CN-122005212-A - Patch containing improved release liner system

Abstract

The present invention relates to a patch containing an improved release liner for the treatment of various skin conditions.

Inventors

• Ravi Ranjit
• Michael Tallinn
• SAIN eskovic

Assignees

• 优而美公司

Dates

Publication Date

20260512

Application Date

20171229

Priority Date

20161230

Claims (20)

1. 1. A flexible patch arrangement comprising, in the following order: a flexible patch comprising: A backing having two sides, and said backing being waterproof and breathable and achieving a MVTR >500 g/m 2 /24 h, and A therapeutic adhesive composition coated on the entire face of the backing, wherein the therapeutic adhesive composition is capable of adhering to mammalian skin and comprises one or more of a hydrocolloid and a hydrogel, the therapeutic adhesive composition being in the form of a layer and the adhesive composition layer having a thicker portion at the center of the composition than at the edges of the composition layer, and A release liner that completely covers the adhesive composition, wherein the release liner comprises means for easily separating the liner into two parts, each part being in contact with the adhesive composition, wherein the means for separating the release liner into two parts is a perforation pattern or slit that partially or completely penetrates the release liner, wherein the area of the release liner is greater than the area of the flexible patch to form a grip; Wherein the flexible patch has a circular or oval shape and a diameter of 0.2 inch to 0.5 inch (5.08 mm to 12.7 mm).
2. 2. The flexible patch arrangement of claim 1, wherein the therapeutic adhesive composition further comprises a topical acne agent.
3. 3. A patch arrangement according to claim 1, wherein the two portions of the liner are of different sizes.
4. 4. A patch arrangement according to claim 1, wherein the two portions of the liner are substantially similar in size.
5. 5. The patch arrangement of claim 1, wherein the liner and the patch are different in color.
6. 6. A patch arrangement according to claim 1, wherein the arrangement is enclosed in a sealed package.
7. 7. The patch arrangement of claim 1, wherein the arrangement is encapsulated in a sealing paper or poly/plastic packaging material, or a combination thereof.
8. 8. The patch arrangement of claim 7, wherein the adhesive and packaging material are sterilizable.
9. 9. The patch arrangement of claim 1, wherein the liner comprises one or more of a polyester film, a polyolefin film, siliconized paper, or plastic laminated paper.
10. 10. The patch arrangement of claim 1, wherein the liner has a thickness of about 0.01 to about 0.5 mm.
11. 11. The patch arrangement of claim 1, wherein the backing is porous.
12. 12. The patch arrangement of claim 1, wherein the backing is closed.
13. 13. The patch arrangement of claim 1, wherein the backing has a thickness of about 0.02mm to about 1.0mm.
14. 14. The patch arrangement of claim 1, wherein the backing has a thickness of about 0.05mm to about 0.3mm.
15. 15. The patch arrangement of claim 1, wherein the backing comprises a poly cellulose film, a polyurethane film, a polyester film, a polyethylene film, a polyolefin film, or any mixture thereof.
16. 16. The patch arrangement of claim 1 wherein the therapeutic adhesive composition comprises one or more hydrocolloids selected from alginic acid and salts thereof, chitin, chitosan, pectin, cellulose ethers, cellulose esters, carboxyalkyl celluloses, hydroxyalkyl celluloses, polyvinyl alcohol, polyvinylpyrrolidone, agar and gelatin, xanthan gum, guar gum, hydrocolloids, starch, vinyl acetate copolymers, polyvinylpyrrolidone, polyvinyl alcohol, polyethylene oxide, polyacrylates, polymaleic acid, polymaleic anhydride, polyurethanes, polyureas, maltodextrins, carboxymethyl cellulose and carboxypropyl cellulose.
17. 17. The patch arrangement of claim 1, wherein the therapeutic adhesive composition comprises one or more of carboxymethyl cellulose and carboxypropyl cellulose.
18. 18. The patch arrangement of claim 1, wherein the therapeutic adhesive composition has a thickness of about 0.01mm to about 1.5 mm.
19. 19. The patch arrangement of claim 1, wherein the therapeutic adhesive composition comprises a topical acne agent, wherein the topical acne agent is selected from the group consisting of salicylic acid, resorcinol, benzoyl peroxide, sulfur, retinol, retinal, retinoic acid, alpha-hydroxy acid, vitamin C, vitamin a, hyaluronic acid, vegetable oil, coconut oil, jojoba oil, avocado oil, olive oil, hemp oil, peptides, corticosteroids, pharmaceutically acceptable salts of any of the foregoing, and any combination thereof.
20. 20. The patch arrangement of claim 19, wherein the topical acne agent is present in an amount of about 0.05% to about 10% by weight of the therapeutic adhesive composition.

