CN-122005161-A - Antibacterial anti-inflammatory bile duct support

CN122005161ACN 122005161 ACN122005161 ACN 122005161ACN-122005161-A

Abstract

The invention provides an antibacterial anti-inflammatory bile duct support, which belongs to the technical field of biological materials and comprises a support body, wherein the support body comprises a plurality of wavy rings arranged along a first direction, a connecting piece connected with a support piece, a drainage channel is formed by the wavy rings, a functional coating is arranged on the support body, and the functional coating comprises a ternary compound formed by self-assembly of metal ions, polyphenol compounds and quaternary ammonium compounds. The bile duct bracket can effectively dilate a narrow biliary tract, restore the normal flow of bile, keep the bile duct unobstructed, and realize multiple synergistic effects of resisting tumor progression, bacterial infection and inflammation.

Inventors

Zan rui
SUO TAO
HUANG RAN
LI YANG
YANG SHI
MAO QIANPING
WANG GUIQING
SUN SHENG

Assignees

义乌中复新材料科技有限公司

Dates

Publication Date: 20260512
Application Date: 20260206

Claims (10)

1. An antibacterial anti-inflammatory bile duct stent, comprising: The bracket comprises a bracket body, a plurality of connecting pieces and a plurality of connecting pieces, wherein the bracket body comprises a plurality of wavy rings arranged along a first direction, the connecting pieces are connected with the wavy rings, and a drainage channel is formed by the wavy rings; The stent body is provided with a functional coating, and the functional coating comprises a ternary complex formed by self-assembly of metal ions, polyphenol compounds and quaternary ammonium compounds.
2. The antibacterial anti-inflammatory bile duct stent according to claim 1, wherein an anti-displacement structure is arranged on the stent body, and the anti-displacement structure is provided with the functional coating.
3. The antibacterial anti-inflammatory bile duct stent of claim 2, wherein the displacement preventing structure is a plurality of barbs arranged on the outer surface of the stent body, and the barbs are degradable magnesium alloy biological material parts.
4. The antibacterial anti-inflammatory bile duct stent of claim 1, wherein the functional coating further comprises a polydopamine coating, the ternary complex being supported on the stent body by the polydopamine coating.
5. The antibacterial anti-inflammatory bile duct stent according to any one of claims 1 to 4, wherein the wavy ring is a hollow tube, the hollow tube is filled with antibacterial anti-inflammatory drugs, and drug release micropores are formed in the wall of the hollow tube.
6. The anti-bacterial anti-inflammatory bile duct stent according to any of claims 1-4, wherein said undulating ring comprises a plurality of peak segments and a plurality of trough segments, the peak segments of each two of said undulating rings being disposed adjacent to each other, said connector being connected to at least one of the peak segments of at least two of said undulating rings.
7. The antibacterial anti-inflammatory bile duct stent of any of claims 1 to 4, wherein the stent body is a magnesium alloy elastic member.
8. The antibacterial anti-inflammatory bile duct stent according to any of claims 1 to 4, wherein the stent body is a right circular cylinder or one or both ends are bell mouth shaped.
9. The antibacterial anti-inflammatory bile duct stent according to claim 1, wherein the metal ion is at least one selected from the group consisting of Cu 2+ 、Fe 2+ 、Fe 3+ 、Mn 2+ 、Zn 2+ 、Mg 2+ , and/or, The polyphenols compound is selected from at least one of gallic acid, epicatechin gallate, quercetin, curcumin, tannic acid, and/or, The quaternary ammonium salt compound is at least one selected from dodecyl trimethyl ammonium bromide, hexadecyl trimethyl ammonium bromide and benzalkonium chloride.
10. The antibacterial anti-inflammatory bile duct stent according to claim 1 or 9, wherein the mass ratio of the metal ions is 5% -50%, the mass ratio of the polyphenols is 5% -60%, and the mass ratio of the quaternary ammonium salt is 5% -60% based on the total mass of the raw materials of the ternary complex.

