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CN-122005160-A - Targeting drug release type cardiovascular stent system for preventing vascular restenosis

CN122005160ACN 122005160 ACN122005160 ACN 122005160ACN-122005160-A

Abstract

The invention discloses a targeted drug release type cardiovascular stent system for preventing vascular restenosis, which belongs to the technical field of interventional medical instruments and comprises a stent framework adapting to a coronary artery lumen, a microfluidic drug storage component integrated and embedded in the stent framework, an intelligent driving component correspondingly assembled in a microfluidic channel and a targeted release mechanism arranged in the stent framework, wherein the microfluidic drug storage component comprises a plurality of independently sealed drug storage bins and corresponding microfluidic channels, and the intelligent driving component realizes time sequence unlocking and dynamic adjustment of drug release quantity along with a body temperature gradient according to a vascular repair stage through a venturi tube, a body temperature response type diameter adjusting part, a time sequence degradation sealing part and an elastic self-reset sealing part. The invention can realize full-period staged accurate drug delivery, avoid unbalanced drug release and unexpected release, and improve the effect of the stent on preventing vascular restenosis and clinical reliability.

Inventors

  • YAO SHUXIA
  • GAO XIUMEI
  • LI DONGYAN

Assignees

  • 锦州医科大学附属第一医院

Dates

Publication Date
20260512
Application Date
20260410

Claims (10)

