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CN-122005124-A - Oral cavity base station with medicine slow-release function

CN122005124ACN 122005124 ACN122005124 ACN 122005124ACN-122005124-A

Abstract

The invention discloses an oral cavity base station with a medicine slow-release function, and relates to the technical field of medical implantation. The invention designs an oral cavity base station with a medicine slow-release function, which aims to solve the problem of poor treatment effect caused by insufficient medicine concentration in the prior art, and is mainly characterized by having three medicine release modes which are mutually matched and linked, wherein the three medicine release modes comprise a sustained release mode structure, an inflammation release mode structure and a stress release mode structure, a proper amount of medicine is continuously released through an osmotic pump to maintain basic treatment concentration in a daily state, after the mucosa around an implant is inflamed, the temperature of an inflammation part is detected to be increased, the release dosage is increased through the inflammation release mode structure so as to strengthen the treatment effect, and when a patient is pressed and bitten, the medicine release amount is further supplemented through the stress release mode structure. The invention obviously improves the treatment effect of the mucositis around the implant and promotes the repair and regeneration of the tissue around the implant.

Inventors

  • NI FENG
  • YE WENMIN
  • MAO ANLIN
  • LI WEIKANG
  • ZHAO TINGTING

Assignees

  • 中国人民解放军空军军医大学

Dates

Publication Date
20260512
Application Date
20260228

Claims (9)

  1. 1. An oral cavity abutment with a drug release function, characterized by having three drug release modes of mutually cooperating linkage, comprising: a sustained release mode structure (100) provided on an implant (400) combined with bone tissue in an alveolar bone; an inflammation release pattern structure (200) disposed within the sustained release pattern structure (100); a force release pattern structure (300) disposed at an upper portion of the sustained release pattern structure (100) and extending to an outside of the sustained release pattern structure (100); the top of the implant (400) wraps around the bottom of the sustained release mode structure (100).
  2. 2. The oral cavity base station with the medicine slow release function according to claim 1, wherein the sustained release mode structure (100) is composed of an osmotic pump, the osmotic pump is composed of a semipermeable membrane (103), a medicine storage layer (101) and a pushing layer (102) from outside to inside in sequence, and a plurality of medicine release small holes (104) are formed in the osmotic pump in a penetrating mode; -the push layer (102) is internally provided with the inflammatory release pattern structure (200); The moisture in saliva enters the water-absorbing expansion pushing layer (102) through the semipermeable membrane (103), the pushing layer (102) expands to increase the pressure of the medicine storage layer (101), and the medicine solution is released from the medicine release small hole (104) under the driving of the pressure.
  3. 3. The oral abutment with drug delivery function according to claim 2, wherein the inflammatory release pattern structure (200) comprises: A liquid bag (201) having a heating function and provided inside the push layer (102); The support rod (202) is vertically arranged inside the liquid sac (201) and extends to the outside of the liquid sac (201); One end of each spring (205) is respectively connected with the part of the supporting rod (202) immersed in the liquid bag (201); one side of the push plates (203) is connected with the end part of the spring (205) far away from the support rod (202), and the other side is attached to the inner wall of the liquid sac (201); The spring (205) is deformed by heating the liquid in the liquid bag (201) to drive the push plate (203) to move outwards, the liquid bag (201) is expanded along with the deformation, and the pushing layer (102) and the medicine storage layer (101) are extruded to release the medicine solution from the medicine release small hole (104).
  4. 4. An oral abutment with a drug delivery function according to claim 3, characterized in that the spring (205) is made of a memory alloy.
  5. 5. The oral cavity abutment with the drug release function according to claim 4, wherein a telescopic rod (204) is arranged inside the spring (205) in a penetrating manner and used for guiding the spring (205), one end of the telescopic rod (204) is connected with the supporting rod (202), and the other end of the telescopic rod is connected with the push plate (203).
  6. 6. An oral abutment with a drug delivery function according to claim 3, characterized in that the heating assembly of the capsule (201) comprises: A set of heating plates (206) respectively arranged at the top and the bottom in the liquid bag (201); a temperature sensor (207) provided on the top of the implant (400); Wherein, after the temperature sensor (207) detects the temperature rise caused by inflammation, the heating plate (206) is controlled to heat the liquid in the liquid sac (201).
  7. 7. An oral cavity abutment with a drug release function according to claim 3, wherein an elastic tube (105) communicated with the drug release small hole (104) is connected to the outer side of the drug release small hole, and a release hole matched with the elastic tube (105) is formed in the top of the implant (400) in a penetrating manner.
  8. 8. The oral abutment with drug delivery function according to claim 7, wherein the force release pattern structure (300) comprises: a piston (301) provided at the upper part of the support rod (202); A rope (302) having one end connected to the piston (301) and the other end connected to the elastic tube (105); When the patient performs the biting action, the piston (301) is forced to move downwards, the piston (301) extrudes the osmotic pump to release the drug solution, and meanwhile drives the rope (302) to move downwards, so that the elastic tube (105) is opened, and the drug solution enters the oral cavity of the patient through the elastic tube (105).
  9. 9. The oral abutment with a drug release function according to claim 8, wherein a return spring (303) is provided between the piston (301) and the support bar (202); -compressing said return spring (303) when said piston (301) is forced downwards; When the piston (301) is not stressed, the return spring (303) is restored to deform so as to enable the piston (301) to move upwards, the rope (302) is driven to move upwards, and the elastic tube (105) is closed by the rope (302).

