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CN-122004254-A - Efficient and safe plant essential oil mosquito repellent and preparation method thereof

CN122004254ACN 122004254 ACN122004254 ACN 122004254ACN-122004254-A

Abstract

The invention discloses a high-efficiency safe plant essential oil mosquito repellent and a preparation method thereof, belonging to the field of repellent. The invention relates to a high-efficiency safe plant essential oil mosquito repellent, which comprises a core essential oil component, a solvent and an emulsifier, wherein the core essential oil component comprises at least two of peppermint essential oil, perilla essential oil, citronella essential oil, mugwort leaf essential oil, cinnamon essential oil and grassleaf sweelflag rhizome essential oil, the total mass fraction of the core essential oil component is 0.5-2.5% of the total mass of the repellent, the solvent is an ethanol aqueous solution, the volume fraction of ethanol in the aqueous solution is 5-20%, and the mass fraction of the emulsifier is 0.1-5% of the total mass of the composition.

Inventors

  • HOU YINXU
  • ZHANG JIE
  • XU QINGHUA
  • MA CHAO
  • LI MUYANG
  • Hou Haoyu

Assignees

  • 安徽省疾病预防控制中心(省预防医学科学院、省血吸虫病防治研究所)

Dates

Publication Date
20260512
Application Date
20260204

Claims (10)

  1. 1. The efficient and safe plant essential oil mosquito repellent is characterized by comprising a core essential oil component, a solvent and an emulsifier; The core essential oil component comprises peppermint essential oil, perilla essential oil and at least two of citronella essential oil, mugwort leaf essential oil, cinnamon essential oil and grassleaf sweelflag rhizome essential oil, and the total mass fraction of the core essential oil component is 0.5% -2.5% of the total mass of the repellent; The solvent is ethanol water solution, and the volume fraction of the ethanol in the water solution is 5% -20%; the mass fraction of the emulsifier is 0.1% -5% of the total mass of the composition.
  2. 2. The efficient and safe plant essential oil mosquito repellent according to claim 1, further comprising a synergistic component and a cooling and soothing component, wherein the synergistic component is at least one of vitamin E, tea polyphenol and rosemary extract, the mass fraction of the synergistic component is 0.05% -2% of the total mass of the composition, the cooling and soothing component is one of natural menthol and limonene, and the mass fraction of the cooling and soothing component is 0.1% -1% of the total mass of the composition.
  3. 3. The high-efficiency safe plant essential oil mosquito repellent according to claim 2, wherein when the core essential oil component comprises peppermint essential oil and perilla essential oil: the volume ratio of the mint essential oil to the perilla essential oil is 1:1, and the total volume of the mint essential oil and the perilla essential oil accounts for 20% -40% of the total volume of the core essential oil component.
  4. 4. The efficient and safe plant essential oil mosquito repellent according to claim 3, wherein the cinnamon essential oil is subjected to a de-stimulation treatment, wherein the de-stimulation treatment comprises the steps of mixing the cinnamon essential oil with anhydrous sodium sulfate, standing for 2 to 4 hours, and filtering to obtain the low-stimulation cinnamon essential oil.
  5. 5. The efficient and safe plant essential oil mosquito repellent according to claim 4, wherein the emulsifier is selected from at least one or more of PEG-40 hydrogenated castor oil, polyglycerol fatty acid ester, tween 80 and span 60.
  6. 6. The efficient and safe plant essential oil mosquito repellent according to claim 5, wherein when the emulsifier is a compound of PEG-40 hydrogenated castor oil and polyglycerin fatty acid ester, the mass ratio of the two is (1-3): 1.
  7. 7. A method for preparing the efficient and safe plant essential oil mosquito repellent according to any one of claims 2 to 6, which is characterized by comprising the following steps: firstly, weighing core essential oil components according to a proportion, and uniformly mixing to obtain mixed essential oil; step two, adding an ethanol water solution into the mixed essential oil, and stirring until the ethanol water solution is primarily dissolved; thirdly, adding an emulsifying agent, and stirring for 10-20min at 20-30 ℃ to obtain a premix; Fourthly, performing ultrasonic emulsification treatment on the premix, wherein the ultrasonic power is 100-300W, and the ultrasonic time is 5-15min, so as to obtain stable emulsion; step five, adding the synergistic component and the refreshing and soothing component after the ultrasonic emulsification in the step four, and stirring for 5-10min until the components are completely dispersed; and step six, regulating the pH value of the system to 5.5-7.0, and standing and degassing to obtain the mosquito repellent.
  8. 8. The method for preparing the efficient and safe plant essential oil mosquito repellent according to claim 7, wherein the repellent effect of the repellent prepared in the step six is verified by the following scheme: A. adopting an attractive blood sucking device, carrying two parallel blood sucking units on the device, covering a Parafilm artificial membrane on the surface of the units, and adding constant-temperature pig blood under the membrane to simulate human blood; B. 300 test mosquitoes are put into a testing cavity of the device, one side of the blood sucking unit is sprayed with 1-2 pumps of repellent, each pump is 0.1-0.2ml, the test set is used, and the other side of the test set is sprayed with 5% ethanol water solution with the same amount, and the test set is used as a blank set; C. starting timing from spraying, recording the stopping numbers of mosquitoes on the surfaces of the two groups of artificial films within 2 minutes at intervals of 0.5 hour, and continuously detecting for 3.5 hours; D. and drawing a repellent effect curve of the repellent by taking time as an abscissa and the stopping times as an ordinate.
  9. 9. The method for preparing the efficient and safe plant essential oil mosquito repellent according to claim 8, wherein the experimental mosquito in the step B is subjected to experimental screening of aggression, and the specific method is as follows: By adopting the attractive blood sucking device, the single blood sucking unit is not subjected to repellent treatment, the retention number of 300 test mosquitoes in 2min is more than or equal to 20, the blood sucking rate is more than or equal to 80%, namely the attractive force is qualified, and the unqualified test mosquitoes are forbidden to be used for repellent experiments.
  10. 10. The efficient and safe plant essential oil mosquito repellent and the preparation method thereof according to claim 7, wherein when the prepared repellent contains peppermint essential oil and perilla essential oil: In the second step, the volume fraction of ethanol in the ethanol water solution is limited to 5%, and the volume ratio of the mixed essential oil to the ethanol water solution is 1:19; in the third step, PEG-40 hydrogenated castor oil is selected as the emulsifier, the adding amount of the emulsifier is 1% -1.5% of the total mass of the composition, the stirring temperature is 25-28 ℃, and the stirring speed is 300-400r/min; In the fourth step, the ultrasonic emulsification power is 200-250W, the ultrasonic time is 8-12min, the temperature of the system is controlled to be not more than 30 ℃ through ice water bath in the ultrasonic process, and the particle size of the emulsion after ultrasonic treatment is 100-500nm.

