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CN-122004470-A - Double-target-point nerve conduction supporting nutritional composition and preparation method thereof

CN122004470ACN 122004470 ACN122004470 ACN 122004470ACN-122004470-A

Abstract

The invention discloses a nutritional composition for supporting nerve conduction through double targets and a preparation method thereof, and belongs to the technical field of nutritional products. The composition is prepared from shinyleaf yellowhorn oil nervonic acid and L-magnesium threonate serving as dual-core targets by compounding DHA algae oil, phosphatidylserine, EGCG and B vitamins, so that a 'myelin sheath repair + signal conduction acceleration' dual-target synergistic system is formed, and meanwhile, membrane structure maintenance, antioxidation, anti-inflammatory and neurotransmitter synthesis support are realized, nerve conduction efficiency is systematically improved, and instruction-execution delay is shortened. The problem of uneven mixing and agglomeration of liquid oil and powder is solved by microencapsulation, and the process is mature, the safety is high and the stability is good. Animal experiments show that the composition can shorten the time of simple reaction by 30.5% (p < 0.01), shorten the time of selective reaction by 29.9% (p < 0.01), has unobvious and unexpected technical effects, and is suitable for long-term nutrition supplement of middle-aged and elderly people and people in the convalescence period of cerebral apoplexy.

Inventors

  • CHEN GANG
  • Wei Zheyan

Assignees

  • 河北雄安福赛生态科技有限公司

Dates

Publication Date
20260512
Application Date
20260409

Claims (10)

  1. 1. The nutritional composition for supporting nerve conduction by double targets is characterized by comprising, by mass, 200-600 parts of shinyleaf yellowhorn oil (containing nervonic acid), 100-400 parts of L-magnesium threonate, 50-200 parts of DHA algae oil, 20-150 parts of phosphatidylserine, 20-100 parts of EGCG and 10-80 parts of vitamin B mixture.
  2. 2. The nutritional composition according to claim 1, wherein the vitamin B group mixture comprises vitamin B1, vitamin B6 and vitamin B12 in a mass ratio of (5-15): 0.01-0.1.
  3. 3. The nutritional composition according to claim 1, wherein the content of nervonic acid in the shinyleaf yellowhorn oil is not less than 2%.
  4. 4. Nutritional composition according to claim 1, characterized in that the DHA content of the DHA algae oil is not less than 20%.
  5. 5. The nutritional composition according to claim 1, wherein the phosphatidylserine is of a purity of 50% or more.
  6. 6. The nutritional composition according to claim 1, wherein the components are used in an amount of 400 parts by mass of shinyleaf yellowhorn oil, 200 parts by mass of magnesium L-threonate, 100 parts by mass of DHA algae oil, 50 parts by mass of phosphatidylserine, 50 parts by mass of EGCG and 30 parts by mass of vitamin B group mixture.
  7. 7. A method of preparing the dual-target nerve conduction supporting nutritional composition of any one of claims 1-6, comprising the steps of: (1) Microencapsulating xanthoceras sorbifolia bunge oil by spray drying to obtain microcapsule powder; (2) Microencapsulating the mixture of the L-magnesium threonate, the EGCG and the vitamin B, wherein DHA algae oil and phosphatidylserine adopt microencapsulated powder; (3) Uniformly mixing all the powders; (4) Filling into hard capsules.
  8. 8. The preparation method of the dry powder coating is characterized in that the process of the step (1) comprises the steps of wall material gelatin, sucrose=1:5, solid content 20%, core material load 35%, dispersion at 10000-15000 rpm for 5-10 min, homogenization at 20-40 MPa for 2-3 times, spray drying at inlet air temperature of 170-180 ℃ and outlet air temperature of 75-85 ℃.
  9. 9. The method according to claim 7, wherein the three-dimensional motion mixer is adopted in the step (3) to mix for 20-30min at 15-20 rpm, the ambient temperature is less than or equal to 25 ℃, and the relative humidity is less than or equal to 45%.
  10. 10. The method according to claim 7, wherein the HPMC plant capsules are used in the step (4), and the weight of each content is 400-800 mg.

