CN-122004795-A - Intelligent biological response regulation and control system for wound repair

CN122004795ACN 122004795 ACN122004795 ACN 122004795ACN-122004795-A

Abstract

The invention relates to the technical field of medical equipment, in particular to an intelligent biological response regulation and control system for wound repair, which comprises a biological signal sensing module, a decision center and a regulation and control module. The biological signal sensing module monitors the pH value, temperature, inflammatory factor concentration and tissue fluid exudation rate of the wound surface in real time, the decision center performs fusion analysis on the multi-source biological signals, intelligently judges the healing stage and generates a regulating and controlling instruction, and the regulating and controlling module precisely controls the time sequence and the dosage release of various bioactive substances according to the instruction through the micro-fluidic chip structure. The invention realizes the monitoring and intervention of wound healing and improves the repairing efficiency.

Inventors

LIU CHENYANG
LI LINGQIAO
BAI KUAN
LUO YING
JIA XIAOLI

Assignees

常州市第一人民医院

Dates

Publication Date: 20260512
Application Date: 20251209

Claims (7)

1. An intelligent biological response regulation and control system for wound repair, comprising: The biological signal sensing module is used for monitoring and collecting key biological markers in the wound surface environment; The decision center is connected with the biological signal sensing module, performs fusion analysis and healing identification on the collected key biomarker signals, and generates a regulation and control instruction; The regulation and control module is connected with the intelligent decision center and is used for receiving regulation and control instructions and executing time sequence control and dosage release on various bioactive substances; The biological signal sensing module at least comprises a pH sensing unit, a temperature sensing unit, an inflammatory factor concentration detection unit and a tissue fluid exudation rate monitoring unit, wherein a discrimination algorithm is arranged in the decision center, the discrimination algorithm is used for preprocessing data from the biological signal sensing module, a high-dimensional feature vector composed of a normalized pH value, a normalized temperature value, a normalized inflammatory factor concentration value and a normalized tissue fluid exudation rate value is constructed, the high-dimensional feature vector is input into a pre-trained healing classification model for pattern recognition, a regulation and control instruction is generated by combining a preset intervention strategy mapping table according to a discriminated healing stage, and the regulation and control module is used for executing regulation and control through a microfluidic chip.
2. The system according to claim 1, wherein the decision center is integrated with a dynamic threshold adaptive adjustment unit, the dynamic threshold adaptive adjustment unit continuously monitors a gradient of change of a specific inflammatory factor concentration, and when detecting that the concentration gradient exceeds a preset acute inflammatory threshold in 2 consecutive monitoring periods, the dynamic threshold adaptive adjustment unit temporarily promotes a decision weight in a healing classification model, which is discriminated as an inflammatory period, and triggers the intelligent biological response regulation system to execute a new anti-inflammatory intervention plan.
3. The system of claim 2, wherein the new anti-inflammatory intervention protocol comprises temporarily increasing the epidermal growth factor release dose of the microfluidic chip-built-in chamber to 1.5 times the basal dose.
4. The system of claim 1, wherein the output interface of the microfluidic chip of the regulating module is integrated with a biocompatible hydrogel slow-release layer, the biocompatible hydrogel slow-release layer is formed by ultraviolet crosslinking and curing of a methacryloylated gelatin material, the inside of the biocompatible hydrogel slow-release layer is of a porous network structure, the average pore diameter of the biocompatible hydrogel slow-release layer is 50-200 microns, and the biocompatible hydrogel slow-release layer is used for carrying out secondary bearing and slow-release on liquid bioactive substances output from the microfluidic chip and forming a microenvironment for continuously releasing factors on the local part of a wound surface.
5. The system of claim 1, wherein the intelligent biological response regulation system further comprises a wireless data communication and remote monitoring interface module, wherein the wireless data communication and remote monitoring interface module is connected with the decision center through a bluetooth low energy protocol and is used for transmitting biological signal data, decision logs and execution states monitored by the system to an external mobile monitoring terminal in real time.
6. The system of claim 1, wherein the preprocessing comprises signal filtering and data normalization.
7. The system of claim 1, wherein the healing classification model is a multi-classifier trained by a support vector machine method based on clinical wound healing process data, and wherein the healing classification model is capable of discriminating a wound state into an inflammatory phase, a proliferative phase, and a remodelling phase.