  1. 1. A targeted drug-release cardiovascular stent system for preventing restenosis in a blood vessel, comprising: A stent framework (1) adapted to the lumen of a coronary artery; The microfluidic medicine storage bin assembly (2), the microfluidic medicine storage bin assembly (2) is integrated and embedded inside the support framework (1), the microfluidic medicine storage bin assembly (2) comprises a plurality of medicine storage bins (21) which are sealed independently and are communicated in a one-to-one correspondence manner, and a plurality of microfluidic channels (22) are communicated, and the medicine storage bins (21) are respectively provided with medicine liquid with different functions; the intelligent driving assembly (3), the intelligent driving assembly (3) is a plurality of groups and is correspondingly assembled in each microfluidic channel (22), each group of intelligent driving assembly (3) comprises a venturi tube (31), a diameter adjusting piece (32) formed by shape memory alloy, a degradation sealing piece (33) and a blocking sealing piece (34), the venturi tubes (31) are correspondingly assembled in the microfluidic channels (22), the diameter adjusting pieces (32) are arranged in the microfluidic channels (22) along the radial direction of the microfluidic channels (22) and the output ends of the diameter adjusting pieces are correspondingly arranged on the venturi tubes (31) so as to adjust the impact force of liquid medicine, the degradation sealing pieces (33) are in sealing fit with the inlet ends of the venturi tubes (31), and the blocking sealing pieces (34) are in sealing fit with the outlet ends of the venturi tubes (31) so as to control the opening and closing of the microfluidic channels based on the impact force of the liquid medicine; The targeted release mechanism (4), targeted release mechanism (4) is assembled inside the support skeleton (1), and the input end of targeted release mechanism (4) is communicated with the output end of venturi (31), the output end of targeted release mechanism (4) comprises a plurality of microtubules (41) arranged in an array, and a plurality of microtubules (41) extend out of the support skeleton (1) so as to release the liquid medicine in a directional manner.
  2. 2. The targeted drug release type cardiovascular stent system for preventing restenosis of blood vessel according to claim 1, wherein the stent framework (1) comprises an inner through pipe (11) and an outer supporting net (12), the outer supporting net (12) is coaxially sleeved outside the inner through pipe (11), the outer supporting net (12) is of a hollowed-out net-shaped supporting structure, and the microfluidic drug storage bin assembly (2), the intelligent driving assembly (3) and the targeted release mechanism (4) are all arranged between the inner through pipe (11) and the outer supporting net (12).
  3. 3. The targeted drug release type cardiovascular stent system for preventing restenosis of blood vessel according to claim 2, wherein the stent framework (1) further comprises a supporting air bag (13), the supporting air bag (13) is of an annular structure, the two supporting air bags (13) are respectively coaxially sleeved at two ends of the inner through pipe (11), the two supporting air bags (13) are connected through an air pipe, one supporting air bag is communicated with an air charging pipe (14), and the air charging end of the air charging pipe (14) extends out of the inner through pipe (11) to charge the two air bags through a pressure air charging ball which is detachably connected.
  4. 4. A targeted drug release cardiovascular stent system for preventing restenosis of blood vessel according to claim 3, wherein the drug storage bin (21) is of an arc structure and is fixedly attached to the inner through tube (11), the drug storage bin (21) is positioned between the two supporting air bags (13), the outer edge end of the drug storage bin (21) is fixedly connected with the inner side of the outer supporting net (12) so that the outer supporting net (12) can move along the radial direction, the microfluidic channel (22) is of an arc structure and is attached to the outer wall of the inner through tube (11), and the outer edge end of the microfluidic channel is arranged at intervals with the outer supporting net (12).
  5. 5. The targeted drug-release cardiovascular stent system for preventing restenosis of blood vessel as claimed in claim 4, wherein the drug storage bins (21) are respectively provided with drug solution injection pipes (211), a plurality of the drug solution injection pipes (211) are respectively arranged along the axial direction of the inner through pipe (11), and the end parts of each drug solution injection pipe (211) are respectively arranged close to the end parts of the inner through pipe (11) so as to respectively supplement the drug solution.
  6. 6. The targeted drug-release cardiovascular stent system for preventing restenosis of blood vessel according to claim 4, wherein the output end of the microfluidic channel (22) is integrally fixed with an output end (221), the output end (221) is arranged along the radial direction of the inner tube (11), and the output end (221) is communicated with the input end of the targeted release mechanism (4).
  7. 7. The targeted drug delivery type cardiovascular stent system for preventing restenosis according to claim 6, wherein the targeted drug delivery mechanism (4) comprises a connecting pipe (42) and a dispersion disc (43), the connecting pipe (42) is in a horn shape and is communicated with the output end (221), a horn mouth of the connecting pipe (42) is integrally fixed with the dispersion disc (43), the dispersion disc (43) is in an arc structure, the outer edge end of the dispersion disc is attached to the inner side of the outer support net (12), the dispersion disc (43) is hollow, and the micro-tube (41) array is arranged at the outer edge end of the dispersion disc (43) and is inserted into a mesh hole of the outer support net (12) in a penetrating way, so that the liquid medicine is sprayed on the wall of the blood vessel through a plurality of micro-tubes (41).
  8. 8. The targeted drug-release cardiovascular stent system for preventing restenosis of blood vessel according to claim 1, wherein the venturi tube (31) comprises an inlet section (311), an outlet section (312) and a throat section (313), wherein the ends of the inlet section (311) and the outlet section (312) are tightly adhered and fixed on the inner side wall of the microfluidic channel (22), the throat section (313) is an elastic structure which can extend along the axial direction thereof, the two ends of the throat section (313) are respectively connected with the inlet section (311) and the outlet section (312) in a sealing way, and the diameter adjusting piece (32) is arranged between the throat section (313) and the wall of the microfluidic channel (22) so as to adjust the diameter of the throat section (313) based on the temperature change of the body temperature.
  9. 9. The targeted drug release type cardiovascular stent system for preventing restenosis of blood vessel according to claim 8, wherein the microfluidic drug storage component (2) and the intelligent driving component (3) are both of heat conduction structures, the degradation sealing element (33) is a stage time sequence type self-degradation sealing film so as to automatically degrade based on the period of vascular repair, the plugging sealing element (34) is an elastic self-resetting tension film, the elastic self-resetting tension film adaptively adjusts the opening degree according to the impact force of the liquid medicine, and the opening degree is in direct proportion to the impact force so as to realize dynamic regulation of the drug quantity according to the thermal gradient of the body.
  10. 10. The targeted drug-release cardiovascular stent system for preventing restenosis according to claim 9, wherein the drug reservoirs (21) are respectively filled with a drug solution matched with symptoms of a plurality of vascular repair phases, the extension lengths of the diameter adjusting members (32) are respectively matched with the temperature change ranges of the symptoms of the vascular repair phases, and the opening time of the time-series self-degradable sealing membranes of the phases is synchronous with the repair phases.