Description

Double-target-point nerve conduction supporting nutritional composition and preparation method thereof Technical Field The invention belongs to the technical field of nutritional products, and particularly relates to a nutritional composition for supporting nerve conduction through double targets and a preparation method thereof. Background The nerve conduction velocity reduction is mainly caused by three aspects, namely, signal jump conduction is blocked due to myelin sheath degradation, and the efficiency of signal proteins such as G protein coupled receptors is reduced to cause transduction delay, oxidative stress and nerve inflammation to accelerate nerve aging. Clinically, the method is characterized by reduced reaction speed, delayed instruction-execution and reduced limb coordination, and seriously affects independent life ability. Cerebral apoplexy is the main cause of serious nerve conduction damage, 70% -80% of survivors leave limb movement dysfunction, the core mechanism is nerve conduction channel damage such as cortex spinal cord bundles and the like, and brain instructions cannot be transmitted to muscles efficiently. Currently there is a clinical lack of specialized oral nutritional support protocols for nerve conduction repair. Nervonic acid (C24:1) is used as a myelin marker structural component, can up-regulate myelin basic protein MBP expression, promote nerve fiber repair, and improve limb functions after cerebral ischemia. The L-threonic acid magnesium can break through the blood brain barrier to improve the brain magnesium level, improve the NMDA receptor function and synaptic plasticity, obviously shorten the reaction time and improve the coordination ability of movement. Phosphatidylserine (PS) and DHA algae oil have a synergistic effect of a membrane structure, DHA provides a structural basis, and PS improves signal transmission efficiency. EGCG can scavenge free radicals, inhibit neuroinflammation, and protect mitochondria. B vitamins are involved in neurotransmitter synthesis and are important cofactors for nerve conduction. The shinyleaf yellowhorn oil is in a liquid state, and is directly mixed with the powder components, so that the problems of uneven, caking, incapability of filling and the like are easily caused, and the shinyleaf yellowhorn oil needs to be subjected to microencapsulation treatment. The prior shinyleaf yellowhorn oil microcapsule technology has been reported, but the prior nervonic acid related composition has single action target point for improving focus memory and cognition, and does not have any prior art disclosure or suggestion of combining nervonic acid and L-magnesium threonate to form a double-target cooperative mode and is applied to the specific technical problem of improving instruction-execution delay. Although the literature relates to complex formulations of nervonic acid and magnesium, the addition of PQQ, NMN, SOD and other active ingredients is essentially different from the six-component system of the invention, and no systematic functional design is made for nerve conduction efficiency and instruction-execution delay. Therefore, the prior art lacks a nutritional composition which has double-target synergism, multi-dimensional support and can obviously improve nerve conduction speed, and the development of the product has important practical significance. Disclosure of Invention Aiming at the defects of single target point, lack of double-target point systematic nerve conduction support, difficult liquid-solid raw material mixing process and the like of the nutritional composition in the prior art, the invention provides the nutritional composition which has double-target point synergy and can obviously improve instruction-execution delay, and simultaneously provides a preparation method which has stable process and is suitable for industrial production. The application provides a nutritional composition for supporting nerve conduction by double targets, which comprises the following components in parts by mass: 200-600 parts of shinyleaf yellowhorn oil (containing nervonic acid) 100-400 Parts of L-threonic acid magnesium 50-200 Parts of DHA algae oil 20-150 Parts of phosphatidylserine 20-100 Parts of EGCG 10-80 Parts of vitamin B group mixture Wherein the mass ratio of vitamin B1, vitamin B6 and vitamin B12 is (5-15): (0.01-0.1). The mass part of the invention is the mass proportion relation among the active ingredients, does not contain auxiliary materials such as microcapsule wall materials and the like, and can enlarge or reduce the feeding amount in proportion in production. Preferably, the content of nervonic acid in the shinyleaf yellowhorn oil is more than or equal to 2%, the content of DHA in the DHA algae oil is more than or equal to 20%, and the purity of phosphatidylserine is more than or equal to 50%. Further preferably, the amounts of the components are as follows in parts by mass: 300-500 parts of shinyleaf yellowhorn oil 150