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CN-122005319-A - Plaque-developed tooth Zhou Kangmin whitening toothpaste and preparation method thereof

CN122005319ACN 122005319 ACN122005319 ACN 122005319ACN-122005319-A

Abstract

The invention discloses tooth Zhou Kangmin whitening toothpaste with plaque color development and a preparation method thereof, belonging to the technical field of oral care. The pH response type color developing factor is embedded in the microcapsule with the particle size of 8-20 mu m, stably exists in the paste, and only releases color under the conditions of tooth brushing shearing force and plaque acidity, and automatically fades after rinsing. Meanwhile, the triple synergistic anti-allergic system is formed by compounding potassium nitrate, bioactive glass and nano hydroxyapatite, and the blocking effect is obviously superior to that of a single component. The invention also comprises a tooth Zhou Xiuhu, a mild physical whitening and green hyposensitive preservative system, and does not contain SLS, fluorine, alcohol and nipagin ester. The stability of the product is ensured by the gradient cooling and low-temperature protection technology. The invention solves the industry problems of unstable color development, multi-component conflict and the like, can realize industrial production, and is an oral care product which integrates visual detection, multiple repair, safety and comfort and is suitable for integration.

Inventors

  • LI MINGYANG

Assignees

  • 北京名扬口腔门诊部有限公司

Dates

Publication Date
20260512
Application Date
20260226

Claims (9)

  1. 1. A plaque chromogenic toothpaste is characterized by comprising pH responsive chromogenic factors embedded in microcapsules, wherein the microcapsules comprise wall materials and a core material, the core material is a food-grade pH chromogenic dye which develops color in a pH <5.5 environment and fades in a pH >6.8 environment, the wall materials are high-molecular film-forming materials, the particle size of the microcapsules is 8-20 mu m, and the microcapsules exist in a toothpaste body stably and are broken under the action of tooth brushing shearing force to release the core material.
  2. 2. The toothpaste according to claim 1, wherein the core material is selected from at least one of gardenia blue pigment, and the wall material is selected from a gelatin-gum arabic system or a sodium alginate-chitosan system.
  3. 3. The toothpaste according to claim 1 or 2, further comprising a triple anti-sensitization system, wherein the anti-sensitization system is composed of potassium nitrate, bioactive glass and nano-hydroxyapatite in a compounding mode, the weight portion ratio of the potassium nitrate, the bioactive glass, the nano-hydroxyapatite=1, 0.5-1.5, and 1.5-2.5, and the triple anti-sensitization system has a synergistic effect, and is characterized in that the dentinal tubule blocking rate and the nerve potential inhibition rate of the triple anti-sensitization system are obviously higher than those of any single component.
  4. 4. The toothpaste of claim 1, further comprising a tooth Zhou Xiuhu system, wherein the repair system is composed of centella asiatica extract, dipotassium glycyrrhizinate, sodium hyaluronate and zinc citrate.
  5. 5. The toothpaste according to claim 1, comprising soft hydrated silica as physical abrasive and being free of sodium lauryl sulfate, free of fluoride, free of parabens preservatives.
  6. 6. The toothpaste according to claim 1, wherein the adult pattern comprises, by weight, deionized water 55.03%, sorbitol 28.00%, polyethylene glycol-8.50%, soft hydrated silica 5.00%, nano-hydroxyapatite 2.00%, bioactive glass 1.00%, sodium lauroyl sarcosinate 1.40%, microcapsule color factor 0.16%, potassium nitrate 1.00%, dipotassium glycyrrhizinate 0.10%, centella asiatica extract 0.12%, sodium hyaluronate 0.10%, zinc citrate 0.08%, xanthan gum 0.55%, guar gum 0.25%, edible essence 0.80%, WS-23 cooling agent 0.01%, stevioside 0.04%, vitamin E0.05%, 1, 2-hexanediol 0.45%, p-hydroxyacetophenone 0.36%.
  7. 7. The toothpaste according to claim 1, wherein the children's pattern comprises, by weight, 56.41% deionized water, 28.50% sorbitol, polyethylene glycol-8.20% ultra soft hydrated silica 4.80%, nano hydroxy apatite 1.80%, sodium lauroyl sarcosinate 1.10%, microcapsule color-developing factor 0.15%, dipotassium glycyrrhizinate 0.06%, centella asiatica extract 0.08%, vitamin B5.06%, xanthan gum 0.50%, guar gum 0.25%, edible essence 0.80%, stevioside 0.04%, 1, 2-hexanediol 0.40%, p-hydroxyacetophenone 0.32%.
  8. 8. A method of preparing a toothpaste according to any one of claims 1 to 7, comprising the steps of: (1) Preparing the rubber at a high temperature, namely mixing and swelling the water-based component and the thickener at a temperature of between 70 and 80 ℃ to form a rubber base; (2) Mixing at medium temperature, namely cooling to 40-50 ℃, adding the friction agent and the mineral powder, and uniformly stirring in vacuum; (3) Keeping the temperature at low temperature, namely continuously cooling to be less than or equal to 38 ℃, adding microcapsule color development factors, and controlling the stirring speed to be lower than 500rpm; (4) And (3) after-treatment, uniformly mixing, vacuum degassing, standing and curing for 24 hours, and aseptically filling and forming.
  9. 9. The method according to claim 8, wherein the microcapsule color developing factor in step (3) is prepared in advance by a complex coacervation method, and has an average particle diameter of 10 to 15 μm.

