Search

CN-122004228-A - Epoxiconazole nano-suspension agent and preparation method and application thereof

CN122004228ACN 122004228 ACN122004228 ACN 122004228ACN-122004228-A

Abstract

The invention provides a epoxiconazole nano-suspension agent and a preparation method and application thereof, belonging to the technical field of pesticides. The epoxiconazole nano-suspension comprises, by mass, 5-20% of epoxiconazole, 10-30% of azoxystrobin, 2-5% of a wetting agent, 6-12% of a dispersing agent, 0.2-2% of a thickening agent, 1-5% of an antifreezing agent, 0.01-0.5% of a preservative, 0.1-2% of a defoaming agent and the balance of water. The epoxiconazole and azoxystrobin nanometer suspending agent is compounded, has good particle size stability (the particle size D 90 is less than or equal to 500 nm), and can keep good particle size stability with time under low dilution (within 100 times). The nanometer suspending agent can obviously enhance the prevention and treatment effect on fungal diseases, expand the prevention and treatment spectrum, delay the development of resistance to single effective components, adapt to the application of the flying prevention, and fully exert the use advantages of the nanometer suspending agent.

Inventors

  • YANG BIN
  • MA WEI
  • AN HAO
  • LIU XIAOCHENG
  • REN JIANRONG

Assignees

  • 上海慧华生物科技有限公司

Dates

Publication Date
20260512
Application Date
20260203

Claims (10)

  1. 1. The epoxiconazole nano-suspension agent is characterized by comprising the following components in percentage by mass: 5-20% of epoxiconazole, 10-30% of azoxystrobin, 2-5% of wetting agent, 6-12% of dispersing agent, 0.2-2% of thickening agent, 1-5% of antifreezing agent, 0.01-0.5% of preservative, 0.1-2% of defoaming agent and the balance of water; The dispersant comprises alkylphenol polyoxyethylene ether formaldehyde condensate sulfonate and block polyether phosphate.
  2. 2. The epoxiconazole nano-suspension agent according to claim 1, wherein the alkylphenol polyoxyethylene ether formaldehyde condensate sulfonate is Dispersogen, 1494 and liq, the block polyether phosphate is CF-20S, and the mass ratio of Dispersogen, 1494 and liq to CF-20S is 1:3-3:1.
  3. 3. The epoxiconazole nanosuspension of claim 1, wherein the wetting agent comprises one or both of a block polyether and a C8-C14 fatty alcohol ethoxy propoxylate.
  4. 4. The epoxiconazole nanosuspension of claim 3, wherein the block polyether is AGRIGEN B848 and the C8-C14 fatty alcohol ethoxy propoxylate is T80.
  5. 5. The epoxiconazole nanosuspension of claim 1, wherein the thickener comprises one or both of magnesium aluminum silicate and xanthan gum.
  6. 6. The epoxiconazole nanosuspension of claim 1, wherein the antifreeze comprises at least one of ethylene glycol, propylene glycol, and propylene glycol.
  7. 7. The epoxiconazole nanosuspension of claim 1, wherein the preservative comprises at least one of sodium benzoate and pinocembron.
  8. 8. The fluorine according to claim 1a nano suspension agent of azoxystrobin, the defoaming agent is an organosilicon defoaming agent.
  9. 9. The preparation method of the epoxiconazole nano-suspension agent according to any one of claims 1 to 8, which is characterized by comprising the following steps: Mixing a dispersing agent, a wetting agent, an antifreezing agent and a part of defoaming agent with water to obtain a first mixed solution; Mixing azoxystrobin and epoxiconazole with the first mixed solution, and carrying out first homogenization to obtain a second mixed solution; coarsely grinding the second mixed solution, and then circularly grinding the second mixed solution in a grading way until the grain diameter D 90 of the material is less than or equal to 500nm to obtain a third mixed solution; and mixing the third mixed solution with a thickening agent, a preservative and the rest of defoamer, and carrying out second homogenization to obtain the epoxiconazole nano-suspension.
  10. 10. The application of the epoxiconazole nano-suspension agent according to any one of claims 1 to 8 or the epoxiconazole nano-suspension agent prepared by the preparation method according to claim 9 in the pesticide field.

