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CN-122005199-A - Digital twin and pneumatic self-cleaning-based portable intelligent constant-temperature eye atomization drug delivery system

CN122005199ACN 122005199 ACN122005199 ACN 122005199ACN-122005199-A

Abstract

The invention discloses a digital twin and pneumatic self-cleaning-based portable intelligent constant-temperature eye atomization drug delivery system, and relates to the technical field of ophthalmic medical appliances. The system comprises a portable host unit and an end effector worn on eyes, wherein a micro-channel heating module, a gas-liquid separation buffer cavity and a microporous piezoelectric atomizing sheet are integrated in the end effector, and a unidirectional clean air compensating valve with a microporous sterilization filter membrane is arranged on the side wall of the buffer cavity. When the drug administration is finished, the system executes a pneumatic bridge-cut-off self-cleaning program, the precise delivery pump generates reverse negative pressure to open the air compensating valve, clean air is introduced to cut off a liquid medicine bridge on the inner side surface of the micropore piezoelectric atomizing sheet, residual liquid medicine is retracted to a deep position, and crystallization blockage and back suction pollution are physically prevented. Meanwhile, a tear film digital twin model and a reinforcement learning algorithm are built in the central control unit, the tear film rupture time is predicted in real time by combining multidimensional sensor data, and the drug administration strategy is optimized in a self-adaptive mode according to subjective feedback of a user. The invention effectively solves the problems of cold stimulation, easy blockage of the nozzle, reverse pollution, control lag and the like in the prior art, and realizes constant-temperature, sanitary, accurate and personalized ocular administration.

Inventors

  • TIAN XINRAN
  • REN JIANLI

Assignees

  • 华融精控(北京)科技有限公司
  • 北京谊和医疗科技有限公司

Dates

Publication Date
20260512
Application Date
20260130

Claims (10)