Description

Oral cavity base station with medicine slow-release function Technical Field The invention relates to the technical field of medical implantation, in particular to an oral cavity base station with a medicine slow-release function. Background In the field of stomatology, implant restoration techniques have become an important treatment for patients with tooth loss. However, peri-implant mucositis presents a potential threat to the oral health of the patient as a common complication following implantation. The incidence rate of the traditional Chinese medicine composition is in an ascending trend year by year, and mainly comes from factors such as improper maintenance of oral hygiene, bacterial infection and the like. If not treated effectively, peri-implant mucositis may lead to peri-implant bone resorption, ultimately leading to implant failure, which not only increases patient pain and economic burden, but may also cause a series of oral dysfunction. Traditional peri-implant mucositis treatment methods are mostly local irrigation, drug administration or oral antibiotics. The local flushing and medicine feeding operations are inconvenient, the residence time of the medicine in the inflammation part is short, the effective medicine concentration is difficult to maintain, the oral antibiotics can cause systemic adverse reactions, the concentration of the medicine is greatly reduced when the medicine reaches the inflammation area around the implant, and the curative effect is limited. In recent years, with the rapid development of biological material science and drug controlled release technology, a trigger is provided for the treatment innovation in the field of oral implantation. The intelligent material such as the shape memory alloy shows unique physical characteristics and can respond to environmental changes, the osmotic pump technology has remarkable effect on the aspect of drug slow release, the accurate and continuous release of the drug can be realized, and the utilization of physiological actions such as occlusion and the like provides a new thought for drug delivery as required. Based on the support of the advanced technologies, a novel implant temporary abutment with a drug slow release function is provided for overcoming the defects of the traditional treatment method. The patent with publication number CN116831760B discloses an anti-inflammatory antibacterial drug slow-release base station applied to oral implant, which comprises a wireless power receiving device arranged on a phototherapy implant, the top of the wireless power receiving device is connected with a conductor bar, the surface of the wireless power receiving device is also connected with a base station shell, the conductor bar is positioned in the base station shell, anti-inflammatory antibacterial drug liquid can be filled in the base station shell, a drug outlet hole is formed in the base station shell, and a sealing cover is movably connected to the position of the base station shell corresponding to the drug outlet hole. By arranging the conductor bars, the conductor rings, the plastic film and the sealing cover, the invention solves the problems that the existing phototherapy device does not have the storage and release functions of various liquid medicines capable of being photo-excited to resist inflammation and the like, but limits the anti-bacterial and anti-inflammatory effects to a certain extent, the recovery time is inconvenient to shorten, and the comfort level of planted patients is possibly reduced. The invention has the improved direction of adding the storage and release functions of various liquid medicines capable of being stimulated by light to resist inflammation and the like, and the improved direction of controlling the dosage and the release time of the medicines. Disclosure of Invention Aiming at the problems, the technical thought adopted by the invention for solving the technical problems is as follows: The three mutually matched and linked drug release modes realize the intelligent, accurate and efficient delivery of the drug at the peripheral parts of the implant. The sustained release of the medicine is realized by the osmotic pump at ordinary times, the release medicine amount is increased by the inflammatory release mode structure after the inflammation is detected, and when a patient bites, the medicine amount is increased by the stress release mode structure and the medicine amount is reduced when the patient bites. The specific scheme is as follows: the oral cavity base with the medicine slow release function has three medicine release modes which are in linkage and matched with each other, and comprises a continuous release mode structure, an inflammation release mode structure, a stress release mode structure and a top part, wherein the continuous release mode structure is arranged on an implant combined with bone tissue in an alveolar bone, the inflammation release mode structure is arranged i