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CN-122004480-A - Brain peptide oral liquid for tonifying kidney, strengthening spleen and improving intelligence and preparation method thereof

CN122004480ACN 122004480 ACN122004480 ACN 122004480ACN-122004480-A

Abstract

The application relates to the technical field of health-care beverage preparation, and in particular discloses a brain peptide oral liquid for tonifying kidney, strengthening spleen and improving intelligence and a preparation method thereof, wherein the brain peptide oral liquid comprises the following raw materials: longan pulp, medlar, mulberry, red jujube, poria cocos, fructus alpiniae oxyphyllae, dried ginger, peptide components, DHA algae oil, N-acetylneuraminic acid, gamma-aminobutyric acid, vitamin B 12 , stevioside, concentrated apple juice and purified water. The preparation method of the brain peptide oral liquid comprises the steps of mixing longan pulp, medlar, mulberries, red dates, poria cocos, fructus alpiniae oxyphyllae, dried ginger and purified water, decocting, mixing decoctions to obtain a traditional Chinese medicine extract, adding peptide components and DHA algae oil into the traditional Chinese medicine extract, uniformly stirring, adding N-acetylneuraminic acid, gamma-aminobutyric acid, vitamin B 12 , stevioside and concentrated apple juice, adjusting pH, and sterilizing to obtain the brain peptide oral liquid. The prepared brain peptide oral liquid for tonifying kidney, strengthening spleen and improving intelligence has remarkable effects of tonifying kidney and strengthening spleen.

Inventors

  • CHEN CHUXIN
  • Hou jundai

Assignees

  • 湖北研妆实业有限公司

Dates

Publication Date
20260512
Application Date
20260413

Claims (9)

  1. 1. The brain peptide oral liquid is characterized by comprising, by weight, 3-5 parts of longan pulp, 3-6 parts of medlar, 3-8 parts of mulberries, 3-6 parts of red dates, 2-6 parts of poria cocos, 0.5-2 parts of fructus alpiniae oxyphyllae, 0.05-0.1 part of dried ginger, 8-12 parts of peptide components, 0.01-0.05 part of DHA algae oil, 0.05-0.1 part of N-acetylneuraminic acid, 1-3 parts of gamma-aminobutyric acid, 0.002-0.004 part of vitamin B 12 , 0.05-0.1 part of stevioside, 12-15 parts of concentrated apple juice and the balance of purified water.
  2. 2. The brain peptide oral liquid for tonifying kidney, strengthening spleen and improving intelligence according to claim 1, wherein the preparation method of the peptide component comprises the following preparation steps: Step 1, adding deionized water after homogenizing sheep brain, adjusting the pH to 6.5-7.0, adding compound protease, carrying out enzymolysis for 2.5-3 hours, and centrifuging to obtain supernatant after enzyme deactivation to obtain sheep brain peptide; Step 2, crushing oyster meat, adding deionized water to obtain a fermentation substrate, inoculating bacillus natto into the fermentation substrate, fermenting for 18-24 hours to obtain a fermentation liquid, adding neutral protease into the fermentation liquid, carrying out enzymolysis for 2-5 hours, inactivating enzyme, centrifuging, and taking supernatant to obtain oyster peptide; Step 3, mixing the walnut with the soybean, crushing, sieving, adding deionized water, uniformly mixing, adjusting the pH to 8.0-8.5 to obtain soybean walnut liquid, adding alkaline protease into the soybean walnut liquid, carrying out enzymolysis for 2-3 hours, adding flavourzyme, carrying out enzymolysis for 1-3 hours, inactivating enzyme, centrifuging, and taking the supernatant to obtain the soybean walnut compound peptide; and step 4, mixing the sheep brain peptide, the oyster peptide and the soybean walnut compound peptide, concentrating in vacuum until the solid content is 20-25%, and freeze-drying to obtain peptide components.
  3. 3. The brain peptide oral liquid for tonifying kidney, strengthening spleen and improving intelligence according to claim 2, wherein the compound protease in the step 1 consists of subtilisin, elastase and aminopeptidase with a mass ratio of 10-12:5-8:2-5.
  4. 4. The brain peptide oral liquid for tonifying kidney, strengthening spleen and improving intelligence according to claim 2, wherein the mass ratio of the compound protease to the sheep brain in the step 1 is 1-3:200-300.
  5. 5. The brain peptide oral liquid for tonifying kidney, strengthening spleen and improving intelligence according to claim 2, wherein the inoculation amount of bacillus natto in the step 2 is 2-5% of the mass of the fermentation substrate.
  6. 6. The brain peptide oral liquid for tonifying kidney, strengthening spleen and improving intelligence according to claim 2, wherein the mass ratio of the fermentation liquid to the neutral protease in the step 2 is 100-200:3-5.
  7. 7. The brain peptide oral liquid for tonifying kidney, strengthening spleen and improving intelligence according to claim 2, wherein the mass ratio of the soybean walnut liquid, the alkaline protease and the flavourzyme in the step 3 is 200-300:3-5:1-3.
  8. 8. The brain peptide oral liquid for tonifying kidney, strengthening spleen and improving intelligence according to claim 2, wherein the mass ratio of sheep brain peptide, oyster peptide and soybean walnut compound peptide in the step 4 is 3-6:2-5:1-2.
  9. 9. A method for preparing the brain peptide oral liquid for tonifying kidney, strengthening spleen and improving intelligence according to any one of claims 1-8, which is characterized by comprising the following preparation steps: Mixing arillus longan, fructus Lycii, mori fructus, fructus Jujubae, poria, fructus Alpinae Oxyphyllae, zingiberis rhizoma and purified water, decocting for 2-3 times each for 1-2 hr, mixing decoctions, filtering, concentrating to obtain Chinese medicinal extract, adding peptide component and DHA algae oil into the Chinese medicinal extract, stirring, adding N-acetylneuraminic acid, gamma-aminobutyric acid, vitamin B 12 , stevioside and concentrated apple juice, stirring, adding purified water to total volume, adjusting pH to 6.0-7.0, filtering, sterilizing, cooling, and aseptic packaging to obtain brain peptide oral liquid with effects of invigorating kidney and spleen and improving intelligence.

