CN-122004964-A - Membrane implant for promoting thickening of soft tissues

CN122004964ACN 122004964 ACN122004964 ACN 122004964ACN-122004964-A

Abstract

The invention relates to the technical field of medical instruments, in particular to a membrane implant for increasing the thickness of soft tissues. The membrane implant comprises a soft tissue thickening membrane, soft tissue anchoring spikes and bone tissue anchoring spikes, wherein the soft tissue anchoring spikes and the bone tissue anchoring spikes are respectively positioned at two sides of the soft tissue thickening membrane, the soft tissue anchoring spikes incline towards the central axis direction of the soft tissue thickening membrane to penetrate soft tissue, the length of the soft tissue anchoring spikes is 400-1200 mu m and is smaller than the thickness of a dermis layer at a part to be penetrated, the bone tissue anchoring spikes incline away from the central axis direction of the soft tissue thickening membrane to anchor bone tissue and provide space for thickening the soft tissue, and the ratio of the length of the bone tissue anchoring spikes to the length of the soft tissue anchoring spikes is 0.5-2:0.5-2. The membrane implant can be implanted into the interface of bone tissue and soft tissue, and forms a dedicated soft tissue thickening supporting space between the bone tissue and the soft tissue, so that the soft tissue adhesive force is enhanced, and the soft tissue thickening is efficiently promoted.

Inventors

LI YANFENG
LI YIHE
Pan Xiyun
LIANG YIJIE
ZHANG ZHENBAO
QI YUHAN

Assignees

李岩峰

Dates

Publication Date: 20260512
Application Date: 20260213

Claims (10)

1. A membrane implant for promoting thickening of soft tissue, characterized in that the membrane implant comprises a soft tissue thickening membrane (1), soft tissue anchoring spikes (2) and bone tissue anchoring spikes (3); the soft tissue anchoring spikes (2) and the bone tissue anchoring spikes (3) are respectively positioned at two sides of the soft tissue thickening film (1); The soft tissue anchoring spike (2) is inclined towards the central axis direction of the soft tissue thickening film (1) so as to penetrate soft tissues, the length of the soft tissue anchoring spike (2) is 400-1200 mu m and is smaller than the thickness of a dermis layer of a part to be penetrated; The bone tissue anchoring spike (3) is inclined towards the central axis direction far away from the soft tissue thickening film (1) so as to anchor bone tissue and provide space for soft tissue thickening, and the ratio of the length of the bone tissue anchoring spike (3) to the length of the soft tissue anchoring spike (2) is 0.5-2:0.5-2.
2. The membrane implant for promoting soft tissue thickening according to claim 1, characterized in that the soft tissue thickening membrane (1) comprises a thickening membrane and several vascular channels (4); the thickening film is of a single-layer or multi-layer sponge structure, and each layer of the thickening film has the same structure and the thickness of 100-500 mu m; the blood vessel-like channels (4) are distributed in the thickening film in a staggered way, and the openings of the blood vessel-like channels are arranged on the surface of the thickening film, and the diameter of the blood vessel-like channels is 7-300 mu m.
3. The membrane implant for promoting soft tissue thickening according to claim 1, wherein the soft tissue anchoring spikes (2) are arranged in an array having a density of 50-400 needles per square centimeter and/or, The angle of inclination between the soft tissue anchoring spike (2) and the plane of the soft tissue thickening film (1) is 30-90 degrees.
4. The membrane implant for promoting soft tissue thickening according to claim 1, wherein the bone tissue anchoring spikes (3) are arranged in an array having a density of 5-50 needles per square centimeter and/or, The bone tissue anchoring spike (3) is inclined at an angle of 60-90 DEG to the plane of the soft tissue augmentation film (1).
5. The membrane implant for promoting soft tissue thickening according to claim 1, wherein at least 1 barb (5) is provided on each of the soft tissue anchoring spike (2) and the bone tissue anchoring spike (3), and the barb (5) has a needle-like structure and has a tip; The tip of the barb (5) is oriented opposite to the tip of the soft tissue anchoring spike (2) or the tip of the bone tissue anchoring spike (3).
6. The membrane implant for promoting soft tissue thickening according to claim 5, wherein the barb (5) has a length of 1/5 to 1/3 of the length of the anchored spike, and the angle between the soft tissue anchoring spike (2) and the bone tissue anchoring spike (3) is 30 to 75 °.
7. The membrane implant for promoting soft tissue thickening according to claim 6, wherein the soft tissue anchoring spikes (2), bone tissue anchoring spikes (3) and barbs (5) are hollow structures (6), the hollow structures (6) being used for delivering blood transport.
8. The membrane implant for promoting soft tissue thickening according to claim 6, wherein the soft tissue thickening membrane (1), soft tissue anchoring spikes (2), bone tissue anchoring spikes (3), vascular-like channels (4), barbs (5) and/or hollow structures (6) are loaded with a drug for promoting soft tissue regeneration.
9. The membrane implant for promoting soft tissue thickening according to claim 8, wherein the drug is loaded in a manner of being filled in the vessel-like channel (4) or the hollow structure (6), being coated on the surface of the soft tissue thickening membrane (1), the soft tissue anchoring spike (2), the bone tissue anchoring spike (3) and the barb (5) or being incorporated into the preparation material of the soft tissue thickening membrane (1), the soft tissue anchoring spike (2), the bone tissue anchoring spike (3) or the barb (5).
10. The membrane implant for promoting thickening of soft tissues according to claim 1, wherein said soft tissue thickening membrane (1) is made of a biodegradable material selected from one or more of collagen, chitosan, polylactic acid, methacryloyl hyaluronic acid, methacryloyl gelatin or a degradable metal, and/or, The soft tissue anchoring spike (2) and the bone tissue anchoring spike (3) are each independently selected from biodegradable polymers or one of medical grade degradable metals and/or non-degradable metals.

