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CN-122004916-A - System and method for detecting branch blood flow disorder in coronary bifurcation lesion interventional therapy

CN122004916ACN 122004916 ACN122004916 ACN 122004916ACN-122004916-A

Abstract

The invention discloses a system and a method for detecting branch blood flow disorder in coronary bifurcation lesion interventional therapy. The system comprises a physiological signal acquisition unit, an angiography unit, a coronary intravascular ultrasound unit, a data processing and control unit and a display unit. The method is realized by the steps of calculating baseline functional indexes and extracting baseline morphological parameters based on contrast and vascular ultrasonic images before operation, synchronously collecting real-time contrast and ultrasonic images before and after key steps in operation, calculating real-time functional indexes and real-time morphological parameters according to the real-time contrast and ultrasonic images, fusing real-time data and baseline data, calculating comprehensive damage indexes, and generating a grading early warning signal in real time according to whether the indexes exceed preset thresholds or not. The invention utilizes the image data which can be obtained conventionally in the operation to realize the real-time fusion and quantitative evaluation of the function and the form information, provides objective decision support in the operation for operators, is beneficial to accurately grasping the intervention time and improves the safety and the curative effect of the operation.

Inventors

  • MENG HUIMING

Assignees

  • 安阳市第六人民医院(安阳市口腔医院)

Dates

Publication Date
20260512
Application Date
20260211

Claims (8)

  1. 1. A system for detecting branch blood flow disorders in coronary bifurcation lesion interventional therapy, comprising: the physiological signal acquisition unit is used for acquiring or calculating functional indexes reflecting the hemodynamic state of the target branch blood vessel in real time based on coronary angiography and an ultrasonic image sequence in a coronary blood vessel in the interventional treatment process; An angiography unit for acquiring a sequence of angiography images containing a target bifurcation site in real-time during an interventional procedure; The coronary intravascular ultrasound unit is used for collecting real internal conditions including a target bifurcation part in real time in interventional operation and assisting in contrast image sequences; The data processing and control unit is respectively in communication connection with the physiological signal acquisition unit, the angiography unit and the coronary intravascular ultrasound unit, and the unit comprises: The data receiving and synchronizing module is used for receiving and synchronizing the functional index from the physiological signal acquisition unit and the contrast image sequence from the angiography unit and the image sequence of the coronary intravascular ultrasound unit in real time; The image processing module is used for carrying out blood vessel segmentation and reconstruction on the contrast image sequence and the ultrasonic image sequence, generating a model of the bifurcation part, and quantitatively extracting real-time morphological parameters at the opening of the branch blood vessel from the model; the data fusion and calculation module is used for carrying out synchronous fusion processing on the functional index and the real-time morphological parameter which are acquired in real time based on the baseline functional index and the baseline morphological parameter which are acquired before the intervention operation starts, and calculating to obtain a comprehensive damage index reflecting the damage degree of the function and the morphological coupling of the branch blood vessel; The early warning judging module is used for comparing the comprehensive damage index with a preset early warning threshold value and an alarm threshold value in real time and generating a corresponding early warning or alarm signal according to a comparison result; The display unit is connected with the data processing and control unit and is used for synchronously displaying the functional index, the real-time morphological parameter, the comprehensive damage index and the change trend thereof and the early warning or alarm signal in real time.
  2. 2. A system for detecting branch blood flow disorders in coronary bifurcation lesion interventional procedures as defined in claim 1, wherein, The data fusion and calculation module calculates the comprehensive damage index CII through the following formula: CII = α* F +β* M, Wherein α and β are preset weighting coefficients, and α+β=1, α > β is satisfied; F is a functional variation component; M is a morphological change component.
  3. 3. The system of claim 1, wherein the data processing and controlling unit further comprises a data storage and management module for storing intraoperative monitoring data, and the system further comprises a model optimization module for iteratively optimizing the weighting coefficient for calculating the comprehensive injury index and the preset threshold value by a machine learning algorithm based on the historically stored monitoring data and corresponding clinical outcome data.
  4. 4. The system for detecting branch blood flow disorders in a coronary bifurcation lesion interventional procedure as recited in claim 1 wherein said real-time morphological parameters include at least one of a ratio of branch opening area stenosis, an amount of angular change of the branch opening relative to a baseline condition, and a ratio of coverage area of the main support beam to the branch opening.
  5. 5. The system for detecting branch blood flow disorders in interventional therapy of coronary bifurcation lesions according to claim 1, further comprising a model optimization module for iteratively optimizing the weighting coefficients for calculating the integrated damage index and the preset threshold by a machine learning algorithm based on historical monitoring data and clinical outcome.
  6. 6. A method for detecting branch blood flow disorders in coronary bifurcation lesion interventional therapy according to claim 1, comprising the steps of: S1, system initialization and baseline data acquisition, namely, before interventional therapy, calculating a baseline functional index of a target branch vessel based on baseline radiography and intravascular ultrasound images, and extracting baseline morphological parameters of the target branch vessel; S2, real-time synchronous monitoring circulation, namely acquiring a real-time contrast image sequence before and after a key intervention step, synchronously calculating a real-time functional index and a real-time morphological parameter based on the real-time contrast image sequence, and calculating a comprehensive damage index in real time based on the baseline functional index, the baseline morphological parameter, the real-time functional index and the real-time morphological parameter; s3, intelligent early warning and decision support, namely comparing the comprehensive damage index with a preset early warning threshold value and an alarm threshold value, and generating a corresponding early warning or alarm signal according to the condition that the threshold value is exceeded; s4, generating an operation report, namely generating a monitoring report containing the real-time functional index, the real-time morphological parameter and the comprehensive damage index change trend after operation; and S5, off-line verification and model optimization, namely, optimizing and calculating the weighting coefficient of the comprehensive damage index, the early warning threshold value and the alarm threshold value based on the accumulated intraoperative monitoring data and clinical outcome data.
  7. 7. The method for detecting branch blood flow disorders in a coronary bifurcation lesion interventional procedure according to claim 6, wherein said critical interventional step comprises at least one of pre-dilation of a main vessel, stent positioning, stent release, post-dilation.
  8. 8. The method for detecting branch blood flow disorders in interventional therapy of coronary bifurcation lesions according to claim 6, wherein step S2 performs data acquisition and calculation both before and after each critical step is performed.