Description

Plaque-developed tooth Zhou Kangmin whitening toothpaste and preparation method thereof Technical Field The invention belongs to the technical field of oral care products, and particularly relates to toothpaste integrating plaque visual detection and multi-effect synergistic repair, in particular to toothpaste containing a specific microcapsule color development system and having synergistic stability with an anti-allergy and repair system and a preparation method thereof. Background With the promotion of national oral health consciousness, the functional compounding performance and effect visualization requirements of consumers on toothpaste products are continuously improved. However, the prior art has the following technical drawbacks: the function is single and the effect is not clear, the common cleaning toothpaste can only realize basic decontamination, can not realize visual self-inspection of bacterial plaque biomembrane, and a consumer is difficult to intuitively judge whether the tooth brushing cleaning effect reaches the standard. The anti-allergic mechanism is single, the traditional anti-allergic toothpaste mostly adopts single components, only can realize a single action path of nerve relief or small tube blocking, and is difficult to achieve both quick-acting relief and long-acting remineralization restoration. The multi-component compound has poor stability, and the problems of early leakage of the color developing agent, inactivation of the anti-allergic component, water separation, layering, pigment migration and the like easily occur when the multi-functional components such as the color developing agent, the anti-allergic agent, the whitening friction agent and the like are compounded. In particular, the existing plaque chromogenic toothpaste mostly adopts a mode of directly adding chromogenic agents such as erythrosin, anthocyanin and the like (as described in CN 110575401A), so that the chromogenic agents have poor stability in paste, and are easy to cause indiscriminate dyeing on oral soft tissues, obvious pigment residues are caused after rinsing, and the user experience is poor. Although attempts have been made to chemically modify the developer (as described in CN116251027 a), the problem of color specificity has not been fundamentally solved. The formula has strong irritation, and the conventional toothpaste mostly uses SLS as a foaming agent, so that potential irritation exists for the teeth Zhou Mingan, the people after oral surgery, children and the pregnant people. In the prior art, an integrated toothpaste product capable of simultaneously solving the problems of color development stability, multi-component compatibility, sensitization resistance, cooperativity and low irritation safety is still required to be developed. Disclosure of Invention The invention aims to overcome the defects of the prior art and provide the synergistic toothpaste which has high component compatibility, excellent long-term stability and plaque visualization and multiple repairing functions. The core technical conception of the invention is as follows: The microcapsule with specific structure, specific particle size and specific response condition is used for embedding the pH response type color developing factor, so that the pH response type color developing factor is stable and does not leak in the toothpaste body for a long time, and can accurately release and develop color only under the conditions of tooth brushing shearing force and oral plaque acidity, and the pH response type color developing factor automatically fades and does not stain after gargling. The triple synergistic anti-allergic system of potassium nitrate, bioactive glass and nano hydroxyapatite is constructed, and the blocking rate and the analgesic effect of far exceeding the single component are realized through the synergistic interaction among the components. The stability problem during the compounding of the thermosensitive microcapsule, the mineral powder and the functional components is solved by the gradient cooling and low-temperature protection preparation process, and the industrialized stable production is realized. Plaque visualization chromogenic system Comprises microcapsule embedding pH response type chromogenic factor. The microcapsule is composed of a wall material and a core material, wherein the core material is selected from food-grade pH color-changing dye such as xylenol orange, anthocyanin derivative or curcumin, and is capable of developing color in a plaque acidic environment with pH of less than 5.5 and automatically fading in a neutral water environment with pH of more than 6.8, and the wall material is prepared from gelatin-Arabic gum or sodium alginate-chitosan by a complex coacervation method, so that the microcapsule has good film forming property and moderate strength. The average grain diameter of the microcapsule is 8-20 μm, the thickness of the wall material is 0.5-2 μm, the microcapsule is k