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CN-122004467-A - Composite formula for reducing fat and resisting sugar and preparation method thereof

CN122004467ACN 122004467 ACN122004467 ACN 122004467ACN-122004467-A

Abstract

The invention discloses a compound formula for reducing fat and resisting sugar and a preparation method thereof, and relates to the technical field of health-care foods. The invention mainly comprises the following raw materials, by weight, 60-75 parts of resistant dextrin, 10-20 parts of beta-glucan, 8-15 parts of mulberry leaf extract, 1.5-4 parts of kudzuvine root extract and 1-3 parts of lotus leaf extract. The invention has remarkable inhibition activity to alpha-glucosidase and pancrelipase through the synergistic effect of various dietary fibers and plant active ingredients, and is beneficial to supplementing the dietary fibers and inhibiting the activity of related enzymes, thereby assisting in maintaining healthy blood sugar and blood fat levels.

Inventors

  • LIU YAN
  • LI JIARONG
  • ZHANG JIEYI
  • CHEN YONGHUI
  • ZHANG JUANPING
  • HUANG MENG
  • ZHOU RANG

Assignees

  • 成都市中西医结合医院(成都市第一人民医院、成都市中医医院)

Dates

Publication Date
20260512
Application Date
20260410

Claims (10)

  1. 1. The compound formula for reducing fat and resisting sugar is characterized by mainly comprising the following raw materials in parts by weight: 60-75 parts of resistant dextrin, 10-20 parts of beta-glucan, 8-15 parts of mulberry leaf extract, 1.5-4 parts of kudzuvine root extract and 1-3 parts of lotus leaf extract.
  2. 2. The complex formulation for aiding in the reduction of fat and sugar according to claim 1, wherein the product form of the complex formulation is a solid beverage, a granule or a powder.
  3. 3. The complex formulation for aiding in the reduction of fat and sugar according to claim 1, wherein the mulberry leaf extract is prepared by the following method: a) Pulverizing dry folium Mori to 20-40 mesh, extracting with acidic water solution with pH value of 4.0-5.0 as solvent at 40-55deg.C and ultrasonic power of 300-500W and ultrasonic power of 30-50 min for 2 times according to feed-liquid ratio of 1 (10-15) g/mL; b) Mixing the extractive solutions, filtering, loading the filtrate onto pretreated D101 macroporous adsorbent resin column, eluting with 3-5 times of deionized water, eluting with 4-6 times of 20-40% ethanol water solution, and collecting ethanol eluate; c) Concentrating the collected ethanol eluent to obtain extract with relative density of 1.10-1.20 under the conditions that the temperature is less than or equal to 60 ℃ and the vacuum degree is more than or equal to-0.08 MPa, and then spray drying, wherein the air inlet temperature is 160-180 ℃ and the air outlet temperature is 80-90 ℃ to obtain mulberry leaf extract powder.
  4. 4. A method for preparing a complex formulation for aiding in the reduction of fat and sugar according to any one of claims 1 to 3, comprising the steps of: s1, raw material pretreatment and microencapsulation: mixing mulberry leaf extract, kudzuvine root extract and lotus leaf extract with embedding medium according to the weight ratio of (0.5-1): 1, wherein the embedding medium is a mixture of maltodextrin and Arabic gum according to the weight ratio of (2-4): 1, treating the mixture by a colloid mill until the particle size is less than or equal to 5 mu m, preparing microencapsulated plant extract powder by a spray drying technology, wherein the embedding rate of the microencapsulated plant extract powder on active ingredients is more than or equal to 90%; Simultaneously, the resistant dextrin and the beta-glucan are dried respectively under the environment that the temperature is less than or equal to 25 ℃ and the relative humidity is less than or equal to 35% until the moisture content is less than or equal to 4%; S2, sectional temperature control and atmosphere protection mixing: The first stage of mixing, namely putting all the dried resistant dextrin and beta-glucan into a three-dimensional motion mixer, sealing, vacuumizing to-0.095 to-0.08 MPa, keeping 5-10 min, then charging nitrogen to normal pressure, and mixing 15-30 min under inert atmosphere to obtain basic mixed powder; The second stage of mixing, namely maintaining the equipment to be airtight, adding all the microencapsulated kudzuvine root extract powder, the microencapsulated lotus leaf extract powder and 40 percent of the total weight of the microencapsulated mulberry leaf extract powder prepared in the step S1 into the basic mixed powder, and mixing 20-40 min by controlling the jacket water temperature of a mixer at 10-20 ℃ to obtain a primary mixture; A third mixing step, in which the equipment is kept closed and is bathed in low temperature water, and the microencapsulated mulberry leaf extract powder accounting for 60 percent of the total weight is added into the primary mixture to be mixed with 25 to 50min to obtain a final mixture; S3, low-temperature curing and split charging: Transferring the final mixture to a constant temperature and humidity box filled with nitrogen under the protection of the nitrogen, curing at 20-25 ℃ and 30-40% relative humidity for 1.5-3.5 h, intermittently turning for 1-2 min every 30-45 min during curing, and subpackaging, wherein the moisture content of the finished product is less than or equal to 3.5%.
  5. 5. The method according to claim 4, wherein the microencapsulated plant extract powder prepared in step S1 has a particle size of 50 to 200. Mu.m.
  6. 6. The method according to claim 4, wherein the step S2 between the first stage mixing and the second stage mixing further comprises a step of sieving the basic mixed powder with a 60 mesh sieve to obtain particles, and the particles after the particles are crushed to a particle size of 150 μm or less are returned to the mixing apparatus.
  7. 7. The method according to claim 4, wherein in the second-stage mixing and the third-stage mixing in step S2, the real-time temperature of the materials in the mixing chamber is monitored by a temperature sensor, and the jacket water temperature is feedback-controlled, so that the material temperature is always not higher than 28 ℃.
  8. 8. The method according to claim 4, wherein in step S1, the resistant dextrin and the beta-glucan with bulk densities of 0.45-0.65 g/cm 3 are selected, and the resistant dextrin and the beta-glucan are dried to a moisture content of 4% or less in an environment with a temperature of 25 ℃ or less and a relative humidity of 35% or less, respectively.
  9. 9. The method according to claim 8, wherein in step S1, the spray drying process parameters are that the inlet air temperature is 165-175 ℃, the outlet air temperature is 85-90 ℃ and the feeding rate is 15-25 mL/min, and the bulk density of the prepared plant extract powder is 0.55-0.65 g/cm 3 .
  10. 10. The preparation method according to claim 9, wherein in step S1, the first microencapsulated mulberry leaf extract powder having a bulk density of 0.55-0.65 g/cm 3 and the second microencapsulated mulberry leaf extract powder having a bulk density of 0.50-0.58 g/cm 3 are prepared by controlling the process parameters of spray drying, respectively, the first microencapsulated mulberry leaf extract powder being used for the second stage mixing of step S2 and the second microencapsulated mulberry leaf extract powder being used for the third stage mixing of step S2.

