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CN-122004355-A - Application of neoagaro-oligosaccharide in preparing canine food with efficacy of improving immunity and intestinal flora of working dogs

CN122004355ACN 122004355 ACN122004355 ACN 122004355ACN-122004355-A

Abstract

The invention discloses an application of neoagaro-oligosaccharide in preparing canine food with the effects of improving the immunity of working dogs and improving intestinal flora, belonging to the technical field of specific therapeutic activity of compounds. The invention also discloses a canine food with the effects of improving the immunity of working dogs and improving intestinal flora, which comprises the neoagalloch oligosaccharide and basic canine food, wherein the addition amount of the neoagalloch oligosaccharide is 0.05% -0.5%. According to the invention, the neoagalloch oligosaccharide is added into the food for dogs, and the functional activity of the neoagalloch oligosaccharide is verified through blood routine, immune index and detection analysis of intestinal flora, so that researches show that the neoagalloch oligosaccharide can improve the hematopoietic capacity of bone marrow of dogs, remarkably increase the contents of organisms IgA, igM, IL-2 and IL-6, strengthen the immunity of the organisms of dogs, improve the intestinal microbial flora structure of dogs, form special microbial abundance, inhibit the growth of harmful flora and increase the abundance of beneficial flora.

Inventors

  • MAO XIANGCHAO
  • BI WANGHUA
  • XU YAFEI
  • HUANG PENG
  • JIANG HONG
  • YANG WENZHE

Assignees

  • 中国海洋大学
  • 青岛海润深蓝生物科技有限公司

Dates

Publication Date
20260512
Application Date
20260212

Claims (8)

  1. 1. The application of the neoagalloch in preparing the dog food with the efficacy of improving the immunity of working dogs and improving intestinal flora.
  2. 2. The method of claim 1, wherein the working dog is a Sabina.
  3. 3. The use according to claim 1, wherein the immunity improvement is embodied by an increase in reticulocyte count, an increase in the percentage of high fluorescence intensity reticulocytes, and an increase in the average platelet volume.
  4. 4. The use according to claim 1, characterized in that the improvement of intestinal flora is embodied by inhibiting the growth of clostridium difficile (Peptoclostridium), prevotella (Prevotellaceae _ga6a1) and megamonas (Megamonas) flora, and by significantly increasing the abundance of the spirochete (Oscillospira), rochanteria (Roseburia), erwinia (Erwinia), sphingomonas (candidatus stoquefichus), bifidobacterium (bifidobactirium) and prevotella (Prevotellaceae UCG 001) flora.
  5. 5. The application of claim 1, wherein the neoagalloch oligosaccharide is added into the basic canine food in a weight percentage of 0.05% -0.5%.
  6. 6. The method according to claim 5, wherein the neoagalloch oligosaccharide is added in an amount of 0.05% or 0.5%.
  7. 7. The canine food with the effects of improving the immunity of working dogs and improving intestinal flora is characterized by comprising neoagalloch oligosaccharides and basic canine food, wherein the adding amount of the neoagalloch oligosaccharides is 0.05% -0.5% by weight.
  8. 8. The canine food with the efficacy of improving the immunity and the intestinal flora of working dogs according to claim 7, wherein the food consists of neoagalloch and basic canine food, and the addition amount of the neoagalloch is 0.05% or 0.5%.

Description

Application of neoagaro-oligosaccharide in preparing canine food with efficacy of improving immunity and intestinal flora of working dogs Technical Field The invention relates to an application of neoagaro-oligosaccharide in preparing canine food with the effects of improving the immunity of working dogs and improving intestinal flora, belonging to the technical field of specific therapeutic activity of compounds. Background The neoagaropectin (neoagarooligo saccharides) is an oligosaccharide with the polymerization degree of 2-10, which is generated by hydrolyzing agaropectin by beta-agarase, and has the structure that beta-D-galactose and 3, 6-endo-alpha-L-galactose are connected by disaccharide repeating units of beta-1, 3 glycosidic bond, has the characteristics of good water solubility and easy absorption, and can be used as a filling agent of high-sweetness sweetener and a dispersing agent in low-calorie foods such as beverages, bread and the like. The working dogs are specially trained dogs in the public security system, and the quality of feed consumed by the working dogs not only directly influences the growth, development, propagation and health of the working dogs, but also relates to the self safety of the working dogs, so that the feeding level and the dog food quality are decisive factors for influencing the health of the working dogs. Shi Binge dogs are one of the common working dogs, and have medium body shape and exogenously arranged character, so that the dogs are very loyal to people and can participate in a plurality of works through training. Improving the physical performance of the binge dogs through the study on the dog food formula is the key point of common study of police officers and scientific researchers. Reticulocyte count (RET), high fluorescence intensity reticulocyte percentage (HFR), average platelet volume (MPV) are important indicators for assessing bone marrow erythrocyte hematopoietic function and the cellular status of blood, wherein RET reflects the number of immature erythrocytes in bone marrow, is a direct indicator for assessing bone marrow erythrocyte hematopoietic function, the level of which can reflect bone marrow erythrocyte hematopoietic ability, HFR is one of the subset of reticulocytes, representing the highest reticulocyte fraction of the youngest immature degree, which can reflect the rate of bone marrow hematopoietic, and MPV reflects the average volume size of individual platelets in peripheral blood, which is related to platelet production, maturation and function, the level of which can reflect platelet renewal and platelet production or maturation. Intestinal flora plays an important role in the physical health and diseases of dogs, can participate in important physiological metabolic processes of hosts, and the abundance of the intestinal flora can reflect the health or physical health condition of the gastrointestinal tract, is also one of important reference indexes for the pathogenesis of certain diseases, and has important clinical significance. Disclosure of Invention The invention provides an application of neoagalloch oligosaccharide in preparing canine food with the effects of improving the immunity of working dogs and improving intestinal flora, and belongs to the technical field of specific therapeutic activity of compounds. The invention is realized by the following technical scheme: The application of the neoagalloch in preparing the dog food with the efficacy of improving the immunity of working dogs and improving intestinal flora. Further, the breed of working dogs is a sping dog. Further, the immunity enhancement is embodied by an increase in reticulocyte count, an increase in the percentage of high fluorescence intensity reticulocytes, and an increase in the average platelet volume. Further, the intestinal flora improvement is specifically characterized by inhibiting the growth of harmful flora such as clostridium difficile (Peptoclostridium), prevotella (Prevotellaceae _Ga6A1) and megamonas (Megamonas), and remarkably increasing the abundance of beneficial flora such as Oscilla (Oscillospira), rosibutia (Roseburia), erwinia (Erwinia), sphingomonas (candidatus stoquefichus), bifidobacterium (Bifidobacterium) and Prevotella (Prevotellaceae _UCG001). Further, in specific application, the neoagalloch oligosaccharide is added into the basic dog food, wherein the addition amount of the neoagalloch oligosaccharide is 0.05% -0.5% by weight. The canine food with the effects of improving the immunity of working dogs and improving intestinal flora comprises neoagalloch and basic canine food, wherein the adding amount of the neoagalloch is 0.05% -0.5%, and the neoagalloch is calculated according to weight percentage. The basic dog food can be purchased conventionally and comprises chicken, beef bone meal, sweet potato powder, pea powder, fermented soybean meal, chicken oil, soybean oil, fish meal, yucca, astragalus mongholicus, honey-fried lic