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CN-122004475-A - Nanometer suspension containing vitamin and mineral substances and preparation method thereof

CN122004475ACN 122004475 ACN122004475 ACN 122004475ACN-122004475-A

Abstract

The invention provides a vitamin mineral nano suspension, which is prepared from the following raw materials, by weight, 10-50 parts of a nutrient supplement, 0.1-2 parts of a thickener, 1-6 parts of an emulsifier, 0.1-5 parts of a charge stabilizer and the balance of water, wherein the charge stabilizer comprises at least one of tremella polysaccharide, zymosan and chondroitin sulfate sodium by high-speed shearing and high-pressure homogenization. The vitamin mineral nano suspension provided by the invention can obviously reduce the particle size of insoluble mineral components in the suspension through high-pressure homogenization, obviously improve the aggregation phenomenon of mineral particles after high-pressure homogenization treatment, improve the dispersion uniformity of the mineral particles, improve the palatability and simultaneously enhance the stability of products. After the polysaccharide raw material is introduced, the aggregation phenomenon of the suspension after high-pressure homogenization can be further improved. In addition, the nano suspension nutrient has high stability by detecting the content change of the contrast vitamin and the mineral.

Inventors

  • ZHANG YAN
  • LIU ZUHAO
  • XIAO MINGHUA
  • ZHANG XIAOLI
  • CHEN ZHIXIAN
  • CHENG QIAN
  • TAN RONGXIN

Assignees

  • 安琪酵母股份有限公司
  • 安琪纽特股份有限公司

Dates

Publication Date
20260512
Application Date
20260407

Claims (10)

  1. 1. The vitamin mineral nanosuspension is characterized in that the vitamin mineral nanosuspension is prepared from the following raw materials in parts by weight by high-speed shearing and high-pressure homogenization: 10-50 parts of nutrient supplement, 0.1-2 parts of thickener, 1-6 parts of emulsifier, 0.1-5 parts of charge stabilizer and the balance of water; The charge stabilizer comprises at least one of tremella polysaccharide, yeast polysaccharide and chondroitin sulfate sodium.
  2. 2. The vitamin mineral nanosuspension according to claim 1, wherein the nutrient supplement comprises one or more than two of vitamin a, vitamin B, vitamin C, vitamin D, vitamin E, vitamin K, calcium salt, magnesium salt, zinc salt, iron salt, selenium enriched yeast.
  3. 3. The vitamin mineral nanosuspension according to claim 1, wherein the thickening agent comprises at least one of xanthan gum, carrageenan, pectin, guar gum, locust bean gum, sodium carboxymethyl cellulose.
  4. 4. The vitamin mineral nanosuspension according to claim 1, wherein the emulsifier comprises at least one of acacia, mono-, di-glycerol fatty acid ester, phospholipid, succinic acid monoglyceride, sucrose fatty acid ester.
  5. 5. The vitamin mineral nanosuspension according to claim 1, further comprising an acidity regulator; The acidity regulator comprises at least one of citric acid, DL-malic acid, fumaric acid, sodium citrate, potassium citrate, lactic acid and sodium bicarbonate; the nano-suspension comprises 0.1-3 parts of acidity regulator by 100 parts by weight.
  6. 6. The vitamin mineral nanosuspension according to claim 1, further comprising a sweetener; The sweetener is at least one selected from sorbitol, sorbitol solution, xylitol, erythritol, maltitol solution, isomalt, isomaltulose, mannitol, sucrose, trehalose, glucose, mogroside, sucralose, stevioside; 5-20 parts of sweetener are included based on 100 parts by weight of the nanosuspension.
  7. 7. The vitamin mineral nanosuspension according to claim 1, further comprising a prebiotic; the prebiotics are selected from at least one of fructo-oligosaccharide, galacto-oligosaccharide, inulin, resistant dextrin, polydextrose and isomalto-oligosaccharide; The probiotic is included in an amount of 2-20 parts by weight based on 100 parts by weight of the nanosuspension.
  8. 8. The vitamin mineral nanosuspension according to claim 1, further comprising a further synergistic ingredient selected from at least one of yeast beta-glucan, glucosamine, zinc-enriched edible yeast powder, yeast extract, glutathione yeast powder; The nanometer suspension comprises 0.1-10 parts of other synergistic components based on 100 parts by weight of the nanometer suspension.
  9. 9. A method for preparing a vitamin mineral nanosuspension according to any one of claims 1 to 8, comprising the steps of: A) Mixing, heating and stirring a thickening agent, an emulsifying agent and water to obtain a mixed solution; b) Cooling the mixed solution, adding a nutrient supplement to perform high-speed shearing, adding a charge stabilizer to mix and stir, and filtering to obtain a mixed material; C) And (3) homogenizing the mixed material under high pressure, filling, and sterilizing to obtain the vitamin and mineral nanometer suspension.
  10. 10. The method according to claim 9, wherein in step a), the stirring speed is 500 to 1000rpm; in the step B), the high-speed shearing speed is 2000-9000rpm, and the time is 5-20min; In the step C), the pressure of the high-pressure homogenization is 40-70 MPa, the cycle times are 2-5, and the temperature in the high-pressure homogenization process is controlled to be always lower than 40 ℃.