Description

Membrane implant for promoting thickening of soft tissues Technical Field The invention relates to the technical field of medical instruments, in particular to a membrane implant for increasing the thickness of soft tissues. Background In thickening or widening (lengthening) type incremental surgery, which is performed on soft tissue defects, promoting good soft tissue growth and achieving effective thickening is a key goal to improve the effectiveness of the surgery. At present, no special soft tissue incremental membrane product exists in clinic, and related operations mainly depend on traditional schemes such as autologous tissue transplantation or skin expander expansion. The self tissue transplantation has the problems of large wound of a supply area, limited tissue quantity and the like, and the expansion of the skin expander can only realize the expansion of the area of soft tissues, so that the core requirement of the thickening of the soft tissues can not be met, and the accurate requirement of clinical incremental repair of the soft tissues is difficult to meet. In order to solve the above problems, the art tries to construct a soft tissue growth space in a physical support manner to assist the increment, but in the prior art, a specific membrane is lacking, if the conventional soft tissue increment operation is adopted for the increment, although the goal can be realized to a certain extent, the soft tissue tension can be obviously increased, a second operation area is opened up, a series of problems such as infection and aggravated wound after operation are further caused, and the effect and popularization and application of the soft tissue increment operation are further limited. Disclosure of Invention In order to solve the technical problems, the invention provides a membrane implant for promoting soft tissue thickening, which can be implanted into the interface of bone tissue and soft tissue to form a dedicated soft tissue thickening supporting space between the bone tissue and the soft tissue, so as to enhance the adhesion of the soft tissue, simultaneously stimulate controllable bleeding through soft tissue anchoring spike penetration into the soft tissue, optimize the soft tissue proliferation microenvironment and promote the soft tissue thickening efficiently. The present invention provides in an alternative embodiment a membrane implant that promotes soft tissue thickening, the membrane implant comprising a soft tissue thickening membrane, soft tissue anchoring spikes, and bone tissue anchoring spikes; The soft tissue anchoring spike and the bone tissue anchoring spike are respectively positioned at two sides of the soft tissue thickening film; The soft tissue anchoring spike is inclined to the central axis direction of the soft tissue thickening film so as to penetrate soft tissue, the length of the soft tissue anchoring spike is 400-1200 mu m and is smaller than the thickness of a dermis layer of a part to be penetrated; The bone tissue anchoring spike is inclined to the central axis direction far away from the soft tissue thickening film so as to anchor the bone tissue and provide space for thickening the soft tissue, and the ratio of the length of the bone tissue anchoring spike to the length of the soft tissue anchoring spike is 0.5-2:0.5-2. In the invention, the membrane implant can be implanted into the interface of bone tissue and soft tissue, a dedicated soft tissue thickening supporting space is formed between the bone tissue and the soft tissue, the soft tissue adhesion is enhanced, meanwhile, the soft tissue anchoring spike is penetrated into the soft tissue to stimulate the controllable bleeding, the soft tissue proliferation microenvironment is optimized, and the soft tissue thickening is efficiently promoted. Preferably, the soft tissue thickening film comprises a thickening film and a plurality of blood vessel-like channels, wherein the thickening film is of a single-layer or multi-layer sponge structure, each layer of the thickening film is of the same structure and has the thickness of 100-500 mu m, the blood vessel-like channels are distributed in the thickening film in a staggered way, and the openings of the blood vessel-like channels are arranged on the surface of the thickening film and have the diameter of 7-300 mu m. The invention has the advantages that the sponge structure has excellent porosity, can accommodate cell growth and allow nutrient substances to permeate, provides a basic environment for soft tissue repair, is suitable for the diameters of dermis and subcutaneous tissue blood vessel networks, is provided with a plurality of channels which are distributed in the thickening film in a staggered way to form a reticular structure with openings penetrating through the upper surface and the lower surface of the film, and can accelerate nutrient substance delivery and cell migration and rapidly deliver blood transport to the thickening space; Preferably, th