Description

Patch containing improved release liner system The application is a divisional application of the application patent application with the application number 201780081812.5. Technical Field The present invention relates to a patch containing an improved release liner system for treating various skin conditions. The improved release liner system allows for quick application of the patch to the skin while minimizing the risk of damaging the patch during the process and also minimizing contact by the applicator during patch application. Background Adhesive dressings or patches are used to cover and treat different skin conditions, such as scars, wounds, insect bites, acne, eczema, herpes and warts, and may be used to mask irregularities while treating skin conditions. In addition, the adhesive dressing or patch (e.g., those containing hydrogels or hydrocolloids) is selected to promote a moist environment and may itself promote healing of the skin condition. This healing effect can be further enhanced by the use of various active ingredients. In view of the often sensitive nature of the skin area and the optimal therapeutic benefit achieved by proper placement of the dressing or patch, there is a continuing need to improve the ease and reproducibility of application of the adhesive dressing or patch to the target skin area. The present invention addresses this need by employing an improved release liner system that achieves rapid and consistently accurate positioning of an adhesive dressing or patch to a target skin area with minimal problems. The improved anti-adhesive system is particularly effective when incorporated into small, thin skin patches that previously lacked an anti-adhesive system that allowed minimal finger contact by the applicator during application, as well as lacked a way to prevent the patch from folding or bending upon itself. Disclosure of Invention One aspect of the invention is a flexible patch arrangement comprising (i) a flexible patch comprising a backing having two sides, and a therapeutic adhesive composition coated on at least a portion of one of the sides of the backing, Wherein the therapeutic adhesive composition is capable of adhering to mammalian skin, and (ii) a liner that completely covers the adhesive composition, wherein the liner comprises means for easily dividing the liner into two parts, each part being in contact with the adhesive composition. In an exemplary embodiment, the means for separating is a perforation pattern, or a slit that penetrates the liner partially or completely. In one exemplary embodiment, the two portions of the liner are different in size. In one exemplary embodiment, the two portions of the liner are substantially similar in size. In one exemplary embodiment, the area of the liner is greater than the area of the adhesive composition. In various embodiments, the adhesive composition covers 10 to 100%, such as 20 to 100%, such as 25 to 100%, such as 30 to 100%, such as 35 to 100%, such as 40 to 100%, such as 45 to 100%, such as 50 to 100%, such as 60 to 100%, such as 70 to 100%, such as 80 to 100%, such as 90 to 100% of the liner surface area. In one exemplary embodiment, the liner comprises one or more of a polyester film, a polyolefin film, siliconized paper, and plastic laminated paper. In an exemplary embodiment, the liner has a thickness of about 0.01 to about 0.5mm, such as 0.01 to 0.4mm, such as about 0.01 to 0.3mm, such as 0.05 to 0.5mm, such as 0.05 to 0.3 millimeters. In one exemplary embodiment, the backing is porous and/or penetrable. In another embodiment, the backing is closed. In a specific embodiment, the closed backing achieves a Moisture Vapor Transmission Rate (MVTR) of <100 g/m 2/24 h. In another embodiment, the backing is waterproof and breathable and achieves a MVTR >500 g/m 2/24 h. In an exemplary embodiment, the backing has a thickness of about 0.02 to about 1.0mm, such as about 0.04 to about 1.0mm, such as about 0.05 to about 1.0mm, such as about 0.02 to about 0.8mm, such as about 0.02 to about 0.5mm, such as about 0.05 to about 0.3mm. In an exemplary embodiment, the backing comprises a cellulosic fiber, a polyester fiber, a polyurethane fiber, a polyolefin fiber, a polyamide fiber, a cotton fiber, a copolyester fiber, or any mixture thereof. In another exemplary embodiment, the backing comprises a poly cellulose film, a polyurethane film, a polyester film, a polyethylene film, a polyolefin film, or any mixture thereof. In an exemplary embodiment, the therapeutic adhesive composition is a pressure adhesive composition and may include one or more of polyacrylamide, xanthan gum, guar gum, hydrocolloid, starch, vinyl acetate copolymer, polyvinylpyrrolidone, polyvinyl alcohol, polyethylene oxide, polyacrylate, polymaleic acid, polymaleic anhydride, polyurethane, polyurea, maltodextrin, carboxymethyl cellulose, and carboxypropyl cellulose. In one exemplary embodiment, the therapeutic adhesive composition includes one or more of