Description

Efficient and safe plant essential oil mosquito repellent and preparation method thereof Technical Field The invention relates to the technical field of repellents, in particular to a high-efficiency safe plant essential oil mosquito repellent and a preparation method thereof. Background As widely distributed sanitary insect pests, mosquitoes can not only be used for biting and sucking blood to invade human and livestock and cause skin inflammation, but also be capable of spreading malaria, dengue fever, epidemic encephalitis B, lymphofilariasis and other various virulent infectious diseases, thus forming serious threat to human health, especially in tropical, subtropical areas and summer high-temperature and humid environments, the mosquito hazard is more prominent, and therefore, the development of efficient and safe mosquito repellent is an important requirement for guaranteeing public health safety and daily life quality of people. In the long-term fight of human and mosquito, chemical synthesis repellent (such as mosquito repellent amine, mosquito repellent ester and the like) has become a mainstream product due to quick acting property, but the safety of the chemical preparation is always controversial, the long-term or improper use of the chemical preparation can cause irritation to human skin and respiratory systems, especially the potential risks of infants and sensitive people are more obvious, meanwhile, the long-term single use of the chemical repellent is easy to cause the drug resistance of the mosquito, the prevention and control effect is reduced, and the chemical substance residues pollute the ecological environment such as soil, water body and the like, which is contrary to the development concept of green environmental protection. The modern research shows that the plant essential oil has the advantages of being green and environment-friendly, low in toxicity and residue, not easy to cause the mosquitoes to generate drug resistance and the like, becomes a research hot spot in the field of mosquito chemical prevention, so far, more than 500 plants with mosquito repelling and killing activities are found globally, the plants are concentrated in Labiatae, compositae, lauraceae and other families, the regions of China are wide, the climates are various, the plant essential oil has rich mosquito repelling plant resources, and sufficient raw material guarantee is provided for the development of the plant essential oil. However, the research and the application of the mosquito repellent with plant essential oil still have a plurality of urgent problems to be solved, namely, firstly, part of the high-activity essential oil has stability defects, such as the cinnamon essential oil is easy to delaminate in an aqueous solution to influence the use effect of a product, secondly, part of the essential oil has skin irritation to limit the application of the cinnamon essential oil in sensitive people, thirdly, the existing compound formula is mainly simply mixed, and the system optimization of component proportion and synergistic mechanism is not needed, so that the long-acting property of the repellent is insufficient, and the pertinence and the application range of the product are influenced. Disclosure of Invention The invention aims to solve the problems in the prior art, and provides a high-efficiency safe plant essential oil mosquito repellent and a preparation method thereof. In order to achieve the above purpose, the present invention adopts the following technical scheme: A high-efficiency safe plant essential oil mosquito repellent comprises a core essential oil component, a solvent and an emulsifier; The core essential oil component comprises peppermint essential oil, perilla essential oil and at least two of citronella essential oil, mugwort leaf essential oil, cinnamon essential oil and grassleaf sweelflag rhizome essential oil, and the total mass fraction of the core essential oil component is 0.5% -2.5% of the total mass of the repellent; The solvent is ethanol water solution, and the volume fraction of the ethanol in the water solution is 5% -20%; the mass fraction of the emulsifier is 0.1% -5% of the total mass of the composition. Preferably, the composition further comprises a synergistic component and a cooling and soothing component, wherein the synergistic component is at least one of vitamin E, tea polyphenol and rosemary extract, the mass fraction of the synergistic component is 0.05% -2% of the total mass of the composition, the cooling and soothing component is one of natural menthol and limonene, and the mass fraction of the cooling and soothing component is 0.1% -1% of the total mass of the composition. Further, when the core essential oil component includes peppermint essential oil and perilla essential oil: the volume ratio of the mint essential oil to the perilla essential oil is 1:1, and the total volume of the mint essential oil and the perilla essential oil accounts for