability (such as WO2018060865A1 and WO2012146374A 3), and the structural fragment is an important factor which leads to the poor stability of the compounds and restricts the field application of the compounds. Currently, most of the highly active strigolactone agonists, such as nijmegen-1, MP1, etc., cannot be used in practical production due to their poor stability. Therefore, there is a need for new compounds that are stable and can be effectively applied in agronomic growth. Disclosure of Invention The invention aims to provide a novel amide compound with at least one of the effects of seed germination, crop yield improvement, plant growth regulation, soil microbial population structure regulation and soil fertility improvement. In order to achieve the above object, a first aspect of the present invention provides an amide-based compound having a structure represented by formula (I), Wherein, in the formula (I), R 1 and R 2 are each independently selected from H, substituted or unsubstituted C 1-12 alkyl, substituted or unsubstituted C 3-12 cycloalkyl,A substituted or unsubstituted heterocyclic ring of C 1-8 containing a heteroatom selected from at least one of N, O and S, wherein R 7、R8、R9、R10 and R 11 are each independently selected from H, halogen, nitro, cyano, phenyl, benzyl, alkyl of C 1-6, cycloalkyl of C 3-6, C 1-6 alkyl substituted with 1-9 halogens, alkoxy of C 1-6, C 1-6 alkoxy substituted with 1-9 halogens, alkylthio of C 1-6, alkyl of C 1-6 alkylthio of-COO-C 1-6 and alkyl of-S (O) 2-C1-6, or any adjacent two of R 7、R8、R9、R10、R11 are cyclic together to form a 3-8 membered cyclic structure; And each of the substituents optionally present on R 1 and R 2 is independently selected from alkyl of C 1-12, phenyl; R 3、R4、R5 and R 6 are each independently selected from the group consisting of alkyl of H, C 1-12 and cycloalkyl of C 3-12; n is 0,1, 2, 3 or 4; X is O, S, -S (O) -or-S (O) 2 -, Y is O, S, CH 2, NH or-N (CH 3) -. A second aspect of the present invention provides a process for producing the amide-based compound described in the first aspect, which comprises subjecting a compound represented by the formula (V-1) to a contact reaction with a compound represented by the formula (V-2); Wherein the substitution of the substituents in the formulae (V-1) and (V-2) corresponds to the same as the substitution in the amide-based compound described in the first aspect, and one of Z 1 and Z 2 is-Br, the other is-XH, and th