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CN-122004921-A - Wearable hydrogel patch structure based on ultrasonic sensor

CN122004921ACN 122004921 ACN122004921 ACN 122004921ACN-122004921-A

Abstract

The invention relates to the technical field of hydrogel patches, in particular to a wearable hydrogel patch structure based on an ultrasonic sensor, which is characterized in that a medical silica gel film is cut into a rectangle with the thickness of 20mm multiplied by 30mm and used as a flexible substrate supporting layer, a prepolymerization liquid is dripped on the upper surface of the medical silica gel film, a PET mask is covered, and then ultraviolet curing is carried out for 60 seconds, so that a solid hydrogel coupling layer with the thickness of 1mm and the size slightly smaller than that of a substrate is formed. And then aligning and pasting the flexible PMUT array on the surface of the hydrogel, covering and sealing the polyurethane film with the thickness of 25 mu m by a hot pressing method to form a sealing protection layer, wherein the hot pressing temperature is 85 ℃, the pressure is 0.3MPa, and the time is 10s, so that the outer edge of the polyurethane is fused and combined with a silica gel substrate, and meanwhile, the PMUT array is completely packaged between hydrogel/polyurethane interfaces, so that the integration of hydrogel-array-sealing is realized.

Inventors

  • WANG YIMING
  • ZHANG XIAOQING
  • Wang Feixian

Assignees

  • 超鹿大生(南通)生命科学有限公司

Dates

Publication Date
20260512
Application Date
20260311

Claims (7)

  1. 1. The wearable hydrogel patch structure based on the ultrasonic sensor is characterized by comprising a flexible substrate supporting layer, a solid hydrogel coupling layer, a sealing protection layer, an ultrasonic sensor array layer, a conductive transition layer, a sticking fixing layer and a release layer; The solid hydrogel coupling layer is arranged above the flexible substrate supporting layer, the sealing protection layer covers the upper surface of the solid hydrogel coupling layer, the ultrasonic sensor array layer is embedded between the sealing protection layer and the solid hydrogel coupling layer, the conductive transition layer is electrically connected with the ultrasonic sensor array layer, the adhesion fixing layer is arranged on the edge of the lower surface of the flexible substrate supporting layer, and the release layer is attached to the lower surface of the adhesion fixing layer.
  2. 2. A wearable hydrogel patch structure based on an ultrasound sensor as recited in claim 1, The flexible substrate supporting layer is a medical silica gel film, the thickness is 0.1-0.3mm, and the tensile elongation is more than or equal to 200%.
  3. 3. A wearable hydrogel patch structure based on an ultrasound sensor as recited in claim 1, The solid hydrogel coupling layer is polyacrylamide-gelatin interpenetrating network hydrogel, the water content is 70% -90%, and the thickness is 0.5-1.5mm.
  4. 4. A wearable hydrogel patch structure based on an ultrasound sensor as recited in claim 1, The sealing protection layer is a polyurethane film with the thickness of 0.05-0.1mm.
  5. 5. A wearable hydrogel patch structure based on an ultrasound sensor as recited in claim 1, The ultrasonic sensor array layer is a flexible PMUT array, the center frequency is 2-10MHz, and the thickness of the device is less than 0.2mm.
  6. 6. A wearable hydrogel patch structure based on an ultrasound sensor as recited in claim 1, The conductive transition layer is a flexible printed circuit board and is bonded with the ultrasonic sensor array layer through anisotropic conductive adhesive in a hot pressing mode.
  7. 7. A wearable hydrogel patch structure based on an ultrasound sensor as recited in claim 1, The adhesive fixing layer is a hyposensitization medical acrylate adhesive tape, the peeling strength is 0.5-2N/cm, and the adhesive fixing layer can be continuously worn for 12-24 hours.