Description

System and method for detecting branch blood flow disorder in coronary bifurcation lesion interventional therapy Technical Field The invention relates to the technical field of medical diagnosis and detection, in particular to a system and a method for detecting branch blood flow disorder in coronary bifurcation lesion interventional therapy. Background In coronary bifurcation lesion interventional therapy, the intraoperative assessment of branch blood flow state mainly relies on visual observation of contrast images by the operator. This method is subjective and insensitive to early, non-occlusive hemodynamic changes, and does not provide a quantitative determination. In the prior art, techniques exist for noninvasively calculating fractional flow reserve based on conventional contrast images. However, these techniques are mainly used for offline, static evaluation before surgery, and cannot fuse functional indicators with morphological changes in real time and dynamically in the critical operation steps of surgery to provide immediate risk early warning. Disclosure of Invention Aiming at the technical defects, the invention aims to provide a system and a method for detecting branch blood flow disorder in coronary bifurcation lesion interventional therapy, so as to solve the problems mentioned in the background art. In order to solve the technical problems, the invention adopts the following technical proposal that the invention provides a system and a method for detecting branch blood flow disorder in coronary bifurcation lesion interventional therapy, In a first aspect, the present invention provides a system for detecting branch blood flow disorders in interventional therapy of coronary bifurcation lesions, comprising: The physiological signal acquisition unit is used for acquiring or calculating functional indexes reflecting the hemodynamic state of a target branch vessel in real time based on coronary angiography and intravascular ultrasonic image sequences in the interventional treatment process; An angiography unit for acquiring a sequence of angiography images containing a target bifurcation site in real-time during an interventional procedure; The coronary intravascular ultrasound unit is used for collecting real internal conditions including a target bifurcation part in real time in interventional operation and assisting in contrast image sequences; The data processing and control unit is respectively in communication connection with the physiological signal acquisition unit, the angiography unit and the coronary intravascular ultrasound unit, and the unit comprises: The data receiving and synchronizing module is used for receiving and synchronizing the functional index from the physiological signal acquisition unit and the contrast image sequence from the angiography unit and the image sequence of the coronary intravascular ultrasound unit in real time; The image processing module is used for carrying out blood vessel segmentation and reconstruction on the contrast image sequence and the ultrasonic image sequence, generating a model of the bifurcation part, and quantitatively extracting real-time morphological parameters at the opening of the branch blood vessel from the model; the data fusion and calculation module is used for carrying out synchronous fusion processing on the functional index and the real-time morphological parameter which are acquired in real time based on the baseline functional index and the baseline morphological parameter which are acquired before the intervention operation starts, and calculating to obtain a comprehensive damage index reflecting the damage degree of the function and the morphological coupling of the branch blood vessel; The early warning judging module is used for comparing the comprehensive damage index with a preset early warning threshold value and an alarm threshold value in real time and generating a corresponding early warning or alarm signal according to a comparison result; The display unit is connected with the data processing and control unit and is used for synchronously displaying the functional index, the real-time morphological parameter, the comprehensive damage index and the change trend thereof and the early warning or alarm signal in real time. Further, the physiological signal acquisition unit calculates the functional index in real time by processing the contrast image sequence and adopting a quantitative blood flow fraction analysis algorithm or an optical blood flow fraction analysis algorithm. This is one of the important technical paths for implementing the present invention, and its basic algorithm is already the prior art. Further, the data fusion and calculation module calculates the integrated damage index by the following formula: CII = α * F + β * M The CII is a comprehensive damage index, alpha and beta are preset weighting coefficients, alpha+beta=1 and alpha > beta are satisfied, F is a functional variation component, Q_ba