Description

Targeting drug release type cardiovascular stent system for preventing vascular restenosis Technical Field The invention relates to the technical field of interventional medical instruments, in particular to a targeted drug-release cardiovascular stent system for preventing vascular restenosis. Background The cardiovascular stent technology mainly refers to an implantable medical device applied to coronary artery lumen support, the technology takes a physical stenosed vessel as a core function, a part of stent surface is attached with a drug coating, and the intervention of basic anti-intimal hyperplasia is realized through natural diffusion of the drug, which belongs to a conventional intervention technology combining passive support and basic drug release. The prior art generally has the defects that the time-sequence unlocking drug release can not be realized according to different stages of vascular repair, the drug release is easy to occur with error release or release lag, the drug release with fixed dosage and fixed flow rate can only be realized, the drug release targeting property and the suitability are poor, the local drug concentration is easy to be too high or the drug administration is insufficient, the ineffective drug release under the non-target working condition is difficult to avoid, the vascular restenosis can not be prevented in a full-period and precise manner, and the clinical requirements are difficult to be met with the overall drug release controllability and the treatment effect. Disclosure of Invention The invention aims to provide a targeted drug release type cardiovascular stent system for preventing vascular restenosis, which solves the technical problems. In order to achieve the above object, the present invention provides a targeted drug-releasing cardiovascular stent system for preventing restenosis of blood vessel, comprising: a stent framework adapted to the lumen of the coronary artery; the microfluidic medicine storage bin assembly is integrated and embedded in the bracket framework, and comprises a plurality of medicine storage bins which are mutually independent and sealed and a plurality of microfluidic channels which are communicated in a one-to-one correspondence manner, and the medicine storage bins are respectively provided with medicine liquid with different functions; The intelligent driving components are in multiple groups and are assembled in each microfluidic channel in a one-to-one correspondence manner, each group of intelligent driving components comprises a venturi tube, a diameter adjusting piece formed by shape memory alloy, a degradation sealing piece and a plugging sealing piece, the venturi tubes are correspondingly assembled in the microfluidic channels, the diameter adjusting pieces are arranged in the microfluidic channels in the radial direction of the microfluidic channels, the output ends of the diameter adjusting pieces are correspondingly arranged on the venturi tubes so as to adjust the impact force of liquid medicine, the degradation sealing pieces are in sealing fit with the inlet ends of the venturi tubes, and the plugging sealing pieces are in sealing fit with the outlet ends of the venturi tubes so as to control the opening and closing of the venturi tubes based on the impact force of the liquid medicine; The targeted release mechanism is assembled inside the bracket framework, the input end of the targeted release mechanism is communicated with the output end of the venturi tube, the output end of the targeted release mechanism comprises a plurality of microtubules arranged in an array, and the microtubules extend out of the bracket framework to directionally release the liquid medicine. Preferably, the support skeleton comprises an inner through pipe and an outer support net, the outer support net is coaxially sleeved outside the inner through pipe, the outer support net is of a hollowed-out net-shaped support structure, and the microfluidic medicine storage bin assembly, the intelligent driving assembly and the targeting release mechanism are all arranged between the inner through pipe and the outer support net. Preferably, the support skeleton further comprises a support airbag, the support airbag is of an annular structure, the two support airbags are respectively coaxially sleeved at two ends of the inner through pipe, the two support airbags are connected through an air pipe, one support airbag is communicated with an inflation pipe, and the inflation end of the inflation pipe extends out of the inner through pipe so as to inflate the two through the pressure inflation balls which are detachably connected. Preferably, the medicine storage bin is of an arc structure and is attached and fixed on the inner through pipe, the medicine storage bin is positioned between the two supporting air bags, the outer edge end of the medicine storage bin is fixedly connected with the inner side of the outer supporting net so that the outer supp