CN-122004205-A - Method for preparing hectorite-based chlorantraniliprole nanosuspension based on high-pressure micro-jet homogenization technology

Abstract

The invention discloses a method for preparing a hectorite-based chlorantraniliprole nanometer suspending agent based on a high-pressure micro-jet homogenizing technology, which comprises the steps of dispersing hectorite in water to obtain a colloid suspending liquid, dispersing chlorantraniliprole powder in a reaction liquid, stirring at a high speed to form a uniform suspension, treating the suspension by a high-pressure micro-jet homogenizer, and then adopting natural polymers for encapsulation treatment to obtain the nanometer pesticide suspending agent. The invention utilizes colloid property, adsorptivity, carrier function of hectorite and encapsulation treatment of natural polymer, and effectively solves the key stuck point problems of poor water dispersibility, large average particle diameter, poor storage stability and the like of pesticides by a high-pressure micro-jet homogenization technology.

Inventors

• WANG QIN
• WANG AIQIN
• MOU BIN
• LU YUSHEN
• XU JIANG
• LIU YAN

Assignees

• 中国科学院兰州化学物理研究所

Dates

Publication Date

20260512

Application Date

20260211

Claims (4)

1. 1. The method for preparing the hectorite-based chlorantraniliprole nanosuspension based on the high-pressure micro-jet homogenization technology is characterized by comprising the following steps of: (1) Dispersing hectorite with the mass percentage concentration of 0.5% -5.0% in water to form a colloid suspension; (2) Adding the chlorantraniliprole powder which is sieved by a 200-mesh sieve into the suspension obtained in the step (1), and stirring for 10-15 min at the rotating speed of 4000-10000 rpm to form uniform suspension, wherein the mass percentage concentration of the chlorantraniliprole in a final system is 15% -40%; (3) Carrying out high-pressure microjet homogenization treatment on the suspension obtained in the step (2) under the pressure of 10-150 MPa so as to peel off hectorite lamellar aggregates and realize nanoscale dispersion; (4) And (3) adding natural polymer with the mass percentage concentration of 0.1% -2.0% into the homogenized system in the step (3), stirring at the rotating speed of 1000-3000 rpm for 1-4 hours, and encapsulating to obtain the nano suspending agent, wherein the natural polymer is chitosan or at least one of alkylated, hydroxylated and carboxylated derivatives thereof.
2. 2. The method of claim 1, wherein the average particle size of the hectorite-based chlorantraniliprole nanosuspension prepared by the method is less than 100 nm.
3. 3. A hectorite-based chlorantraniliprole nanosuspension prepared by the method of any one of claims 1-2.
4. 4. The nanosuspension according to claim 3, wherein the nanosuspension is free from water separation, delamination or sedimentation after 14 days of sealed storage at 54℃and 7 days of sealed storage at 1 ℃.

Description

Method for preparing hectorite-based chlorantraniliprole nanosuspension based on high-pressure micro-jet homogenization technology Technical Field The invention relates to a nano pesticide suspending agent, in particular to a method for preparing a hectorite-based chlorantraniliprole nano suspending agent based on a high-pressure micro-jet homogenizing technology, and belongs to the technical field of nano pesticide application. Background At present, the preparation process of the common pesticide nanometer suspending agent mainly comprises a bottom-up method and a top-down method. The bottom-up method is a preparation technology for constructing nano particles through molecular or atomic assembly, and the preparation technology is complex, low in yield and high in cost, and most of researches are still in a laboratory and difficult to produce in a large scale. The top-down method is to apply high-strength mechanical force to gradually refine large-particle pesticides and finally obtain nano-scale pesticide particles with uniform particle size distribution, and mainly comprises a medium grinding method (CHEMICAL ENGINEERING Journal,2025, 503:158168), a high-pressure homogenizing method (pesticide science report, 2014, 16 (6): 635-643), a microfluidic method (20241031305. X) and the like. The time required for preparing the nano suspending agent by using the grinding method is long, and a large amount of heat generated by long-time grinding is easy to cause the thermal aggregation phenomenon among particles, so that the stability of the nano suspending agent is influenced, and the production energy consumption is high. The high-pressure homogenizing technology is used for crushing and dispersing samples by mechanical shearing and impact under high pressure, has the advantages of simple operation, narrow particle size distribution and the like, but is easy to wear and has limited processing capacity on high-concentration and high-viscosity materials (modern pesticides, 2025,24 (3): 1-8). The high-pressure micro-jet homogenizing technology is to jet out the sample with high-pressure gas and to accelerate and disperse the sample at micron level jet and room temperature to make the dispersed particle size in nanometer level. Compared with the high-pressure homogenizing technology, the high-pressure micro-jet homogenizing technology adopts the shearing force and the impact force generated by high-speed air flow to disperse the sample, so that the obtained particles have narrower particle size distribution range and better dispersing effect. Therefore, on the basis of the invention patent 20241041020556. X, the invention aims to adopt a high-pressure micro-jet homogenizing technology to peel off lamellar aggregates of hectorite so as to nanocrystallize the lamellar aggregates, and then combine a natural polymer encapsulation technology to prepare the nano pesticide suspending agent which is stable in long-term dispersion in water. Disclosure of Invention The invention aims to overcome the defects of complex process, dependence on various chemical auxiliary agents, incomplete carrier nanocrystallization, insufficient long-term physical stability of a preparation and the like in the existing chlorantraniliprole nanometer suspending agent preparation technology, and provides a chlorantraniliprole nanometer suspending agent which has simple process, is green and environment-friendly, and can synchronously realize efficient nanocrystallization of the carrier and high stability of the preparation, and a preparation method thereof. To achieve the above object, the first aspect of the present invention provides a method for preparing a hectorite-based chlorantraniliprole nanosuspension based on a high-pressure micro-jet homogenization technique. The method creatively combines the carrier function of laponite, the deep stripping of high-pressure micro-jet homogenization with nanocrystallization capability and the environment-friendly encapsulation stabilization effect of natural polymers, and synchronously completes the steps in a continuous and efficient process system. The method specifically comprises the following steps: (1) The preparation of the hectorite colloid suspension comprises the steps of dispersing laponite with the mass percentage concentration of 0.5% -5.0% in water to initially form the colloid suspension. In this step, the hectorite begins to hydrate and expand, but its lamellae remain in an aggregated state. (2) The preparation of the medicine premix suspension comprises the steps of adding the crushed and 200-mesh-sieved chlorantraniliprole raw powder into the suspension obtained in the step (1) to enable the mass percentage concentration of the chlorantraniliprole raw powder in a final system to reach 15% -40%. And stirring for 10 minutes under high-speed shearing at 4000-10000 rpm, and primarily dispersing and attaching the medicine on the surface and the interlayer of the hectorite aggregate by usi