CN-122004472-A - Application of bacillus coagulans JA845 in preparation of health care products or foods for assisting in reducing blood pressure

Abstract

The invention provides application of bacillus coagulans JA845 in preparation of health-care products or foods for assisting in reducing blood pressure, and belongs to the technical field of health-care products. The bacillus coagulans JA845 has unique physiological activity, the invention discovers and proves that the bacillus coagulans JA845 has the effect of assisting in reducing blood pressure for the first time, fills up the application blank of the bacillus coagulans in the field of hypertension assisting treatment, has uniqueness in the action mode of improving the vascular function by taking antioxidation as a core mechanism, and provides a new microbial preparation selection for assisting treatment of hypertension.

Inventors

• ZHAO ZIJIAN
• LI SHENGYU
• LI SHENGNAN
• ZHAO YUJUAN
• KANG YOU
• GAO YANSONG
• YANG GE
• GAO LEI

Assignees

• 吉林省农业科学院(中国农业科技东北创新中心)

Dates

Publication Date

20260512

Application Date

20260120

Claims (7)

1. 1. The application of the bacillus coagulans JA845 in preparing the health care product for assisting in reducing blood pressure is characterized in that the effective viable count of the bacillus coagulans JA845 is 1 multiplied by 10 8 -1×10 10 CFU/mL.
2. 2. The use according to claim 1, wherein the effective viable count of bacillus coagulans JA845 is 1 x 10 9 CFU/mL.
3. 3. The use according to claim 1, wherein the formulation of the health product comprises one of a tablet, a capsule, a paste, a granule, a powder, an oral solution, a soft drink, and a beverage.
4. 4. Application of bacillus coagulans JA845 in preparing food for assisting in reducing blood pressure.
5. 5. The use according to claim 4, wherein the effective viable count of bacillus coagulans JA845 is 1 x 10 8 -1×10 10 CFU/mL.
6. 6. The use according to claim 5, wherein the effective viable count of bacillus coagulans JA845 is 1 x 10 9 CFU/mL.
7. 7. The use according to claim 4, wherein the food product is in a dosage form comprising one of a tablet, a capsule, a paste, a granule, a powder, an oral solution, a soft candy product and a beverage.

Description

Application of bacillus coagulans JA845 in preparation of health care products or foods for assisting in reducing blood pressure Technical Field The invention relates to the technical field of health products, in particular to application of bacillus coagulans JA845 in preparation of health products or foods for assisting in reducing blood pressure. Background Hypertension is a chronic disease characterized by continuously increasing arterial blood pressure, is the most important risk factor for cardiovascular and cerebrovascular diseases, can cause serious complications such as cerebral apoplexy, myocardial infarction, heart failure, chronic kidney diseases and the like, and forms a great threat to human health. Along with the change of life style and the aging of population, the incidence of hypertension is in an increasing trend year by year, so that the development of safe, effective and definite-mechanism-of-action hypertension prevention and treatment means has important clinical significance and social value. As a class of active microorganisms beneficial to host health, probiotics have been widely demonstrated in terms of regulating intestinal flora balance, improving metabolic diseases, and the like. In recent years, the potential of probiotics in cardiovascular disease prevention and treatment is gradually explored, and partial lactobacillus and bifidobacterium are reported to have certain blood pressure reducing effect, and the mechanism of the probiotics is mainly related to the regulation of intestinal flora, the inhibition of angiotensin converting enzyme activity and the like. However, the physiological functions of different probiotic strains are highly specific, and the mechanism of action and efficacy differences between strains are significant, not all probiotics have hypotensive activity. Bacillus coagulans is a facultative anaerobic gram-positive bacterium, has the characteristics of gastric acid resistance and bile resistance, has strong field planting capacity in intestinal tracts, can produce beneficial metabolites such as lactic acid, antibacterial peptide and the like, and has wide application in the aspects of improving intestinal functions, enhancing immunity and the like. However, there is no report on the use of Bacillus coagulans strains with unique antioxidant activity for the adjuvant treatment of hypertension. Disclosure of Invention The invention aims to provide application of bacillus coagulans JA845 in preparing health care products or foods for assisting in reducing blood pressure, and the strain takes antioxidation as a core mechanism, so that the application blank of bacillus coagulans in the field of hypertension assisting treatment is filled. In order to achieve the above object, the present invention provides the following technical solutions: The invention provides application of bacillus coagulans JA845 in preparing a health care product for assisting in reducing blood pressure, wherein the effective viable count of the bacillus coagulans JA845 is 1 multiplied by 10 8-1×1010 CFU/mL. Preferably, the effective viable count of the bacillus coagulans JA845 is 1X 10 9 CFU/mL. Preferably, the formulation of the health product comprises one of a tablet, a capsule, a paste, a granule, a powder, an oral solution, a soft candy product and a beverage. The invention also provides application of bacillus coagulans JA845 in preparing food for assisting in reducing blood pressure. Preferably, the effective viable count of the bacillus coagulans JA845 is 1X 10 8-1×1010 CFU/mL. Further preferably, the effective viable count of the Bacillus coagulans JA845 is 1X 10 9 CFU/mL. Preferably, the dosage form of the food comprises one of a tablet, a capsule, a paste, a granule, a powder, an oral solution, a soft candy product, and a beverage. Compared with the prior art, the invention has the beneficial effects that: (1) The invention fills up the technical blank that bacillus coagulans JA845 has the effect of assisting in reducing blood pressure for the first time, fills up the related technical blank that bacillus coagulans is not applied to the field of assisting in treating hypertension in the prior art, provides a brand new thought and method for assisting in treating hypertension, and provides a new direction for the study of assisting in reducing blood pressure by probiotics. (2) The bacillus coagulans JA845 is a human-body-tolerant probiotic, has the advantages of gastric acid resistance, bile resistance, strong field planting capacity and the like, has no obvious adverse reaction after being taken, is suitable for long-term taking, and is particularly suitable for the adjuvant therapy of patients with hypertension and mild patients. (3) The method has wide application prospect, can be used for preparing health care products and foods for assisting in reducing blood pressure, can meet the requirements of different crowds, and has remarkable application value and market potential.