Description

Intelligent biological response regulation and control system for wound repair Technical Field The invention relates to the technical field of medical instruments, in particular to an intelligent biological response regulation and control system for wound repair. Background The wound repair and tissue regeneration technology is a key research direction for improving the life quality of patients and reducing the medical burden, and the field relates to the cross fusion of cell biology, material science and clinical medicine, and aims to promote the reconstruction and recovery of functional tissues by intervening in the wound healing process. The prior art generally depends on a static dressing or a single-factor slow-release system, lacks real-time perception and feedback on the dynamic change of a wound surface, and simultaneously cannot carry out self-adaptive adjustment according to the fluctuation of key biomarkers such as the pH value, the temperature, the inflammatory factor concentration and the like of the wound surface, so that intervention measures are not matched with a healing stage. Disclosure of Invention The invention aims to provide an intelligent biological response regulation and control system for wound repair, which solves the technical problem that intervention measures in the existing wound repair technology lack real-time sensing feedback on the change of the microenvironment of a wound. The invention provides an intelligent biological response regulation and control system for wound repair, which comprises the following components: The biological signal sensing module is used for monitoring and collecting key biological markers in the wound surface environment; The decision center is connected with the biological signal sensing module, performs fusion analysis and healing identification on the collected key biomarker signals, and generates a regulation and control instruction; The regulation and control module is connected with the intelligent decision center and is used for receiving regulation and control instructions and executing time sequence control and dosage release on various bioactive substances; The biological signal sensing module at least comprises a pH sensing unit, a temperature sensing unit, an inflammatory factor concentration detection unit and a tissue fluid exudation rate monitoring unit, wherein a discrimination algorithm is arranged in the decision center, the discrimination algorithm is used for preprocessing data from the biological signal sensing module, a high-dimensional feature vector composed of a normalized pH value, a normalized temperature value, a normalized inflammatory factor concentration value and a normalized tissue fluid exudation rate value is constructed, the high-dimensional feature vector is input into a pre-trained healing classification model for pattern recognition, a regulation and control instruction is generated by combining a preset intervention strategy mapping table according to a discriminated healing stage, and the regulation and control module is used for executing regulation and control through a microfluidic chip. In some embodiments, the decision center is integrated with a dynamic threshold adaptive adjustment unit, the dynamic threshold adaptive adjustment unit continuously monitors a change gradient of a specific inflammatory factor concentration, and when detecting that the concentration gradient exceeds a preset acute inflammatory threshold in 2 continuous monitoring periods, the dynamic threshold adaptive adjustment unit temporarily promotes decision weights in a healing classification model, which are judged to be inflammatory periods, and triggers the intelligent biological response regulation system to execute a new anti-inflammatory intervention plan. In some embodiments, the new anti-inflammatory intervention protocol comprises temporarily increasing the epidermal growth factor release dose of the microfluidic chip-built-in chamber to 1.5 times the basal dose. In some embodiments, a biocompatible hydrogel slow-release layer is integrated at an output interface of a microfluidic chip of the regulation module, the biocompatible hydrogel slow-release layer is formed by ultraviolet crosslinking and curing of a methacryloylated gelatin material, a porous network structure is arranged in the biocompatible hydrogel slow-release layer, the average pore diameter of the biocompatible hydrogel slow-release layer is 50-200 microns, and the biocompatible hydrogel slow-release layer is used for carrying and slow-releasing liquid bioactive substances output from the microfluidic chip for the second time and forming a microenvironment for continuously releasing factors on a wound surface part. In some embodiments, the intelligent biological response regulation and control system further comprises a wireless data communication and remote monitoring interface module, wherein the wireless data communication and remote monitoring interf