  1. 1. A digital twin and pneumatic self-cleaning based portable intelligent constant-temperature eye atomization drug delivery system comprises a portable host unit (10), wherein a drug storage unit (100), a precise delivery pump (200), a central control unit (500) and a rechargeable power supply module (800) are integrated in the portable host unit, the input end of the precise delivery pump (200) is connected with the drug storage unit (100), the portable intelligent constant-temperature eye atomization drug delivery system further comprises an end effector (300) which is arranged to be worn near the eyes of a patient and is connected with the output end of the precise delivery pump (200) through a drug liquid conduit (400), and a sensor module (600) and a human-computer interaction terminal (700) which are connected with the central control unit (500); The micro-fluidic channel self-cleaning device is characterized in that the end effector (300) comprises a shell, a micro-fluidic channel heating module (310), a gas-liquid separation buffer cavity (320) and a micro-pore piezoelectric atomizing sheet (330), wherein the micro-fluidic channel heating module (310) is wrapped on the outer side of a liquid medicine channel, the gas-liquid separation buffer cavity (320) is positioned between the micro-fluidic channel heating module and the micro-pore piezoelectric atomizing sheet (330) and is used for temporarily storing heated liquid medicine, a one-way clean air supplementing valve (340) is arranged on the side wall of the gas-liquid separation buffer cavity (320), the one-way clean air supplementing valve is communicated with the outside atmosphere and the inside of the buffer cavity, a micro-pore sterilizing filter membrane (342) is integrated in a valve body, the central control unit (500) is configured to control the precise conveying pump (200) to execute a 'pneumatic bridge-breaking self-cleaning program' when an administration command is finished, the precise conveying pump (200) is driven to generate reverse negative pressure, so that the one-way air supplementing valve (340) is opened due to pressure difference, external air is filtered by the micro-pore sterilizing filter membrane and then enters the gas-liquid separation buffer cavity (320), the introduced air flow is utilized to cut off the inner side surface of the micro-pore sterilizing filter membrane (330) to form a micro-fluidic channel to be deep; The sensor module (600) comprises an environment sensing unit (610) arranged on the surface of the host unit (10) and an eye surface physiological sensor group (620) arranged on the inner side of the end effector (300), wherein the eye surface physiological sensor group (620) comprises a non-contact infrared eye surface temperature sensor (621) and a capacitive biosensor (622) for detecting instant eyes and tear overflow; The central control unit (500) is internally provided with a tear film digital twin model and a reinforcement learning algorithm module, and is configured to (a) receive data of the sensor module (600) to calculate a predicted tear evaporation rate, dynamically adjust the flow rate of the precise delivery pump (200), the power of the micro-channel heating module (310) and the start and stop of the micro-porous piezoelectric atomizing sheet (330) in combination with feedback of the sensor module (600), (b) receive a user subjective feedback instruction from the man-machine interaction terminal (700) through the wireless communication module, and (c) adaptively correct key parameters in the tear film digital twin model based on the user subjective feedback instruction to construct a personalized drug delivery model.
  2. 2. The system according to claim 1, wherein the microporous piezoelectric atomizing sheet (330) is a metal microporous plate driven by an annular piezoelectric ceramic vibrator with a central opening, the microporous aperture of the microporous plate is 3-8 μm, the inner side surface of the microporous plate is coated with a nano super-hydrophobic coating to reduce the adhesion force of liquid drops in cooperation with the pneumatic bridge-cutoff self-cleaning procedure, and the introduced air of the unidirectional clean air supplementing valve (340) is blown laterally and laterally towards the inner side surface of the microporous piezoelectric atomizing sheet (330).
  3. 3. The system of claim 1, wherein the central control unit (500) has a tear film digital twin model and a reinforcement learning algorithm module built-in, the tear film digital twin model configured to receive the ambient temperature collected by the sensor module (600) Relative humidity of environment Eye surface temperature And calculates a "predicted tear evaporation rate" according to the following tear evaporation kinetic formula ”: Wherein, the For a predetermined mass transfer coefficient, For an effective ocular surface evaporation area, Is the temperature The value of saturated water vapor pressure is approximately determined by an Antoine equation, and the tear film digital twin model also calculates the predicted tear film rupture time according to the following tear film stability formula ”: Wherein, the Is the critical rupture thickness constant of the tear film, For the last instant interval of time, The coefficient is supplemented for the secretion of tears, Is a lipid layer stability correction factor; the reinforcement learning algorithm module adopts Q-learning or SARSA strategy to realize current environmental state And taking as input the administration action, the environmental state Comprises And The administration action Comprises a flow rate, a time length and a temperature, and is based on a reward signal fed back by the man-machine interaction terminal (700) Iteratively updating the action cost function of the dosing strategy according to the following bellman update formula : Wherein, the In order for the rate of learning to be high, As a discount factor, the number of times the discount is calculated, In order to perform the next state after the action, Is the maximum expected value in the next state.
  4. 4. The system of claim 3, wherein the opening pressure threshold of the one-way clean air make-up valve (340) is set at 0.5kPa to 1.5kPa, the microporous sterilizing filter membrane (342) Is used for blocking bacteria and particles from entering the buffer cavity.
  5. 5. The system of claim 1, wherein the precision transfer pump (200) is a high-precision piezoelectric pump or a peristaltic pump driven by a stepper motor, and in the pneumatic bridge-cutoff self-cleaning procedure, the precision transfer pump outputs a pulse negative pressure waveform with a frequency of 5-20 Hz to generate a fluid oscillation effect to assist in stripping crystal residues at the microporous piezoelectric atomizer plate.
  6. 6. The system of claim 3, wherein the human-machine interaction terminal (700) provides a multi-level subjective comfort assessment interface, and wherein the reinforcement learning algorithm module maps the user's score to a reward signal Wherein "comfort" is mapped to a positive prize value, and "dryness" or "foreign body sensation" is mapped to a negative prize value, and when reflective tear flow is detected by the biosensor, it is mapped to a strong negative prize value.
  7. 7. The system of claim 1, wherein the medical fluid conduit (400) is of a double-layer coaxial structure, the inner tube is used for transporting medical fluid, and an annular gap between the inner tube and the outer tube is filled with a phase change heat storage material or an aerogel heat insulation layer for maintaining temperature stability of the medical fluid during transportation.
  8. 8. A system according to claim 3, wherein the central control unit is loaded with a general purpose in an initial state The parameter value is dynamically adjusted by the reinforcement learning algorithm module according to the reward signal history of a specific user in the running process And Parameter values to achieve personalized calibration of the digital twin model.
  9. 9. The system of claim 1, wherein the micro-channel heating module (310) comprises a flexible PTC heating film (311) surrounding the medical fluid channel and an insulating layer (312) surrounding the flexible PTC heating film (311), the micro-channel heating module (310) being configured such that when the pneumatic bridge cut-off self-cleaning procedure is started, the micro-channel heating module (310) maintains a heated state for a certain time to dry the medical fluid channel.
  10. 10. The system according to claim 1, wherein the housing of the portable host unit (10) is provided with a wearing connection structure, the system is configured in any wearing form of (a) an ear-hanging structure, wherein after the host unit (10) is attached to the ear of a patient in an arc shape, the end effector extends to the front of the eye surface through a semi-rigid gooseneck, (b) a split hanging structure, wherein the host unit (10) is provided with a back clip or a rope hanging hole and is configured to be fixed at the collar or the waistband of the patient, the liquid medicine conduit is an anti-winding silicone tube with adjustable length, and (c) a glasses frame integrated structure, wherein the host unit (10) is embedded in the inside of a glasses leg of the glasses frame, and the end effector extends to the nose pad or the edge of a glasses frame.