Description

Antibacterial anti-inflammatory bile duct support Technical Field The invention relates to the technical field of biological materials, in particular to an antibacterial anti-inflammatory bile duct bracket. Background Malignant obstruction of bile duct is a critical disorder commonly seen in clinic, and is often caused by compression or infiltration of malignant tumors such as bile duct cancer, pancreatic cancer and the like. One of its most serious complications is acute suppurative obstructive cholangitis (Acute Obstructive Suppurative Cholangitis, AOSC), the pathological course of which includes biliary obstruction, cholestasis, bacterial infection and severe inflammatory reactions. Currently, implantation of biliary stents under endoscopic retrograde cholangiography (Endoscopic Retrograde Cholangiopancreatography, ERCP) is the treatment of choice to relieve obstruction and drain bile, but there is no effective treatment to address these tumor progression, bacterial infection and inflammation at the same time. Disclosure of Invention The invention provides an antibacterial anti-inflammatory bile duct stent which can effectively treat malignant biliary tract obstruction caused by bile duct cancer, liver cancer or other metastatic cancers and can cooperatively play the roles of resisting tumor, bacteria and inflammation so as to enhance the tumor treatment effect. In order to solve the above problems, the present invention provides an antibacterial anti-inflammatory bile duct stent, comprising: The bracket comprises a bracket body, a plurality of connecting pieces and a plurality of connecting pieces, wherein the bracket body comprises a plurality of wavy rings arranged along a first direction, the connecting pieces are connected with the wavy rings, and a drainage channel is formed by the wavy rings; The stent body is provided with a functional coating, and the functional coating comprises a ternary complex formed by self-assembly of metal ions, polyphenol compounds and quaternary ammonium compounds. As one embodiment of the invention, the support body is provided with an anti-displacement structure, and the anti-displacement structure is provided with the functional coating. As one embodiment of the invention, the anti-displacement structure is a plurality of barbs arranged on the outer surface of the bracket body, and the barb structure is a degradable magnesium alloy biological material part. As an embodiment of the present invention, the functional coating further includes a polydopamine coating, and the ternary complex is supported on the stent body through the polydopamine coating. As one embodiment of the invention, the wavy ring is a hollow tube, the hollow tube is filled with antibacterial and anti-inflammatory drugs, and drug release micropores are arranged on the wall of the hollow tube. As one embodiment of the present invention, the wave ring includes a plurality of peak segments and a plurality of trough segments, the peak segments of each two wave rings are disposed adjacent to each other, and the connecting member is connected to at least one of the peak segments of at least two wave rings. As an embodiment of the present invention, the bracket body is a magnesium alloy elastic member. As an embodiment of the present invention, the bracket body is a right circular cylinder, or one or both ends are bell mouth-shaped. As an embodiment of the present invention, the metal ion is selected from at least one of Cu 2+、Fe2+、Fe3+、Mn2+、Zn2+、Mg2+, and/or, The polyphenols compound is selected from at least one of gallic acid, epicatechin gallate, quercetin, curcumin, tannic acid, and/or, The quaternary ammonium salt compound is at least one selected from dodecyl trimethyl ammonium bromide, hexadecyl trimethyl ammonium bromide and benzalkonium chloride. According to one embodiment of the invention, the mass ratio of the metal ions is 5% -50%, the mass ratio of the polyphenols is 5% -60% and the mass ratio of the quaternary ammonium salt is 5% -60% based on the total mass of the raw materials of the ternary complex. Due to the technical scheme, the invention has at least the following beneficial effects: The antibacterial anti-inflammatory bile duct bracket provided by the embodiment of the invention consists of the wavy ring, and the structure has good flexibility and elasticity, can conform to the bending and changing of bile ducts in the placing process, provides enough supporting force, can effectively dilate a narrow biliary duct, recovers the normal flow of bile, and keeps the bile duct unobstructed, thereby relieving the symptoms of patients and improving the quality of life. In addition, the surface of the stent body is provided with a functional coating, the functional coating comprises a ternary complex formed by self-assembly of metal ions, polyphenol compounds and quaternary ammonium salt compounds, and the coating generates multiple synergistic effects of resisting tumor progression, bacteri