Description

Brain peptide oral liquid for tonifying kidney, strengthening spleen and improving intelligence and preparation method thereof Technical Field The application relates to the technical field of health-care beverage preparation, in particular to brain peptide oral liquid capable of tonifying kidney, strengthening spleen and improving intelligence and a preparation method thereof. Background With the aging of population and the expansion of sub-health population, the symptoms such as memory decline, cognitive function decline, soreness and weakness of waist and knees, weakness of spleen and stomach and the like are high, and the market has urgent demands for health products with functions of conditioning viscera and improving brain. The theory of traditional Chinese medicine holds that the kidney stores essence, generates marrow and communicates with the brain, the spleen is the source of qi and blood biochemistry, the brain function strength is closely related to the spleen and kidney functions, and the kidney tonifying and spleen strengthening are the core thought for improving the brain function. In the prior art, most preparations for tonifying kidney and strengthening spleen are pills and powder, which have the problems of slow absorption and low bioavailability, and the nootropic products depend on chemical synthesis components and are easy to produce side effects after long-term administration. The brain peptide is taken as a natural active substance in brain and has important effects on nerve cell repair and cognitive function regulation, but the directly extracted brain peptide has poor stability and is easily damaged by digestive juice. The existing brain peptide products mostly adopt a single extraction process, do not combine with the viscera conditioning theory of traditional Chinese medicine, have the defects of low retention rate of active ingredients, insufficient preparation stability and the like, and are difficult to realize the synergistic effect of 'spleen and kidney homoeopathy and brain and body homoeopathy'. Therefore, the development of the brain peptide oral liquid which has scientific and reasonable formula, advanced preparation process, double effects of tonifying kidney and strengthening spleen and developing intelligence and strengthening brain, good stability and high bioavailability has important significance for meeting clinical requirements and improving product competitiveness. Disclosure of Invention In order to solve the technical problems in the background art, the application provides a brain peptide oral liquid for tonifying kidney, strengthening spleen and improving intelligence and a preparation method thereof. In a first aspect, the application provides a brain peptide oral liquid for tonifying kidney, strengthening spleen and improving intelligence, which adopts the following technical scheme: The brain peptide oral liquid for tonifying kidney, strengthening spleen and improving intelligence comprises the following raw materials, by weight, 3-5 parts of longan pulp, 3-6 parts of medlar, 3-8 parts of mulberries, 3-6 parts of red dates, 2-6 parts of poria cocos, 0.5-2 parts of fructus alpiniae oxyphyllae, 0.05-0.1 part of dried ginger, 8-12 parts of peptide components, 0.01-0.05 part of DHA algae oil, 0.05-0.1 part of N-acetylneuraminic acid, 1-3 parts of gamma-aminobutyric acid, 0.002-0.004 parts of vitamin B 12, 0.05-0.1 part of stevioside, 12-15 parts of concentrated apple juice and the balance of purified water. Preferably, the preparation method of the peptide component comprises the following preparation steps: Step 1, adding deionized water after homogenizing sheep brain, adjusting the pH to 6.5-7.0, adding compound protease, carrying out enzymolysis for 2.5-3 hours, and centrifuging to obtain supernatant after enzyme deactivation to obtain sheep brain peptide; Step 2, crushing oyster meat, adding deionized water to obtain a fermentation substrate, inoculating bacillus natto into the fermentation substrate, fermenting for 18-24 hours to obtain a fermentation liquid, adding neutral protease into the fermentation liquid, carrying out enzymolysis for 2-5 hours, inactivating enzyme, centrifuging, and taking supernatant to obtain oyster peptide; Step 3, mixing the walnut with the soybean, crushing, sieving, adding deionized water, uniformly mixing, adjusting the pH to 8.0-8.5 to obtain soybean walnut liquid, adding alkaline protease into the soybean walnut liquid, carrying out enzymolysis for 2-3 hours, adding flavourzyme, carrying out enzymolysis for 1-3 hours, inactivating enzyme, centrifuging, and taking the supernatant to obtain the soybean walnut compound peptide; and step 4, mixing the sheep brain peptide, the oyster peptide and the soybean walnut compound peptide, concentrating in vacuum until the solid content is 20-25%, and freeze-drying to obtain peptide components. Preferably, the compound protease in the step 1 consists of subtilisin, elastase and aminope