Description

Composite formula for reducing fat and resisting sugar and preparation method thereof Technical Field The invention relates to the technical field of health-care food. More particularly, the invention relates to a compound formula for reducing fat and resisting sugar and a preparation method thereof. Background With the rise of healthy diet demand, foods rich in dietary fiber and natural plant extracts are receiving a great deal of attention. The common products mostly adopt single dietary fiber components (such as resistant dextrin) or certain plant extracts (such as mulberry leaf extracts) as main raw materials. The resistant dextrin and the beta-glucan are used as soluble dietary fibers, have the functions of supplementing the dietary fibers and inhibiting fat and saccharide absorption to a certain extent. The mulberry leaf extract belongs to the traditional medicinal and edible raw materials and is commonly used for assisting in maintaining blood sugar health, and the kudzuvine root extract and the lotus leaf extract are also considered to have a certain inhibition effect on sugar and fat absorption. However, existing such products have focused on simple compounding of a single or small number of ingredients. Because the physical characteristics (such as hygroscopicity, bulk density and particle size) of different raw materials are obviously different, the conventional physical mixing process is easy to cause uneven mixing of products, and the component content of the products in different batches and even the same batch can be fluctuated, so that the accuracy of the edible dosage is affected. In addition, some plant active ingredients are sensitive to processing environments (e.g., oxygen, temperature) and may exhibit reduced activity during ordinary mixing and storage, which makes long-term stability of the product and consistency of the desired effect challenging. How to keep the auxiliary functions of the raw materials as much as possible while ensuring the uniformity and physical stability of the product through a reasonable formula and a stable preparation process is a problem to be solved in actual production. Disclosure of Invention The invention provides a compound formula which is beneficial to reducing fat and resisting sugar, has remarkable inhibition activity on alpha-glucosidase and pancreatic lipase through the synergistic effect of various dietary fibers and plant active ingredients, and is beneficial to supplementing the dietary fibers and inhibiting related enzyme activities, thereby assisting in maintaining healthy blood sugar and blood fat levels. The invention provides a preparation method of a compound formula for reducing fat and resisting sugar, which solves the technical problems of easy inactivation, poor physical stability, uneven mixing and the like of active ingredients of the existing product by carrying out targeted microencapsulation on plant extracts and combining with the refining processes of whole-course inert atmosphere protection, low-temperature mixing, gradient bulk density addition and the like. To achieve these objects and other advantages and in accordance with the purpose of the invention, there is provided a complex formulation for reducing fat and resisting sugar, comprising mainly the following raw materials in parts by weight: 60-75 parts of resistant dextrin, 10-20 parts of beta-glucan, 8-15 parts of mulberry leaf extract, 1.5-4 parts of kudzuvine root extract and 1-3 parts of lotus leaf extract. Preferably, the product form of the composite formulation is a solid beverage, a granule or a powder. Preferably, the mulberry leaf extract is prepared by the following method: a) Pulverizing dry folium Mori to 20-40 mesh, extracting with acidic water solution with pH value of 4.0-5.0 as solvent at 40-55deg.C and ultrasonic power of 300-500W and ultrasonic power of 30-50 min for 2 times according to feed-liquid ratio of 1 (10-15) g/mL; b) Mixing the extractive solutions, filtering, loading the filtrate onto pretreated D101 macroporous adsorbent resin column, eluting with 3-5 times of deionized water, eluting with 4-6 times of 20-40% ethanol water solution, and collecting ethanol eluate; c) Concentrating the collected ethanol eluent to obtain extract with relative density of 1.10-1.20 under the conditions that the temperature is less than or equal to 60 ℃ and the vacuum degree is more than or equal to-0.08 MPa, and then spray drying, wherein the air inlet temperature is 160-180 ℃ and the air outlet temperature is 80-90 ℃ to obtain mulberry leaf extract powder. The preparation method of the compound formula for reducing fat and resisting sugar comprises the following steps: s1, raw material pretreatment and microencapsulation: mixing mulberry leaf extract, kudzuvine root extract and lotus leaf extract with embedding medium according to the weight ratio of (0.5-1): 1, wherein the embedding medium is a mixture of maltodextrin and Arabic gum according to the weight ra