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CN-122004203-A - Suspending agent containing enestroburin and validamycin A and application thereof

CN122004203ACN 122004203 ACN122004203 ACN 122004203ACN-122004203-A

Abstract

The invention relates to the field of agricultural bactericides, in particular to a suspending agent containing enestroburin and validamycin A and application thereof. The suspending agent comprises 1-70% of active ingredients, 0.1-10% of stabilizing agents, and water, wherein the active ingredients are the enestroburin and the validamycin A, and the stabilizing agents are meglumine (N-methyl-D-glucosamine). The suspending agent prepared by the technical scheme of the invention effectively inhibits the increase of the particle size of the sample in the thermal storage process of the preparation, effectively improves the suspension rate of the enestroburin after the thermal storage of the preparation, improves the pesticide utilization rate and ensures the normal exertion of the pesticide effect. Meanwhile, the stabilizer-containing bactericide has stable quality of active components in the quality guarantee period, the stabilizer is added without causing decomposition of active components, and the preparation does not generate obvious physical or chemical changes.

Inventors

  • CHOU JINGYU
  • TAO XIAOGUANG
  • YU LU
  • WANG BIN

Assignees

  • 沈阳中化农药化工研发有限公司
  • 江苏扬农化工股份有限公司

Dates

Publication Date
20260512
Application Date
20241112

Claims (10)

  1. 1. The suspending agent comprises 1-70% of active ingredient, 0.1-10% of stabilizer, wherein the active ingredient is the alkene oxime amine and the validamycin A, and the stabilizer is meglumine (N-methyl-D-glucosamine).
  2. 2. The suspension containing the enestroburin and the validamycin A, which is disclosed in claim 1, is characterized in that the enestroburin accounts for 1-40% of the weight of the preparation, and the validamycin A accounts for 1-40% of the weight of the preparation.
  3. 3. The suspension containing the enestroburin and the validamycin A, which is disclosed in claim 2, is characterized in that the enestroburin accounts for 1-10% of the weight of the preparation, and the validamycin A accounts for 1-20% of the weight of the preparation.
  4. 4. The suspending agent containing the enestroburin and the validamycin A, which is disclosed in claim 1, is characterized in that the auxiliary agent is one or more of wetting dispersant, thickener, defoamer and antifreezing agent, and each component accounts for 1-20% of the weight of the preparation, 0-2% of the thickener, 0-2% of the defoamer, 0-2% of the preservative and 0-10% of the antifreezing agent.
  5. 5. The suspending agent containing the enestroburin and the validamycin A as set forth in claim 4, wherein the wetting dispersant is one or more selected from lignin sulfonate, sodium salt of alkyl naphthalene sulfonate polycondensate, alkyl naphthalene sulfonate formaldehyde condensate, polycarboxylate, EO/PO block copolymer, phosphate anion, sulfate anion, polyacrylate copolymer, fatty alcohol polyoxyethylene ether, sorbitan fatty acid ester polyoxyethylene ether, and methacrylic acid grafted comb copolymer.
  6. 6. The suspension containing the enestroburin and the validamycin A, as claimed in claim 5, wherein the wetting dispersant is a mixture of sodium salt of alkyl naphthalene sulfonic acid polycondensate and one or more of lignin sulfonate, alkyl naphthalene sulfonate formaldehyde condensate, polycarboxylate, EO/PO block copolymer, phosphate anions, sulfate anions, polyacrylate copolymer, fatty alcohol polyoxyethylene ether, sorbitan fatty acid ester polyoxyethylene ether, and methacrylic acid grafted comb copolymer.
  7. 7. The suspension concentrate containing the enestroburin and the validamycin A as claimed in any of claims 1-6, wherein the mass ratio of the stabilizer meglumine (N-methyl-D-glucosamine) to the sodium salt of the alkyl naphthalene sulfonic acid polycondensate in the wetting dispersant is 1:1-1:10.
  8. 8. The suspending agent containing the enestroburin and the validamycin A, which is characterized in that the thickening agent is one or more selected from xanthan gum, bentonite, gelatin, gum arabic, polyvinyl acetate, polyvinylpyrrolidone, magnesium aluminum silicate, polyvinyl alcohol, polyethylene glycol, phenolic resin, shellac and hydroxymethyl cellulose; the defoamer is one or more selected from SAG-1522, SAG-1572, silicone, C8-10 fatty alcohol, phosphate, C10-20 saturated fatty acid (such as capric acid) and amide; the preservative is selected from one or more of sodium benzoate, pinus (2-methyl-4-isothiazolin-3-one and (B) 5-chloro-2-methyl-4-isothiazolin-3-one), potassium sorbate, sodium dehydroacetate or others; the antifreezing agent is one or more selected from ethylene glycol, propylene glycol, glycerol or urea.
  9. 9. The use of the suspension containing the enestroburin and the validamycin A as claimed in claim 1, wherein the suspension is used as an agricultural bactericide.
  10. 10. The use of the suspension concentrate containing the enestroburin and the validamycin A as claimed in claim 9, wherein the preparation is applied to a germ to be controlled or a medium for growth of the germ to be controlled in an amount of 10-500 g/hectare, and can be used for preventing and treating one or more plant diseases selected from rice sheath blight, rice blast, wheat powdery mildew, wheat rust, soybean gray leaf spot, cotton damping-off, cotton anthracnose, cucumber powdery mildew, cucumber downy mildew, grape downy mildew, apple alternaria leaf spot, apple powdery mildew, banana leaf spot, tomato early blight, strawberry powdery mildew and rape sclerotium disease.