Description

Epoxiconazole nano-suspension agent and preparation method and application thereof Technical Field The invention relates to the technical field of pesticides, in particular to a epoxiconazole nano-suspension agent, a preparation method and application thereof. Background The suspending agent is a multiphase dispersion system formed by dispersing and homogenizing solid raw materials which are slightly soluble or insoluble in water and various auxiliary agents in an aqueous medium, and belongs to a thermodynamically unstable system. In the 54 ℃ heat storage test, the particle size of the active ingredient is generally increased to a certain extent in the test process due to the Oryza curing effect. The nanometer suspending agent has smaller particle size, so that the active ingredient has larger solubility in the water medium, thereby exacerbating the Oryza ripening effect, and the D 98 particle size is easy to exceed 1000nm, so that the excellent effect of the nanometer preparation cannot be exerted. The nanometer suspending agent has smaller particle size and better permeability than common suspending agents, so that the utilization rate and quick acting performance of the medicament can be improved on the basis of keeping the advantages (such as no dust, no organic solvent and the like) of the suspending agent in production and use, thereby improving the control effect. In the current agricultural production, the flying prevention operation is more and more important, wherein the time stability of a matched preparation under low-power dilution (20-100 times) can directly influence the application effect. In particular, for a nanosuspension, maintaining the particle size in the nanometer range at low dilution is one of the important conditions for exerting an effect stronger than that of a general nanosuspension. Under the condition of low-power dilution, on one hand, the concentration of part of auxiliary agent is lower than CMC value, so that the functions of dispersing, wetting and the like cannot be well exerted, on the other hand, the three-dimensional network in the system is destroyed due to the reduction of the concentration of the thickener, and meanwhile, the collision among particles is aggravated along with the higher concentration of the particles, so that the energy barrier is broken through more easily, and larger particle clusters are formed. At present, epoxiconazole and azoxystrobin are respectively provided with a single-dose nanosuspension, for example, patent CN118511877A, and the invention provides a epoxiconazole nanosuspension and a preparation method thereof, wherein the measurement of particle size stability in the storage process is related, but the measurement of particle size stability under the condition of low-multiple dilution of flight protection is not related. Patent CN102626084a, the invention relates to an azoxystrobin nano-water suspension, wherein the particle size stability test under the conditions of storage process and low-multiple dilution of flight protection is not involved. However, there have been no reports on the formulation of epoxiconazole and azoxystrobin nanosuspensions. Therefore, there is a need for a epoxiconazole nano-suspension agent with small particle size, good thermal storage stability and good particle size stability after low-power dilution. Disclosure of Invention The invention aims to provide a epoxiconazole nano-suspension agent, a preparation method and application thereof, wherein the epoxiconazole nano-suspension agent has small particle diameter (the particle diameter D 90 is less than or equal to 500 nm), good heat storage stability and good particle diameter stability after low-power dilution. In order to achieve the above object, the present invention provides the following technical solutions: The invention provides a epoxiconazole nano-suspension agent, which comprises the following components in percentage by mass: 5-20% of epoxiconazole, 10-30% of azoxystrobin, 2-5% of wetting agent, 6-12% of dispersing agent, 0.2-2% of thickening agent, 1-5% of antifreezing agent, 0.01-0.5% of preservative, 0.1-2% of defoaming agent and the balance of water; The dispersant comprises alkylphenol polyoxyethylene ether formaldehyde condensate sulfonate and block polyether phosphate. Preferably, the alkylphenol polyoxyethylene ether formaldehyde condensate sulfonate is Dispersogen, 1494 and liq, the block polyether phosphate is CF-20S, and the mass ratio of Dispersogen, 1494 and liq to CF-20S is 1:3-3:1. Preferably, the wetting agent comprises one or both of a block polyether and a C8-C14 fatty alcohol ethoxy propoxylate. Preferably, the block polyether is AGRIGEN B to 848, and the C8-C14 fatty alcohol ethoxy propoxylate is T80. Preferably, the thickener comprises one or both of magnesium aluminum silicate and xanthan gum. Preferably, the antifreeze agent includes at least one of ethylene glycol, propylene glycol and propylene glycol. Preferably, th