CN-122004981-A - Spring ring with embolism effect and controllable degradation characteristic and use method thereof

CN122004981ACN 122004981 ACN122004981 ACN 122004981ACN-122004981-A

Abstract

The application belongs to the technical field of medical appliances and provides a spring coil with embolism effect and controllable degradation characteristic and a use method thereof, wherein the method comprises the steps of acquiring blood vessel data through medical imaging equipment, inputting the acquired blood vessel data into a preset intelligent algorithm model, analyzing the blood vessel data and outputting adaptive spring coil diameter, length and degradation period parameters; in interventional operation, acquiring implantation track data of a spring coil in real time by means of a developing and marking technology, synchronously analyzing image data to generate information for adjusting implantation angle and depth, periodically acquiring postoperative data of the degradation state of the spring coil and the vascular healing condition by image inspection after operation, dynamically analyzing the acquired postoperative data to judge whether the corresponding degradation progress accords with a preset period, and generating intervention suggestion information if degradation abnormality occurs until the spring coil is completely degraded and the blood vessel is restored to normal physiological functions.

Inventors

ZHAO HAO
LIANG YONGPING
SUN JUNZHAO

Assignees

中国人民解放军总医院第六医学中心

Dates

Publication Date: 20260512
Application Date: 20260319

Claims (10)

1. A method of using a spring coil having both embolic and controlled degradation characteristics, the method comprising: Acquiring blood vessel data including the size, shape, position and vascular condition of an aneurysm through medical imaging equipment, inputting the acquired blood vessel data into a preset intelligent algorithm model, analyzing the blood vessel data by the intelligent algorithm model, and outputting the diameter, length and degradation period parameters of an adaptive spring coil so as to ensure that the spring coil can completely fill the aneurysm and match the vascular healing speed of the patient; In interventional operation, acquiring implantation track data of the spring coil in real time by means of a developing and marking technology, synchronously analyzing image data, generating information for adjusting implantation angle and depth so as to adjust the implantation angle and depth, enabling the spring coil to tightly fill an aneurysm cavity to realize efficient embolism, and simultaneously avoiding damaging surrounding normal vascular tissues; The method comprises the steps of acquiring postoperative data of the degradation state of a spring coil and the healing condition of a blood vessel through image examination at regular intervals after operation, dynamically analyzing the acquired postoperative data, judging whether the corresponding degradation progress accords with a preset period, and generating intervention suggestion information if degradation abnormality occurs until the spring coil is completely degraded and the blood vessel is restored to normal physiological functions.
2. The method of claim 1, wherein the acquiring, by the medical imaging device, blood vessel data comprises: Scanning the part where the aneurysm is located through at least one of a computer tomography device, a magnetic resonance imaging device or a digital subtraction angiography device to obtain two-dimensional or three-dimensional image data comprising the size, the shape and the position of the aneurysm and the vessel diameter and the vessel wall elasticity of a patient so as to generate the vessel data.
3. The method of claim 1, further comprising, prior to said entering said acquired vessel data into a predetermined intelligent algorithm model: Collecting blood vessel data of a historical aneurysm patient, the diameter and length of a used spring ring, degradation period parameters and corresponding postoperative blood vessel healing effect data, and forming a training data set; Training an initial algorithm model by using the training data set, optimizing model parameters of the initial algorithm model by a machine learning algorithm, and enabling the initial algorithm model to output parameters of the diameter, the length and the degradation period of a spring ring matched with the postoperative vascular healing effect according to input vascular data to acquire an intelligent algorithm model after training; after training is completed, the intelligent algorithm model is verified, and accuracy of output parameters of the intelligent algorithm model is ensured.
4. The method of claim 1, further comprising, prior to said inputting said acquired blood vessel data into a predetermined intelligent algorithm model, analyzing the blood vessel data and outputting adapted spring coil diameter, length and degradation cycle parameters: Preprocessing the acquired blood vessel data, removing noise in the image data by utilizing an image noise reduction algorithm, converting the blood vessel data from different sources into a unified format by data normalization processing, extracting geometrical characteristic parameters of aneurysms and physiological characteristic parameters of blood vessels of patients, forming standardized input data, and inputting the standardized input data into the intelligent algorithm model.
5. The method of claim 1, wherein the acquiring implantation trajectory data of the spring coil in real time via a development marking technique comprises: And setting a metal developing mark or a fluorescent developing mark on the spring ring, capturing the position information of the developing mark in real time through angiography equipment or fluorescent imaging equipment in the interventional operation process, acquiring coordinate data of the developing mark according to a preset time interval, generating implantation track data of the spring ring, and transmitting the track data to an operation navigation system in real time.
6. The method of claim 1, wherein the synchronously analyzing the image data to generate information for adjusting the implant angle and depth comprises: Three-dimensional registration is carried out on spring ring implantation track data acquired in real time and an aneurysm filling model preset before operation, and an image processing algorithm is utilized to calculate the angle deviation and the depth deviation between the current position of the spring ring and the target position; Based on the angle deviation and the depth deviation, combining physical characteristic parameters of the spring ring, generating operation guide information for adjusting the implantation angle and the depth, wherein the operation guide information comprises an angle adjustment value and a depth advancing or retracting value.
7. The method of claim 1, wherein adjusting the implantation angle and depth to allow the coil to tightly fill the aneurysm cavity for efficient embolization while avoiding damage to surrounding normal vascular tissue comprises: according to the generated information for adjusting the implantation angle and depth, adjusting the implantation angle of the spring ring by a surgical operation instrument, and controlling the pushing depth of the spring ring; In the adjusting process, the filling density of the spring ring to the aneurysm cavity and the pressure value to the peripheral vascular wall are monitored in real time, and when the filling density reaches a preset threshold value and the pressure value is within a safe range, the adjusting operation is stopped.
8. The method according to claim 1, wherein dynamically analyzing the acquired post-operative data to determine whether the corresponding degradation schedule corresponds to a preset period comprises: Acquiring volume change data of the spring coil and vascular endothelial cell coverage condition data through medical image examination, and taking the volume change data and the vascular endothelial cell coverage condition data as postoperative data; Comparing the postoperative data with a preset spring ring degradation rate curve and a preset vascular healing process curve by using a time sequence analysis algorithm, and calculating a degradation progress deviation value; And judging whether the degradation progress of the spring ring is in a preset period range or not according to the degradation progress deviation value.
9. The method of claim 1, wherein generating intervention advice information if degradation abnormality occurs until the coil is completely degraded and the blood vessel resumes normal physiological function, comprises: when judging that the degradation progress is abnormal, analyzing the type of the degradation abnormality, and if the degradation is too fast, generating information of local administration of the drug for inhibiting the biodegradation; if the degradation is too slow, generating information which recommends increasing local temperature or magnetic field stimulation to accelerate the degradation; And after performing intervention operation according to the intervention suggestion information, continuously and periodically acquiring postoperative data, and repeating the dynamic analysis and judgment process until the spring ring is completely degraded and angiography shows that the vascular cavity is unobstructed and endothelial cells are completely covered.
10. A spring coil having both embolic and controlled degradation properties for use in carrying out the method of any one of claims 1-9, said spring coil comprising: The main body is a spiral main body made of degradable biological materials, the main body is made of polylactic acid materials, and the degradation period of the main body is preset to be matched with the healing period of a blood vessel through the material characteristics; The developing mark is embedded on the surface or the inside of the spiral structure of the main body and is used for developing under medical imaging equipment so as to track the implantation track and the filling state of the main body; The spiral diameter and length parameters of the main body are adaptively set according to the size and the shape of the aneurysm and the vascular conditions of a patient so as to tightly fill the aneurysm cavity, and the distribution density and the position of the developing mark meet the definition requirement of real-time image monitoring in operation.