Description

Digital twin and pneumatic self-cleaning-based portable intelligent constant-temperature eye atomization drug delivery system Technical Field The invention relates to the technical field of medical equipment and intelligent drug delivery, in particular to a digital twin and pneumatic self-cleaning based portable intelligent constant-temperature eye atomization drug delivery system. Background Dry eye and post-ocular care require long-term and frequent delivery of medical fluids to the eye. The existing portable device (such as CN 219700291U) mainly adopts a mode of directly pushing the liquid medicine by a pump driving piston. The technology has the obvious defects of cold stimulation and low absorptivity that the liquid medicine at room temperature is directly dripped into the ocular surface to cause instantaneous cold shock, so that the liquid medicine is flushed away by reflective lacrimation. And the traditional liquid drop volume is far beyond the conjunctival sac capacity, so that overflow waste is serious. Lack of environmental prejudgement, which is to rely on eye state feedback only to be a hysteresis response, and can not intervene in advance when entering a dry environment. The system lacks individuation adaptation, the sensitivity difference of different patients to dryness is huge, and the existing system adopts a fixed algorithm and cannot meet individuation requirements. Hygienic risk is that residual liquid medicine at the tail end of the catheter is easy to crystallize and block the nozzle or bacteria are bred. The prior patent such as CN108938187A (wet room glasses) adopts a glasses leg to store water and heat to generate steam, or CN113230504A adopts a long pipeline to convey fog. The common problems of the schemes are that mist is easy to condense into water drops in a long pipeline, the dosage is inaccurate, and the tail end of the pipeline is moist for a long time, so that bacteria are easy to breed. Existing devices are also based on simple threshold control (e.g., detecting a blink > X times, i.e., spraying). However, the sensitivity of different patients to the environment is different, a single rule cannot accommodate the comfort requirement of "thousand people thousand sides" and lacks the ability to actively predict tear film state. Disclosure of Invention The invention aims to solve the problems and provides a systematic solution, wherein the problems are solved by an intelligent eye administration system with functions of constant-temperature atomization administration, environment active sensing, negative pressure self-cleaning and man-machine interaction self-adaptive learning. The specific technical scheme is as follows: The invention provides a digital twin and pneumatic self-cleaning-based portable intelligent constant-temperature eye atomization drug delivery system, which comprises a portable host unit, an end effector, a sensor module, a man-machine interaction terminal, a control module and a control module, wherein the portable host unit is internally integrated with a drug storage unit, a precise delivery pump, a central control unit and a chargeable power module; The end effector comprises a shell, a micro-flow channel heating module, a gas-liquid separation buffer cavity and a micro-pore piezoelectric atomizing sheet, wherein the micro-flow channel heating module is wrapped outside a liquid medicine flow channel, the gas-liquid separation buffer cavity is positioned between the micro-flow channel heating module and the micro-pore piezoelectric atomizing sheet and is used for temporarily storing heated liquid medicine, a one-way clean air supplementing valve is arranged on the side wall of the gas-liquid separation buffer cavity and is communicated with the outside atmosphere and the inside of the buffer cavity, a micro-pore sterilization filter membrane is integrated in a valve body, the central control unit is configured to control the precise conveying pump to execute a 'pneumatic bridge-cut-off self-cleaning program' when a medicine feeding instruction is finished, the precise conveying pump is driven to generate reverse negative pressure, so that the one-way clean air supplementing valve is opened due to pressure difference, the outside air enters the gas-liquid separation buffer cavity after being filtered by the micro-pore sterilization filter membrane, and the liquid medicine bridge formed on the inner side surface of the micro-pore piezoelectric atomizing sheet is cut off by using introduced air flow, and the residual liquid medicine is retracted to the depth of the micro-flow channel; The sensor module comprises an environment sensing unit arranged on the surface of the host unit and an eye surface physiological sensor group arranged on the inner side of the end effector, wherein the eye surface physiological sensor group comprises a non-contact infrared eye surface temperature sensor and a capacitive biosensor for detecting transient and tear overflow; Th