Description

Nanometer suspension containing vitamin and mineral substances and preparation method thereof Technical Field The invention belongs to the technical field of suspension preparation, and particularly relates to a vitamin mineral-containing nano suspension and a preparation method thereof. Background At present, the dosage forms of the oral vitamin and mineral supplement mainly comprise tablets, powder and capsules, and the market scale of the liquid oral preparation is gradually enlarged along with the improvement of the health consciousness of people and the importance of nutrition supplement. The liquid dosage form generally has good taste, is easy to swallow, is especially suitable for children, the elderly and dysphagia patients, can improve the edible compliance of patients, and ensures sufficient intake of nutrient substances. Most vitamin products in the market are large in size, and the old and children often have the problems of difficulty in chewing, swallowing and eating, and also often have poor mouthfeel. Among them, calcium-supplementing products are most typical, and most of the calcium sources are calcium carbonate, so that the utilization rate is low and the stomach is not gentle enough. The liquid vitamin and mineral preparation not only can solve the problems of inconvenient taking and dysphagia, but also has the advantages of good dispersibility in gastrointestinal tracts, large surface area, capability of rapidly dissolving and releasing nutrients, easier absorption by the intestinal tracts, high utilization rate, rapid absorption, good taste and the like. However, some minerals have low solubility in water, and fat-soluble vitamins are insoluble in water, which can affect product quality and nutrient absorption and utilization. The quality control of the liquid suspension is relatively complex, the liquid preparation in the market at present mainly adopts a thickening agent combined with high-speed shearing mode to suspend insoluble mineral raw materials in water so as to ensure that the mineral raw materials do not settle and layer in the shelf life, but mineral particles prepared by the mode are larger in size and generally distributed above 1 mu m, the dispersion uniformity is poor, the particle substances cause poor palatability in eating, and fat-soluble vitamins are solubilized by adopting an emulsifying agent so as to ensure the stability of the vitamins in the liquid preparation, but emulsion drops are easily influenced by various factors to break, so that the vitamin content is greatly attenuated. Therefore, providing a vitamin mineral-containing nanosuspension with small particle size, high dispersion uniformity, good stability of active ingredients and good palatability is a problem to be solved. Disclosure of Invention In view of the above, the technical problem to be solved by the invention is to provide a vitamin mineral-containing nano suspension and a preparation method thereof. The invention provides a vitamin and mineral nano suspension, which is prepared from the following raw materials in parts by weight by high-speed shearing and high-pressure homogenization: 10-50 parts of nutrient supplement, 0.1-2 parts of thickener, 1-6 parts of emulsifier, 0.1-5 parts of charge stabilizer and the balance of water; The charge stabilizer comprises at least one of tremella polysaccharide, yeast polysaccharide and chondroitin sulfate sodium. Preferably, the nutrient supplement comprises one or more of vitamin A, vitamin B, vitamin C, vitamin D, vitamin E, vitamin K, calcium salt, magnesium salt, zinc salt, ferric salt and selenium-enriched yeast. Preferably, the thickener comprises at least one of xanthan gum, carrageenan, pectin, guar gum, locust bean gum, and sodium carboxymethyl cellulose. Preferably, the emulsifier comprises at least one of acacia, mono-di-glyceride fatty acid ester, phospholipid, succinic acid monoglyceride, sucrose fatty acid ester. Preferably, the composition further comprises an acidity regulator; The acidity regulator comprises at least one of citric acid, DL-malic acid, fumaric acid, sodium citrate, potassium citrate, lactic acid and sodium bicarbonate; the nano-suspension comprises 0.1-3 parts of acidity regulator by 100 parts by weight. Preferably, a sweetener is also included; The sweetener is at least one selected from sorbitol, sorbitol solution, xylitol, erythritol, maltitol solution, isomalt, isomaltulose, mannitol, sucrose, trehalose, glucose, mogroside, sucralose, stevioside; 5-20 parts of sweetener are included based on 100 parts by weight of the nanosuspension. Preferably, a prebiotic is also included; the prebiotics are selected from at least one of fructo-oligosaccharide, galacto-oligosaccharide, inulin, resistant dextrin, polydextrose and isomalto-oligosaccharide; The probiotic is included in an amount of 2-20 parts by weight based on 100 parts by weight of the nanosuspension. Preferably, the food additive further comprises other synergistic