Description

Spring ring with embolism effect and controllable degradation characteristic and use method thereof Technical Field The invention belongs to the technical field of medical instruments, and particularly relates to a spring ring with an embolism effect and controllable degradation characteristics and a use method thereof. Background Permanent retention type spring coils (such as metal spring coils) widely used in traditional aneurysm embolism treatment cannot be degraded, and long-term retention in vivo can cause vascular endothelial stimulation, chronic inflammatory reaction, long-term thrombosis and other complications. Although the introduction of degradable biological materials (such as polylactic acid) provides a new direction for solving the problems, the existing degradable spring ring technology still has the obvious defects that firstly, the preoperative specification selection depends on subjective judgment of doctors' experience, the accurate matching of the anatomical features of aneurysms and the individual vascular healing speed of patients is difficult, the insufficient embolism or the unsynchronized degradation period and tissue repair are easily caused, secondly, the real-time dynamic monitoring means are lacked in the implantation process in operation, the spring ring filling density and the position adjustment depend on the experience of doctors, the risk of damaging normal blood vessels or the insufficient embolism efficiency exists, thirdly, the quantitative tracking and intervention mechanism of the degradation process is lacked in operation, the degradation process cannot be dynamically adjusted according to individual differences, and early embolism failure or excessively slow long-term risk is possibly caused by excessively quick degradation. Accordingly, a need exists for a method that addresses at least one of the problems described above. Disclosure of Invention The application provides a spring ring with embolic effect and controllable degradation characteristic and a use method thereof, and aims to solve the problems that in the prior art, the combination of degradable materials and developing technology only stays on material level improvement, the application of an intelligent algorithm is mostly limited to a single link (such as preoperative image analysis or postoperative data statistics), and a closed-loop intelligent control system which runs through the whole process of preoperative-intraoperative-postoperative is not formed yet. Therefore, how to deeply integrate the biodegradable material characteristics, the development monitoring technology and the intelligent algorithm, and realize the integrated solutions of self-adaptive matching of the spring ring specification, accurate regulation and control of the implantation track and dynamic tracking of the degradation process is a technical bottleneck to be broken through in the field. In a first aspect, the present application provides a method of using a spring coil having both embolic and controlled degradation properties, the method comprising: Acquiring blood vessel data including the size, shape, position and vascular condition of an aneurysm through medical imaging equipment, inputting the acquired blood vessel data into a preset intelligent algorithm model, analyzing the blood vessel data by the intelligent algorithm model, and outputting the diameter, length and degradation period parameters of an adaptive spring coil so as to ensure that the spring coil can completely fill the aneurysm and match the vascular healing speed of the patient; In interventional operation, acquiring implantation track data of the spring coil in real time by means of a developing and marking technology, synchronously analyzing image data, generating information for adjusting implantation angle and depth so as to adjust the implantation angle and depth, enabling the spring coil to tightly fill an aneurysm cavity to realize efficient embolism, and simultaneously avoiding damaging surrounding normal vascular tissues; The method comprises the steps of acquiring postoperative data of the degradation state of a spring coil and the healing condition of a blood vessel through image examination at regular intervals after operation, dynamically analyzing the acquired postoperative data, judging whether the corresponding degradation progress accords with a preset period, and generating intervention suggestion information if degradation abnormality occurs until the spring coil is completely degraded and the blood vessel is restored to normal physiological functions. In some embodiments, the acquiring the blood vessel data by the medical imaging device includes scanning a location of the aneurysm by at least one of a computed tomography device, a magnetic resonance imaging device, or a digital subtraction angiography device to obtain two-dimensional or three-dimensional image data including a size, a morphology, a location of the aneurysm, and a vessel