Description

Wearable hydrogel patch structure based on ultrasonic sensor Technical Field The invention relates to the technical field of hydrogel patches, in particular to a wearable hydrogel patch structure based on an ultrasonic sensor. Background Existing wearable ultrasonic monitoring devices still use a smeared liquid couplant for acoustic matching. The couplant has no fixed form, cannot be prefabricated into a three-dimensional structure complementary with the ultrasonic probe, cannot be conformally laminated with the flexible sensor array and the packaging layer, and is always in a split state, and when the probe slides or stretches the skin, the couplant is pushed away instantly, air faults occur frequently, signals are attenuated transiently, and continuous and stable acoustic channels cannot be formed. In addition, the liquid coupling agent has edge volatilization in an open environment for 5-8min, the thickness of the coupling agent is reduced by more than 30 percent in 10-15min, repeated coating is needed every 3-5min, in-situ monitoring for more than 15min is difficult to realize, the flowing state characteristic of the coupling agent cannot be hot pressed or injection molded together with a PMUT array and a flexible circuit for packaging, the wearing-attaching-packaging integrated process cannot fall to the ground, the coupling layer thickness is randomly distributed, unquantifiable impedance mutation is introduced, imaging consistency is hindered, and standardized mass production of the wearable ultrasonic patch is limited. Therefore, there is a need for a solid-state hydrogel coupling structure that can be preformed, shaped for a long period of time, and integrally packaged with a sensor array to overcome the substantial bottlenecks in form, time, and process of conventional smear-type couplants. Disclosure of Invention The invention aims to provide a wearable hydrogel patch structure based on an ultrasonic sensor, and aims to solve the problems that a traditional smearing type couplant cannot be integrated with an ultrasonic probe in a conformal way due to no fixed shape and is easy to form an air fault to cause transient attenuation of signals. In order to achieve the above purpose, the invention provides a wearable hydrogel patch structure based on an ultrasonic sensor, which comprises a flexible substrate supporting layer, a solid hydrogel coupling layer, a sealing protection layer, an ultrasonic sensor array layer, a conductive transition layer, a pasting fixing layer and a release layer; The solid hydrogel coupling layer is arranged above the flexible substrate supporting layer, the sealing protection layer covers the upper surface of the solid hydrogel coupling layer, the ultrasonic sensor array layer is embedded between the sealing protection layer and the solid hydrogel coupling layer, the conductive transition layer is electrically connected with the ultrasonic sensor array layer, the adhesion fixing layer is arranged on the edge of the lower surface of the flexible substrate supporting layer, and the release layer is attached to the lower surface of the adhesion fixing layer. Wherein the flexible substrate supporting layer is a medical silica gel film, the thickness is 0.1-0.3mm, and the tensile elongation is more than or equal to 200%. Wherein the solid hydrogel coupling layer is polyacrylamide-gelatin interpenetrating network hydrogel, the water content is 70% -90%, and the thickness is 0.5-1.5mm. Wherein the sealing protection layer is a polyurethane film with the thickness of 0.05-0.1mm. The ultrasonic sensor array layer is a flexible PMUT array, the center frequency is 2-10MHz, and the thickness of the device is less than 0.2mm. The conductive transition layer is a flexible printed circuit board and is bonded with the ultrasonic sensor array layer through anisotropic conductive adhesive in a hot pressing mode. Wherein the adhesive fixing layer is a hypoallergenic medical acrylate adhesive tape, the peeling strength is 0.5-2N/cm, and the adhesive fixing layer can be continuously worn for 12-24 hours. According to the wearable hydrogel patch structure based on the ultrasonic sensor, a medical silica gel film is cut into a rectangle with the thickness of 20mm multiplied by 30mm and used as a flexible substrate supporting layer, a prepolymerization liquid is dripped on the upper surface of the medical silica gel film, a PET mask is covered, ultraviolet curing is carried out for 60s, and a solid hydrogel coupling layer with the thickness of 1mm and the size slightly smaller than that of the substrate is formed. And then aligning and pasting the flexible PMUT array on the surface of the hydrogel, covering and sealing the polyurethane film with the thickness of 25 mu m by a hot pressing method to form a sealing protection layer, wherein the hot pressing temperature is 85 ℃, the pressure is 0.3MPa, and the time is 10s, so that the outer edge of the polyurethane is fused and combined with a silic