Description

Suspending agent containing enestroburin and validamycin A and application thereof Technical Field The invention relates to the field of agricultural bactericides, in particular to a suspending agent containing enestroburin and validamycin A and application thereof. Background The enoxim has wide bactericidal spectrum and has the functions of protection and treatment. It has better control effect on various plant diseases such as powdery mildew, downy mildew and the like. In terms of action mechanism, the enestroburin can inhibit the growth and reproduction of germs by interfering with the normal physiological functions of germ cells. The enestroburin has the characteristics of high efficiency, low toxicity, environmental friendliness and the like. This compound is disclosed in CN1309897 a. Validamycin A is an antibiotic bactericide produced by streptococcus hygroscopicus, belongs to biological pesticides, has stronger systemic property, and can be absorbed by plants and transmitted in vivo. The validamycin A is mainly used for controlling rice sheath blight, and the action mechanism is to control diseases by inhibiting the growth of germ hyphae. The long-term use of chemical bactericides in large quantities can cause the enhancement of the drug resistance of pathogenic bacteria and the increasing of pesticide residue. In order to promote the green development of agriculture in China, the biopesticide has the advantages of low toxicity, good ecological environment compatibility, difficult generation of drug resistance and the like, and plays a positive role in reducing the use of chemical pesticides, ensuring the quality safety of agricultural products and the like. However, the registered biopesticides in China are few at present, and the prevention and control effect of the biopesticides alone is not very good. Because biopesticides and chemical pesticides have different action mechanisms on pathogenic bacteria, the synergistic use of the biopesticides and the chemical pesticides has a larger development space in the application of chemical agent reduction and synergism. Chinese patent CN101836631B reports that the combined use of the enestroburin and the validamycin has good control effect on rice sheath blight, false smut and wheat sheath blight, the control rate can reach more than 97% through field experiments, the persistence is strong, and the control rate can reach more than 92% after the application of the medicines for controlling rice and wheat sheath blight for 14 days. The method is characterized in that biological activity research after two active ingredients are combined is lack of screening research on a pesticide formulation with excellent performance, suspension formulations are mentioned in specific examples, only drug effect data of corresponding partial targets are given, but the suspension needs to have good physical indexes, good physicochemical stability of a product in shelf life is guaranteed, wherein the suspension rate is a key performance index of the suspension, and the suspension rate can be used for indicating that the formulation development is successful only when the suspension rate is not lower than 90% according to the current formulation suspension rate standard. Patent CN103749493a reports that the suspension prepared by compounding validamycin a and thifluzamide is easy to have high viscosity, cannot be sanded, has problems of wall sticking, black floccule production and the like in the placing process, and solves the problems by adding a special polyether polyol with a low HLB value as a deflocculant. Patent CN103734139A discloses a pesticide suspending agent compounded by validamycin and hexaconazole, and the suspending rate of the suspending agent is increased by selecting an antirust additive alpha- [ tri (phenylmethyl) phenyl ] -omega-hydroxy poly (oxy-1, 2-ethylene) as a nonionic surfactant to act together with diisooctyl sodium sulfosuccinate. Patent CN107535488A discloses a pesticide suspending agent compounded by validamycin and epoxiconazole and a preparation method thereof, and the suspending agent also has the problems of low suspension rate, poor stability and the like. Patent CN108651464A discloses a suspending agent of a compound bactericide of validamycin A and metconazole and a preparation method thereof, and the suspending agent inhibits the growth of the particle size of an active ingredient by adding an anti-high-salt system stabilizer (phenolic resin sulfonate), so that the stability of a formula is improved. In the research process of preparing the suspending agent from the enestroburin and the validamycin A, the prepared suspending agent diluent is easy to cause lower suspension rate of the enestroburin due to aggregation of particles, especially in a thermal storage acceleration test (54+/-2 ℃ and 14 d), and the suspension rate of the enestroburin is unqualified due to the increase of the particle size of the particles, so that the use of the